Antiestrogenic effects Physiological effect
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Drostanolone propionate

Antiestrogenic effects Physiological effect
Product Name
Drostanolone propionate
CAS No.
521-12-0
Chemical Name
Drostanolone propionate
Synonyms
MDHT;32379;2MDTP;Mast P;357429;Re 346;rs1567;Drolban;2M-DHTP;RS 1567
CBNumber
CB0239590
Molecular Formula
C23H36O3
Formula Weight
360.54
MOL File
521-12-0.mol
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Drostanolone propionate Property

Melting point:
114-120°C
alpha 
D +24°
Boiling point:
432.53°C (rough estimate)
Density 
1.0669 (rough estimate)
refractive index 
1.4700 (estimate)
storage temp. 
Controlled Substance, -20°C Freezer
solubility 
DMF:30.0(Max Conc. mg/mL);83.21(Max Conc. mM)
DMSO:24.0(Max Conc. mg/mL);66.57(Max Conc. mM)
Ethanol:2.0(Max Conc. mg/mL);5.55(Max Conc. mM)
form 
A crystalline solid
InChI
InChI=1/C23H36O3/c1-5-21(25)26-20-9-8-17-16-7-6-15-12-19(24)14(2)13-23(15,4)18(16)10-11-22(17,20)3/h14-18,20H,5-13H2,1-4H3/t14-,15+,16+,17+,18+,20+,22+,23+/s3
InChIKey
NOTIQUSPUUHHEH-DEMPVMEFNA-N
SMILES
C[C@]12C[C@@H](C)C(=O)C[C@]1([H])CC[C@@]1([H])[C@]3([H])CC[C@H](OC(=O)CC)[C@@]3(C)CC[C@]21[H] |&1:1,3,8,12,14,18,24,28,r|
CAS DataBase Reference
521-12-0(CAS DataBase Reference)
NIST Chemistry Reference
Dromostanolone propionate(521-12-0)
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Safety

Toxicity
LD50 subcutaneous in mouse: > 2gm/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H351Suspected of causing cancer

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
NMIS025
Product name
Drostanolone propionate
Purity
NMI Australia
Packaging
20MG
Price
$191
Updated
2023/06/20
Matrix Scientific
Product number
099251
Product name
Dromostanolone propionate
Purity
95+%
Packaging
250mg
Price
$32
Updated
2021/12/16
Matrix Scientific
Product number
099251
Product name
Dromostanolone propionate
Purity
95+%
Packaging
1g
Price
$75
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0078918
Product name
DROSTANOLONE PROPIONATE
Purity
95.00%
Packaging
100MG
Price
$739.2
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0078918
Product name
DROSTANOLONE PROPIONATE
Purity
95.00%
Packaging
1G
Price
$1871.1
Updated
2021/12/16
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Drostanolone propionate Chemical Properties,Usage,Production

Antiestrogenic effects

Dromostanolone Propionate is the propionate salt form of dromostanolone, a synthetic anabolic steroid related to dihydrotestosterone that has antiestrogenic effects. Dromostanolone inhibits the growth of estrogen receptor-presenting breast cancers; its virilizing effects limit its clinical usefulness.
Drostanolone propionate is a modified form of drostanolone, where a carboxylic acid ester (propionic acid) has been attached to the 17-beta hydroxyl group.Drostanolone Propionate is a synthetic androgenic anabolic steroid and is approximately 5 times as potent as natural methyltestosterone.

Physiological effect

Like testosterone and other androgenic hormones, dromostanolone binds to the androgen receptor. This causes downstream genetic transcriptional changes. This ultimately causes retention of nitrogen, potassium, and phosphorus; increases protein anabolism; and decreases amino acid catabolism. The antitumour activity of dromostanolone appears related to reduction or competitive inhibition of prolactin receptors or estrogen receptors or production.
Specifically, Masteron is the DHT hormone that has been structurally altered by the addition of a methyl group at the carbon 2 position, This protects the hormone from the metabolic breakdown by the 3-hydroxysteroid dehydrogenase enzyme, which is found in the skeletal muscle.

Description

17b-Hydroxy-2a-methyl-5a-androstan-3-one propionate, also known as drostanolone propionate, is a synthetic anabolic-androgenic steroid. It has similar properties to dihydrotestosterone. It had been used for the treatment of breast cancer in the past. However, it is now mainly used by athletes and bodybuilder as an anabolic steroid. It has two major effects including enhancing the physical/athletic performance (such as endurance and strength) and enhancing physical health (muscle buildup and fat loss). It should be administrated via intramuscular injection instead of oral taking.

Chemical Properties

White Solid

Originator

Drolban,Lilly,US,1961

Uses

Drostanolone propionate is the propionate salt form of dromostanolone, a synthetic anabolic steroid related to dihydrotestosterone that has antiestrogenic effects. It is used as an antineoplastic for use in females, for palliation of androgenresponsive recurrent mammary cancer in women who are more than one year but less than five years postmenopausal. Now it is used to help improve athletic performance and muscle gain.

