ChemicalBook > CAS DataBase List > 3,5-Bis(trifluoromethyl)aniline

3,5-Bis(trifluoromethyl)aniline

Product Name
3,5-Bis(trifluoromethyl)aniline
CAS No.
328-74-5
Chemical Name
3,5-Bis(trifluoromethyl)aniline
Synonyms
3,5-DI(TRIFLUOROMETHYL)ANILINE;MBT-NH2;3,5-Bis(Trifluoro;AKOS BBS-00003710;TIMTEC-BB SBB000690;3,5-Di(trifluorometh;3,5-Bis(trifluormethyl)aniline;3,5-BIS(TRIFLUOROMETHYL)AMILINE;3,5-bis(trifluoromethyl)-anilin;3,5-BIS(TRIFLUOROMETHYL)ANILINE
CBNumber
CB3134320
Molecular Formula
C8H5F6N
Formula Weight
229.12
MOL File
328-74-5.mol
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3,5-Bis(trifluoromethyl)aniline Property

Melting point:
168.2-169.2 °C
Boiling point:
85 °C15 mm Hg(lit.)
Density 
1.467 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.434(lit.)
Flash point:
182 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
Liquid
pka
2.15±0.10(Predicted)
Specific Gravity
1.473
color 
Clear light yellow to yellow-brown
Water Solubility 
Not miscible in water.
BRN 
654318
InChIKey
CDIDGWDGQGVCIB-UHFFFAOYSA-N
CAS DataBase Reference
328-74-5(CAS DataBase Reference)
NIST Chemistry Reference
Benzenamine, 3,5-bis(trifluoromethyl)-(328-74-5)
EPA Substance Registry System
Benzenamine, 3,5-bis(trifluoromethyl)- (328-74-5)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
33-36/37/38-20/21/22
Safety Statements 
26-36/37/39-36
RIDADR 
2810
WGK Germany 
3
RTECS 
ZE9800000
Hazard Note 
Irritant
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
III
HS Code 
29214910
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
193135
Product name
3,5-Bis(trifluoromethyl)aniline
Purity
97%
Packaging
10g
Price
$52.5
Updated
2024/03/01
Sigma-Aldrich
Product number
193135
Product name
3,5-Bis(trifluoromethyl)aniline
Purity
97%
Packaging
50g
Price
$110
Updated
2024/03/01
TCI Chemical
Product number
B1324
Product name
3,5-Bis(trifluoromethyl)aniline
Purity
>97.0%(GC)
Packaging
10g
Price
$16
Updated
2024/03/01
TCI Chemical
Product number
B1324
Product name
3,5-Bis(trifluoromethyl)aniline
Purity
>97.0%(GC)
Packaging
25g
Price
$44
Updated
2024/03/01
Alfa Aesar
Product number
A15289
Product name
3,5-Bis(trifluoromethyl)aniline, 98%
Packaging
10g
Price
$23.65
Updated
2024/03/01
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3,5-Bis(trifluoromethyl)aniline Chemical Properties,Usage,Production

Chemical Properties

clear light yellow to yellow-brown liquid

Uses

3,5-Bis(trifluoromethyl)aniline was found to be a highly efficient monodentate transient directing group (MonoTDG) for the palladium-catalyzed direct dehydrogenative cross-coupling of benzaldehydes with arenes.

Synthesis

The synthesis of 3,5-Bis(trifluoromethyl)aniline is as follows is as follows：Put 259g (1mol) 3,5-Bis(trifluoromethyl)nitrobenzeneand 500g ethyl acetate into a 1L autoclave, add 5g palladium-carbon as a catalyst, raise the temperature to 60℃, then pass the hydrogen pressure to 2MPa, keep the temperature and react for 20 hours, then cooling, filtration, concentration, and distillation to obtain 3,5-Bis(trifluoromethyl)aniline with a purity of 98.5% and a yield of 87%.

3,5-Bis(trifluoromethyl)aniline Preparation Products And Raw materials

Raw materials

Toluene Nitric acid

Preparation Products

5,7-BIS(TRIFLUOROMETHYL)-4-HYDROXYQUINOLINE 5,7-BIS(TRIFLUOROMETHYL)-4-CHLOROQUINOLINE 4-HYDROXY-5,7-BIS-TRIFLUOROMETHYL-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER 5,7-BIS(TRIFLUOROMETHYL)-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID
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3,5-Bis(trifluoromethyl)aniline Suppliers

