Common hormone Properties Pharmacological effects Pharmacokinetics Indications Function and Application Side effects Drug Interactions Precautions
ChemicalBook > CAS DataBase List > Nandrolone phenylpropionate

Nandrolone phenylpropionate

Common hormone Properties Pharmacological effects Pharmacokinetics Indications Function and Application Side effects Drug Interactions Precautions
Product Name
Nandrolone phenylpropionate
CAS No.
62-90-8
Chemical Name
Nandrolone phenylpropionate
Synonyms
NTPP;19Ntpp;Activin;Durabol;Nerobil;SK 22271;NSC-23162;Durabolin;Fenobolin;Nandrolin
CBNumber
CB3680120
Molecular Formula
C27H34O3
Formula Weight
406.57
MOL File
62-90-8.mol
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Nandrolone phenylpropionate Property

Melting point:
85-87°C
alpha 
D +58° (chloroform)
Boiling point:
487.61°C (rough estimate)
Density 
1.0140 (rough estimate)
refractive index 
1.5460 (estimate)
storage temp. 
Controlled Substance, -20°C Freezer
InChIKey
UBWXUGDQUBIEIZ-QNTYDACNSA-N
CAS DataBase Reference
62-90-8(CAS DataBase Reference)
NIST Chemistry Reference
4-Androstene-17-beta-ol-3-one, 19-nor-delta-, phenylpropionate(62-90-8)
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22-40
Safety Statements 
23-36
RTECS 
KG7995000
Toxicity
LD50 intraperitoneal in mouse: > 1gm/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H351Suspected of causing cancer

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
BP260
Product name
Nandrolone phenylpropionate
Purity
British Pharmacopoeia (BP) Reference Standard
Price
$190
Updated
2021/03/22
Sigma-Aldrich
Product number
1456003
Product name
Nandrolone phenpropionate
Packaging
250mg
Price
$448.35
Updated
2018/11/20
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Nandrolone phenylpropionate Chemical Properties,Usage,Production

Common hormone

Nandrolone Phenylpropionate is a commonly used hormone for promoting the synthesis metabolism of protein. It is produced by the esterification reaction between 19-nor-testosterone and phenylpropionyl chloride. Its dosage type is oily injection through intramuscular injection for administration. It can promote the protein synthesis as well as the savings of calcium, phosphorus, and potassium for treating severe osteoporosis, premature children, growth retardation, dwarfism, and severe malnutrition; it can also be used for inoperable breast cancer, dysfunctional uterine bleeding, and uterine muscle aneurysm. However, this product has a slightly masculine role which is not suitable for not long-term use; patients of prostate cancer, hypertension and pregnant women is disabled; patients of heart, liver and kidney dysfunction should take with caution.

Properties

It is white or white crystalline powder with special smell. Its melting point is 95~99 °C and relative density is 1.14g/cm3, [α] D20 + 48~+ 51 °C (dioxane). It is soluble in alcohol, tea oil, slightly soluble in vegetable oil but almost insoluble in water.

Pharmacological effects

This anabolic effect of this product is 12 times as high as testosterone propionate but has a relative small androgenic which is only 1.5 times as high as the latter one. It can promote protein synthesis and inhibit protein gluconeogenesis, and can also promote the deposition of calcium and phosphorus and the growth of bone tissue growth. Its effect of intramuscular injection can be maintained for 1 to 2 weeks.
The above information is edited by the Chemicalbook of Dai Xiongfeng.

Pharmacokinetics

Metabolism: hormone is mainly excreted in the urine with most part existing in the form of conjugate. However, the hormones in feces are mainly excreted in its free from while the major metabolized product of Nandrolone Phenylpropionate and nor-androstenediol in the urine is mainly 19-nor-androsterone (19-NA).

Indications

In the field of dermatology, it is mainly applied as a adjuvant treatment method for treating the negative nitrogen balance caused by high dose of corticosteroids, while increasing the protein in food; it is also used for treating exfoliative dermatitis, pemphigus, dermatomyositis, scleroderma, and senile pruritus. In addition, it can also used for treating severe burns, malignant tumor before and after surgery, refractory fractures and severe osteoporosis, premature children, significant growth retardation, dwarfism, severe malnutrition, loss of appetite, diarrhea and other serious chronic wasting diseases. In the mean time of other treatments, the product can be administrated. It can also alleviate the symptoms of inoperable breast cancer. It is also suitable to be applied to functional uterine bleeding, and uterine fibroids.

Function and Application

It is kind of anabolic hormones whose major effects include promoting protein synthesis, inhibiting protein degradation, promoting muscle growth, promoting weight increase, further retaining water, sodium, calcium, and phosphorus. It is clinical mainly used for treating the cases of lack of enough protein synthesis and increased protein decomposition such as malnutrition, stunted children, severe burns, post-operative recovery period, refractory fractures, osteoporosis in the elderly and chronic wasting disease (such as chronic kidney disease, malignant tumor, hyperthyroidism and anemia); also used for treating the negative nitrogen balance caused by long-term frequent use of glucocorticoids. However, at the mean time of administration, it is also necessary to increase the protein content contained in the food. This product has a unique foul smell; it is almost insoluble in water but soluble in ethanol and fatty oil.

