ChemicalBook > CAS DataBase List > 1-beta-D-Arabinofuranosyluracil

1-beta-D-Arabinofuranosyluracil

Product Name
1-beta-D-Arabinofuranosyluracil
CAS No.
3083-77-0
Chemical Name
1-beta-D-Arabinofuranosyluracil
Synonyms
ARABINOFURANOSYLURACIL;Ara-Ur;arauridine;Spongouridine;Uracyl Arabinoside;1-β-D-Arabinofuranosyluracil;URACIL-1-BETA-D-ARABINOFURANOSIDE;ARA-U;NSC 68928;Uracil 1-
CBNumber
CB8698876
Molecular Formula
C9H12N2O6
Formula Weight
244.2
MOL File
3083-77-0.mol
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1-beta-D-Arabinofuranosyluracil Property

Melting point:
220-222°C
storage temp. 
-20°C
solubility 
Methanol (Slightly), Water (Slightly)
form 
Powder
pka
pK1:9.30 (25°C)
Density 
1.674±0.06 g/cm3(Predicted)
color 
White to Off-white
biological source
synthetic (organic)
Water Solubility 
water: 50mg/mL, clear, colorless
BRN 
28749
Major Application
pharmaceutical
InChI
InChI=1/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7+,8-/s3
InChIKey
DRTQHJPVMGBUCF-YEZNIHIWNA-N
SMILES
O[C@H]1[C@@H]([C@@H](CO)O[C@H]1N1C=CC(=O)NC1=O)O |&1:1,2,3,7,r|
CAS DataBase Reference
3083-77-0(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
22-24/25-36-26
WGK Germany 
3
RTECS 
YQ8818000
F 
3
HS Code 
29349990
Storage Class
13 - Non Combustible Solids
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

H341Suspected of causing genetic defects

H361Suspected of damaging fertility or the unborn child

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P281Use personal protective equipment as required.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P314Get medical advice/attention if you feel unwell.

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
U5377
Product name
Uracil 1-β-D-arabinofuranoside
Purity
lymphoma antiproliferative
Packaging
250mg
Price
$541
Updated
2025/07/31
Sigma-Aldrich
Product number
U0100000
Product name
Uracil arabinoside
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
60 mg
Price
$156
Updated
2025/07/31
Sigma-Aldrich
Product number
PHR3260
Product name
Uracil Arabinoside
Purity
pharmaceutical secondary standard, certified reference material
Packaging
100MG
Price
$233.7
Updated
2025/07/31
Sigma-Aldrich
Product number
1705800
Product name
Uracil arabinoside
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
50mg
Price
$406
Updated
2025/07/31
TCI Chemical
Product number
A2356
Product name
1-beta-D-Arabinofuranosyluracil
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$16
Updated
2025/07/31
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1-beta-D-Arabinofuranosyluracil Chemical Properties,Usage,Production

Description

1-β-D-Arabinofuranosyluracil (ara-U) is an inactive metabolite of cytarabine . Ara-U is formed when cytarabine undergoes deamination by cytidine deaminase.

Chemical Properties

White to Off-White Solid

Uses

1-beta-D-Arabinofuranosyluracil is used for the treatment of severe acute respiratory syndrome (SARS).

Definition

ChEBI: A natural product found in Lepisorus contortus.

Synthesis

A classic synthetic method for 1-beta-D-Arabinofuranosyluracil (arabinoside Ara-U) is a two-step process using uridine as a starting material: First, uridine is heated with diphenyl carbonate in dimethylformamide (DMF) with potassium carbonate or sodium bicarbonate as a catalyst, resulting in dehydration cyclization to generate the key intermediate 2,2'-anhydrouridine. Subsequently, under acidic conditions (e.g., using 2 N HCl), hydrolysis occurs, causing nucleophilic ring-opening of the dehydration bond and introducing a β-hydroxyl group at the C-2' position, ultimately yielding the target product Ara-U.

References

[1] DI LIANG . Simultaneous determination of 1-β-d-Arabinofuranosylcytosine and two metabolites, 1-β-d-Arabinofuranosyluracil and 1-β-d-Arabinofuranosylcytosine triphosphate in leukemic cell by HPLC-MS/MS and the application to cell pharmacokinetics[J]. Journal of Chromatography B, 2014, 962: Pages 14-19. DOI: 10.1016/j.jchromb.2014.05.003
[2] YOUCEF MEHELLOU . Phosphoramidates of 2′-β-d-arabinouridine (AraU) as phosphate prodrugs; design, synthesis, in vitro activity and metabolism[J]. Bioorganic & Medicinal Chemistry, 2010, 18 7: Pages 2439-2446. DOI:10.1016/j.bmc.2010.02.059.

1-beta-D-Arabinofuranosyluracil Preparation Products And Raw materials

Raw materials

Preparation Products

Vidarabine
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1-beta-D-Arabinofuranosyluracil Suppliers

