Methylamine hydrochloride

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Methylamine hydrochloride

Product Name: Methylamine hydrochloride
CAS No.: 593-51-1
Chemical Name: Methylamine hydrochloride
Synonyms: MACl;METHYLAMINE HCL;METHYLAMMONIUM CHLORIDE;CH3NH3Cl;Methyl-ammonium;MONOMETHYLAMINE HCL;Methanaminium chloride;AMINOMETHANE HYDROCHLORIDE;LT-S9151;Methaniminium
CBNumber: CB7122563
Molecular Formula: CH5N.ClH
Formula Weight: 67.52
MOL File: 593-51-1.mol

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Methylamine hydrochloride Property

Melting point:: 231-233 °C(lit.)
Boiling point:: 225-230 °C15 mm Hg(lit.)
Density: 0.8306 (rough estimate)
vapor pressure: 0.134Pa at 25℃
refractive index: 1.5500 (estimate)
Flash point:: 225-230°C/15mm
storage temp.: Store below +30°C.
solubility: soluble
form: powder
color: White crystalline
Odor: Odorless
PH Range: 5 - 7 at 10 g/l at 20 °C
PH: 5-7 (10g/l, H2O, 20℃)
Water Solubility: soluble
Sensitive: Hygroscopic
Merck: 14,6014
BRN: 3588822
Stability:: Stable, but may be moisture sensitive. Incompatible with strong oxidizing agents.
InChIKey: NQMRYBIKMRVZLB-UHFFFAOYSA-N
LogP: -3.82
CAS DataBase Reference: 593-51-1(CAS DataBase Reference)
NIST Chemistry Reference: Methylammonium chloride(593-51-1)
EPA Substance Registry System: Methylamine hydrochloride (593-51-1)

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 26-37/39
WGK Germany: 1
RTECS: PA0603000
F: 10
TSCA: Yes
HS Code: 29211190

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: M0505
Product name: Methylamine hydrochloride
Purity: ≥98%
Packaging: 100g
Price: $28.9
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.06020
Product name: Methylammonium chloride
Purity: for synthesis
Packaging: 5G
Price: $32.3
Updated: 2024/03/01

Sigma-Aldrich

Product number: M0505
Product name: Methylamine hydrochloride
Purity: ≥98%
Packaging: 500g
Price: $137
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.06020
Product name: Methylammonium chloride
Purity: for synthesis
Packaging: 250g
Price: $60.8
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.06020
Product name: Methylammonium chloride
Purity: for synthesis
Packaging: 1kg
Price: $176
Updated: 2024/03/01

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Methylamine hydrochloride Chemical Properties,Usage,Production

Description

Methylamine Hydrochloride is a colorless organic solid that has an odor similar to that of fish and is used as an essential part for the synthesis of a wide variety of commercial compounds such as ephedrine, theophylline and other intermediates for a wide range of agricultural chemicals, including herbicides, fungicides, insecticides, biocides, and miticides. Methylamine hydrochloride is also a key ingredient in the synthesis of methamphetamine

Chemical Properties

white to light tan solid

Uses

Methylamine is used as a building block for the synthesis of other organic compounds. It is on the DEA watchlist for chemical precursors because of clandestine use in manufacture of the drug MDMA (ecstasy) and methamphetamine.
The HCl salt is in the form of white deliquescent crystals, and is frequently substitutable for the aq. soln. in many synthesis preparations. Methylamines are used directly as catalysts or as raw materials to produce other compounds with catalytic activity. Fuel additives are used to improve engine performance in a variety of ways. Trimethylamine is used to make paper chemicals. The manufacture of intermediates to make pharmaceuticals is one of the most diverse uses of methylamines.

Application

Methylamine hydrochloride can be used as a reactant to synthesize:
Betahistine via aza-Michael reaction with 2-vinylpyridine in water.
Azatripyrrolic and azatetrapyrrolic macrocycles by reacting with pyrrole and formaldehyde via base-catalyzed Mannich reaction.
Tetrahydropyridines via Aza-Diels–Alder reaction with dienes and aldehydes.
N-methylsecondary arylamines from aryl chlorides via nickel-catalyzed amination reaction.

Definition

ChEBI: The hydrochloride formed from methylamine.

Preparation

Methylamine hydrochloride is prepared by heating a mixture of aqueous formaldehyde and ammonium chloride; the residual water and the formic acid produced in the reaction are removed via vacuum distillation. This leaves behind solid methylamine hydrochloride. The solid is then purified by organic extractions and additional vacuum distillations. Methylamine gas for the reaction with P2P is generated in situ by heating the hydrochloride salt with sodium hydroxide. Alternatively, methylamine can be liberated from the hydrochloride with base and collected in a cold finger or flask immersed in a dry ice bath.

Pharmacology

Methylamine hydrochloride reduces blood pressure in both normotensive and hypertensive individuals. It has a gradual onset of action (1/2 to 2 hours) and a long-lasting effect (usually 6 to 12 hours or more). A small oral dosage often produces a smooth and predictable reduction of blood pressure. Although this antihypertensive effect is predominantly orthostatic, the supine blood pressure is also significantly reduced.

Solubility in organics

Very soluble in N,N-Dimethylformamide,Soluble in methanol,Sparingly soluble inglacial acetic acid, Very slightly soluble inchloroform.

Solubility in water

The experimental water solubility of Methylamine hydrochloride at 20 ℃ was 1080mg/L. Methylamine hydrochloride is highly soluble in water.

storage

Keep in a dry, cool and well-ventilated place. Keep container tightly close

Purification Methods

Crystallise the salt from n-butanol, absolute EtOH or MeOH/CHCl3. Wash it with CHCl3 to remove traces of dimethylamine hydrochloride. Dry it under vacuum first with H2SO4 then P2O5. It is deliquescent; store it in a desiccator over P2O5. [Beilstein 4 IV 122.]

Methylamine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

N-Methyl-1,2-benzenediamine dihydrochloride 1-METHYL-1H-IMIDAZOLE-5-CARBOXALDEHYDE 4-N-Boc-4-N-Methyl-aminopiperidine Betahistine N-METHYL-2-NITROANILINE 1-Methyl-4-(methylamino)piperidine 1-(4-HYDROXY-3-METHOXYPHENYL)-2-NITROETHENE 1-Boc-4-Methylaminopiperidine

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View Lastest Price from Methylamine hydrochloride manufacturers

Dorne Chemical Technology co. LTD

Product: Methylamine hydrochloride 593-51-1
Price: US $10.00-10.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 99%
Supply Ability: 10 tons
Release date: 2024-03-26

Hong Kong Excellence Biotechnology Co., Ltd.

Product: Methylamine hydrochloride 593-51-1
Price: US $50.00-30.00/kgkg
Min. Order: 1kgkg
Purity: >99%
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Release date: 2023-05-29

Hong Kong Excellence Biotechnology Co., Ltd.

Product: Methylamine Hydrochloride 593-51-1
Price: US $45.00-40.00/KG
Min. Order: 1KG
Purity: 99.9%
Supply Ability: 45 TONS
Release date: 2023-05-29

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