Overview Receptors Indication Pharmacodynamics Pharmacology Mechanism of neuroprotective effect Toxicity
ChemicalBook > CAS DataBase List > CANNABIDIOL

CANNABIDIOL

Overview Receptors Indication Pharmacodynamics Pharmacology Mechanism of neuroprotective effect Toxicity
Product Name
CANNABIDIOL
CAS No.
13956-29-1
Chemical Name
CANNABIDIOL
Synonyms
CBD;CBD Isolate;CBD oil;cannabidiol (CBD);(-)-CANNABIDIOL;(-)-Cannabidiol;CBD isolate powder;2-[(1R,6R)-3-METHYL-6-(1-METHYLETHENYL)-2-CYCLOHEXEN-1-YL]-5-PENTYL-1,3-BENZENEDIOL;C07578;CBD crystal
CBNumber
CB7673434
Molecular Formula
C21H30O2
Formula Weight
314.46
MOL File
13956-29-1.mol
More
Less

CANNABIDIOL Property

Melting point:
62-63°C
alpha 
D27 -125° (0.066 g in 5 ml 95% ethanol); D18 -129° (c = 0.45 in ethanol)
Boiling point:
bp2 187-190° (bath temp 220°); bp0.001 130°
Density 
d440 1.040
refractive index 
nD20 1.5404
Flash point:
11 °C
storage temp. 
2-8°C
solubility 
Soluble to 75 mM in ethanol and to 75 mM in DMSO
form 
powder
color 
White
InChIKey
QHMBSVQNZZTUGM-ZWKOTPCHSA-N
LogP
6.600 (est)
EPA Substance Registry System
1,3-Benzenediol, 2-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl- (13956-29-1)
More
Less

Safety

Hazard Codes 
F,T
Risk Statements 
11-23/24/25-39/23/24/25
Safety Statements 
36/37-45-16-7
RIDADR 
UN 1230 3/PG 2
WGK Germany 
1
RTECS 
VH1600000
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H301Toxic if swalloed

H311Toxic in contact with skin

H331Toxic if inhaled

H370Causes damage to organs

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P311Call a POISON CENTER or doctor/physician.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C6395
Product name
Cannabidiol solution
Purity
1.0mg/mL in methanol, analytical standard, for drug analysis
Packaging
1ml
Price
$116
Updated
2022/05/15
Sigma-Aldrich
Product number
C-045
Product name
Cannabidiol solution
Purity
1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant?
Packaging
1mL
Price
$32.8
Updated
2022/05/15
Cayman Chemical
Product number
90080
Product name
Cannabidiol
Purity
≥98%
Packaging
5mg
Price
$60
Updated
2023/06/20
Cayman Chemical
Product number
90080
Product name
Cannabidiol
Purity
≥98%
Packaging
10mg
Price
$106
Updated
2023/06/20
Cayman Chemical
Product number
ISO60156
Product name
Cannabidiol (CRM)
Packaging
1mg
Price
$32
Updated
2023/06/20
More
Less

CANNABIDIOL Chemical Properties,Usage,Production

Overview

Cannabidiol[CBD] is the main non-psychotropic component of the glandular hairs of Cannabis sativa. It displays a plethora of actions including anticonvulsive, sedative, hypnotic, antipsychotic, and anti-inflammatory and neuroprotective properties. It is a major phyto-cannabinoid, accounting for up to 40% of the Cannabis plant's extract, that binds to a wide variety of physiological targets of the endocannabinoid system within the body. Although the exact medical implications are currently being investigated, CBD has shown promise as a therapeutic and pharmaceutical drug target. In particular, CBD has shown promise as an analgesic, anticonvulsant, muscle relaxant, anxiolytic, antipsychotic and has shown neuroprotective, anti-inflammatory, and antioxidant activity, among other currently investigated uses[1, 2].
Cannabidiol was isolated from marijuana in the late 1930s, but only in the 1963 were its structure and stereochemistry first elucidated[3]. Early studies focusing on CBD pharmacology started in the 1970s, with the first relevant finding concerning its hypnotic and anticonvulsant properties, published in 1981[4]. Since then, a large body of pharmacological effects has been demonstrated, both in preclinical and in clinical studies.

