Drostanolone propionate
Antiestrogenic effects Physiological effect- Product Name
- Drostanolone propionate
- CAS No.
- 521-12-0
- Chemical Name
- Drostanolone propionate
- Synonyms
- MDHT;32379;2MDTP;Mast P;357429;Re 346;rs1567;Drolban;2M-DHTP;RS 1567
- CBNumber
- CB0239590
- Molecular Formula
- C23H36O3
- Formula Weight
- 360.54
- MOL File
- 521-12-0.mol
Drostanolone propionate Property
- Melting point:
- 114-120°C
- alpha
- D +24°
- Boiling point:
- 432.53°C (rough estimate)
- Density
- 1.0669 (rough estimate)
- refractive index
- 1.4700 (estimate)
- storage temp.
- Controlled Substance, -20°C Freezer
- solubility
- DMF:30.0(Max Conc. mg/mL);83.21(Max Conc. mM)
DMSO:24.0(Max Conc. mg/mL);66.57(Max Conc. mM)
Ethanol:2.0(Max Conc. mg/mL);5.55(Max Conc. mM) - form
- A crystalline solid
- InChI
- InChI=1/C23H36O3/c1-5-21(25)26-20-9-8-17-16-7-6-15-12-19(24)14(2)13-23(15,4)18(16)10-11-22(17,20)3/h14-18,20H,5-13H2,1-4H3/t14-,15+,16+,17+,18+,20+,22+,23+/s3
- InChIKey
- NOTIQUSPUUHHEH-DEMPVMEFNA-N
- SMILES
- C[C@]12C[C@@H](C)C(=O)C[C@]1([H])CC[C@@]1([H])[C@]3([H])CC[C@H](OC(=O)CC)[C@@]3(C)CC[C@]21[H] |&1:1,3,8,12,14,18,24,28,r|
- CAS DataBase Reference
- 521-12-0(CAS DataBase Reference)
- NIST Chemistry Reference
- Dromostanolone propionate(521-12-0)
Safety
- Toxicity
- LD50 subcutaneous in mouse: > 2gm/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H351Suspected of causing cancer
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313IF exposed or concerned: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- NMIS025
- Product name
- Drostanolone propionate
- Purity
- NMI Australia
- Packaging
- 20MG
- Price
- $191
- Updated
- 2023/06/20
- Product number
- 099251
- Product name
- Dromostanolone propionate
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $32
- Updated
- 2021/12/16
- Product number
- 099251
- Product name
- Dromostanolone propionate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- CHM0078918
- Product name
- DROSTANOLONE PROPIONATE
- Purity
- 95.00%
- Packaging
- 100MG
- Price
- $739.2
- Updated
- 2021/12/16
- Product number
- CHM0078918
- Product name
- DROSTANOLONE PROPIONATE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1871.1
- Updated
- 2021/12/16
Drostanolone propionate Chemical Properties,Usage,Production
Antiestrogenic effects
Dromostanolone Propionate is the propionate salt form of dromostanolone, a synthetic anabolic steroid related to dihydrotestosterone that has antiestrogenic effects. Dromostanolone inhibits the growth of estrogen receptor-presenting breast cancers; its virilizing effects limit its clinical usefulness.
Drostanolone propionate is a modified form of drostanolone, where a carboxylic acid ester (propionic acid) has been attached to the 17-beta hydroxyl group.Drostanolone Propionate is a synthetic androgenic anabolic steroid and is approximately 5 times as potent as natural methyltestosterone.
Physiological effect
Like testosterone and other androgenic hormones, dromostanolone binds to the androgen receptor. This causes downstream genetic transcriptional changes. This ultimately causes retention of nitrogen, potassium, and phosphorus; increases protein anabolism; and decreases amino acid catabolism. The antitumour activity of dromostanolone appears related to reduction or competitive inhibition of prolactin receptors or estrogen receptors or production.
Specifically, Masteron is the DHT hormone that has been structurally altered by the addition of a methyl group at the carbon 2 position, This protects the hormone from the metabolic breakdown by the 3-hydroxysteroid dehydrogenase enzyme, which is found in the skeletal muscle.
