Diquafosol

Product Name: Diquafosol
CAS No.: 59985-21-6
Chemical Name: Diquafosol
Synonyms: Up4U;Kpy 998;Dikuafoso;Diquafosol;Unii-7828vc80fj;Diquafosol [inn];Diquafosol [inn:ban];Diquafosol USP/EP/BP;Diquafosol Free Base;5'-ester with uridine
CBNumber: CB31876298
Molecular Formula: C18H26N4O23P4
Formula Weight: 790.31
MOL File: 59985-21-6.mol

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Diquafosol Property

Density: 2.044±0.06 g/cm3(Predicted)
storage temp.: Store at 0-8 °C
solubility: Water (Slightly)
pka: 0.40±0.50(Predicted)
form: Solid
color: White to Pale Beige
Stability:: Hygroscopic
InChIKey: NMLMACJWHPHKGR-BTTIJRIRNA-N

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Usbiological

Product number: 010844
Product name: Diquafosol, Sodium Salt
Packaging: 5mg
Price: $496
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0000676
Product name: UP4U
Purity: 95.00%
Packaging: 5MG
Price: $816.75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD159189
Product name: Diquafosol
Packaging: 500mg
Price: $1500
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD159189
Product name: Diquafosol
Packaging: 1g
Price: $2000
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0000676
Product name: UP4U
Purity: 95.00%
Packaging: 50MG
Price: $2194.5
Updated: 2021/12/16

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Diquafosol Chemical Properties,Usage,Production

Uses

Diquafosol is a dinucleoside derivative of uridine that acts as a selective P2Y2 receptor agonist. Diquafosol is used as a therapeutic agent in the treatment of dry eye syndrome.

Definition

ChEBI: A pyrimidine ribonucleoside 5'-tetraphosphate compound having 5'-uridinyl residues at the P1- and P4-positions.

in vivo

Diquafosol (ophthalmic solution 3%; eyedrop, four times daily for 28 days) reduces intracellular ROS levels, apoptosis, and inflammation in rat^[1].

Animal Model:	6 weeks, 160-180 g Wistar female rats (dry eye model)^[1]
Dosage:	ophthalmic solution 3%
Administration:	eyedrop, four times daily (8, 12 AM; 4, 8 PM) for 28 days
Result:	Increased the expression of phospho-Erk1/2, phospho-Akt, and phospho-p90RSK, inhibits apoptosis, decreased the IL-1β, TNF-α expression.

IC 50

P2Y2 Receptor

Diquafosol Preparation Products And Raw materials

Raw materials

Preparation Products

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Diquafosol Suppliers

Canada 1 China 97 Germany 1 India 3 United Kingdom 1 United States 5 Global 108

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15402
Advantage: 60

Nanjing Sunlida Biological Technology Co., Ltd.

Tel: 025-57798810
Fax: 025-57019371
Email: sales@sunlidabio.com
Country: China
ProdList: 3239
Advantage: 55

Finetech Industry Limited

Tel: 027-87465837 19945049750
Fax: 027-8777-2287
Email: sales@finetechnology-ind.com
Country: China
ProdList: 9637
Advantage: 58

Xishi Chemical (Shanghai) Co., Ltd.

Tel: 021-60499358 13661956116
Fax: +86 (21) 5106-9359
Email: info@cs-pharm.com
Country: China
ProdList: 223
Advantage: 58

Jinan Putubio Tech Co., Ltd.

Tel: +86 (531) 8099-2215
Fax: +86 (531) 8099-2215
Email: putubio@outlook.com
Country: China
ProdList: 1261
Advantage: 55

Pharmacodia (Beijing) Co.,Ltd

Tel: +86-400-851-9921
Fax: +86-10-82826195
Email: sales@pharmacodia.com
Country: China
ProdList: 2317
Advantage: 55

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

Roark Standards

Tel: 0755-83552066 15986688328
Fax: 0755-83552066
Email: service@roarkstandards.com
Country: China
ProdList: 1442
Advantage: 58

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View Lastest Price from Diquafosol manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Diquafosol 59985-21-6
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-25

Guangzhou Tosun Pharmaceutical Ltd

Product: Diquafosol Sodium 59985-21-6
Price: US $0.00-0.00/kg
Min. Order: 5kg
Purity: 98%-102%
Supply Ability: 200kg
Release date: 2024-12-27

Hangzhou ICH Biofarm Co., Ltd

Product: Diquafosol 59985-21-6
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 500kg
Release date: 2023-07-05

59985-21-6, DiquafosolRelated Search:

Uridine 5'-monophosphate Diquafosol Tetrasodium Uridine-5'-triphosphoric acid trisodium salt UDP-rhamnose Uridine 5'-diphosphoglucose disodium salt Uridine 5′-monophosphate disodium salt Uridine-5'-diphosphate disodium salt Diquafosol URIDINE 5'-TRIPHOSPHATE TRISODIUM SALT Diquafosol Impurity 1 uridine 5'-tetraphosphate Diquafosol Impurity 2 DUTP, 100MM SOLUTION Diquafosol Impurity 3 Tafluprost Pranoprofen Diquafosol

[[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-[[[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-phosphinic acid

Diquafosol

Diquafosol [inn:ban]

Diquafosol [inn]

Kpy 998

p1,p4-Bis(5'-uridyl) tetrahydrogen tetraphosphate

Unii-7828vc80fj

P1,P4-Diuridine 5'-Tetraphosphate

Uridine 5'-(Pentahydrogen Tetraphosphate), P'''→5'-Ester with Uridine

Diquafosol Sodium Salt

P(1),P(4)-bis(uridin-5'-yl) tetraphosphate

[[[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl] [(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl hydrogen phosph

Diquafosol intermediate

Uridine 5'-(pentahydrogen tetraphosphate)

5'-ester with uridine

Uridine5'-(pentahydrogen tetraphosphate), P'''&reg

Diquafosol USP/EP/BP

Up4U

(2E,4Z,7Z)-trideca-2,4,7-trienal

[[[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-...

Dikuafoso

Diquafosol Free Base

DIQUAFOSOL SODIUM NON-STERILE DRUG SUBSTANCE

59985-21-6

C18H26N4O23P4

Agonists

Bases & Related Reagents

Intermediates & Fine Chemicals

Nucleotides

Pharmaceuticals