Figure 1 the chemical structure of Cannabidiol;

Receptors

So far, two membrane receptors for cannabidiol, both coupled to G protein and named CB1 and CB2, have been identified. While CB1 receptors are mainly expressed in the central and the peripheral nervous systems, CB2 receptors have been reported to be more abundantly detected in cells of the immune system[5]. Moreover, two orphan G protein-coupled receptors, GPR119 and GPR55, possibly activated by multiple different cannabinoid ligands[6], have been recently proposed as novel cannabinoid receptors.

Indication

Being used in combination with delta-9-tetrahydrocannabinol as the product Sativex, cannabidiol was applied for the following indications: 1) as adjunctive treatment for symptomatic relief of spasticity in adult patients with multiple sclerosis[MS] who have not responded adequately to other therapy and who demonstrate meaningful improvement during an initial trial of therapy [7]; Sativex was also given a Notice of Compliance with Conditions(NOC/c) by Health Canada for the following indications: 1) as adjunctive treatment for the symptomatic relief of neuropathic pain in adult patients with multiple sclerosis; 2) as adjunctive analgesic treatment in adult patients with advanced cancer who experience moderate to severe pain during the highest tolerated dose of strong opioid therapy for persistent background pain[7].

Pharmacodynamics

The correct use of CBD in human therapy necessarily requires basic information related to pharmacokinetics. Cannabis derivatives are usually inhaled or orally administered. Other routes, including rectal, transdermic, eye drops, aerosols and intravenous have been used in a small number of studies so that the relevance of findings is limited. Recently, it was demonstrated in rabbits that sublingual administration of a solid CBD/beta-cyclodextrin complex might provide an alternative formulation for sublingual administration[8]. The pharmacokinetics of CBD is quite complicated and in many aspects resembles that of Δ9-THC. Once taken orally, CBD bioavailability ranges between 13% and 19%, due to a marked first-pass effect, while the systemic bioavailability of inhaled CBD in a group of cannabis users was 31%(range 11– 45%). The plasma pattern was similar to that of Δ9-THC. Daily oral doses of CBD 10 mg/kg/day chronically administered resulted in mean plasma concentrations of 5.9–11.2 ng/mL[9]. CBD is rapidly distributed when intravenously administered, and easily passes the blood–brain barrier. CBD shows a prolonged elimination; its terminal half-life is about 9 h, and it is excreted preferentially in the urine, both free and as its glucuronide compound[10]. Cannabidiol impairs hepatic drug metabolism in several animal species, and inhibits mouse hepatic metabolism through the inactivation of specific cytochrome P450 belonging to the 2C and 3A subfamilies[11]. The metabolism of CBD showed biotransformation routes typically observed for cannabinoids[12]. It undergoes multiple hydroxylations, oxidations to carboxylic acids, beta-oxidation, conjugation and epoxidation[13]. Conjugation with fatty acids, first observed with Δ9and Δ8-THC, provides a potent means of increasing the lipophilicity and, hence, tissue accumulation[14]. CBD-7-oic acid together with CBD glucuronide represent the most abundant products of CBD metabolism detected in human urine[13]. Unlike Δ9-THC a remarkable percentage of unchanged CBD is excreted in the faeces[15].

Pharmacology

Cannabinoid pharmacology is a field rapidly expanding and the therapeutic properties of cannabinoid receptor agonists include analgesia, muscle relaxation, immunosuppressant, antiinflammatory and antiallergic effects, improvement of mood, stimulation of appetite, antiemesis, lowering of intraocular pressure, bronchodilatation, neuroprotection and antineoplastic effects[16]. Despite the emerging evidence regarding therapeutic activities of CBs, their effective introduction in clinical use is still controversial and strongly limited by the unavoidable psychotropic effects exhibited by many of them. Since it was previously demonstrated that CBD binds with a low affinity to both CB1 and CB2 cannabinoid receptors, much research was aimed at recognizing CB1 and CB2 independent modes of action for this phytocannabinoid. To date, different molecular targets have been proposed. The first evidence that CBD can bind to sites different from cannabinoid receptors was offered by the observation that natural CBD and the[+]-synthetic one both stimulate the type-1 vanilloid receptor[17]. Other studies indicated that CBD also binds to 5-HT1A and such an interaction was suggested to account for the attenuation of cerebral infarction size occurring during ischemia[18] and also for its anxiolytic effect[19]. It has been also reported that CBD may behave as an allosteric modulator at μ and δ opioid receptors, even if the effects occur at very high levels of phytocannabinoid, so that this modulation cannot be expected to contribute markedly to the CBD actions exerted in vivo[20]. However, although CBD displays very low affinity for both CB1 and CB2, it has been reported recently that it can operate as a CB2 receptor inverse agonist and this may, at least in part, contribute to its widely documented antiinflammatory properties[21].
Furthermore it is commonly recognized that many CBD effects are mainly due to its antioxidant activity as first demonstrated by Hampson et al.(1998)[22] that exposed rat cortical neuron cultures to a toxic level of the excitatory neurotransmitter glutamate. On that occasion, the authors showed that CBD exerted a potent antioxidant activity, resulting in a more protective effect than either ascorbate or α-tocopherol, against glutamate-mediated neurotoxicity.