Description
17b-Hydroxy-2a-methyl-5a-androstan-3-one propionate, also known as drostanolone propionate, is a synthetic anabolic-androgenic steroid. It has similar properties to dihydrotestosterone. It had been used for the treatment of breast cancer in the past. However, it is now mainly used by athletes and bodybuilder as an anabolic steroid. It has two major effects including enhancing the physical/athletic performance (such as endurance and strength) and enhancing physical health (muscle buildup and fat loss). It should be administrated via intramuscular injection instead of oral taking.
Chemical Properties
White Solid
Originator
Drolban,Lilly,US,1961
Uses
Drostanolone propionate is the propionate salt form of dromostanolone, a synthetic anabolic steroid related to dihydrotestosterone that has antiestrogenic effects. It is used as an antineoplastic for use in females, for palliation of androgenresponsive recurrent mammary cancer in women who are more than one year but less than five years postmenopausal. Now it is used to help improve athletic performance and muscle gain.
Definition
ChEBI: Drostanolone propionate is a steroid ester and a 3-oxo-5alpha-steroid. It has a role as an antineoplastic agent. It is functionally related to a metholone.
Preparation
Drostanolone propionate is prepared from 9,11-dehydro-17a-methyl-testosterone raw material, reacts with lithium chloride and N-chlorosuccinimide to generate 9a,11-dichloro-17a-methyl- 95 testosterone is further prepared by esterification with propionin.
Manufacturing Process
A suspension of 10 grams of dihydrotestosterone in 500 cc of anhydrous
benzene free of thiophene was mixed with10 cc of ethyl formate and 3 grams
of sodium hydride and the mixture was stirred for 5 hours under an
atmosphere of nitrogen and at a temperature of approximately 25°C. The
resulting suspension was filtered, the resulting mixture of the sodium salt of
the hydroxymethylene compound and the excess of sodium hydride was
washed with benzene and dried. This mixture was slowly added to a
vigorously stirred solution of 20 cc of concentrated hydrochloric acid in 500 cc
of water, and the stirring was continued for 30 minutes at the end of which
the precipitate was collected and well washed with distilled water. After drying
in vacuo, there was obtained 9.7 grams of 2-hydroxymethylenedihydrotestosterone.
A mixture of 1 gram of 2-hydroxymethylene-dihydrotestosterone, 10 cc of
pyridine and 2 cc of propionic anhydride was allowed to react at room
temperature for 16 hours and then poured into water. The resulting
suspension was heated for 1 hour on the steam bath to hydrolyze the excess
of propionic anhydride, cooled and extracted with methylene dichloride. The
extract was consecutively washed with dilute hydrochloric acid, sodium
bicarbonate solution and water, dried over anhydrous sodium sulfate and
evaporated to dryness under vacuum. There was thus obtained the
dipropionate of 2-hydroxymethylenedihydrotestosterone which was treated
with hydrogen, in methanol solution.
When the uptake of hydrogen ceased, the catalyst was filtered and the
solution was evaporated to dryness under vacuum. The residue was dissolved
in a mixture of benzene-hexane, transferred to a chromatographic column
with neutral alumina and the product was eluted with mixtures of benzenehexane, gradually increasing the proportion of benzene in the mixture.
Crystallization of the eluates from acetone-hexane yielded the propionate of
2α-methyldihydrotestosterone.
brand name
Drolban (Lilly).
Therapeutic Function
Cancer chemotherapy
Side effects
As to be expected with all steroids, it's essential that you're aware of all potential side effects of Drostanolone propionate, before you consider a cycle. Side effects of drostanolone propionate include symptoms of masculinization like acne, increased hair growth, voice changes, and increased sexual desire. It has no risk of liver damage.
References
https://en.wikipedia.org/wiki/Drostanolone_propionate
http://www.chemspider.com/Chemical-Structure.194604.html
http://steroid.es/drostanolone.html
Chowdhury, M. S., et al. "A comparison of drostanolone propionate (Masteril) and nandrolone decanoate (Deca-durabolin) in the treatment of breast carcinoma. " 2.3(1976):203-206.
