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Methylamine hydrochloride

Product Name
Methylamine hydrochloride
CAS No.
593-51-1
Chemical Name
Methylamine hydrochloride
Synonyms
MACl;METHYLAMINE HCL;METHYLAMMONIUM CHLORIDE;CH3NH3Cl;Methyl-ammonium;MONOMETHYLAMINE HCL;Methanaminium chloride;AMINOMETHANE HYDROCHLORIDE;LT-S9151;Methaniminium
CBNumber
CB7122563
Molecular Formula
CH5N.ClH
Formula Weight
67.52
MOL File
593-51-1.mol
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Methylamine hydrochloride Property

Melting point:
231-233 °C(lit.)
Boiling point:
225-230 °C15 mm Hg(lit.)
Density 
0.8306 (rough estimate)
vapor pressure 
0.134Pa at 25℃
refractive index 
1.5500 (estimate)
Flash point:
225-230°C/15mm
storage temp. 
Store below +30°C.
solubility 
soluble
form 
powder
color 
White crystalline
Odor
Odorless
PH Range
5 - 7 at 10 g/l at 20 °C
PH
5-7 (10g/l, H2O, 20℃)
Water Solubility 
soluble
Sensitive 
Hygroscopic
Merck 
14,6014
BRN 
3588822
Stability:
Stable, but may be moisture sensitive. Incompatible with strong oxidizing agents.
InChIKey
NQMRYBIKMRVZLB-UHFFFAOYSA-N
LogP
-3.82
CAS DataBase Reference
593-51-1(CAS DataBase Reference)
NIST Chemistry Reference
Methylammonium chloride(593-51-1)
EPA Substance Registry System
Methylamine hydrochloride (593-51-1)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26-37/39
WGK Germany 
1
RTECS 
PA0603000
10
TSCA 
Yes
HS Code 
29211190
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M0505
Product name
Methylamine hydrochloride
Purity
≥98%
Packaging
100g
Price
$28.9
Updated
2024/03/01
Sigma-Aldrich
Product number
8.06020
Product name
Methylammonium chloride
Purity
for synthesis
Packaging
5G
Price
$32.3
Updated
2024/03/01
Sigma-Aldrich
Product number
M0505
Product name
Methylamine hydrochloride
Purity
≥98%
Packaging
500g
Price
$137
Updated
2024/03/01
Sigma-Aldrich
Product number
8.06020
Product name
Methylammonium chloride
Purity
for synthesis
Packaging
250g
Price
$60.8
Updated
2024/03/01
Sigma-Aldrich
Product number
8.06020
Product name
Methylammonium chloride
Purity
for synthesis
Packaging
1kg
Price
$176
Updated
2024/03/01
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Methylamine hydrochloride Chemical Properties,Usage,Production

Description

Methylamine Hydrochloride is a colorless organic solid that has an odor similar to that of fish and is used as an essential part for the synthesis of a wide variety of commercial compounds such as ephedrine, theophylline and other intermediates for a wide range of agricultural chemicals, including herbicides, fungicides, insecticides, biocides, and miticides. Methylamine hydrochloride is also a key ingredient in the synthesis of methamphetamine

Chemical Properties

white to light tan solid

Uses

Methylamine is used as a building block for the synthesis of other organic compounds. It is on the DEA watchlist for chemical precursors because of clandestine use in manufacture of the drug MDMA (ecstasy) and methamphetamine.
The HCl salt is in the form of white deliquescent crystals, and is frequently substitutable for the aq. soln. in many synthesis preparations. Methylamines are used directly as catalysts or as raw materials to produce other compounds with catalytic activity. Fuel additives are used to improve engine performance in a variety of ways. Trimethylamine is used to make paper chemicals. The manufacture of intermediates to make pharmaceuticals is one of the most diverse uses of methylamines.

Application

Methylamine hydrochloride can be used as a reactant to synthesize:
Betahistine via aza-Michael reaction with 2-vinylpyridine in water.
Azatripyrrolic and azatetrapyrrolic macrocycles by reacting with pyrrole and formaldehyde via base-catalyzed Mannich reaction.
Tetrahydropyridines via Aza-Diels–Alder reaction with dienes and aldehydes.
N-methylsecondary arylamines from aryl chlorides via nickel-catalyzed amination reaction.