Mechanism of neuroprotective effect

The neuroprotective actions of CBD, mainly due to its antiinflammatory and antioxidant properties, have been well documented[22]. Recently, a neuroprotective mechanism of CBD has also been confirmed in a mouse model of ischemia, where CBD explicates the cerebroprotective action via a cannabinoid receptor-independent myeloperoxidase-inhibiting mechanism[23], in addition to a 5HT1A receptor action[18]. It has also been demonstrated that CBD reverses binge ethanol-induced neurotoxicity, once again, via a cannabinoid receptor independent antioxidant mechanism[24]. The potential of CBD to attenuate the excessive formation of peroxynitrites induced by glutamate also contributes to its neuroprotective effects, as demonstrated by the in vitro results pointing to the ability of CBD to induce the prevention of retinal apoptosis[25].

Toxicity

Cannabidiol exhibits very low toxicity in humans and in other species: the LD50 after intravenous administration to rhesus monkeys was 212 mg/kg[26]. The oral LD50 has not been established, but in 1981 Rosenkrantz showed that an oral dose of CBD 20–50 times larger than the intravenous route is required to initiate severe intoxication[26]. CBD does not cause relevant CNS alterations. Moreover, a large body of studies failed to reveal teratogenic or mutagenic effects induced by CBD[27, 28].

Description

Cannabidiol (CRM) (Item No. ISO60156) is a certified reference material categorized as a phytocannabinoid. Unlike Δ9-THC (Item Nos. ISO60157 | 12068), cannabidiol is non-psychoactive. This product is intended for research and forensic applications.

Chemical Properties

Off-White Solid

Uses

Major non-psychoactive constituent of Cannabis. Exhibits multiple bioactivities including anticonvulsant, anxiolytic and anti-inflammatory effects. The (+)-isomers were more active than the (-)-isomers.

Definition

ChEBI: An cannabinoid that is cyclohexene which is substituted by a methyl group at position 1, a 2,6-dihydroxy-4-pentylphenyl group at position 3, and a prop-1-en-2-yl group at position 4.

Biological Activity

Non-psychotropic constituent of cannabis that is anticonvulsive, antihyperalgesic and neuroprotective in vivo . GPR55 and weak CB 1 antagonist (IC 50 values are 0.445 and 3.35 μ M), CB 2 receptor inverse agonist and inhibitor of anandamide uptake (IC 50 = 27.5 μ M). Also a weak agonist at VR1 vanilloid receptors (EC 50 = 3.5 μ M).

Pharmacology

Cannabidiol, a constituent of the cannabis plant, has been receiving considerable attention of late for its potential therapeutic utility, including potential anxiolytic, anticonvulsant,anti-inflammatory, and neuroprotective effects. Cannabidiol has a complex pharmacology. In contrast to THC, cannabidiol has minimal affinity for CB1 and CB2 receptors and produces no intoxication. The effects of cannabidiol in combination with THC have been mixed, with some data suggesting it may reduce THC’s mood-altering and cognitive effects, while others show no effect. If oral cannabidiol reduces cannabis intoxication, it could be a potential medication to treat CUD. However, Haney et al. tested a range of cannabidiol doses (200–800 mg) in combination with active and placebo cannabis and found no cannabidiol effect on the subjective, reinforcing, or cardiovascular effects of smoked cannabis, providing little support for cannabidiol’s utility as a medication to reduce cannabis’ positive reinforcing and subjective effects.

