Indications and Usage Drug Interactions Adverse reactions Contradictions Warnings and Precautions
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Metandienone

Indications and Usage Drug Interactions Adverse reactions Contradictions Warnings and Precautions
Product Name
Metandienone
CAS No.
72-63-9
Chemical Name
Metandienone
Synonyms
DBOL;Metandrostenolone;Danabol;Dianabole;Crein;Abirol;Geabol;Naposim;Nerobol;Anabolin
CBNumber
CB0502711
Molecular Formula
C20H28O2
Formula Weight
300.44
MOL File
72-63-9.mol
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Metandienone Property

Melting point:
165-166 °C
Boiling point:
381.66°C (rough estimate)
Density 
1.0597 (rough estimate)
refractive index 
1.4800 (estimate)
Flash point:
-2℃
storage temp. 
2-8°C
solubility 
Acetonitrile: 1 mg/ml; Ethanol: 1 mg/ml; Methanol: 1 mg/ml
pka
15.12±0.60(Predicted)
optical activity
[α]1.15/D 0.5±0.5° in chloroform
Merck 
5951
BRN 
2056255
InChI
InChI=1/C20H28O2/c1-18-9-6-14(21)12-13(18)4-5-15-16(18)7-10-19(2)17(15)8-11-20(19,3)22/h6,9,12,15-17,22H,4-5,7-8,10-11H2,1-3H3/t15-,16+,17+,18+,19+,20+/s3
InChIKey
XWALNWXLMVGSFR-HLXURNFRSA-N
SMILES
[C@]12(CCC3=CC(=O)C=C[C@]3(C)[C@]1(CC[C@]1(C)[C@](O)(C)CC[C@@]21[H])[H])[H] |&1:0,9,11,14,16,21,r|
CAS DataBase Reference
72-63-9(CAS DataBase Reference)
NIST Chemistry Reference
Methandrostenolone(72-63-9)
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Safety

Hazard Codes 
F,T
Risk Statements 
60-61-11-19-38
Safety Statements 
53-45
RIDADR 
3249
WGK Germany 
3
RTECS 
BV8000000
8
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29329970
Hazardous Substances Data
72-63-9(Hazardous Substances Data)
Toxicity
LD50 oral in rat: > 1gm/kg
DEA Controlled Substances
CSCN: 4000
CSA SCH: Schedule III
NARC: No
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H332Harmful if inhaled

Precautionary statements

P201Obtain special instructions before use.

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M-912
Product name
Methandienone solution
Purity
1.0?mg/mL in 1,2-dimethoxyethane, ampule of 1?mL, certified reference material, Cerilliant?
Packaging
1mL
Price
$101
Updated
2024/03/01
Sigma-Aldrich
Product number
90151
Product name
17β-Hydroxy-17-methylandrosta-1,4-dien-3-one
Purity
analytical standard
Packaging
100mg
Price
$166
Updated
2024/03/01
Cayman Chemical
Product number
21172
Product name
Metandienone
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
21172
Product name
Metandienone
Purity
≥98%
Packaging
10mg
Price
$139
Updated
2024/03/01
Aronis compounds
Product number
BBC/585
Product name
17-hydroxy-17-methylandrosta-1,4-dien-3-one
Packaging
1g
Price
$133
Updated
2021/12/16
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Metandienone Chemical Properties,Usage,Production

Indications and Usage

Metandienone is a dehydrogenation derivative of methyltestosterone. Its protein assimilating effects are similar to those of testosterone propionate, but its androgen effects are slightly weaker and are about 1/100 those of the latter. This drug can promote protein synthesis, inhibit protein heterogeneity, maintain a positive nitrogen balance, improve appetite, aid muscle growth, and encourage weight gain. It can cause calcium and phosphorous deposition in bone tissue, promote bone mesenchymal cell formation, and increase bone calcification and growth. It can encourage tissue generation and granulation and speed up healing of wounds. It lowers blood cholesterol and improves fat metabolism.
Metandienone is an androgen and anabolic hormone drug. It is suitable for people with insufficient protein synthesis and increased protein decomposition, such as patients with negative nitrogen balance caused by chronic wasting diseases, severe infections, trauma, and burns, as well as malignant tumors, osteoporosis, stunted children, dwarfism, fractures, less healing, and high cholesterol.

Drug Interactions

When Metandienone is used with oxyphenbutazone, the blood concentration of oxyphenbutazone may increase.

