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Drostanolone

Product Name
Drostanolone
CAS No.
58-19-5
Chemical Name
Drostanolone
Synonyms
Metholone;Medrotestron;DROSTANOLONE;Dromostanolone;58-19-5 Dromostanolone;Drostanolone/Dromostanolone;Dihydro-2α-Methyltestosterone;2α-Methyl-5α-dihydrotestosterone;2α-Methyl-5α-androstan-17β-ol-3-one;5α-ANDROSTAN-2α-METHYL-17β-OL-3-ONE
CBNumber
CB1911442
Molecular Formula
C20H32O2
Formula Weight
304.47
MOL File
58-19-5.mol
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Drostanolone Property

Melting point:
145-147°C
alpha 
D +32° (ethanol)
Boiling point:
420.3±45.0 °C(Predicted)
Density 
1.058±0.06 g/cm3(Predicted)
storage temp. 
Refrigerator
solubility 
Acetonitrile: 1 mg/mL; Ethanol: 1 mg/mL; Methanol: 1 mg/mL
form 
A crystalline solid
pka
15.09±0.70(Predicted)
CAS DataBase Reference
58-19-5
NIST Chemistry Reference
Drostanolone(58-19-5)
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Safety

Hazardous Substances Data
58-19-5(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21170
Product name
Drostanolone
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
21170
Product name
Drostanolone
Purity
≥98%
Packaging
5mg
Price
$93
Updated
2024/03/01
American Custom Chemicals Corporation
Product number
SHG0000431
Product name
DROSTANOLONE
Purity
95.00%
Packaging
100MG
Price
$779.63
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
SHG0000431
Product name
DROSTANOLONE
Purity
95.00%
Packaging
1G
Price
$2194.5
Updated
2021/12/16
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Drostanolone Chemical Properties,Usage,Production

Description

Drostanolone, also known as Dromostanolone[58-19-5], is an anabolic hormone and a derivative of methyltestosterone. Its action is similar to that of Conviron. Its anabolic effect is 4 times that of methyltestosterone and its androgenic activity is 0.39 times that of the latter. It is clinically used in the treatment of chronic wasting disease, pediatric underdevelopment, old age and frailty, serious illness and postoperative weakness, osteoporosis, aplastic anemia, leukopenia, thrombocytopenia, and hyperlipidemia.

Chemical Properties

White or off-white crystalline powder, odorless. Insoluble in water, slightly soluble in ethanol, slightly soluble in ether, soluble in chloroform.

Originator

Drolban,Lilly,US,1961

Uses

Drostanolone is a synthetic estrogen antagonist and is classified as an anabolic androgenic steroid. It has been used in sports to improve athletic performance and can be detected in urine. In the United States, Drostanolone is classified as a Schedule III substance, indicating it is regulated and controlled. This product is intended for research and forensic applications.

Definition

ChEBI: Metholone is a 17beta-hydroxy steroid, an anabolic androgenic steroid and a 3-oxo-5alpha-steroid. It has a role as an anabolic agent and an antineoplastic agent.

Manufacturing Process

A mixture of 1 gram of 2-hydroxymethylene-dihydrotestosterone, 10 cc of pyridine and 2 cc of propionic anhydride was allowed to react at room temperature for 16 hours and then poured into water. The resulting suspension was heated for 1 hour on the steam bath to hydrolyze the excess of propionic anhydride, cooled and extracted with methylene dichloride. The extract was consecutively washed with dilute hydrochloric acid, sodium bicarbonate solution and water, dried over anhydrous sodium sulfate and evaporated to dryness under vacuum. There was thus obtained the dipropionate of 2-hydroxymethylenedihydrotestosterone which was treated with hydrogen, in methanol solution.
When the uptake of hydrogen ceased, the catalyst was filtered and the solution was evaporated to dryness under vacuum. The residue was dissolved in a mixture of benzene-hexane, transferred to a chromatographic column with neutral alumina and the product was eluted with mixtures of benzenehexane, gradually increasing the proportion of benzene in the mixture. Crystallization of the eluates from acetone-hexane yielded the propionate of 2α-methyldihydrotestosterone(Dromostanolone).

brand name

Drolban (Lilly).

Therapeutic Function

Cancer chemotherapy

Synthesis

Drostanolone is prepared by this “one-pot-reaction”-step the conversion to the 1α-methyl-group is performed simultaneously with the cleavage of the protective group at the 17β-alcohol: 10.60 g Hydroxymethylene-precusor 2-Hydroxymethylene-androstan-17β-((tetrahydro-2H-pyran-2-yl)oxy)-3-one was nearly dissolved in 800 ml ethanol at 55°C. This solution was hydrogenated in a pressure vessel (Parr reactor) with 6.00 g palladium on charcoal (5%) at 4 bar and room temperature for 24 h. The mixture was filtered twice through paper and the corresponding ethanol solution was evaporated, to yield 9.50 g colorless oil, still contains traces of charcoal and ethanol. The crude product was purified by column chromatography on silica gel by using hexane-ethyl acetate (8:2) as an eluent, to afford 5.45 g purified Drostanolone as a colorless solid (69%) . MS (ESI+): m/z = 304.96 (calculated MW: 304.47 g/mol) Rf: 0.35, hexane/ethyl acetate 7:3, visualized by Seebach derivatization reagent. 1 H NMR(300 MHz, DMSO-d6) : δ 4.42 (d, 1 H, OH), 3.42 (m, 1H, HCHOH), 3.32 (s, 1H, CH), 2.37 (t, 1 H, CH), 1.99 (dd, 1 H, ), 1.84 (dd, 1H), 1.78 – 1.84 (m, 1H), 1.72 (m, 1H), 1.61 (m, 1H), 1.22-1.58 (m, 8H), 1.08 – 1.22 (m, 1H), 1.03 (s, 3H, CH3), 0.76-1.01 (m + d, 7H, 2α-CH3 +X), 0.65 – 0.72 (m, 1H), 0.64 (s, 3H, CH3).