Definition

ChEBI: Drostanolone propionate is a steroid ester and a 3-oxo-5alpha-steroid. It has a role as an antineoplastic agent. It is functionally related to a metholone.

Preparation

Drostanolone propionate is prepared from 9,11-dehydro-17a-methyl-testosterone raw material, reacts with lithium chloride and N-chlorosuccinimide to generate 9a,11-dichloro-17a-methyl- 95 testosterone is further prepared by esterification with propionin.

Manufacturing Process

A suspension of 10 grams of dihydrotestosterone in 500 cc of anhydrous benzene free of thiophene was mixed with10 cc of ethyl formate and 3 grams of sodium hydride and the mixture was stirred for 5 hours under an atmosphere of nitrogen and at a temperature of approximately 25°C. The resulting suspension was filtered, the resulting mixture of the sodium salt of the hydroxymethylene compound and the excess of sodium hydride was washed with benzene and dried. This mixture was slowly added to a vigorously stirred solution of 20 cc of concentrated hydrochloric acid in 500 cc of water, and the stirring was continued for 30 minutes at the end of which the precipitate was collected and well washed with distilled water. After drying in vacuo, there was obtained 9.7 grams of 2-hydroxymethylenedihydrotestosterone.
A mixture of 1 gram of 2-hydroxymethylene-dihydrotestosterone, 10 cc of pyridine and 2 cc of propionic anhydride was allowed to react at room temperature for 16 hours and then poured into water. The resulting suspension was heated for 1 hour on the steam bath to hydrolyze the excess of propionic anhydride, cooled and extracted with methylene dichloride. The extract was consecutively washed with dilute hydrochloric acid, sodium bicarbonate solution and water, dried over anhydrous sodium sulfate and evaporated to dryness under vacuum. There was thus obtained the dipropionate of 2-hydroxymethylenedihydrotestosterone which was treated with hydrogen, in methanol solution.
When the uptake of hydrogen ceased, the catalyst was filtered and the solution was evaporated to dryness under vacuum. The residue was dissolved in a mixture of benzene-hexane, transferred to a chromatographic column with neutral alumina and the product was eluted with mixtures of benzenehexane, gradually increasing the proportion of benzene in the mixture. Crystallization of the eluates from acetone-hexane yielded the propionate of 2α-methyldihydrotestosterone.

brand name

Drolban (Lilly).

Therapeutic Function

Cancer chemotherapy

Side effects

As to be expected with all steroids, it's essential that you're aware of all potential side effects of Drostanolone propionate, before you consider a cycle. Side effects of drostanolone propionate include symptoms of masculinization like acne, increased hair growth, voice changes, and increased sexual desire. It has no risk of liver damage.

References

https://en.wikipedia.org/wiki/Drostanolone_propionate
http://www.chemspider.com/Chemical-Structure.194604.html
http://steroid.es/drostanolone.html
Chowdhury, M. S., et al. "A comparison of drostanolone propionate (Masteril) and nandrolone decanoate (Deca-durabolin) in the treatment of breast carcinoma. " 2.3(1976):203-206.

Drostanolone propionate Preparation Products And Raw materials

Raw materials

Preparation Products

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Drostanolone propionate Suppliers

Shangqiu Ladybug Network Technology Co., LTD
Tel
17550092151
Fax
03702782809
Email
3628320093@qq.com
Country
China
ProdList
4206
Advantage
58
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
China DongFan Chemical Co.,LTD
Tel
86-0571-85151182
Fax
86-0571-85151182
Country
China
ProdList
5691
Advantage
66
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768850
Email
1791901229@qq.com
Country
China
ProdList
8836
Advantage
52
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
Advantage
57
BioBioPha Co., Ltd.
Tel
0871-65217109 13211707573;
Fax
0871-65215563
Email
y.liu@mail.biobiopha.com
Country
China
ProdList
5653
Advantage
65
Beijing Yisiyan Technology Research Center
Tel
010-56645598 13366904824
Fax
01062230033
Email
bjkaida@163.com
Country
China
ProdList
1637
Advantage
59
China Nobel Chem Co., Limited
Tel
+86(0)21 60484900
Fax
+86(0)21 60484900
Country
China
ProdList
764
Advantage
50
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View Lastest Price from Drostanolone propionate manufacturers

Shaanxi Xianhe Biotech Co., Ltd
Product
Dromostanolone propionate / Masteron propionate 521-12-0
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000 kg
Release date
2024-12-10
hebei hongtan Biotechnology Co., Ltd
Product
Drostanolone Propionate 521-12-0
Price
US $30.00-10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20
Release date
2024-05-11
Apeloa production Co.,Limited
Product
Dromostanolone propionate 521-12-0
Price
US $1.00/g
Min. Order
1g
Purity
98%
Supply Ability
999g
Release date
2024-05-22

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