2,5-Bis(trifluoromethyl)aniline

Product Name: 2,5-Bis(trifluoromethyl)aniline
CAS No.: 328-93-8
Chemical Name: 2,5-Bis(trifluoromethyl)aniline
Synonyms: 2,5-DI;2,5-Bis(trifL;TIMTEC-BB SBB000691;2,5-Bis(trifluoromet;Dutasteride Impurity 34;2,5-DI(TRIFLUOROMETHYL)ANILINE;2,5-BIS(TRIFLUOROMETHYL)AMILINE;2,5-BIS(TRIFLUOROMETHYL)ANILINE;2,5-DIS(TRIFLUOROMETHYL)ANILINE;2,5-Bis(trifluoromethyl)aniline98%
CBNumber: CB8124180
Molecular Formula: C8H5F6N
Formula Weight: 229.12
MOL File: 328-93-8.mol

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2,5-Bis(trifluoromethyl)aniline Property

Boiling point:: 70-71 °C15 mm Hg(lit.)
Density: 1.467 g/mL at 25 °C(lit.)
refractive index: n20/D 1.432(lit.)
Flash point:: 160 °F
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
form: Oil
pka: 0.24±0.10(Predicted)
Specific Gravity: 1.467
color: Clear Colourless
BRN: 2653046
InChI: InChI=1S/C8H5F6N/c9-7(10,11)4-1-2-5(6(15)3-4)8(12,13)14/h1-3H,15H2
InChIKey: XWMVIJUAZAEWIE-UHFFFAOYSA-N
SMILES: C1(N)=CC(C(F)(F)F)=CC=C1C(F)(F)F
CAS DataBase Reference: 328-93-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,T,Xi
Risk Statements: 20/21/22-36/37/38
Safety Statements: 26-36/37/39-45-36
RIDADR: 2810
WGK Germany: 3
Hazard Note: Toxic/Irritant
HazardClass: 6.1
PackingGroup: III
HS Code: 29214990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 331546
Product name: 2,5-Bis(trifluoromethyl)aniline
Purity: 99%
Packaging: 5g
Price: $90.5
Updated: 2025/07/31

TCI Chemical

Product number: B2544
Product name: 2,5-Bis(trifluoromethyl)aniline
Purity: >98.0%(GC)
Packaging: 5g
Price: $45
Updated: 2025/07/31

TCI Chemical

Product number: B2544
Product name: 2,5-Bis(trifluoromethyl)aniline
Purity: >98.0%(GC)
Packaging: 25g
Price: $179
Updated: 2025/07/31

TRC

Product number: B585490
Product name: 2,5-Bis(trifluoromethyl)aniline
Packaging: 5g
Price: $95
Updated: 2021/12/16

TRC

Product number: B585490
Product name: 2,5-Bis(trifluoromethyl)aniline
Packaging: 10g
Price: $185
Updated: 2021/12/16

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2,5-Bis(trifluoromethyl)aniline Chemical Properties,Usage,Production

Chemical Properties

Clear colorless liquid

Uses

2,5-Bis(trifluoromethyl)aniline is a haloalkul substituted aniline used in the preparation of anti-benign prostatic hyperplasia drug, Dutasteride (D735000).

Uses

2,5-Bis(trifluoromethyl)aniline may be used in chemical synthesis.

Synthesis

320-88-7

328-93-8

Example 8: To an autoclave was added 1.05 g of Raney nickel catalyst (10 wt%) and 100 mL of isopropanol followed by 10.0 g of 2,5-bis(trifluoromethyl)nitrobenzene. Hydrogen was passed under stirring until the pressure reached 5 kg/cm2 and the temperature was raised to 70 °C. The reaction was continued at 70-90°C for 8 hours. After completion of the reaction, the temperature was allowed to drop to room temperature, the hydrogen pressure was released, the catalyst was removed by filtration and the filtrate was washed with isopropanol. The filtrate was concentrated to give 6.42 g of 2,5-bis(trifluoromethyl)aniline in 73% yield and 99.4% GC purity. The structure of the product was confirmed by GC-MS, 1H-NMR and 19F-NMR analysis.

