Organic Chemicals Poisoning Uses Production method
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Methylamine

Organic Chemicals Poisoning Uses Production method
Product Name
Methylamine
CAS No.
74-89-5
Chemical Name
Methylamine
Synonyms
MMA-40;MMA-50;CH3NH2;AMINE C1;Metilamine;Methylamin;Metyloamina;MERCURIALIN;METHYLAMINE;ai3-15637-x
CBNumber
CB4387750
Molecular Formula
CH5N
Formula Weight
31.06
MOL File
74-89-5.mol
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Methylamine Property

Melting point:
-93 °C(lit.)
Boiling point:
-6.3 °C(lit.)
Density 
0.785 g/mL at 25 °C
vapor density 
1.08 (20 °C, vs air)
vapor pressure 
27 psi ( 20 °C)
refractive index 
n20/D 1.371
Flash point:
61 °F
storage temp. 
Flammables area
solubility 
highly soluble in water (108g/100g) at 25°C; soluble in alcohol and miscible with ether; HCl salt is soluble in water and absolute alcohol; compound is insoluble in chloroform, acetone, ether, and ethyl acetate
pka
10.63(at 25℃)
Specific Gravity
0.901 (20℃/4℃) (40% Soln.)
PH
14 (H2O, 20°C)
explosive limit
4.9-20.8%
Water Solubility 
Miscible with water, ethanol, benzene, acetone and ether.
Merck 
14,6014
BRN 
741851
Henry's Law Constant
(x 10-5 atm?m3/mol): 1.11 at 25 °C (Christie and Crisp, 1967)
Exposure limits
TLV-TWA 10 ppm (~12.3 mg/m3)(ACGIH, MSHA, and OSHA); IDLH 100 ppm (NIOSH).
Stability:
Stable. Highly flammable. Note wide explosion limits. Incompatible with oxidizing agents, acids, alkalies, alkaline earth metals, copper and its alloys, zinc and its alloys.
CAS DataBase Reference
74-89-5(CAS DataBase Reference)
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Safety

Hazard Codes 
F+,Xn,C,F,T
Risk Statements 
12-20-37/38-41-34-20/22-11-39/23/24/25-36/37/38-23/24/25-40-19
Safety Statements 
7-16-26-36/37-45-29-36/37/39-3/7-3-39-33
RIDADR 
UN 3286 3/PG 2
WGK Germany 
2
RTECS 
PF6300000
4.5-31
Autoignition Temperature
806 °F
TSCA 
Yes
HazardClass 
3
PackingGroup 
II
HS Code 
29211100
Toxicity
LD50 orally in rats: 100-200 mg/kg (Kinney); LC50 in rats: 0.448 ml/l (Sarkar, Sastry)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H220Extremely flammable gas

H225Highly Flammable liquid and vapour

H280Contains gas under pressure; may explode if heated

H301Toxic if swalloed

H302Harmful if swallowed

H311Toxic in contact with skin

H314Causes severe skin burns and eye damage

H315Causes skin irritation

H318Causes serious eye damage

H331Toxic if inhaled

H332Harmful if inhaled

H333May be harmful if inhaled

H335May cause respiratory irritation

H351Suspected of causing cancer

H370Causes damage to organs

Precautionary statements

P201Obtain special instructions before use.

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P310Immediately call a POISON CENTER or doctor/physician.

P377Leaking gas fire: Do not extinguish, unless leak can be stopped safely.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P370+P378In case of fire: Use … for extinction.

P405Store locked up.

P403+P235Store in a well-ventilated place. Keep cool.

P410+P403Protect from sunlight. Store in a well-ventilated place.

