ChemicalBook > CAS DataBase List > Doxifluridine

Doxifluridine

Product Name
Doxifluridine
CAS No.
3094-09-5
Chemical Name
Doxifluridine
Synonyms
flutron;5'-DFUR;5'DFURD;furtulon;AMC 0101;5-F-5‘-dU;RO-21-9738;5-cl-5'-dU;Doxifluidine;DOXIFLURIDINE
CBNumber
CB4461786
Molecular Formula
C9H11FN2O5
Formula Weight
246.19
MOL File
3094-09-5.mol
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Doxifluridine Property

Melting point:
188-192 °C(lit.)
alpha 
D25 +18.4° (c = 0.419 in water)
Density 
1.3751 (estimate)
refractive index 
20 ° (C=1, H2O)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
7.4(at 25℃)
color 
White
Merck 
14,3437
CAS DataBase Reference
3094-09-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-24/25
WGK Germany 
2
RTECS 
YU7526000
Hazard Note 
Irritant
HazardClass 
IRRITANT, IRRITANT-HARMFUL
HS Code 
29349990
Toxicity
LD50 (14 day) in mice or rats (mg/kg): >1000 i.v.: >2000 s.c.; in male, female mice, male, female rats (mg/kg): >5000, >5000, 3471, 3390 orally (Shimizu)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
F8791
Product name
5-Fluoro-5′-deoxyuridine
Packaging
25MG
Price
$86.6
Updated
2023/06/20
Sigma-Aldrich
Product number
Y0001644
Product name
Capecitabine impurity B
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
Y0001644
Price
$218
Updated
2023/06/20
Sigma-Aldrich
Product number
F8791
Product name
5-Fluoro-5′-deoxyuridine
Packaging
100MG
Price
$267
Updated
2023/06/20
Sigma-Aldrich
Product number
F8791
Product name
5-Fluoro-5′-deoxyuridine
Packaging
250MG
Price
$466
Updated
2023/06/20
Sigma-Aldrich
Product number
PHR2850
Product name
5′-deoxy-5-fluorouridine
Purity
certified reference material, pharmaceutical secondary standard
Packaging
50MG
Price
$452
Updated
2022/05/15
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Doxifluridine Chemical Properties,Usage,Production

Description

Doxifluridine is a prodrug derivative of 5-fluorouracil (5-FU). As an antineoplastic it is more potent than 5-FU in the treatment of breast, stomach, colon and rectal cancers.

Chemical Properties

White Solid

Originator

Hoffmann-LaRoche (USA)

Uses

A prodrug of 5-Flurouridine. A fluorinated pyrimidine nucleoside with cytostatic activity

Uses

An antitumor agent efficient in tumors, cell lines or in fibroblasts tranformed by H-ras or trk oncogenes. A metabolite of Capecitabine

Uses

antineoplastic, pyrimidine antimetabolite

Uses

5’-Deoxy-5-fluorouridine is a metabolite of the chemotherapeutic agent Capecitabine (C175650). 5’-Deoxy-5-fluorouridine is an antitumor agent efficient in tumors, cell lines or in fibroblasts tranformed by H-ras or trk oncogenes.

Definition

ChEBI: A pyrimidine 5'-deoxyribonucleoside that is 5-fluorouridine in which the hydroxy group at the 5' position is replaced by a hydrogen. It is an oral prodrug of the antineoplastic agent 5-fluorouracil. Designed to circumvent the rapid degradation of 5-fluoro racil by dihydropyrimidine dehydrogenase in the gut wall, it is converted into 5-fluorouracil in the presence of pyrimidine nucleoside phosphorylase.

brand name

Furtulon

Biochem/physiol Actions

Doxifluridine is an antitumor agent efficient in tumors, cell lines or in fibroblasts transformed by H-ras or trk oncogenes. Possesses anticachectic activity which is independent of its antiproliferative activity.

Doxifluridine Preparation Products And Raw materials

Raw materials

Palladium carbon fine chemical catalyzer p-Toluenesulfonic acid monohydrate Ethyl acetate Triphenylantimony Iodomethane 2,2-Dimethoxypropane

Preparation Products

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Doxifluridine Suppliers

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View Lastest Price from Doxifluridine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
5-Fluoro-5′-deoxyuridine 3094-09-5
Price
US $0.00/g
Min. Order
1g
Purity
≥98.0%
Supply Ability
10kg/month
Release date
2021-09-28
Hong Kong Tiansheng New Material Trading Co., Ltd
Product
Doxifluridine 3094-09-5
Price
US $19.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100tons
Release date
2021-12-06
Zhuozhou Wenxi import and Export Co., Ltd
Product
Doxifluridine 3094-09-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

3094-09-5, DoxifluridineRelated Search:

5-Fluorouridine Chenodeoxycholic acid 1-beta-D-Arabinofuranosyluracil Ursodeoxycholic acid 5-Fluorouracil DL-PHENYLEPHRINE HYDROCHLORIDE Trifluridine Floxuridine 3'-O-(5'-Deoxy-α-D-ribofuranosyl) Capecitabine 5'-Deoxy-5-fluorocytidine 2'-O-(5'-Deoxy-β-D-ribofuranosyl) Capecitabine 5'-deoxy-5-fluore-N-[(pentoyloxy)carbonyl]cytidine 2',3'-diacetate CAPECITABINE related substance USP 5'-Deoxy-5-fluoro-N-[(2-methylbutoxy)carbonyl]cytidine alpha-Capecitabine 2',3'-Di-O-acetyl-5'-deoxy-5-fuluro-D-cytidine 5'-Deoxy-5-fluoro-N4-(isopentyloxycarbonyl)cytidine uridine diphosphate glucose {= UDP-glucose}

  • 5’-deoxy-5-fluoro-uridin
  • Doxifluridine/5-Fluoro-5′-deoxyuridine
  • 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyl-oxolan-2-yl]-5-fluoro-pyrimidine-2,4-dione
  • 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyloxolan-2-yl]-5-fluoropyrimidine-2,4-dione
  • 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyl-tetrahydrofuran-2-yl]-5-fluoro-pyrimidine-2,4-quinone
  • Capecitabine Related Compound B (20 mg) (5'-deoxy-5-fluorouridine)
  • 5μdFUrd, Doxifluridine
  • 5μdFUrd, 5-Fluoro-5μ-deoxyuridine
  • 5’-Deoxy-5-fluomuridine
  • 2,4(1H,3H)-Pyrimidinedione, 1-(5-deoxy-b-D-ribofuranosyl)-5-fluoro-
  • 5Urd, 5-Fluoro-5deoxyuridine
  • URIDINE,5''-DEOXY-5-FLUORO
  • 1-[(2s,3s,4r,5s)-3,4-dihydroxy-5-methyltetrahydrofuran-2-yl]-5-fluoropyrimidine-2,4(1h,3h)-dione
  • flutron
  • furtulon
  • Doxifluridine 3094-9-5
  • 1-(5-Deoxy-beta-D-ribofuranosyl)-5-fluorouracil
  • 5’dUrd, 5-Fluoro-5’-deoxyuridine, 5’-DFUR, Doxifluridine
  • 5'-dFUrd Doxifluridine 1-(5-Deoxy-beta-D-ribofuranosyl)-5-fluorouracil
  • Doxifluridine(Ro 21-9738)
  • CAPECITABINE related substance USP B
  • Capecitabine Impurity 16（Capecitabine EP Impurity B）
  • 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyl-2-oxolanyl]-5-fluoropyrimidine-2,4-dione
  • RO-21-9738
  • (+)-5-FLUORO-5'-DEOXYURIDINE
  • 5-FLUORO-5'-DEOXYURIDINE
  • 5'-DEOXY-5-FLUOROURIDINE
  • 5'-DEOXYFLUOROURIDINE
  • 5'-DFUR
  • 5'DFURD
  • DOXIFLURIDINE
  • MURINE RECOMBINANT
  • Doxifluridine (furtulon)
  • DOXIFLUIRDINE
  • 5'-Deoxy-fluorouridine(DFUR)/Doxifluridine
  • (+)-5-FLUORO-5'-DEOXYURIDINE 97%
  • 5-FLURO-5’-DEOXYURIDINE
  • 5Deoxy-5-fluorouridine, 5DFUR, 5dFUrd, Ro-21-9738
  • Doxifluidine
  • DOXIFLURIDINE(SUBJECTTOPATENTFREE)
  • (+)-5-Fluoro-5'-deoxyuridine98%
  • 5-Fluorodesoxyuridine
  • Uridine, 5'-deoxy-5-fluoro- (8CI, 9CI)
  • 5-FLUORO-5''-DEOXYURIDINE / DOXIFLURIDINE / 5''-DEOXY-FLUOROURIDINE
  • (+)-Doxifluridine, (+)-1-(beta-D-5'-Deoxyribofuranosyl)-5-fluorouracil
  • 5-F-5‘-dU
  • 5'-DFUR-13C5 (5'-Deoxy-5-fluorouridine, Doxifluridine-13C5)
  • AMC 0101
  • 5-cl-5'-dU
  • Doxifluridine, >=98.5%
  • Capecitabine USP RC B
  • Doxifluridine Doxifluridine
  • Capecitabine Impurity B
  • 5'-Deoxy-5-fluorouridine&gt
  • Capecitabine EP Impurity B (5'-DFUR, Doxifluridine)
  • 5’-deoxy-5-fluorouridine, Doxifluridine 5'-DFUR
  • Doxifluridine USP/EP/BP
  • Capecitabine EP Impurity B/ Capecitabine Related Compund B (Doxifluridine/ Deoxy-5-fluorouridine)