4-N-Boc-4-N-Methyl-aminopiperidine
- Product Name
- 4-N-Boc-4-N-Methyl-aminopiperidine
- CAS No.
- 108612-54-0
- Chemical Name
- 4-N-Boc-4-N-Methyl-aminopiperidine
- Synonyms
- tert-butyl methyl(piperidin-4-yl)carbamate;4-N-Boc-4-N-ethyla-aminopiperidine;tert-butyl N-methyl-N-(piperidin-4-yl)carbamate;BUTTPARK 90\06-17;4-Boc-methylaminopiperidine ;4-Boc-4-methylaminopiperidine;4-N-Boc-amino-piperidinecitrate;4-(N-Boc-N-methylamino)piperidine;4-N-Boc-4-(MethylaMino)piperidine;4-N-BOC-4-N-METHYL-AMINOPIPERIDINE
- CBNumber
- CB3160008
- Molecular Formula
- C11H22N2O2
- Formula Weight
- 214.3
- MOL File
- 108612-54-0.mol
4-N-Boc-4-N-Methyl-aminopiperidine Property
- Melting point:
- 50°C(lit.)
- Boiling point:
- 287.9±29.0 °C(Predicted)
- Density
- 1.01±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- crystalline powder
- pka
- 10.05±0.10(Predicted)
- color
- White
- InChI
- InChI=1S/C11H22N2O2/c1-11(2,3)15-10(14)13(4)9-5-7-12-8-6-9/h9,12H,5-8H2,1-4H3
- InChIKey
- DJJOYDXRUBOZON-UHFFFAOYSA-N
- SMILES
- C(OC(C)(C)C)(=O)N(C)C1CCNCC1
- CAS DataBase Reference
- 108612-54-0(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-28-36-44
- Hazard Note
- Irritant
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B4466
- Product name
- tert-Butyl Methyl(4-piperidyl)carbamate
- Purity
- >97.0%(GC)
- Packaging
- 200mg
- Price
- $57
- Updated
- 2021/12/16
- Product number
- B4466
- Product name
- tert-Butyl Methyl(4-piperidyl)carbamate
- Purity
- >97.0%(GC)
- Packaging
- 1g
- Price
- $204
- Updated
- 2021/12/16
- Product number
- B657943
- Product name
- 4-N-Boc-4-N-methyl-aminopiperidine
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B657943
- Product name
- 4-N-Boc-4-N-methyl-aminopiperidine
- Packaging
- 500mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- J94217
- Product name
- 4-N-Boc-4-N-methyl-aminopiperidine
- Packaging
- 1g
- Price
- $25
- Updated
- 2021/12/16
4-N-Boc-4-N-Methyl-aminopiperidine Chemical Properties,Usage,Production
Uses
4-N-Boc-4-N-methyl-aminopiperidine, or Tert-butyl methyl(piperidin-4-yl)carbamate (TBMPC) is a derivative of piperidine and is structurally similar to other carbamates. It inhibits the enzyme cyclooxygenase and modulates the activity of the neurotransmitter GABA. This compound has demonstrated anticonvulsant and anti-inflammatory activity. TBMPC has been studied for its potential use in various in vivo and in vitro applications. It has been reported to reduce the frequency and duration of seizures in animal models and reduce the production of pro-inflammatory cytokines in cell culture.
Synthesis
139062-92-3
108612-54-0
General procedure for the synthesis of 4-N-tert-butoxycarbonyl-4-N-methylaminopiperidine from tert-butyl (1-benzylpiperidin-4-yl)(methyl)carbamate: 10% (w/w) humidity Pd/C catalyst (1.1 g) was added to a 250 mL three-necked flask. After sealing the flask, three evacuations and backfilling with nitrogen were performed. Subsequently, a methanol solution of 1-benzyl-4-(N-Boc-N-methyl)aminopiperidine (10.7 g, 35.2 mmol) was added to the flask. The operation was again carried out with three evacuations and backfilled with hydrogen. The reaction mixture was stirred at room temperature for three days, during which the progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, three evacuations and backfilling with nitrogen were performed. The reaction mixture was filtered and the filtrate was concentrated under vacuum to give 6.8 g of the target product 4-N-tert-butoxycarbonyl-4-N-methylaminopiperidine as a white solid in 90% yield.
References
[1] Journal of Medicinal Chemistry, 1999, vol. 42, # 24, p. 4981 - 5001
[2] Tetrahedron Letters, 2017, vol. 58, # 20, p. 1976 - 1979
[3] Patent: US2012/71461, 2012, A1. Location in patent: Page/Page column 144
4-N-Boc-4-N-Methyl-aminopiperidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-N-Boc-4-N-Methyl-aminopiperidine manufacturers
- Product
- 4-N-Boc-4-N-Methyl-aminopiperidine 108612-54-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 25kg
- Release date
- 2019-07-11