Amfepramone hydrochloride

Product Name: Amfepramone hydrochloride
CAS No.: 134-80-5
Chemical Name: Amfepramone hydrochloride
Synonyms: Tenapil;tenuate;Anfamon;Moderatan;tenuate-dospan;regenonhydrochloride;tenuatehydrochloride;amfepramonhydrochloride;Amfepramone Hydrocloride;amfepramone hydrochloride
CBNumber: CB4676232
Molecular Formula: C13H20ClNO
Formula Weight: 241.76
MOL File: 134-80-5.mol

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Amfepramone hydrochloride Property

Melting point:: 180-1810C
Flash point:: 9℃
storage temp.: Controlled Substance, -20°C Freezer
solubility: DMF: 1.25 mg/ml; DMSO: 3 mg/ml; Ethanol: 3 mg/ml; Methanol: 1 mg/ml; PBS (pH 7.2): 10 mg/ml
form: A crystalline solid

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Safety

Hazard Codes: F,T
Risk Statements: 11-23/24/25-39/23/24/25-20/21/22
Safety Statements: 7-16-36/37-45-36
RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany: 1
HS Code: 2922310000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H370Causes damage to organs

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D-121
Product name: Diethylpropion hydrochloride solution
Purity: 1.0?mg/mL in methanol (with 1% 1 M HCl; as free base), certified reference material, Cerilliant?
Packaging: 1mL
Price: $101
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1194009
Product name: Diethylpropion hydrochloride solution
Packaging: 200mg
Price: $506
Updated: 2024/03/01

Cayman Chemical

Product number: 11333
Product name: Diethylcathinone (hydrochloride)
Purity: ≥98%
Packaging: 5mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 11333
Product name: Diethylcathinone (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 11333
Product name: Diethylcathinone (hydrochloride)
Purity: ≥98%
Packaging: 50mg
Price: $231
Updated: 2024/03/01

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Amfepramone hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Originator

Tenuate,Merrell National ,US,1959

Uses

Controlled substance (stimulant). Anorexic.

Definition

ChEBI: The hydrochloride salt of diethylpropion. A central stimulant and indirect-acting sympathomimetic, it is an appetite depressant and is used as an anoretic in the short term management of obesity.

Manufacturing Process

1,145 g of α-bromopropiophenone and 850 g of diethylamine are combined under stirring and heated on a water bath to boiling. The precipitate is filtered off under suction and washed with benzol. The filtrate is shaken up with aqueous hydrogen chloride, the aqueous solution made alkaline and etherified. The solution freed of the ether is fractionated. The boiling point (6 mm) is 140°C and the yield 800 g. The base is dissolved in acetic ester and precipitated with isopropanolic hydrogen chloride. After suction filtration and washing with ether the yield is found to be 750 g (80%)and the melting point 168°C.

Therapeutic Function

Anorexic

General Description

Because it has two large (relative to H or methyl) N-alkylsubstituents, diethylpropion hydrochloride, 1-phenyl-2-diethylaminopropan-1-one hydrochloride (Tenuate, Tepanil),has fewer sympathomimetic, cardiovascular, and CNSstimulatoryeffects than amphetamine. It is reportedly ananorexiant agent that can be used for the treatment of obesityin patients with hypertension and cardiovascular disease.According to the generalization long used for thisgroup of drugs, increasing N-alkyl size reduces central 1effects and increases β effects, even though the effects arelikely mediated principally by indirect NE release.

Amfepramone hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Amfepramone hydrochloride Suppliers

Canada 1 China 12 India 3 Switzerland 1 United Kingdom 6 United States 14 Global 37

Sinopharm Chemical Reagent Co,Ltd.

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Chizhou Kailong Import and Export Trade Co., Ltd.

Tel
Fax: -
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Sigma-Aldrich

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Country: China
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Hefei Molake Biotechnology Co., Ltd.

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HANGZHOU CLAP TECHNOLOGY CO.,LTD

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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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CONIER CHEM AND PHARMA LIMITED

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Hubei Qingbei Yunyan Pharmaceutical Technology Co., Ltd

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Nanjing Shizhou Biology Technology Co.,Ltd

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Advantage: 58

134-80-5, Amfepramone hydrochlorideRelated Search:

3,4'-DIAMINODIPHENYLMETHANE Betaine hydrochloride Diphenyl ether 4-AMINOAZOBENZENE HYDROCHLORIDE Pyridine hydrochloride Phenyl salicylate PHENYL VALERATE Triethylamine hydrochloride D-Glucosamine hydrochloride Methoxyammonium chloride Cysteamine hydrochloride Topotecan hydrochloride Methylamine hydrochloride PHENYL RESIN DIETHYLPROPION 4'-methyl-2-(1-pyrrolidinyl)valerophenone hydrochloride Phenylacetic acid 1-(3',4'-Methylenedioxyphenyl)-2-pyrrolidino-1-pentanone hydrochloride

Moderatan

Tenapil

Diethylpropion Hydrochloride CIV (200 mg)

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1-phenyl-2-diethylamino-1-propanonehydrochloride

1-phenyl-2-diethylaminopropanone-1hydrochloride

2-(diethylamino)-1-phenyl-1-propanonhydrochloride

2-(diethylamino)-propiophenonhydrochloride

alpha-benzoyltriethylaminehydrochloride

alpha-benzoyltriethylammoniumchloride

amfepramonhydrochloride

amphepramonumhydrochloride

diethylpropionehydrochloride

regenonhydrochloride

tenuate

tenuate-dospan

tenuatehydrochloride

DIETHYLPROPION HYDROCHLORIDE

amfepramone hydrochloride

Amfepramone Hydrocloride

DIETHYLPROPION HYDROCHLORIDE SYMPATHOMIM ETIC, ANOR

α-Benzoyl triethyl ammonium chloride

Anfamon

DIETHYLPROPIONHYDROCHLORIDE,USP

amfepramone hydrochloride tablets

AMFEPRAMONE HYDROCHLORIDE (DIETHYLPROPION HYDROCHLORIDE)

Diethylproion hydrochloride

2-(Diethylamino)-1-phenyl-1-propanone Hydrochloride

a-Benzoyltriethylammonium Chloride

Amfepramone hydrochloride, 100ppm

2-(DIETHYLAMINO)PROPIOPHENONE HYDROCHLORIDE

Amfepramone hydrochloride USP/EP/BP

Diethylpropion Hydrochloride (1.0 mg/mL in Methanol)

Diethylpropion Hydrochloride CIV (1194009)

134-80-5

Aromatics

Intermediates & Fine Chemicals

Pharmaceuticals