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Methylamine Chemical Properties,Usage,Production

Organic Chemicals

Methylamine, also known as amino methane, is an important kind of organic chemical raw materials and intermediates and is a flammable colorless gas at normal temperature and pressure. Upon being liquefied or compressed at high concentrations, it has a strong odor of ammonia. It has fishy odor at very low concentrations. It is easily soluble in water and soluble in alcohol and ether. It is flammable and can form explosive mixtures with air with the explosive limit being 4.3% to 21%. It has weak alkalinity with the alkaline being stronger than ammonia. It can interact with inorganic acid to form water-soluble salts. It is obtained through the reaction between methanol and ammonia at high pressure and high temperature in the action of catalyst. Alternatively, it can be obtained through the reaction between formaldehyde and ammonium chloride upon being heated to 300 ℃ in the presence of zinc chloride. Methylamine can be used to make pesticides, pharmaceuticals, rubber vulcanization accelerator, dyes, explosives, leather, petroleum, surfactants, and ion exchange resin, paint strippers, and coatings as well as additives. It is an important raw material for the manufacturing of pesticide dimethoate, carbaryl, and chlordimeform. The inhalation toxicity of methylamine belongs to low toxicity category. The maximum allowable air concentration is 5mg/m3 (0.4ppm). It is corrosive and can cause irritation of the eyes, skin and mucous membranes. In case of fire, high heating temperature, it can cause risk of fire with cylinders and accessories damage being capable of causing an explosion.

Poisoning

Methylamine belongs to moderate-poisoning drug with a strong irritant and corrosive property. During the process of production and in transit, when there is leakage occurring due to accident, it can cause acute poisoning of contacted people.
This product can be subject to inhalation in its gaseous state from the respiratory tract. Its solution can be absorbed through the skin. Its salt can cause poisoning upon mistakenly oral administration. This product has a strong stimulating effect on eye; upper respiratory tract, skin and mucous membranes. Inhalation of it at high concentrations can cause damage to the lungs with people in severe cases getting pulmonary edema and respiratory distress syndrome, finally leading to death. However, it has been no yet reported of cases of systemic poisoning around the world. Liquid methylamine has strong irritation and corrosion effect and can cause eye and skin chemical burning. In case of 40% aqueous methylamine being splashed into the eyes, the victims can get burning eyes, photophobia, lacrimation, conjunctival hyperemia, eyelid irritation, corneal edema and superficial ulcers with those symptoms being able to last 1 to 2 weeks. Long-term exposure to low concentrations of methylamine can cause dryness and discomfort of the eyes, nose, and throat.
[first-aid]
Upon skin contact, the victim should immediately remove the contaminated clothing, wash it thoroughly with a large amount of flowing water. For first-aid, the victim can apply 1 to 2% acetic acid, 0.5% citric acid to wash the skin, mucous membranes and mouth.
When the eyes are contaminated, they should raise the eyelid and wash the eyes with flowing clean water and saline for at least 15 minutes, followed by fluorescein staining. If there is corneal injury occurring, the victims should be invited to an ophthalmologist for treatment.
For patients inhaling nitric methylamine gas and getting poisoned, they should be rapidly transferred from the scene of fresh air and keep the airway open. For patients with breathing difficulties, they should be given oxygen. Patients of respiratory and cardiac arrest should be immediately subject to artificial respiration and sent to hospital immediately after treatment in a timely manner.
This information is edited by Xiongfeng Dai from Chemicalbook.

Uses

Methylamine is an important kind of fatty amines organic chemicals and is used in a variety of industries such as manufacture of dyestuffs, treatment of cellulose, acetate rayon, as fuel additive, rocket propellant, and leather tanning processes. It can be used in the synthesis of the N-methyl-chloroacetamide that is the intermediate of the organic phosphorus insecticide dimethoate and omethoate; synthesis of the intermediate of the monocrotophos, α-chloro acetoacetyl methylamine; synthesis of the intermediates of carbamate pesticide, carbamoyl chloride and methyl isocyanate; as well as the synthesis of other pesticides varieties such as formamidine, amitraz, and tribenuron, etc. In addition, it can also be used in medicine, rubber, dyes, leather industry and photosensitive materials.