Drostanolone propionate Preparation Products And Raw materials
Raw materials
Preparation Products
Drostanolone propionate Suppliers
- Tel
- 0719-0719-7199239 15675290733
- 121628410@qq.com
- Country
- China
- ProdList
- 30
- Advantage
- 58
- Tel
- 0370-2059268 15672839268
- Fax
- 03702782809
- 2352713635@qq.com
- Country
- China
- ProdList
- 4206
- Advantage
- 58
- Tel
- 13533334465
- 396587392@qq.com
- Country
- China
- ProdList
- 113
- Advantage
- 58
- Tel
- 021-54306202 13764082696;
- info@hanhongsci.com
- Country
- China
- ProdList
- 42982
- Advantage
- 64
- Tel
- 86-0571-85151182
- Fax
- 86-0571-85151182
- Country
- China
- ProdList
- 5700
- Advantage
- 66
- Tel
- 0712-0712-2580635 15527768850
- 1791901229@qq.com
- Country
- China
- ProdList
- 8849
- Advantage
- 52
- Tel
- Fax
- E-Mail Inquiry
- info@syntechem.com
- Country
- China
- ProdList
- 12990
- Advantage
- 57
- Tel
- 400 638 7771
- sales@heowns.com
- Country
- China
- ProdList
- 14443
- Advantage
- 57
- Tel
- 0871-65217109 13211707573;
- Fax
- 0871-65215563
- y.liu@mail.biobiopha.com
- Country
- China
- ProdList
- 5654
- Advantage
- 65
- Tel
- 010-56645598 13366904824
- Fax
- 01062230033
- bjkaida@163.com
- Country
- China
- ProdList
- 1666
- Advantage
- 59
- Tel
- +86(0)21 60484900
- Fax
- +86(0)21 60484900
- Country
- China
- ProdList
- 764
- Advantage
- 50
- Tel
- 027-87666700
- Fax
- 027-87666700 skype-lydia0189
- xuri@hbdatongchem.com
- Country
- China
- ProdList
- 147
- Advantage
- 55
- Tel
- 025-57798810
- Fax
- 025-57019371
- sales@sunlidabio.com
- Country
- China
- ProdList
- 3750
- Advantage
- 55
- Tel
- 021-57171705 13817537615
- Fax
- QQ3095748324
- sales@run-biotech.com
- Country
- China
- ProdList
- 2601
- Advantage
- 58
- Tel
- 13971561712, 13995564702, 027-50664929
- Fax
- 027-50664927
- hbeixys2001@163.com
- Country
- China
- ProdList
- 3123
- Advantage
- 55
- Tel
- 021-60549325 18616193163
- Fax
- 021-33250306
- Country
- China
- ProdList
- 4528
- Advantage
- 56
- Tel
- 021-021-56795766
- Fax
- +86-21-56795266
- sales@worldyachem.com
- Country
- China
- ProdList
- 9352
- Advantage
- 58
- Tel
- 0510-85629785 18013409632
- Fax
- 051085625359
- sales@reading-chemicals.com
- Country
- China
- ProdList
- 15185
- Advantage
- 58
- Tel
- 021-60345187 13671753212
- Fax
- 021-34702061
- lzz841106@aliyun.com
- Country
- China
- ProdList
- 10287
- Advantage
- 55
- Tel
- 027-59420981,18702770802
- Fax
- 027-83322098
- Country
- China
- ProdList
- 1975
- Advantage
- 50
- Tel
- Fax
- -
- xg01_gj@163.com
- Country
- China
- ProdList
- 9503
- Advantage
- 50
- Tel
- 86 15387057351
- Fax
- 86 027 87050469
- sales@biocar.cn
- Country
- China
- ProdList
- 114
- Advantage
- 55
- Tel
- +86 (531) 8099-2215
- Fax
- +86 (531) 8099-2215
- putubio@outlook.com
- Country
- China
- ProdList
- 1261
- Advantage
- 55
- Tel
- 0571-0571-87157530-8001-8003 18008611859
- Fax
- 0571-87156470
- sales@dingyanchem.com
- Country
- China
- ProdList
- 1997
- Advantage
- 58
- Tel
- 0371-86658258
- Fax
- 0371-60996044
- info@coreychem.com
- Country
- China
- ProdList
- 10457
- Advantage
- 58
- Tel
- 02781293128
- orders@biochemsafebuy.com
- Country
- China
- ProdList
- 9934
- Advantage
- 55
- Tel
- 025-83453382-8005
- Fax
- 025-83453382
- sale@parabiochem.com
- Country
- China
- ProdList
- 9604
- Advantage
- 55
- Tel
- 025-57798860