Mode of action

It can promote protein synthesis and inhibit protein xenobiosis, reduce calcium and phosphorus excretion and alleviate bone marrow suppression, promote growth and development, promote tissue renewal and granulation, and reduce blood cholesterol, and have preventive and antagonistic effects on adrenocorticotropic hormone long-term use of adrenocorticotropic hypoplasia and protein anisotropy.

References

[1] SCH?NZER W, DONIKE M. Metabolism of anabolic steroids in man: synthesis and use of reference substances for identification of anabolic steroid metabolites[J]. Analytica Chimica Acta, 1993, 275: 23-48. DOI:10.1016/0003-2670(93)80274-O.
[2] KINTZ P, GHEDDAR L. Evidence of use of drostanolone, an anabolic steroid, at the time the subject committed a murder: Place of hair analysis[J]. Toxicologie Analytique et Clinique, 2021. DOI:10.1016/J.TOXAC.2021.05.002.
[3] LIU Y, LU J, YANG S, et al. New drostanolone metabolites in human urine by liquid chromatography time-of-flight tandem mass spectrometry and their application for doping control[J]. Steroids, 2016, 108: 61-67. DOI:10.1016/j.steroids.2016.01.013.

Drostanolone Preparation Products And Raw materials

Raw materials

Preparation Products

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Drostanolone Suppliers

LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2127
Advantage
70
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
132020
Advantage
58
ANHUI WITOP BIOTECH CO., LTD
Tel
+8615255079626
Email
eric@witopchemical.com
Country
China
ProdList
23556
Advantage
58
Hubei xin bonus chemical co. LTD
Tel
86-13657291602
Fax
027-59338440
Email
linda@hubeijusheng.com
Country
CHINA
ProdList
22968
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11289
Advantage
58
Shanghai Saikerui Biotechnology Co. , Ltd.
Tel
021-58000709 15900491054
Email
info@scrbio.com
Country
China
ProdList
9260
Advantage
58
Henan Tianfu Chemical Co.,Ltd.
Tel
+86-0371-55170693 +86-19937530512
Fax
0371-55170693
Email
info@tianfuchem.com
Country
China
ProdList
21700
Advantage
55
Hebei Jiangkai Trading Co., Ltd
Tel
0086-17197824289,17197824028
Country
CHINA
ProdList
260
Advantage
58
Shanghai Hengmao New Materials Technology CO., LIMITED
Tel
+86-0086-1773693-3208 +8617736933208
Email
1137059254@qq.com
Country
China
ProdList
9287
Advantage
58
Hubei Harvest Chemical CO.,Ltd
Tel
+86-13129915771 +86-15623179893
Email
wendy@hb-harvestchem.com
Country
China
ProdList
931
Advantage
58
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View Lastest Price from Drostanolone manufacturers

Henan Tengzan Biotechnology Co. LTD
Product
Dromostanolone 58-19-5
Price
US $200.00-4000.00/Kg/Drum
Min. Order
1Kg/Bag
Purity
99+
Supply Ability
1000kg
Release date
2021-11-01
Hebei Jiangkai Trading Co., Ltd
Product
Drostanolone;dromostanolone 58-19-5
Price
US $8.00/G
Min. Order
1G
Purity
99.8% skype:lila_1646 whatsapp:+8617197824208
Supply Ability
500kg per week
Release date
2018-01-15

58-19-5, DrostanoloneRelated Search:


  • Drostanolone/Dromostanolone
  • (5α)-2α-Methyl-4,5-dihydrotestosterone
  • 17β-Hydroxy-2α-methyl-5α-androstan-3-one
  • Medrotestron
  • Metholone
  • Dromostanolone
  • (2a,5a,17b)-17-Hydroxy-2-methylandrostan-3-one
  • (2R,5S,8R,9S,10S,13S,14S,17S)-17-hydroxy-2,10,13-trimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one
  • (2α,5α,17β)-17-Hydroxy-2-Methylandrostan-3-one
  • 2α-Methyl-17β-hydroxy-5α-androstan-3-one
  • 2α-Methyl-17β-hydroxyandrostan-3-one
  • 2α-Methyl-5α-androstan-17β-ol-3-one
  • 2α-Methyl-5α-dihydrotestosterone
  • Dihydro-2α-Methyltestosterone
  • Androstan-3-one,17-hydroxy-2-Methyl-, (2a,5a,17b)-
  • Androstan-3-one, 17-hydroxy-2-methyl-, (2α,5α,17β)-
  • 58-19-5 Dromostanolone
  • DROSTANOLONE
  • 5α-ANDROSTAN-2α-METHYL-17β-OL-3-ONE
  • 58-19-5
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Steroids