Production method

There are a lot of ways for manufacturing of methylamine. But in industry, people mainly apply methanol amination.
CH3OH + NH3 → CH3NH2 + H2O
2CH3OH + NH3 → (CH3) 2NH + 2H2O
3CH3OH + NH3 → (CH3) 3N + 3H2O
It is obtained through the following process: methanol and ammonia is at a ratio of 1.5 to 4 and subject to continuous vapor phase catalytic amination at high temperature and high pressure with activated alumina as a catalyst to generate the mixture crude product of mono-, di-, trimethylamine. The crude mixture further goes through a series of distillation column for continuous pressure and distillation separation, have cooling for deamination, dehydration can yield respectively mono-, di-, trimethylamine products.

Chemical Properties

Methylamine is a derivative of ammonia in which a methyl group is substituted for a hydrogen (Schweizer et al 1978). Its reactivity is governed primarily by the unshared pair of electrons on the nitrogen, therefore methylamine is a strongly alkaline base whose most characteristic reaction is the formation of salts with acids. It will react with acid halides and acid anhydrides to form N-substituted amines. Methylamine reacts with nitrous acid to form methanol with liberation of nitrogen. It is capable of reacting with aldehydes to form aldimines or Schiffs bases (Astle 1961).

Chemical Properties

colourless gas (or solution in water or methanol)

Chemical Properties

Methylamine is a colorless, fi sh-like smelling gas at room temperature. It is used in a variety of industries, such as the manufacture of dyestuffs, treatment of cellulose, acetate rayon, as a fuel additive, rocket propellant, and in leather tanning processes.

Chemical Properties

Methylamine is a colorless gas with a fish- or ammonia-like odor; at low concentrations a fishy odor. Shipped as a liquefied compressed gas. The odor threshold is 3.2 ppm.

Physical properties

Colorless, flammable gas with a strong ammonia-like odor. An experimentally determined recognition odor threshold concentration of 21 ppbv was reported by Leonardos et al. (1969). Odor threshold concentrations of 4.7 ppmv and 35 ppbv were experimentally determined by Nishida et al. (1979) and Nagata and Takeuchi (1990), respectively.

Uses

Methylamine is used in dyeing and tanning;in photographic developer, as a fuel additive,and as a rocket propellant. It is also usedin organic synthesis and as a polymerizationinhibitor. It occurs in certain plants, such asMentha aquatica.

Uses

Intermediate for accelerators, dyes, pharmaceuticals, insecticides, fungicides, surface active agents, tanning, dyeing of acetate textiles, fuel additive, polymerization inhibitor, component of paint removers, solvent, photographic developer, rocket propellent.

Definition

ChEBI: The simplest of the methylamines, consisting of ammonia bearing a single methyl substituent.

Production Methods

Several methods are currently used for synthesis of methylamine. Virtually all produce a mixture of primary, secondary, and tertiary amines which can be continuously separated by distillation and extraction. The most commonly used synthesis involves heating ammonium chloride and methyl alcohol (ratio varies from 2:1 to 6:1, depending on desired ratio of amines) to about 300°C in the presence of a catalyst such as zinc chloride. Alternatively, methylamine can be synthesized by heating ammonium chloride and formaldehyde in the presence of H2 and a hydrogenation catalyst such as nickel or platinum. Methylamine is generally marketed as a liquid or a 33% aqueous solution (HSDB 1988).

Definition

A colorless flammable gas that smells like ammonia. It is the simplest primary amine, used for making herbicides and other organic chemicals.

Definition

methylamine: A colourless flammablegas, CH3NH2; m.p. –93.5°C; b.p.–6.3°C. It can be made by a catalyticreaction between methanol and ammoniaand is used in the manufactureof other organic chemicals.

General Description

A colorless gas or a liquid. Pungent fishy odor resembling odor of ammonia. The liquid boils at 20.3°F hence vaporizes rapidly when unconfined. Vapors are heavier than air and may collect in low-lying areas. Easily ignited under most conditions. Under prolonged exposure to intense heat the containers may rupture violently and rocket. Used for making pharmaceuticals, insecticides, paint removers, surfactants, rubber chemicals.

Air & Water Reactions

Highly flammable. Very soluble in water; the solutions are strongly basic and therefore corrosive. Liquid fumes in air.

Reactivity Profile

METHYLAMINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated in combination with strong reducing agents, such as hydrides.