- sales@njromanme.com
- Country
- China
- ProdList
- 4534
- Advantage
- 58
- Tel
- 17754423994 17754423994
- Fax
- QQ:2853530913
- 2853530910@QQ.com
- Country
- China
- ProdList
- 8011
- Advantage
- 62
- Tel
- 0371-0371-55629727 13323845623
- Fax
- 037155629727
- 2885676761@qq.com
- Country
- China
- ProdList
- 9859
- Advantage
- 58
- Tel
- 18126413629 0755-23311925 2355327053
- Fax
- 0755-23311925
- abel@ycgmp.com
- Country
- China
- ProdList
- 5115
- Advantage
- 58
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131981
- Advantage
- 58
- Tel
- 0751-2886750 13927877953
- Fax
- 0751-2886750
- 3005811397@qq.com
- Country
- China
- ProdList
- 13360
- Advantage
- 58
- Tel
- 18124570582 TEL：0755-23574479 2355327139
- Fax
- 0755-23229476 QQ: 2355327139
- siliao02@yccreate.com
- Country
- China
- ProdList
- 6120
- Advantage
- 58
- Tel
- 18872289958、027-52304252、3400508168
- Fax
- 027-52304252
- 3400508168@qq.com
- Country
- China
- ProdList
- 1910
- Advantage
- 55
- Tel
- 027-59362599 18674037007
- Fax
- 027-84802889
- zhuoxingwc@163.com
- Country
- China
- ProdList
- 950
- Advantage
- 58
- Tel
- +86 18721201413
- Fax
- +86 (21) 5775-8967
- sales@biopharmaleader.com
- Country
- China
- ProdList
- 1720
- Advantage
- 58
- Tel
- 18578209868 2355327026
- Fax
- 18578209868 QQ：2355327026
- steroidbest@hotmail.com
- Country
- China
- ProdList
- 6504
- Advantage
- 58
- Tel
- 027-87466105 15377573527
- 2678564200@qq.com
- Country
- China
- ProdList
- 17997
- Advantage
- 58
- Tel
- 021-60345187 13917602471
- Fax
- 021-60345187
- lzz841106@aliyun.com
- Country
- China
- ProdList
- 9908
- Advantage
- 58
- Tel
- 17753923223
- Fax
- 0539-6222546
- 2805221329@qq.com
- Country
- China
- ProdList
- 1474
- Advantage
- 58
- Tel
- 13657284589
- Fax
- 027-87781970
- znobio@qq.com
- Country
- China
- ProdList
- 141
- Advantage
- 58
- Tel
- 400-6387771-6038 18902104717
- sales@heowns.com
- Country
- China
- ProdList
- 20512
- Advantage
- 60
- Tel
- 027-51831887 15337167856
- Fax
- 027-51837635 QQ1165326703
- hubeixinyuanshun@163.com
- Country
- China
- ProdList
- 10305
- Advantage
- 58
- Tel
- 028-85157043 15882256948
- 676046971@qq.com
- Country
- China
- ProdList
- 4392
- Advantage
- 58
- Tel
- 400-400-400-9004166 18616739031
- 3007523370@qq.com
- Country
- China
- ProdList
- 52712
- Advantage
- 58
- Tel
- 027-87058617 15872383390
- Fax
- 027-87058617
- hbdibo@163.com
- Country
- China
- ProdList
- 891
- Advantage
- 58
- Tel
- 020-31155029 18902330969
- Fax
- 020-31155029
- sales@tomums.cn
- Country
- China
- ProdList
- 4698
- Advantage
- 58
- Tel
- 0571-85361029
- Fax
- 0571-85361029
- synstar518@163.com
- Country
- China
- ProdList
- 1991
- Advantage
- 58
- Tel
- +8613288715578
- sales@hbmojin.com
- Country
- China
- ProdList
- 12456
- Advantage
- 58
View Lastest Price from Drostanolone propionate manufacturers
- Product
- Drostanolone Propionate 521-12-0
- Price
- US $2700.00/kg
- Min. Order
- 1kg
- Purity
- 99.99%
- Supply Ability
- 2 tons
- Release date
- 2023-03-27
- Product
- Drostanolone Propionate 521-12-0
- Price
- US $30.00-10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20
- Release date
- 2024-03-14
- Product
- Dromostanolone propionate 521-12-0
- Price
- US $11.00-90.00/kg
- Min. Order
- 0.10000000149011612kg
- Purity
- 99%
- Supply Ability
- 10 tons
- Release date
- 2024-03-20