Americas 1 Australia 1 Belgium 2 Canada 3 China 366 Europe 3 France 2 Germany 13 India 15 Italy 3 Japan 2 Poland 1 Russia 1 South Korea 1 Switzerland 3 The Netherlands 1 United Kingdom 15 United States 65 Global 498
Xinxiang Meilin Biotechnology Co., LTD
Tel
15737397775; 15737397775
Email
970007865@qq.com
Country
China
ProdList
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Jiangsu Xinderui Pharmaceutical Technology Co., Ltd
Tel
18861302055;0518-0518-80639699 18861302055;15633631335
Email
shangqingjin@xdrpharm.com;3596610544@QQ.com
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China
ProdList
24
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Jiangxi Yuanxing Biomedical Technology Co., Ltd.
Tel
13642377995
Email
258676831@qq.com
Country
China
ProdList
223
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Xiangyang Meijun Machinery Technology Testing Co., Ltd.
Tel
13774177198
Email
qjuyd@126.com
Country
China
ProdList
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microBioSyn Biotech Co,. Ltd.
Tel
153-0048-7802 15300487802
Email
jlin@microbiosyn.com
Country
China
ProdList
258
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58
Zhengzhou Youyu Enzyme Pharmaceutical Technology Co., Ltd
Tel
13526582427
Email
599157217@qq.com
Country
China
ProdList
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58
Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2208
Advantage
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J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
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Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
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INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3572
Advantage
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View Lastest Price from 1-beta-D-Arabinofuranosyluracil manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Arabinofuranosyluracil 3083-77-0
Price
US $0.00/Kg/Drum
Min. Order
1g
Purity
98%min
Supply Ability
100kgs
Release date
2021-08-03
Henan Aochuang Chemical Co.,Ltd.
Product
1-beta-D-Arabinofuranosyluracil 3083-77-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-29
Hangzhou Verychem Science And Technology Co.Ltd
Product
1-β-D-Arabinofuranosyluracil 3083-77-0
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
1 tons
Release date
2024-10-21

3083-77-0, 1-beta-D-ArabinofuranosyluracilRelated Search:

Floxuridine Doxifluridine Vidarabine monophosphate Cytarabine Vidarabine Trifluridine THYMINE-BETA-D-ARABINOFURANOSIDE uridine diphosphate glucose {= UDP-glucose} sorivudine Uridine 5′-monophosphate disodium salt URIDINE-5'-DIPHOSPHORIC ACID, TRISODIUM URIDINE 5'-TRIPHOSPHATE,URIDINE-5'-TRIPHOSPHATE NA3-SALT,URIDINE 5'-TRIPHOSPHATE SODIUM SALT UDP-ALPHA-D-GALACTOSE DISODIUM SALT URIDINE 5'-DIPHOSPHORIC ACID SODIUM SALT URIDINE 5'-DIPHOSPHOGLUCURONIC ACID TRISODIUM SALT Uridine-5'-diphosphate disodium salt Uridine 5'-monophosphate Netivudine

  • 1--D-Arabinofuranosyl-2,4(1H,3H)-pyrimidinedione
  • NSC 68928
  • 1-BETA-D-ARABINOFURANOSYLURACIL
  • 1-(β-D-Arabinopyranosyl)uracil
  • uracilarabinoside
  • ARABINOSYL-URACIL
  • ARABINOFURANOSYLURACIL
  • ARA-U
  • URACIL B-D-ARABINOFURANOSIDE
  • Arabinfuranosyluracil
  • Uracil arabinofuranoside
  • 1-b-D-Arabinofuranosyluracil
  • 1-SS-D-ARABINOFURANOSYLURACIL
  • ARABINFURANOSYLURACIL, 1-SS-D-ARABINOFURANOSYLURACILCAS
  • DPONGOURIDINE [1-BETA-D-ARABINOFURANOSYLURACIL]
  • URACIL-1-BETA-D-ARABINOFURANOSIDE
  • URACIL BETA-D-ARABINOFURANOSIDE
  • 1-β-D-Arabinofuranosyluracil
  • Uracil 1-β-D-arabinofuranoside
  • 1-beta-D-arabinofuranosyl-(1H,3H)-pyrimidine-2,4-dione
  • 2'-ARAURIDINE
  • 1-beta-d-arabinofuranosyl-uraci
  • 1-[3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
  • 1-beta-D-Ribofuranosyl-2,4(1H,3H)-pyrimidinedione
  • Spongouridine
  • 1-(β-D-Arabinofuranosyl)uracil ,98%
  • Uracil Arabinoside (50 mg)
  • Uracil 1-beta-D-Arabinofuranoside Ara-U
  • 1-((2R,3S,4S,5R)-3,4-Dihydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione
  • Uracil 1-
  • 1-β-D-Arabinofuranosyluracil, Uracil 1-β-D-arabinofuranoside
  • Uracil 1-?-D-arabinofuranoside≥ 99% (HPLC)
  • 3h)-pyrimidinedione,1-beta-d-arabinofuranosyl-4(1h
  • arauridine
  • spongouridin
  • 1-[(2R,3R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione
  • Cytarabine Impurity 5(Cytarabine EP Impurity A)
  • Cytarabine EP Impurity A
  • 2,4(1H,3H)-Pyrimidinedione, 1-β-D-arabinofuranosyl-
  • Ara-Ur
  • 1-beta-D-Arabinofuranosylpyrimidine
  • Uracyl Arabinoside
  • 1-β-D-Arabinofuranosyluracil &gt
  • Arauridine, Spongouridin
  • 1-beta-D-Arabinofuranosyluracil USP/EP/BP
  • 1-(5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
  • 1-β-D-arabinofuranosyl-2,4(1H,3H)-Pyrimidinedione
  • Uracil arabinoside (U0100000)
  • discount Spongouridine
  • Arauridine, spongouridin, Impurity of aracytidine GL101972
  • Cytarabine Impurity A
  • 1- -D-Arabinofuranosyl-uridine
  • 1-beta-D-Arabinofuran
  • Arabinuridine
  • Vidarabine Impurity 2
  • 1-beta-D-Arabinofuranosylpyrimidine-2,4(1H,3H)-dione (Uracil Arabinoside)
  • 1-beta-D-Arabinofuranosyluracil, 10 mM in DMSO
  • Uracil 1-β-<sc>D</sc>-arabinofuranoside