ChemicalBook > CAS DataBase List > Pranoprofen

Pranoprofen

Product Name
Pranoprofen
CAS No.
52549-17-4
Chemical Name
Pranoprofen
Synonyms
2-(5H-Chromeno[2,3-b]pyridin-7-yl)propanoic acid;Niflan;Y 8004;Cesflan;Oftalar;Praprofen;ranoprofen;PRANOPROFEN;pyranoprofen;dl-Pranoprofen
CBNumber
CB9189564
Molecular Formula
C15H13NO3
Formula Weight
255.27
MOL File
52549-17-4.mol
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Pranoprofen Property

Melting point:
182-183°
Boiling point:
398.5°C (rough estimate)
Density 
1.1654 (rough estimate)
refractive index 
1.5500 (estimate)
storage temp. 
2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
4.27±0.10(Predicted)
form 
powder
color 
white to beige
CAS DataBase Reference
52549-17-4(CAS DataBase Reference)
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Safety

RIDADR 
UN 2811 6.1 / PGIII
RTECS 
DJ3100950
Toxicity
LD50 in male mice, rats (mg/kg): 447.3, 87.3 orally (Edanaga)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1423
Product name
Pranoprofen
Purity
≥98% (HPLC)
Packaging
50mg
Price
$38.9
Updated
2024/03/01
Sigma-Aldrich
Product number
SML1423
Product name
Pranoprofen
Purity
≥98% (HPLC)
Packaging
250mg
Price
$115
Updated
2024/03/01
Cayman Chemical
Product number
17875
Product name
Pranoprofen
Purity
≥98%
Packaging
50mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
17875
Product name
Pranoprofen
Purity
≥98%
Packaging
1g
Price
$359
Updated
2024/03/01
Cayman Chemical
Product number
17875
Product name
Pranoprofen
Purity
≥98%
Packaging
100mg
Price
$61
Updated
2024/03/01
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Pranoprofen Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Originator

Niflan, Yoshitomi ,Japan ,1981

Uses

Pranoprofen is an anti-inflammatory used in ophthalmology.

Definition

ChEBI: Pranoprofen is a pyridochromene.

Manufacturing Process

A mixture of 100 g of ethyl 2-cyano-2-(5H-[1]benzopyrano[2,3-b]-pyridin-7yl)propionate, 500 ml of glacial acetic acid and 200 g of concentrated hydrochloric acid is refluxed for 48 hours. The reaction mixture is concentrated, and the residue is dissolved in hot water. The solution is adjusted to pH 2 to 3 by addition of 10% sodium hydroxide. The resulting crystalline precipitate is washed thoroughly with water, and recrystallized from aqueous dioxane to give 74 g of 2-(5H-[1]benzopyrano[2,3-b]-pyridin-7yl)propionic acid as white crystals melting at 183°C to 183.5°C.

Therapeutic Function

Analgesic, Antiinflammatory

General Description

Pranoprofen is an arylalkanoic acid and a non-steroidal anti-inflammatory drug.

Biochem/physiol Actions

Pranoprofen is used in eyes to treat chronic allergic conjunctivitis. It is also used as an anti-inflammatory and analgesic drug after strabismus surgery.

Pranoprofen Preparation Products And Raw materials

Raw materials

Preparation Products

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Pranoprofen Suppliers

Canada 1 China 262 Europe 3 Germany 1 India 2 Japan 1 United Kingdom 5 United States 28 Global 303
Toronto Research Chemicals
Tel
--
Fax
--
Email
info@trc-canada.com
Country
Canada
ProdList
6038
Advantage
71
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View Lastest Price from Pranoprofen manufacturers

airuikechemical co., ltd.
Product
Pranoprofen 52549-17-4
Price
US $0.00-0.00/g
Min. Order
1g
Purity
99.9%
Supply Ability
20 tons
Release date
2024-04-07
Hebei Weibang Biotechnology Co., Ltd
Product
Pranoprofen 52549-17-4
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100 mt
Release date
2024-11-20
Hebei Chuanghai Biotechnology Co,.LTD
Product
Pranoprofen 52549-17-4
Price
US $1.90/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 ton
Release date
2024-08-20

52549-17-4, PranoprofenRelated Search:

Centchroman Imidocarb dipropionate Folic acid Propionic acid Nandrolone phenylpropionate 3-(4-Hydroxyphenyl)propionic acid Ethyl 2-(Chlorosulfonyl)acetate 3-Phenylpropionic acid Ascoric Acid Ibuprofen N,N-dimethylcarbamoylmethyl alpha,2-dimethyl-5H-1-benzopyrano(2,3-b)pyridine-7-acetate ALFA-METHYL-5H-[1] BENZOPYRANO [2,3-B] PYRIDINE-7-ACETIC ACID ETHYL ESTER 4-METHOXY-3-METHYLPHENYLACETIC ACID Pranoprofen l-Pranoprofen,(S)-(+)-Pranoprofen (R)-Pranoprofen,(R)-(-)-Pranoprofen,d-Pranoprofen 2-(4-METHOXY-3-METHYLPHENYL)ACETALDEHYDE ALFA-METHYL-ALFA-CYANO-5H-[1] BENZOPYRANO [2,3-B] PYRIDINE-7-ACETIC ACID ETHYL ESTER

  • PRANOPROFEN
  • (RS)-Pranoprofen
  • 5H-[1]Benzopyrano[2,3-b]pyridine-7-acetic acid, a-methyl- (9CI)
  • a-Methyl-5H-[1]benzopyrano[2,3-b]pyridine-7-ylacetic acid
  • dl-Pranoprofen
  • Niflan
  • Y 8004
  • pyranoprofen
  • (S)-2-[5H-[1]Benzopyrano[2,3-b]pyridin-7-yl]propionic acid
  • [S,(+)]-2-[5H-[1]Benzopyrano[2,3-b]pyridin-7-yl]propionic acid
  • (R)-2-[5H-[1]Benzopyrano[2,3-b]pyridin-7-yl]propionic acid
  • [R,(-)]-2-[5H-[1]Benzopyrano[2,3-b]pyridin-7-yl]propionic acid
  • Cesflan
  • α-Methyl-5H-[1]benzopyrano[2,3-b]pyridine-7-acetic acid
  • 2-(5h-[1]benzopyrano[2,3-b]pyridin-7-yl)propionic acid
  • Oftalar
  • Pranoprofen, >=99%
  • 5H-[1]Benzopyrano[2,3-b]pyridine-7-aceticacid, a-methyl-
  • Pranoprofen-13C-d3
  • Pranoprofen（mixture of isomers）
  • 5H-[1]Benzopyrano[2,3-b]pyridine-7-acetic acid, α-methyl-
  • (2S)-2-(5H-chromeno[2,3-b]pyridin-7-yl)propanoic acid
  • 2-(5H-Chromeno[2,3-b]pyridin-7-yl)propanoic acid
  • Pranoprofen USP/EP/BP
  • Pranoprofen (Pyranoprofen)
  • Antipyretic analgesics Pranoprofen
  • ranoprofen
  • 2-(5H-Chromeno[2,3-b]pyridin-7-yl)propanoic acid , Pranoprofen
  • Praprofen
  • 52549-17-4
  • NIFLAN
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • >97%,BR
  • 52549-17-4