Adverse reactions

1. Metandienone’s adverse are identical to those of regular androgen and anabolic steroids. There may be nausea, vomiting, indigestion, diarrhea, and other digestive tract reactions. Long term, high dosage use may lead to bone weight, water-sodium retention, increased blood supply to skin, hypocalcemia, hyperosteogeny, etc. Women may experience slight virilism, with effects including acne, hirsuitism, lowered voice, clitoral hypertrophy, irregular menstruation, etc. 2. Metandienone’s side effects on the liver include jaundice and liver failure. There have been reports of liver cancer and benign hepatocellular adenoma tied to Metandianone use.

Contradictions

1. Do not use this drug if allergic.
2. Do not use if experiencing liver failure.
3. Do not use during pregnancy or if pregnancy may occur during treatment.
4. Do not use if experiencing prostate cancer, kidney disease, hypertension, or prostate hypertrophy.

Warnings and Precautions

1. Monitor liver functions while using Metandienone.
2. Dosage for elderly patients should be reduced accordingly.
3. Consume appropriate amounts of protein, sugar and vitamins during treatment to improve efficacy.

Chemical Properties

White Solid

Originator

Dianabol,Ciba,US,1960

Uses

Anabolic steroid. Androgen. Controlled substance.

Definition

ChEBI: Methandrostenolone is an organic molecular entity.

Manufacturing Process

As described in US Patent 2,929,763, methandrostenolone may be made by a fermentation route. 2 g of sodium nitrate, 1 g of primary potassium orthophosphate, 0.5 g of magnesium sulfate heptahydrate, 0.5 g of potassium chloride, 50 g of glucose and 1 g of Difco yeast extract are dissolved in one liter of tap water, brought to pH 5 by addition of a sodium hydroxide solution and sterilized. The resulting nutrient solution is inoculated with 50 cc of a 4- day-old shaking culture of Didymella lycopersici and shaken for 48 hours at 27°C, whereby the culture becomes well developed.
To two liters of a culture so prepared there is added under sterile conditions a solution of 500 mg of 17α-methyl-testosterone in 15 cc of acetone. Shaking is carried out for 3 days at 27°C, the mycellium then filtered off with suction, washed with water and ethyl acetate and the combined filtrates extracted with ethyl acetate. The extraction residue obtained after evaporation of the solvent is dissolved in a little acetone. On addition of ether, the 1-dehydro-17αmethyl-testosterone is obtained in compact crystals. MP 163° to 164°C.
An alternative synthetic route is described in US Patent 2,900,398 as follows. A suspension of 30 g of 17α-methyl-testosterone and 10 g of selenium dioxide in 600 cc of tertiary amyl alcohol is treated with 60 g of magnesium powder and 6 cc of glacial acetic acid.
The mixture is refluxed for 24 hours with good stirring in an atmosphere of nitrogen, another 10 g of selenium dioxide being added after 10 hours. After some cooling, the suspension is filtered through some Hyflo and washed thoroughly with ethyl acetate. The resulting brown solution is evaporated in vacuo and the residue dissolved in ethyl acetate.
The ethyl acetate solution is then washed with water, dried and evaporated. To remove any selenium still present, the residue is dissolved in 200 cc of methanol and mixed with 100 g of iron powder and 2 g of active carbon. The mixture is heated for 30 minutes with stirring under reflux, then filtered with suction, washed with methanol and the solution evaporated in vacuo. The residue is then chromatographed on 900 g of aluminum oxide. The residues of the evaporated benzene and ether fractions are treated with active carbon in methanol or acetone, evaporated again, and the residue recrystallized from a mixture of acetone and ether. There are obtained 17.5 g of pure 1-dehydro17α-methyl-testosterone which melts at 163° to 164°C.

