ChemicalBook > CAS DataBase List > 1,8-Diazabicyclo[5.4.0]undec-7-ene

1,8-Diazabicyclo[5.4.0]undec-7-ene

Product Name
1,8-Diazabicyclo[5.4.0]undec-7-ene
CAS No.
6674-22-2
Chemical Name
1,8-Diazabicyclo[5.4.0]undec-7-ene
Synonyms
DBU;Is a;Polycat DBU;U-CAT SA 851;POLYCAT(R) 18;POLYCAT(R) 48;Lupragen N700;1,8-DiazabicycL;LUPRAGEN(R) N 700;Pyrimido[1,2-a]azep
CBNumber
CB6368038
Molecular Formula
C9H16N2
Formula Weight
152.24
MOL File
6674-22-2.mol
More
Less

1,8-Diazabicyclo[5.4.0]undec-7-ene Property

Melting point:
-70 °C
Boiling point:
80-83 °C0.6 mm Hg(lit.)
Density 
1.019 g/mL at 20 °C(lit.)
vapor pressure 
5.3 mm Hg ( 37.7 °C)
refractive index 
n20/D 1.523
Flash point:
>230 °F
storage temp. 
Store below +30°C.
solubility 
soluble
form 
Liquid
pka
13.28±0.20(Predicted)
color 
Clear colorless to light yellow
Odor
Unpleasant
PH
12.8 (10g/l, H2O, 20℃)
PH Range
12.8 at 10 g/l at 20 °C
explosive limit
1.1-6.5%(V)
Water Solubility 
soluble
Sensitive 
Air Sensitive
BRN 
508906
Stability:
Stable. Incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides.
InChIKey
GQHTUMJGOHRCHB-UHFFFAOYSA-N
CAS DataBase Reference
6674-22-2(CAS DataBase Reference)
NIST Chemistry Reference
1,8-diazabicyclo [5.4.0]undec-7-ene(6674-22-2)
EPA Substance Registry System
Pyrimido[1,2-a]azepine, 2,3,4,6,7,8,9,10-octahydro- (6674-22-2)
More
Less

Safety

Hazard Codes 
C,F
Risk Statements 
22-34-52/53-35-40-37-19-11-67
Safety Statements 
26-36/37/39-45-61-27-16
RIDADR 
UN 3267 8/PG 2
WGK Germany 
2
34
Autoignition Temperature
260 °C
TSCA 
Yes
HazardClass 
8
PackingGroup 
II
HS Code 
29339930
Toxicity
LD50 orally in Rabbit: 215 - 681 mg/kg
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H290May be corrosive to metals

H301Toxic if swalloed

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

H335May cause respiratory irritation

H351Suspected of causing cancer

H402Harmful to aquatic life

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P310Immediately call a POISON CENTER or doctor/physician.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P370+P378In case of fire: Use … for extinction.

P405Store locked up.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.03282
Product name
1,8-Diazabicyclo[5.4.0]undec-7-ene
Purity
for synthesis
Packaging
25 mL
Price
$26.55
Updated
2021/03/22
Sigma-Aldrich
Product number
139009
Product name
1,8-Diazabicyclo[5.4.0]undec-7-ene
Purity
98%
Packaging
25g
Price
$29.6
Updated
2021/03/22
Sigma-Aldrich
Product number
8.03282
Product name
1,8-Diazabicyclo[5.4.0]undec-7-ene
Purity
for synthesis
Packaging
100 mL
Price
$75.48
Updated
2021/03/22
Sigma-Aldrich
Product number
33482
Product name
1,8-Diazabicyclo[5.4.0]undec-7-ene
Purity
puriss., ≥99.0% (GC)
Packaging
50 mL
Price
$59.1
Updated
2021/03/22
Sigma-Aldrich
Product number
33482
Product name
1,8-Diazabicyclo[5.4.0]undec-7-ene
Purity
puriss., ≥99.0% (GC)
Packaging
250 mL
Price
$179
Updated
2021/03/22
More
Less

1,8-Diazabicyclo[5.4.0]undec-7-ene Chemical Properties,Usage,Production

Description

1,8-Diazabicyclo[5.4.0]undec-7-ene is a bicyclic amidine base. It is non-nucleophilic, sterically hindered, tertiary amine base in organic chemistry. It is reported to be superior to amine catalyst in Baylis-Hillman reaction.It promotes the methylation reaction of phenols, indoles and benzimidazoles with dimethyl carbonate under mild conditions.