Hazard

(Gas and liquid) Dangerous fire risk. Explosive limits in air 5–21%. Strong irritant to tissue. Eye, skin and upper respiratory tract irritant.

Health Hazard

VAPOR: Irritating to eyes, nose and throat. If inhaled will cause coughing or difficult breathing. LIQUID: Will burn skin and eyes.

Health Hazard

Exposures to methylamine are known to cause adverse health effects among occupational workers. The workers demonstrate symptoms of toxicity that include, but are not limited to, irritation to the eyes, nose, and throat. Studies have indicated that the compound causes injury to the eyes through corneal opacities and edema hemorrhages in the conjunctiva, and injury to the liver. Studies of Guest and Varma indicated no signifi cant deleterious effects on the internal organs or skeletal deformities in experimental mice

Health Hazard

Exposures to methylamine are known to cause adverse health effects among occupational workers. The workers demonstrate symptoms of toxicity that include, but are not limited to, irritation to the eyes, nose, and throat. Studies have indicated that the compound causes injury to the eyes through corneal opacities and edema hemorrhages in the conjunctiva, and injury to the liver. Studies of Guest and Varma indicated no signifi cant deleterious effects on the internal organs or skeletal deformities in experimental mice.

Health Hazard

250 ppm produced damage to respiratorymucosa of the nasal turbinates. Exposureto 750 ppm produced severe body weightlosses, liver damage, and nasal degenerativechanges.
Any adverse health effects in humans dueto methylamine, other than its irritant action,is unknown.
LC50 value, inhalation (mice): 2400 mg/kg/2 h.

Health Hazard

Most of the studies on the toxicity of methylamine suggest it acts locally as an irritant and a sensitizer. Vapors result in eye irritation with tearing and inflammation with repeated exposure capable of inducing corneal damage. Exposure by inhalation irritates the mucous membranes of the nose, throat and lung, leading to coughing and respiratory distress. Skin contact with methylamine can lead to burns and dermatitis (Beard and Noe 1981). First aid for skin exposure requires immediate flushing with water.
Persons exposed to methylamine can detect a faint fishlike odor at less than 10 p.p.m. Little irritation occurs however, above 20 p.p.m. Methylamine can induce temporary irritation of the eyes, nose, and throat. The permissible exposure level (PEL) has been set at 10 p.p.m. (OSHA 1977) and the level immediately dangerous to life or health (IDLH) is 100 p.p.m. (Standards Completion Program, OSHA and NIOSH 1978).

Fire Hazard

FLAMMABLE. POISONOUS GASES MAY BE PRODUCED IN FIRE. Containers may explode in fire. Flashback along vapor trail may occur. Vapor may explode if ignited in an enclosed area. Toxic nitrogen oxides may be formed. Vapors are heavier than air and may travel considerable distance to a source of ignition and flash back.

Industrial uses

Methylamine and its hydrochloride salt are widely used in organic synthesis for introducing the methylamino group. In 1976, industrial consumption was 32,000 tons/year. One of its most important uses is in the preparation of amide-type surfactants. It is also used in the preparation of drugs such as adrenaline and synthetic caffeine. It serves as the base for more than twenty commercial products, among those included are photographic developers, insecticides, and antihistamine drugs (Beard and Noe 1981). It is also widely used in tanning and has been used in the separation of aromatics from aliphatic hydrocarbons (Sittig 1981).

Safety Profile

Poison by subcutaneous route. Moderately toxic by inhalation. A severe skin irritant. Mutation data reported. A strong base. Flammable gas at ordinary temperature and pressure. Very dangerous fire hazard when exposed to heat, flame, or sparks. Explosive when exposed to heat or flame. To fight fire, stop flow of gas. Forms an explosive mixture with nitromethane. When heated to decomposition it emits toxic fumes of NOx. See also AMINES.

Potential Exposure

Methylamine is used in organic synthesis; a starting material for N-oleyltaurine, a surfactant; and p-N-methylaminophenol sulfate, a photographic developer. It has possible uses in solvent extraction systems in separation of aromatics from aliphatic hydrocarbons. It is also used in the synthesis of many different pharmaceuticals; pesticides and rubber chemicals.