References

[1] Patent: EP1468983, 2004, A1. Location in patent: Page 6
[2] Journal of the American Chemical Society, 1953, vol. 75, p. 4967
[3] Patent: WO2011/150156, 2011, A2. Location in patent: Page/Page column 132

2,5-Bis(trifluoromethyl)aniline Preparation Products And Raw materials

Raw materials

Preparation Products

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2,5-Bis(trifluoromethyl)aniline Suppliers

Americas 1 Canada 2 China 261 Europe 3 France 1 Germany 3 India 16 Italy 1 Japan 3 Slovakia 1 South Korea 1 Switzerland 1 The Netherlands 1 Ukraine 2 United Kingdom 22 United States 42 Global 361

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View Lastest Price from 2,5-Bis(trifluoromethyl)aniline manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 2,5-Bis(trifluoromethyl)aniline 328-93-8
Price: US $0.00/KG
Min. Order: 25KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-02-01

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2,5-Bis(trifluoromethyl)aniline 328-93-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-01

Career Henan Chemical Co

Product: 2,5-Bis(trifluoromethyl)aniline 328-93-8
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000kg
Release date: 2018-12-18

328-93-8, 2,5-Bis(trifluoromethyl)anilineRelated Search:

N-Methylaniline 3-(Trifluoromethyl)benzaldehyde Acid Blue 93 p-Toluidine 3-Aminobenzotrifluoride 2-(Trifluoromethyl)benzoic acid 4-Aminobenzotrifluoride 4-(Trifluoromethoxy)aniline 2-Fluoroaniline 2,5-Bis(trifluoromethyl)nitrobenzene Dutasteride N,N-Dimethyl-1,4-phenylenediamine 4-Fluoroaniline 3,3',5,5'-Tetramethylbenzidine dihydrochloride N,N-Dimethylaniline 2-Aminobenzotrifluoride Aniline o-Toluidine

ALPHA,ALPHA,ALPHA,ALPHA',ALPHA',ALPHA'-HEXAFLUORO-2,5-XYLIDINE

2,5-DI(TRIFLUOROMETHYL)ANILINE

2,5-BIS(TRIFLUOROMETHYL)ANILINE

TIMTEC-BB SBB000691

2,5-BIS(TRIFLUOROMETHYL)AMILINE

2,5-Bis(trifluoromethyl)aniline 98%

2,5-Bis(trifluoromethyl)aniline98%

2,5-DIS(TRIFLUOROMETHYL)ANILINE

2,5-Bis-trifluoromethyl-phenylamine

2,5-bis(trifluoromethyl)benzenamine

2,5-DI

2,5-Bis(trifluoromet

2,5-BIS(TRIFLUORO METHUYL) ANILINE

1-Amino-2,5-bis(trifluoromethyl)benzene

α,α,α,α',α',α'-Hexafluoro-2,5-xylidine

Dutasteride Impurity 34

2, 5 - two (three fluorinated Methyl) aniline

2,5-Bis(trifluoromethyl)aniline,99%

2,5-Bis(trifluoromethyl)aniline &gt

2,5-Bis(trifL

Benzenamine, 2,5-bis(trifluoromethyl)-

2,5-Bis(trifluoromethyl)aniline ISO 9001：2015 REACH

2,5-bis(trifluoromethyl)aniline/Manufacturer/High quality/Best price

328-93-8

328-93-9

28-93-8

CF32C6H3NH2

AMINE

Nitrogen Compounds

Organic Building Blocks

Building Blocks

Amines

C8

Aniline series

Nitrogen Compounds

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C8

Anilines, Aromatic Amines and Nitro Compounds

Fluorobenzene