3,5-Bis(trifluoromethyl)aniline

Product Name: 3,5-Bis(trifluoromethyl)aniline
CAS No.: 328-74-5
Chemical Name: 3,5-Bis(trifluoromethyl)aniline
Synonyms: 3,5-DI(TRIFLUOROMETHYL)ANILINE;MBT-NH2;3,5-Bis(Trifluoro;AKOS BBS-00003710;TIMTEC-BB SBB000690;3,5-Di(trifluorometh;3,5-difluoromethylaniline;3,5-Bis(trifluormethyl)aniline;3,5-BIS(TRIFLUOROMETHYL)AMILINE;3,5-bis(trifluoromethyl)-anilin
CBNumber: CB3134320
Molecular Formula: C8H5F6N
Formula Weight: 229.12
MOL File: 328-74-5.mol

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3,5-Bis(trifluoromethyl)aniline Property

Melting point:: 168.2-169.2 °C
Boiling point:: 85 °C15 mm Hg(lit.)
Density: 1.467 g/mL at 25 °C(lit.)
refractive index: n20/D 1.434(lit.)
Flash point:: 182 °F
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: Liquid
pka: 2.15±0.10(Predicted)
Specific Gravity: 1.473
color: Clear light yellow to yellow-brown
Water Solubility: Not miscible in water.
BRN: 654318
InChI: 1S/C8H5F6N/c9-7(10,11)4-1-5(8(12,13)14)3-6(15)2-4/h1-3H,15H2
InChIKey: CDIDGWDGQGVCIB-UHFFFAOYSA-N
SMILES: Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F
CAS DataBase Reference: 328-74-5(CAS DataBase Reference)
NIST Chemistry Reference: Benzenamine, 3,5-bis(trifluoromethyl)-(328-74-5)
EPA Substance Registry System: Benzenamine, 3,5-bis(trifluoromethyl)- (328-74-5)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 33-36/37/38-20/21/22
Safety Statements: 26-36/37/39-36
RIDADR: 2810
WGK Germany: 3
RTECS: ZE9800000
Hazard Note: Irritant
TSCA: TSCA listed
HazardClass: 6.1
PackingGroup: III
HS Code: 29214910
Storage Class: 10 - Combustible liquids
Hazard Classifications: Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 193135
Product name: 3,5-Bis(trifluoromethyl)aniline
Purity: 97%
Packaging: 10g
Price: $54.1
Updated: 2025/07/31

Sigma-Aldrich

Product number: 193135
Product name: 3,5-Bis(trifluoromethyl)aniline
Purity: 97%
Packaging: 50g
Price: $113
Updated: 2025/07/31

TCI Chemical

Product number: B1324
Product name: 3,5-Bis(trifluoromethyl)aniline
Purity: >97.0%(GC)
Packaging: 10g
Price: $16
Updated: 2025/07/31

TCI Chemical

Product number: B1324
Product name: 3,5-Bis(trifluoromethyl)aniline
Purity: >97.0%(GC)
Packaging: 25g
Price: $44
Updated: 2025/07/31

TCI Chemical

Product number: B1324
Product name: 3,5-Bis(trifluoromethyl)aniline
Purity: >97.0%(GC)
Packaging: 250g
Price: $252
Updated: 2025/07/31

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3,5-Bis(trifluoromethyl)aniline Chemical Properties,Usage,Production

Chemical Properties

clear light yellow to yellow-brown liquid

Uses

3,5-Bis(trifluoromethyl)aniline was found to be a highly efficient monodentate transient directing group (MonoTDG) for the palladium-catalyzed direct dehydrogenative cross-coupling of benzaldehydes with arenes.

Synthesis

The synthesis of 3,5-Bis(trifluoromethyl)aniline is as follows is as follows：Put 259g (1mol) 3,5-Bis(trifluoromethyl)nitrobenzeneand 500g ethyl acetate into a 1L autoclave, add 5g palladium-carbon as a catalyst, raise the temperature to 60℃, then pass the hydrogen pressure to 2MPa, keep the temperature and react for 20 hours, then cooling, filtration, concentration, and distillation to obtain 3,5-Bis(trifluoromethyl)aniline with a purity of 98.5% and a yield of 87%.