target

JNK | MAPK | P450 (e.g. CYP17) | TNF-α | COX | NF-kB | Caspase | 5-HT Receptor

storage

-20°C

CANNABIDIOL Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

CANNABIDIOL Suppliers

13956-29-1, CANNABIDIOLRelated Search:


  • (-)-2-[(3R,4R)-p-Mentha-1,8-dien-3β-yl]-5-pentylresorcinol
  • C07578
  • Methanol( test Cannabidiol 1.0 mg/mL)
  • (-)-trans-2-p-mentha-1,8-dien-3-yl-5-pentylresorcinol
  • (-)-trans-Cannabidiol
  • 1,3-Benzenediol,2-[(1R,6R)-3-Methyl-6-(1-Methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-
  • CBD,CANNABIDIOL
  • Cannabidiol (exempt preparation)
  • cannabidiol (CBD)
  • 2-((1R,6R)-6-Isopropenyl-3-methyl-cyclohex-2-enyl)-5-pentyl-benzene-1,3-diol
  • CBD crystal
  • CAS13956-29-1 CBD Oil Canabidiol 100% Natural Organic Hemp
  • CAS13956-29-1 99.99% CBD Cannabidiol isolate Powder Natural hemp extract
  • CBD isolate CANNABIDIOL
  • Nano Liposomal Cannabidiol
  • NanoActive Cannabidiol
  • ,(1r-trans)-
  • 1,3-Benzenediol, 2-[3-methyl-6-(1-methylethenyl)-3-cyclohexen-1-yl]-5-pentyl-
  • 2-(3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl)-5-pentyl-3-benzenediol
  • 2-(6-Isopropenyl-3-methyl-2-cyclohexen-1-yl)-5-pentyl-1,3-benzenediol
  • 8-dien-3-yl-5-pentyl-2-p-mentha-(-)-(e)-resorcino
  • delta1(2)-trans-Cannabidiol
  • Resorcinol, 2-p-mentha-1,8-dien-3-yl-5-pentyl-
  • Resorcinol, 2-p-mentha-1,8-dien-3-yl-5-pentyl-, trans-(-)-
  • (-)-CANNABIDIOL
  • CANNABIDIOL
  • CBD
  • 2-[1R-3-METHYL-6R-(1-METHYLETHENYL)-2-CYCLOHEXEN-1-YL]-5-PENTYL-1,3-BENZENEDIOL
  • 2-[(1R,6R)-3-METHYL-6-(1-METHYLETHENYL)-2-CYCLOHEXEN-1-YL]-5-PENTYL-1,3-BENZENEDIOL
  • CANNABIDIOL METHANOL SOLUTION
  • CANNABIDIOL METABOLITE OF TETRAHY
  • Cannabidiol(DeaControlled)
  • cannabidiol solution
  • Cannabidiol Cbd Isolate Powder
  • Liposomal CANNABIDIOL
  • Cannabidiol Isolate Powder
  • LIPOSOMAL CANNABIS SATIVA LEAF EXTRACT, Hemp leaf extract, Cannabidiol, CBD
  • Pure 99% Cannabidiol Cbd with CAS 13956-29-1
  • CBD oil
  • CBD Isolate
  • Pure 99% Cannabidiol Cbd Isolate Powder with CAS 13956-29-1
  • Cannabidiol (CRM)
  • CANNABIS ISOLATE POWDER
  • cbd hemp flower cannabidiol oil 99% purity cbd oil cbd isolate powder
  • Cannabidoil CBD
  • hemp oil 50%CBD total cannabinoids 90%
  • CBD isolate powder
  • 99% Purity Crystal CBD Isolate Powder CANNABIDIOL CAS: 13956-29-1 kf-wang(at)kf-chem.com
  • Soluble CANNABIDIOL, Soluble CBD
  • (-)-Cannabidiol (Synthetic)
  • Cannabidiol (CBD) Standard@1000 μg/mL in Methanol
  • Cannabidiol CBD powder/ oil
  • High Quality 99% hemp extract Cannabidiol/CBD Isolate Powder
  • cannabidiol CDB
  • Cannabidiol CBD isolate CBD oil
  • (1'R,2'R)-5'-methyl-4-pentyl-2'-(prop-1-en-2-yl)-1',2',3',4'-tetrahydro-[1,1'-biphenyl]-2,6-diol
  • CBD powder 99%
  • CBD water soluble powder