Americas 1 Belgium 2 Canada 2 China 306 Europe 5 France 1 Germany 8 India 13 Italy 1 Japan 6 Jordan 1 Slovakia 1 South Korea 1 Spain 1 Switzerland 2 The Netherlands 1 Ukraine 2 United Kingdom 26 United States 50 Global 430
Acros Organics
Tel
--
Fax
--
Email
info@acros.com
Country
Belgium
ProdList
6772
Advantage
81
Maybridge Chemical Co., Ltd.
Tel
--
Fax
--
Country
Belgium
ProdList
6293
Advantage
73
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View Lastest Price from 3,5-Bis(trifluoromethyl)aniline manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
3,5-Bis(trifluoromethyl)aniline 328-74-5
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-02-24
Hebei Weibang Biotechnology Co., Ltd
Product
3,5-Bis(trifluoromethyl)aniline 328-74-5
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-19
Henan Fengda Chemical Co., Ltd
Product
3,5-Bis(trifluoromethyl)aniline 328-74-5
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-16

328-74-5, 3,5-Bis(trifluoromethyl)anilineRelated Search:

3,5-BIS(TRIFLUOROMETHYL)PHENYL ISOTHIOCYANATE 1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]-2,5-DIMETHYL-1H-PYRROLE 3,5-Bis(trifluoromethyl)aniline 1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]-2-THIOUREA 3,5-BIS(TRIFLUOROMETHYL)ACETANILIDE 1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]PYRROLE 3,5-BIS(TRIFLUOROMETHYL)PHENYL ISOCYANATE 3,5-BIS(TRIFLUOROMETHYL)PHENYLHYDRAZINE 2,5-Bis(trifluoromethyl)nitrobenzene 4-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]-3-THIOSEMICARBAZIDE 2,5-DI(TRIFLUOROMETHYL)ANILINE Aniline 2-CHLORO(BIS-3',5'-TRIFLUOROMETHYLACETANILIDE) N1-[2-(2-PIPERIDYL)ETHYL]-3,5-DI(TRIFLUOROMETHYL)ANILINE 2-AMINO-4-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]AMINO-1,3,5-TRIAZINE 2-BROMO-4,5-DI(TRIFLUOROMETHYL)ANILINE 2-METHYL-3,5-DI(TRIFLUOROMETHYL)ANILINE N1-methyl-3,5-di(trifluoromethyl)aniline

  • ,,,’,’,’-Hexafluoro-3,5-xylidine
  • ,5-Bis-trifluoromethyl-phenylamine
  • ,5-Xylidine, a,a,a,a',a',a'-hexafluoro-
  • ,a,a,a',a',a'-Hexafluoro-3,5-xylidine
  • 3,5-bis(trifluoromethyl)-anilin
  • 3,5-bis(trifluoromethyl)-benzenamin
  • 3,5-Bis(trifluoromethyl)benzenamine
  • 3,5-Di(trifluorometh
  • 3,5-DI(TRIFLUOROMETHYL)ANILINE
  • 5-AMINO-ALPHA,ALPHA,ALPHA,ALPHA',ALPHA',ALPHA'-HEXAFLUORO-M-XYLENE
  • 3,5-BIS(TRIFLUOROMETHYL)AMILINE
  • 3,5-Bis(trifluoromethyl)aniline, 98+%
  • 3,5-Bis(Trifluoro
  • 5-amino-α,α,α,α',α',α'-hexafluoro-m-xylene
  • 5-Amino-α,α,α,αμ,αμ,αμ-hexafluoro-m-xylene, α,α,α,αμ,αμ,αμ-Hexafluoro-3,5-xylidine
  • 3,5-Bis(trifluoromethyl)benzeneamine
  • 3,5-Bis(trifluoroMethyl)aniline, 98+% 10ML
  • 3,5- two(three fluoroMethyl)aniline
  • 3, 5 - double three fluorine Methylaniline
  • 3,5-Xylidine, alpha,alpha,alpha,alpha',alpha',alpha'-hexafluoro-
  • 3,5-Xylidine, alpha,alpha,alpha,alpha,alpha,alpha-hexafluro-
  • alpha,alpha,alpha,alpha’,alpha’,alpha’-hexafluoro-5-xylidine
  • Aniline, 3,5-bis(trifluoromethyl)-
  • TIMTEC-BB SBB000690
  • MBT-NH2
  • ALPHA,ALPHA,ALPHA,ALPHA',ALPHA',ALPHA'-HEXAFLUORO-3,5-XYLIDINE
  • AKOS BBS-00003710
  • A,A,A,A',A',A'-HEXAFLUORO-3,5-XYLIDINE
  • 3,5-BIS(TRIFLUOROMETHYL)ANILINE
  • 3,5-Bis(trifluoromethyl)aniline &gt
  • Benzenamine, 3,5-bis(trifluoromethyl)-
  • α,α,α,α',α',α'-Hexafluor-3,5-xylidin
  • 3,5-Di(trifluoromethyl)aniline CAS NO.328-74-5
  • 3,5-Bis(trifluormethyl)aniline
  • 328-74-5
  • C8H5NF6
  • Organic Building Blocks
  • Nitrogen Compounds
  • Amines
  • Building Blocks
  • C8
  • Aniline series
  • Fluorobenzene
  • Anilines, Aromatic Amines and Nitro Compounds
  • Miscellaneous
  • Trifluoromethylbenzene serise