3,5-Bis(trifluoromethyl)aniline Preparation Products And Raw materials

Raw materials

Toluene Nitric acid

Preparation Products

5,7-BIS(TRIFLUOROMETHYL)-4-HYDROXYQUINOLINE 5,7-BIS(TRIFLUOROMETHYL)-4-CHLOROQUINOLINE 4-HYDROXY-5,7-BIS-TRIFLUOROMETHYL-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER 5,7-BIS(TRIFLUOROMETHYL)-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID

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3,5-Bis(trifluoromethyl)aniline Suppliers

Americas 1 Belgium 2 Canada 2 China 318 Europe 5 France 1 Germany 8 India 13 Italy 1 Japan 6 Jordan 1 Slovakia 1 South Korea 1 Spain 1 Switzerland 2 The Netherlands 1 Ukraine 2 United Kingdom 26 United States 50 Global 442

Nanjing Chuyue Biochemical Technology Co.,Ltd

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Email: njchuyue@163.com
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Dongyang Qiusuo Medical Technology Co., LTD

Tel: 17502510579
Email: 2785299132@qq.com
Country: China
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Nanjing Hengweisheng Pharmaceutical Technology Co., Ltd

Tel: 19941530336
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Nanjing Dilu Pharmaceutical Co., Ltd

Tel: 18014482516; 18014482516
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J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
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Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
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Liaoning Tianhua Chemical Co., Ltd.

Tel: 0418-6530555 2855550
Fax: +86-418-6502885
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3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
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Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
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TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

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View Lastest Price from 3,5-Bis(trifluoromethyl)aniline manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 3,5-Bis(trifluoromethyl)aniline 328-74-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 10000KGS
Release date: 2025-07-04

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 3,5-Bis(trifluoromethyl)aniline 328-74-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-02-24

Hebei Chuanghai Biotechnology Co., Ltd

Product: 3,5-Bis(trifluoromethyl)aniline 328-74-5
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-19

328-74-5, 3,5-Bis(trifluoromethyl)anilineRelated Search:

,,,’,’,’-Hexafluoro-3,5-xylidine

,5-Bis-trifluoromethyl-phenylamine

,5-Xylidine, a,a,a,a',a',a'-hexafluoro-

,a,a,a',a',a'-Hexafluoro-3,5-xylidine

3,5-bis(trifluoromethyl)-anilin

3,5-bis(trifluoromethyl)-benzenamin

3,5-Bis(trifluoromethyl)benzenamine

3,5-Di(trifluorometh

3,5-DI(TRIFLUOROMETHYL)ANILINE

5-AMINO-ALPHA,ALPHA,ALPHA,ALPHA',ALPHA',ALPHA'-HEXAFLUORO-M-XYLENE

3,5-BIS(TRIFLUOROMETHYL)AMILINE

3,5-Bis(trifluoromethyl)aniline, 98+%

3,5-Bis(Trifluoro

5-amino-α,α,α,α',α',α'-hexafluoro-m-xylene

5-Amino-α,α,α,αμ,αμ,αμ-hexafluoro-m-xylene, α,α,α,αμ,αμ,αμ-Hexafluoro-3,5-xylidine

3,5-Bis(trifluoromethyl)benzeneamine

3,5-Bis(trifluoroMethyl)aniline, 98+% 10ML

3,5- two(three fluoroMethyl)aniline

3, 5 - double three fluorine Methylaniline

3,5-Xylidine, alpha,alpha,alpha,alpha',alpha',alpha'-hexafluoro-

3,5-Xylidine, alpha,alpha,alpha,alpha,alpha,alpha-hexafluro-

alpha,alpha,alpha,alpha’,alpha’,alpha’-hexafluoro-5-xylidine

Aniline, 3,5-bis(trifluoromethyl)-

TIMTEC-BB SBB000690

MBT-NH2

ALPHA,ALPHA,ALPHA,ALPHA',ALPHA',ALPHA'-HEXAFLUORO-3,5-XYLIDINE

AKOS BBS-00003710

A,A,A,A',A',A'-HEXAFLUORO-3,5-XYLIDINE

3,5-BIS(TRIFLUOROMETHYL)ANILINE

3,5-Bis(trifluoromethyl)aniline &gt

Benzenamine, 3,5-bis(trifluoromethyl)-

α,α,α,α',α',α'-Hexafluor-3,5-xylidin

3,5-Di(trifluoromethyl)aniline CAS NO.328-74-5

3,5-Bis(trifluormethyl)aniline

3,5-difluoromethylaniline

328-74-5

C8H5NF6

Organic Building Blocks

Nitrogen Compounds

Amines

Building Blocks

C8

Aniline series

Fluorobenzene

Anilines, Aromatic Amines and Nitro Compounds

Miscellaneous

Trifluoromethylbenzene serise