Definition

ChEBI: The hydrochloride formed from methylamine.

Preparation

Methylamine hydrochloride is prepared by heating a mixture of aqueous formaldehyde and ammonium chloride; the residual water and the formic acid produced in the reaction are removed via vacuum distillation. This leaves behind solid methylamine hydrochloride. The solid is then purified by organic extractions and additional vacuum distillations. Methylamine gas for the reaction with P2P is generated in situ by heating the hydrochloride salt with sodium hydroxide. Alternatively, methylamine can be liberated from the hydrochloride with base and collected in a cold finger or flask immersed in a dry ice bath.

Pharmacology

Methylamine hydrochloride reduces blood pressure in both normotensive and hypertensive individuals. It has a gradual onset of action (1/2 to 2 hours) and a long-lasting effect (usually 6 to 12 hours or more). A small oral dosage often produces a smooth and predictable reduction of blood pressure. Although this antihypertensive effect is predominantly orthostatic, the supine blood pressure is also significantly reduced.

Solubility in organics

Very soluble in N,N-Dimethylformamide,Soluble in methanol,Sparingly soluble inglacial acetic acid, Very slightly soluble inchloroform.

Solubility in water

The experimental water solubility of Methylamine hydrochloride at 20 ℃ was 1080mg/L. Methylamine hydrochloride is highly soluble in water.

storage

Keep in a dry, cool and well-ventilated place. Keep container tightly close

Purification Methods

Crystallise the salt from n-butanol, absolute EtOH or MeOH/CHCl3. Wash it with CHCl3 to remove traces of dimethylamine hydrochloride. Dry it under vacuum first with H2SO4 then P2O5. It is deliquescent; store it in a desiccator over P2O5. [Beilstein 4 IV 122.]

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Methylamine hydrochloride Suppliers

SHANGHAI BANGCHENG CHEMICAL Co.,Ltd.
Tel
021-69106960 13701823733
Fax
021-69106780
Email
13701823733@163.com
Country
China
ProdList
4776
Advantage
60
Xinle Furun Biosynthesis Co., LTD
Tel
15031159310
Email
1301448869@qq.com
Country
China
ProdList
2
Advantage
58
Hebei Clavier Biotechnology Co., LTD
Tel
19930508148
Email
1350255213@qq.com
Country
China
ProdList
912
Advantage
58
Hebei Guanlang Biotechnology Co., Ltd.
Tel
19930505208
Email
515253120@qq.com
Country
China
ProdList
306
Advantage
58
Sichuan Hainuowei Technology Co. Ltd.
Tel
13708085536
Fax
QQ : 121102042
Email
hanovichem@163.com
Country
China
ProdList
3390
Advantage
56
Shenyang Snota Biotech Co.,Ltd
Tel
+86-024-31174117 +86-18002429090
Fax
024-31174117
Email
2193387905@qq.com
Country
China
ProdList
103
Advantage
58
Hefei Ergao Chemical Co., Ltd
Tel
13349118557
Email
2782107081@qq.com
Country
China
ProdList
449
Advantage
58
Hebei Guanlang Biotechnology Co., Ltd.
Tel
13383116422
Email
3381425553@qq.com
Country
China
ProdList
997
Advantage
58
JINANJINGSHENGHUAGONGYOUXIANGONGSI
Tel
15795376785 15795376785
Email
3193653335@qq.com
Country
China
ProdList
174
Advantage
58
Jinan New Era Chemical Co., Ltd.
Tel
0531-84319199 18660131512
Email
1417934650@qq.com
Country
China
ProdList
46
Advantage
58
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View Lastest Price from Methylamine hydrochloride manufacturers

Shandong Hanjiang Chemical Co., Ltd
Product
Methylamine hydrochloride 593-51-1
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10T
Release date
2024-01-15
Dorne Chemical Technology co. LTD
Product
Methylamine hydrochloride 593-51-1
Price
US $10.00-10.00/ASSAYS
Min. Order
1ASSAYS
Purity
99%
Supply Ability
10 tons
Release date
2024-03-26
Suzhou Sanyi Polymer Chemical Technology Co., Ltd.
Product
Methylamine hydrochloride 593-51-1
Price
US $20.00/kg
Min. Order
1kg
Purity
99
Supply Ability
20 ton
Release date
2024-03-27

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