Side effects

It has slightly masculine effect. After women’s administration of it, some cases such as hirsutism, acne, thicker sound, clitoral hypertrophy, amenorrhea, or menstrual disorders can occur. In these cases, the administration of this drug should be discontinued immediately. Long-term use can cause jaundice and liver dysfunction, and may also cause edema due to sodium retention.

Drug Interactions

1. Using it in combination with oral anticoagulant drug can improve the efficacy of the latter one and increase the tendency of increased bleeding.
2. Anabolic steroids can reduce glucose tolerance; diabetic patients should pay attention to adjust the dose insulin or orally administrated amount of hypoglycemic medicine during the treatment.
3. Others are the same as methyltestosterone.

Precautions

1. Patients of liver disease, kidney disease, hypertension, prostate cancer, breast cancer and pregnant women should be disabled.
2. It should not be used in healthy children.
3. Patient of benign prostatic hypertrophy, myocardial infarction or with history of coronary artery disease should take with caution.
4. This product is prohibited as long-term nutritional products used in healthy people.
5. During the medication period, patients should increase the uptake of nutrition, especially protein.
6. It demands deep intramuscular injection.

Chemical Properties

White to Off-White Solid

Originator

Durabolin,Organon,US,1959

Uses

Anabolic steroid; androgen.

Manufacturing Process

An ice-cold solution of 1.5 grams of 19-nortestosterone and 1.5 ml of dry pyridine in 10 ml of dry benzene is prepared and a solution of 1.5 ml of β- phenylpropionyl chloride in 5 ml of dry benzene is added dropwise over a period of about 2 minutes with stirring. The resulting mixture is allowed to stand overnight under an atmosphere of nitrogen and then washed successively with cold 5% aqueous hydrochloric acid solution, cold 2.5% aqueous sodium hydroxide solution, and water. After drying over anhydrous sodium sulfate, the solvent is evaporated to give an almost colorless oil. Recrystallization from methanol gives white crystals of 19-nortestosterone 17- β-phenylpropionate, MP 91° to 92.5°C.

brand name

Durabolin (Organon);Anabolicas;Anabolicus;Anabolin depot;Anabolin la-100;Androline;Androlone-d;Anticatabolin;Bexobolic;Deca-durabolin;Docabolin;Durabolin phenpropionate;Dynabalon;Energital;Fherbolico;Hepa-obaton;Hybolin decabiate;Hybolin improved;Kabolin;Keratyl;Kompleteron;Methybol-depot;Neo-durabolic;Nerobolin;Norabol;Noralone;Norandrol;Norandros;Noromon;Norstenol;Nortesto;Sintabolin;Stenabolin;Superbolin;Suprabolin.

Therapeutic Function

Anabolic

World Health Organization (WHO)

Nandrolone phenylpropionate, an anabolic steroid, was introduced in 1959. In 1982, low dosage preparations were prohibited in Bangladesh due to inadmissible promotion of products containing anabolic steroids for malnourished children. Higher dosage preparations of nandrolone phenylpropionate remain available in many countries, including Bangladesh, for several highly specific but limited indications that apply to patients with chronic debilitating and emaciating diseases, particularly associated with neoplasia and some types of aplastic anaemia.

Nandrolone phenylpropionate Preparation Products And Raw materials

Raw materials

Preparation Products

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Nandrolone phenylpropionate Suppliers

Wuhan Biocar Bio-Pharm Co., Ltd.
Tel
86 15387057351
Fax
86 027 87050469
Email
sales@biocar.cn
Country
China
ProdList
114
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Shanghai Boyle Chemical Co., Ltd.
Tel
Mr Qiu:021-50182298(Demestic market) Miss Xu:021-50180596(Abroad market)
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
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TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2346
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Energy Chemical
Tel
021-58432009-
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
43494
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Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
9917
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XiaoGan ShenYuan ChemPharm co,ltd
Tel
0712-2580635- ;0712-2580635
Email
1791901229@qq.com;1791901229@qq.com;
Country
China
ProdList
8940
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Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14457
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57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9844
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Hubei YuanCheng Pharmaceutical Co., Ltd.
Tel
18062666904
Fax
QQ:2355880546
Email
wyy01@ycphar.com
Country
China
ProdList
670
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65
BioBioPha Co., Ltd.
Tel
0871-65217109-
Fax
0871-65215563
Email
sales@mail.biobiopha.com
Country
China
ProdList
5688
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View Lastest Price from Nandrolone phenylpropionate manufacturers

Wuhan Aoliqisi New Material Technology Co., Ltd.
Product
Nandrolone Phenylpropionate (Durabolin/NPP) 62-90-8
Price
US $1.00/g
Min. Order
1000g
Purity
99%
Supply Ability
20ton/month
Release date
2021-07-08
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Product
Nandrolone phenylpropionate/NPP 62-90-8
Price
US $0.00/KG
Min. Order
100g
Purity
98%+
Supply Ability
100kg
Release date
2020-09-07
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Product
Nandrolone phenylpropionate
Price
US $0.00/KG
Min. Order
100g
Purity
98%+
Supply Ability
100kg
Release date
2020-12-28

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