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Di-tert-butyl dicarbonate

Product Name
Di-tert-butyl dicarbonate
CAS No.
24424-99-5
Chemical Name
Di-tert-butyl dicarbonate
Synonyms
BOC;DBDC;DIBOC;BOC O2;(BOC)2O;DIBOC,BOC;(t.-Boc)2O;BOC ANHYDRIDE;(BOC)2O FLUKA;Di-tert-butyL
CBNumber
CB4267614
Molecular Formula
C10H18O5
Formula Weight
218.25
MOL File
24424-99-5.mol
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Di-tert-butyl dicarbonate Property

Melting point:
23 °C (lit.)
Boiling point:
56-57 °C/0.5 mmHg (lit.)
Density 
0.95 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.409(lit.)
Flash point:
99 °F
storage temp. 
2-8°C
form 
Low Melting Crystalline Solid
color 
White
Specific Gravity
0.950
Water Solubility 
Miscible with decalin, toluene, carbon tetrachloride, tetrahydrofuran, dioxane, alcohols, acetone, acetonitrile and dimethylformamide. Immiscible with water.
Sensitive 
Moisture Sensitive
BRN 
1911173
InChIKey
DYHSDKLCOJIUFX-UHFFFAOYSA-N
CAS DataBase Reference
24424-99-5(CAS DataBase Reference)
EPA Substance Registry System
Dicarbonic acid, bis(1,1-dimethylethyl) ester (24424-99-5)
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Safety

Hazard Codes 
T+,T,F,Xi,F+
Risk Statements 
11-19-26-36/37/38-43-10-40
Safety Statements 
16-26-28-36/37-45-7/9-37/39-24-36/37/39-33
RIDADR 
UN 2929 6.1/PG 1
WGK Germany 
3
RTECS 
HT0230000
4.4-10-21
Autoignition Temperature
460 °C
Hazard Note 
Flammable/Irritant/Very Toxic
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
I
HS Code 
29209010
Toxicity
LD50 orally in Rabbit: > 5000 mg/kg LD50 dermal Rabbit > 2000 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H226Flammable liquid and vapour

H228Flammable solid

H302Harmful if swallowed

H304May be fatal if swallowed and enters airways

H315Causes skin irritation

H317May cause an allergic skin reaction

H318Causes serious eye damage

H319Causes serious eye irritation

H330Fatal if inhaled

H335May cause respiratory irritation

H336May cause drowsiness or dizziness

H351Suspected of causing cancer

H370Causes damage to organs

H371May cause damage to organs

H372Causes damage to organs through prolonged or repeated exposure

H373May cause damage to organs through prolonged or repeated exposure

H401Toxic to aquatic life

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P310Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P307+P311IF exposed: call a POISON CENTER or doctor/physician.

P370+P378In case of fire: Use … for extinction.

P405Store locked up.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.52261
Product name
Di-tert-butyl dicarbonate
Purity
Novabiochem?
Packaging
25 g
Price
$26.2
Updated
2021/03/22
Sigma-Aldrich
Product number
205249
Product name
Di-tert-butyl dicarbonate
Purity
ReagentPlus , 99%
Packaging
10g
Price
$44.5
Updated
2021/03/22
Sigma-Aldrich
Product number
34660
Product name
Di-tert-butyl dicarbonate
Purity
≥98.0% (GC)
Packaging
25 g
Price
$47.8
Updated
2021/03/22
Sigma-Aldrich
Product number
8.52261
Product name
Di-tert-butyl dicarbonate
Purity
Novabiochem?
Packaging
100 g
Price
$70.1
Updated
2021/03/22
Sigma-Aldrich
Product number
34660
Product name
Di-tert-butyl dicarbonate
Purity
≥98.0% (GC)
Packaging
100 g
Price
$122
Updated
2021/03/22
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Di-tert-butyl dicarbonate Chemical Properties,Usage,Production

Chemical Properties

White to off-white microcrystalline powder

Chemical Properties

Di-tert-butyl dicarbonate (Boc2O) and di-tert-butyl tricarbonate ((BocO)2CO)  have been used as amine carbonylating reagents to obtain linear or branched aliphatic isocyanates.
most of the known methods for transforming amines into isocyanates are not mild enough and furnish undefined products as a result of uncontrolled side reactions. However, 4-dimethylaminopyridine (DMAP)-catalyzed reaction with activated carbonates as C1 building blocks constitutes a convenient laboratory method for the phosgene-free isocyanation of amines. A procedure has been described whereby alkyl- and arylamines are converted into isocyanates in high yields by reaction with activated carbonates (for example, di-tert-butyl dicarbonate, Boc2O) in the presence of a catalytic amount of a nucleophilic nitrogen base at room temperature.
Di-tert-butyl dicarbonate (Boc2O) is a widely used reagent for introducing protecting groups in peptide synthesis. The reaction of substituted anilines with Boc2O in the presence of a stoichiometric amount of 4-dimethylaminopyridine (DMAP) in an inert solvent (acetonitrile, dichloromethane, ethyl acetate, tetrahydrofuran, toluene) at room temperature leads to aryl isocyanates in almost quantitative yields within 10 min.

Uses

Reagent commonly used in organic chemistry for the introduction of the BOC protecting group.

Uses

reagent for t-BOC-protected amines

Uses

Reagent for the preparation of Boc-amino acids and peptides in high yields.

