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Pranoprofen

Product Name
Pranoprofen
CAS No.
52549-17-4
Chemical Name
Pranoprofen
Synonyms
2-(5H-Chromeno[2,3-b]pyridin-7-yl)propanoic acid;Niflan;Y 8004;Cesflan;Oftalar;PRANOPROFEN;pyranoprofen;dl-Pranoprofen;(RS)-Pranoprofen;Pranoprofen, >=99%
CBNumber
CB9189564
Molecular Formula
C15H13NO3
Formula Weight
255.27
MOL File
52549-17-4.mol
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Pranoprofen Property

Melting point:
182-183°
Boiling point:
398.5°C (rough estimate)
Density 
1.1654 (rough estimate)
refractive index 
1.5500 (estimate)
storage temp. 
2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
4.27±0.10(Predicted)
form 
powder
color 
white to beige
CAS DataBase Reference
52549-17-4(CAS DataBase Reference)
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Safety

RIDADR 
UN 2811 6.1 / PGIII
RTECS 
DJ3100950
Toxicity
LD50 in male mice, rats (mg/kg): 447.3, 87.3 orally (Edanaga)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1423
Product name
Pranoprofen
Purity
≥98% (HPLC)
Packaging
50mg
Price
$38.9
Updated
2024/03/01
Sigma-Aldrich
Product number
SML1423
Product name
Pranoprofen
Purity
≥98% (HPLC)
Packaging
250mg
Price
$115
Updated
2024/03/01
Cayman Chemical
Product number
17875
Product name
Pranoprofen
Purity
≥98%
Packaging
50mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
17875
Product name
Pranoprofen
Purity
≥98%
Packaging
1g
Price
$359
Updated
2024/03/01
Cayman Chemical
Product number
17875
Product name
Pranoprofen
Purity
≥98%
Packaging
100mg
Price
$61
Updated
2024/03/01
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Pranoprofen Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Originator

Niflan, Yoshitomi ,Japan ,1981

Uses

Pranoprofen is an anti-inflammatory used in ophthalmology.

Definition

ChEBI: Pranoprofen is a pyridochromene.

Manufacturing Process

A mixture of 100 g of ethyl 2-cyano-2-(5H-[1]benzopyrano[2,3-b]-pyridin-7yl)propionate, 500 ml of glacial acetic acid and 200 g of concentrated hydrochloric acid is refluxed for 48 hours. The reaction mixture is concentrated, and the residue is dissolved in hot water. The solution is adjusted to pH 2 to 3 by addition of 10% sodium hydroxide. The resulting crystalline precipitate is washed thoroughly with water, and recrystallized from aqueous dioxane to give 74 g of 2-(5H-[1]benzopyrano[2,3-b]-pyridin-7yl)propionic acid as white crystals melting at 183°C to 183.5°C.

Therapeutic Function

Analgesic, Antiinflammatory

General Description

Pranoprofen is an arylalkanoic acid and a non-steroidal anti-inflammatory drug.

Biochem/physiol Actions

Pranoprofen is used in eyes to treat chronic allergic conjunctivitis. It is also used as an anti-inflammatory and analgesic drug after strabismus surgery.

Pranoprofen Preparation Products And Raw materials

Raw materials

Preparation Products

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Pranoprofen Suppliers

Jinan Xuanzheng Pharmaceutical Co. LTD
Tel
18610218799
Email
xuanzhengyaoye@126.com
Country
China
ProdList
14
Advantage
58
Shandong Kehui Pharmaceutical Co. LTD
Tel
13276409687
Email
469553953@qq.com
Country
China
ProdList
32
Advantage
58
ChemStrong Scientific Co.,Ltd
Tel
0755-66853366 15920483169
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
17944
Advantage
56
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chembest Research Laboratories Limited
Tel
021-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6013
Advantage
61
Shijiazhuang Sdyano Fine Chemical Co., Ltd.
Tel
0311-89250318 031166536426
Fax
4000311741
Email
master@sjzsdyn.com
Country
China
ProdList
2883
Advantage
65
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9555
Advantage
66
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
zhangsn@titansci.com
Country
China
ProdList
14113
Advantage
59
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32344
Advantage
50
XiaoGan ShenYuan ChemPharm co,ltd
Tel
0712-0712-2580635 15527768850
Email
1791901229@qq.com
Country
China
ProdList
8850
Advantage
52
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View Lastest Price from Pranoprofen manufacturers

airuikechemical co., ltd.
Product
Pranoprofen 52549-17-4
Price
US $0.00-0.00/g
Min. Order
1g
Purity
99.9%
Supply Ability
20 tons
Release date
2024-03-15
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Product
Pranoprofen 52549-17-4
Price
US $0.00/KG
Min. Order
100g
Purity
98%+
Supply Ability
100kg
Release date
2020-10-29
Shaanxi Dideu Medichem Co. Ltd
Product
Pranoprofen 52549-17-4
Price
US $1.00-1.00/KG
Min. Order
1g
Purity
99%
Supply Ability
50tons
Release date
2020-04-29

52549-17-4, PranoprofenRelated Search:


  • PRANOPROFEN
  • (RS)-Pranoprofen
  • 5H-[1]Benzopyrano[2,3-b]pyridine-7-acetic acid, a-methyl- (9CI)
  • a-Methyl-5H-[1]benzopyrano[2,3-b]pyridine-7-ylacetic acid
  • dl-Pranoprofen
  • Niflan
  • Y 8004
  • pyranoprofen
  • (S)-2-[5H-[1]Benzopyrano[2,3-b]pyridin-7-yl]propionic acid
  • [S,(+)]-2-[5H-[1]Benzopyrano[2,3-b]pyridin-7-yl]propionic acid
  • (R)-2-[5H-[1]Benzopyrano[2,3-b]pyridin-7-yl]propionic acid
  • [R,(-)]-2-[5H-[1]Benzopyrano[2,3-b]pyridin-7-yl]propionic acid
  • Cesflan
  • α-Methyl-5H-[1]benzopyrano[2,3-b]pyridine-7-acetic acid
  • 2-(5h-[1]benzopyrano[2,3-b]pyridin-7-yl)propionic acid
  • Oftalar
  • Pranoprofen, >=99%
  • 5H-[1]Benzopyrano[2,3-b]pyridine-7-aceticacid, a-methyl-
  • Pranoprofen-13C-d3
  • Pranoprofen(mixture of isomers)
  • 5H-[1]Benzopyrano[2,3-b]pyridine-7-acetic acid, α-methyl-
  • (2S)-2-(5H-chromeno[2,3-b]pyridin-7-yl)propanoic acid
  • 2-(5H-Chromeno[2,3-b]pyridin-7-yl)propanoic acid
  • Pranoprofen USP/EP/BP
  • Pranoprofen (Pyranoprofen)
  • Antipyretic analgesics Pranoprofen
  • 52549-17-4
  • NIFLAN
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • >97%,BR
  • 52549-17-4