Source

Methylamine was detected in cauliflower (65 ppm), carrots (3,970 ppm), tea leaves (50 ppm), red and white cabbage (3.4 to 22.7 ppm), corn (27 ppm), kale leaves (16.6 ppm), barley seeds (4.5 ppm), epidermis of apples (4.5 ppm), celery (6.4 ppm), sweetflag, celandine, and tobacco leaves (Duke, 1992).

Environmental Fate

Photolytic. The rate constant for the reaction of methylamine and OH radicals in the atmosphere at 300 K is 1.3 x 10-13 cm3/molecule?sec (Hendry and Kenley, 1979).
Low et al. (1991) reported that the photooxidation of aqueous primary amine solutions by UV light in the presence of titanium dioxide resulted in the formation of ammonium and nitrate ions.
Chemical/Physical. In an aqueous solution, chloramine reacted with methylamine to form Nchloromethylamine (Isaac and Morris, 1983).
Reacts with acids forming water-soluble salts.

Metabolism

Methylamine is a normal body constituent in several species and is known to be generated endogenously from epinephrine (Schayer et al 1952) and creatine (Davis and DeRopp 1961). It has also recently been detected in the urine of male CBA/cA mice treated with N-methylformamide (Kestell et al 1985). Mammalian metabolism of methylamine is rapid yet the enzymes involved are not yet known. Simehnhoff (1975) suggested that methylamine is methylated to dimethylamine as it appeared not to be oxidized by amine oxidases yet was rapidly absorbed and not excreted in the urine. Dar et al (1985) conducted studies using methyl-[14C]- labeled methylamine injected i.p. into rats to assess the role of monoamine oxidase in the metabolism of methylamine in the rats. Methylamine underwent rapid oxidation as more than 30% of the 14C was recovered as 14CO2 in the first 2-6 h following exposure and 52% was expired in the first 24 h. Pretreatment of the rats with long acting monoamine oxidase inhibitors significantly inhibited methylamine metabolism, however short term inhibitors were without effect. Combinations of the drugs suggested that monoamine oxidase was not responsible for metabolism of methylamine and that a closely related enzyme such as methylamine oxidase, previously proposed by Werner and Seiber (1963), may be involved.
It has also been reported that intestinal microflora may degrade methylamine (Iyer and Kailio 1958). Dar et al (1985) found that pretreatment of rats with neomycin to reduce bacterial microorganisms resulted in only a slight inhibition of 14C expiration during the initial 6 h following methylamine administration. These results indicate that, at least in the rat, bacterial oxidation of methylamine in the intestine is negligible.

storage

Methylamine is stored in a cool, well-ventilated noncombustible area separatedfrom possible sources of ignition andoxidizing substances and mercury. Itssolutions are stored in a flammable liquidstorage room or cabinet. The gas is shippedin steel cylinders or tank cars; the liquid isshipped in steel drums or tank cars.

Shipping

UN1061 Methylamine, anhydrous, Hazard Class: 2.1; Labels: 2.1-Flammable gas. UN1235 Methylamine, aqueous solution, Hazard Class: 3; Labels: 3-Flammable liquid, 8-Corrosive material. Cylinders must be transported in a secure upright position, in a well-ventilated truck. Protect cylinder and labels from physical damage. The owner of the compressed gas cylinder is the only entity allowed by federal law (49CFR) to transport and refill them. It is a violation of transportation regulations to refill compressed gas cylinders without the express written permission of the owner.

Purification Methods

Dry the amine with sodium or BaO. It is commercially available in metal cylinders. [Beilstein 4 IV 118.]

Incompatibilities

A medium-strong base. Reacts violently with strong acids; mercury, strong oxidizers; nitromethane. Corrosive to copper, zinc alloys; aluminum, and galvanized surfaces.

Waste Disposal

Return refillable compressed gas cylinders to supplier. Controlled incineration (incinerator equipped with a scrubber or thermal unit to reduce nitrogen oxides emissions).

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Methylamine Suppliers

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