Purification Methods

Melt the ester by heating at ~35o, and distil it in a vacuum. If IR and NMR ( 1810m 1765 cm-1 , in CCl4 1.50 singlet) suggest very max impure, then wash with an equal volume of H2O containing citric acid to make the aqueous layer slightly acidic, collect the organic layer and dry it over anhydrous MgSO4 and distil it in a vacuum. [Pope et al. Org Synth 57 45 1977, Keller et al. Org Synth 63 160 1985, Grehn et al. Angew Chem 97 519 1985.] FLAMMABLE.

Di-tert-butyl dicarbonate Preparation Products And Raw materials

Raw materials

Preparation Products

TERT-BUTYL 4-(4-FORMYL-1,3-THIAZOL-2-YL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE N-4-Boc-2-piperazinecarboxylic acid TERT-BUTYL 4-(HYDROXYMETHYL)PYRIDIN-2-YLCARBAMATE 1-BOC-PIPERAZINE TERT-BUTYL N-(2-HYDROXYETHYL)CARBAMATE TERT-BUTYL 3-(4-AMINO-2,6-DICHLOROPHENOXY)PROPYLCARBAMATE 1-TERT-BUTYL 6-METHYL 3-FORMYL-1H-INDOLE-1,6-DICARBOXYLATE Spermidine 3-[(N-(TERT-BUTYLOXYCARBONYL)AMINO)METHYL]PYRIDINE tert-Butyl N-(2-bromoethyl)carbamate 3-TERT-BUTOXYCARBONYLAMINO-ISONICOTINIC ACID TERT-BUTYL 4-FORMYL-2-METHOXYPHENYL CARB ONATE, 99 (S)-N-Boc-allylglycine N-BOC-piperidine-4-carboxylic acid TERT-BUTYL 3-FORMYLPYRIDIN-4-YLCARBAMATE 4-ALLYL-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER 1-Boc-3-oxopiperazine 2-(2,2-DIMETHYL-PROPIONYLAMINO)-ISONICOTINIC ACID 1-(4-PYRIDYLMETHYL)PIPERAZINE 6-(BOC-AMINO)-HEXYL BROMIDE BOC-L-Isoleucine 1-Boc-piperazine acetate 1-BOC-4-HYDROXY-4-(HYDROXYMETHYL)-PIPERIDINE 4-CHLORO-(N-BOC)ANILINE 97 (S)-(-)-1-Boc-2-pyrrolidinemethanol N,N-DIMETHYL-2-PIPERAZIN-1-YL-ACETAMIDE N-Boc-D-proline N-Boc-N,N-bis(2-chloroethyl)amine 4-(BOC-AMINOMETHYL)PYRIDINE N-1-BOC-N-4-CBZ-2-PIPERAZINECARBOXYLIC ACID T-BUTYL ESTER TERT-BUTYL 4-(METHOXYCARBONYL)PYRIDIN-2-YLCARBAMATE 4-BOCAMINO-NICOTINIC ACID (S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidine 5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE 6-BOC-HYDRAZINONICOTINIC ACID TERT-BUTYL 4-(5-FORMYL-4-METHYL-1,3-THIAZOL-2-YL)PIPERIDINE-1-CARBOXYLATE 6-TERT-BUTOXYCARBONYLAMINO-PYRIDINE-2-CARBOXYLIC ACID (R)-PIPERAZINE-2-CARBOXYLIC ACID (3-HYDROXYMETHYL-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER 1-Boc-4-cyanopiperidine
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Di-tert-butyl dicarbonate Suppliers

NANJING SHUNXIANG PHARMACEUTICAL TECHNOLOGY CO.,LTD.
Tel
025-86819862- ;025-86819863-
Fax
025-86819859
Email
sales@jinchemical.com;sales@jinchemical.com
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China
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Email
17310985352@163.com
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Nanjing Apicci Pharmaceutical Technology Co., Ltd.
Tel
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Email
2853590738@qq.com;2853579352@qq.com
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China
ProdList
399
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Ningxia Jinxiang Pharmaceutical Chemical Co. Ltd.
Tel
13651506233
Email
sales@nxjinxiang.com
Country
China
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Beijing Ouhe Technology Co., Ltd
Tel
010-82967028-
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
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Beijing Bainiannuan Sci.&Tec. Co., Ltd
Tel
10-51765162
Fax
+86-10-51765262
Email
marymeng@bdnchem.com
Country
China
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Shanghai Ze Chong Pharmaceutical Technology Co., Ltd.
Tel
186-21330623- ;199-46064200-
Email
sales@zechongchem.com;angel@zechongchem.com
Country
China
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Nanjing Sinoda Biological Technology Co., Ltd
Tel
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Fax
025-83151634
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sales@njmcn.cn;82830563@qq.com
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Nantong Haigine Pharma Technology Co., Ltd
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0513-86266699-8010
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QQ1355175393
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sales@haigine.com
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Shanghai Qianlai Pharmaceutical Technology Co., Ltd.
Tel
021-57216911- ;021-57216911-
Email
482109853@qq.com;757073385@qq.com
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China
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View Lastest Price from Di-tert-butyl dicarbonate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Di-tert-butyl dicarbonate 24424-99-5
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
99%min
Supply Ability
10 tons
Release date
2021-07-16
Hebei Crovell Biotech Co Ltd
Product
Di-tert-butyl dicarbonate 24424-99-5
Price
US $10.70/Kg/Drum
Min. Order
10g
Purity
50%
Supply Ability
10000kg
Release date
2021-07-21
Baoji Guokang Bio-Technology Co., Ltd.
Product
Di-tert-butyl dicarbonate 24424-99-5
Price
US $15880.00/T
Min. Order
1T
Purity
98%
Supply Ability
1-10mt
Release date
2021-06-03

24424-99-5, Di-tert-butyl dicarbonateRelated Search:


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