Therapeutic Function

Androgen, Anabolic

Metandienone Preparation Products And Raw materials

Raw materials

Preparation Products

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Metandienone Suppliers

Guangzhou Xinyanze Biotechnology Co., LTD
Tel
18120340186
Email
3239311947@qq.com
Country
China
ProdList
375
Advantage
58
INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3576
Advantage
66
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44751
Advantage
61
China DongFan Chemical Co.,LTD
Tel
86-0571-85151182
Fax
86-0571-85151182
Country
China
ProdList
5700
Advantage
66
XiaoGan ShenYuan ChemPharm co,ltd
Tel
0712-0712-2580635 15527768850
Email
1791901229@qq.com
Country
China
ProdList
8850
Advantage
52
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12990
Advantage
57
BioBioPha Co., Ltd.
Tel
0871-65217109 13211707573;
Fax
0871-65215563
Email
y.liu@mail.biobiopha.com
Country
China
ProdList
5658
Advantage
65
Beijing Yisiyan Technology Research Center
Tel
010-56645598 13366904824
Fax
01062230033
Email
bjkaida@163.com
Country
China
ProdList
1669
Advantage
59
NCE Biomedical Co.,Ltd.
Tel
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax
+86-27-87599188
Country
China
ProdList
1494
Advantage
55
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28398
Advantage
80
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View Lastest Price from Metandienone manufacturers

Wuhan Cell Pharmaceutical Co., Ltd
Product
Methandienone 72-63-9
Price
US $850.00/kg
Min. Order
1kg
Purity
99.99%
Supply Ability
2 tons
Release date
2023-04-04
CONTIDE BIOTECH CO.,LTD
Product
Methandrostenolone 72-63-9
Price
US $0.00/G
Min. Order
1G
Purity
99%
Supply Ability
20
Release date
2024-03-27
Hebei Kangcang new material Technology Co., LTD
Product
Metandienone 72-63-9
Price
US $11.00-90.00/kg
Min. Order
0.10000000149011612kg
Purity
99%
Supply Ability
10 tons
Release date
2024-03-20

72-63-9, MetandienoneRelated Search:


  • Methandienone/Methandrostenolone / DBOL(Dianabol )
  • 1,2-Dimethoxyethane (test Methandienone, 1.0 )mg/mL
  • Dianabol Tablet
  • Metandienone (Dianabol) Tablet
  • Methandrostenolone 1-Dehydro-17alpha-methyltestosterone Dianabol Methandienone
  • 1,4-Androstadien-17a-Methyl-17-ol-3-one-2,4,6a-d3
  • 1,4-Androstadien-17a-Methyl-17-ol-3-one-d3
  • Methandrostenolone/Dianabol/Methandienone
  • Methandienone solution
  • (8R,9S,10R,13S,14S,17S)-17-hydroxy-10,13,17-triMethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
  • Methandienone/danabol
  • Androsta-1,4-dien-3-one,17-hydroxy-17-Methyl-, (17b)-
  • Methandione
  • 17-beta-hydroxy-17-alpha-methyl-androsta-4-dien-3-one
  • 17-beta-Hydroxy-17-alpha-methylandrostra-1,4-dien-3-one
  • 17-beta-hydroxy-17-methyl-androsta-4-dien-3-one
  • 17beta-hydroxy-17-methyl-androsta-4-dien-3-one
  • 17-hydroxy-17-methyl-4-dien-3-on(17-beta)-androsta-
  • 17-hydroxy-17-methyl-4-dien-3-on(17beta)-androsta-
  • 17-Hydroxy-17-methylandrosta-1,4-dien-3-one
  • 17-Methyl-17-hydroxy-1,4-androstadi-en-3-one
  • 1-Dehydro-17-methyltestosterone
  • a1-dehydromethyltesterone
  • Abirol
  • Anabolicum Medivet
  • Anabolin
  • Andoredan
  • Androsta-1,4-dien-3-one, 17beta-hydroxy-17alpha-methyl-
  • Androsta-1,4-dien-3-one, 17beta-hydroxy-17-methyl-
  • Androsta-1,4-dien-3-one, 17-hydroxy-17-methyl-, (17beta)-
  • Androsta-1,4-diene-3-one, 17-hydroxy-17-methyl-, (17beta)-
  • Ciba 17309-Ba
  • ciba17309ba
  • ciba17309-ba
  • Compound 17309
  • compound17309
  • Crein
  • Danabol
  • dehydromethyltesterone
  • Dehydromethyltestosterone
  • delta(1)-17alpha-methyltestosterone
  • delta(sup1)-17-alpha-methyltestosterone
  • delta(Sup1)-17alpha-Methyltestosterone
  • delta’-17-methyltestosterone
  • delta-1,17-alpha-Methyltestosterone
  • delta'-17-Methyltestosterone
  • Dianabole
  • Encephan
  • Geabol
  • Metanabol
  • Metandienon
  • Metandienonum
  • Metandrostenolon
  • Metandrostenolone
  • Metastenol
  • Methandrolone
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  • Nerobol