Chemical Properties

Colorless to yellow liquid

Uses

1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU) may be used:

  1. as catalyst for carboxylic acid esterification with dimethyl carbonate
  2. in the synthesis of duocarmycin and CC-1065 analogs
  3. as catalyst in aza-Michael addition and Knovenegal condensation reaction
  4. as base for dehalogenation of halogenated Diels-Alder adducts and the resulting activated 2,4-dienones were subjected to regio- and stereo-directed Michael additions, using Yamamoto′s reagent (CH3Cu · BF3)
  5. in a new synthesis of the ABCD ring system of Camptothecin
  6. 1,8-Diazabicyclo[5.4.0]undec-7-ene may be used as an catalyst for the dissolution and activation of cellulose by a reversible reaction of its hydroxyl groups with carbon dioxide. This dissolved cellulose system can be derivatized to form cellulose mixed esters.
  7. Used in a new synthesis of the ABCD ring system of Camptothecin.

Purification Methods

Fractionally distil DBU under vacuum. Also purify it by chromatography on Kieselgel and eluting with CHCl3/EtOH/25% aqueous NH3 (15:5:2) and checking by IR and MS. [Oediger et al. Chem Ber 99 2012 1962, Angew Chem, Int Ed Engl 6 76 1967, Guggisberg et al. Helv Chim Acta 61 1057 1978, Beilstein 23/5 V 271.]

More
Less

1,8-Diazabicyclo[5.4.0]undec-7-ene Suppliers

Nanjing Apicci Pharmaceutical Technology Co., Ltd.
Tel
;
Fax
QQ2853590738
Email
2853590738@qq.com;2853579352@qq.com
Country
China
ProdList
400
Advantage
58
Shandong Xinhua Pharmceutical Co.,LTD
Tel
0533-2196801
Fax
0533-2196817
Email
yaojianyong@xhzy.com
Country
China
ProdList
71
Advantage
60
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
021-20337333-801
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
24980
Advantage
65
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386 / 800-988-0390
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24555
Advantage
81
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd.
Tel
1867-8026865- ;
Fax
15336364684
Email
sdfantai@163.com;sdfantai@163.com
Country
China
ProdList
787
Advantage
58
Sigma-Aldrich
Tel
021-61415566- ;
Email
orderCN@merckgroup.com;orderCN@merckgroup.com
Country
China
ProdList
48786
Advantage
80
Hangzhou Go Top Peptide Biotech
Tel
0571-88211921- ;0571-88211951-8011
Email
sales@gotopbio.com;sales1@gotopbio.com
Country
China
ProdList
2613
Advantage
58
Tianjin Zhongxin Chemtech Co., Ltd.
Tel
022-66880623;022-89880623
Fax
86(0)22-66880086
Email
sales@tjzxchem.com;sales@tjzxchem.com
Country
China
ProdList
617
Advantage
60
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96500
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
21-61259100-
Fax
86-21-61259102
Email
sh@meryer.com
Country
China
ProdList
40264
Advantage
62
More
Less

View Lastest Price from 1,8-Diazabicyclo[5.4.0]undec-7-ene manufacturers

Hebei Zhanyao Biotechnology Co. Ltd
Product
1,8-Diazabicyclo[5.4.0]undec-7-ene 6674-22-2
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 tons
Release date
2021-10-14
Baoji Guokang Healthchem co.,ltd
Product
1,8-Diazabicyclo[5.4.0]undec-7-ene 6674-22-2
Price
US $7857.10/KG
Min. Order
200KG
Purity
99%
Supply Ability
20000kg
Release date
2021-06-08
Zhuozhou Wenxi import and Export Co., Ltd
Product
1,8-Diazabicyclo[5.4.0]undec-7-ene 6674-22-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

6674-22-2, 1,8-Diazabicyclo[5.4.0]undec-7-eneRelated Search:


  • 1,5-DIAZABICYCLO(5,4,0)UNDEC-5-ENE
  • 1,8-DIAZABICYCLO[5,4,0]-7-UNDECENE
  • 1,8-DIAZABICYCLO[5.4.0]UNDEC-7-ENE
  • 1,8-DIAZABICYCLO[5.4.0]UNDEC-7-ENE (1,5-5)
  • 1,8-DIAZABICYCLO(5,4,0)UNDECENE-7
  • 1,8-DIAZEBICYCLO[5.4.0]UNDEC-7-ENE
  • 1,8-Diazabicyclo[5.4.0]undecane-7-ene
  • 1,8-Diazabicyclo(5 x 4 x 0)undec-7-ene
  • Pyrimido[1,2-a]azep
  • 1,8-Diazabicyclo[5.4.]undec-7-ene
  • 1,8-Diazabicyclo[5.4.0]undec-7-ene, 98% 100GR
  • 1,8-Diazabicyclo[5.4.0]undec-7-ene, 98% 25GR
  • 1,8-Diazabicyclo[5.4.0]undec-7-ene, 98% 500GR
  • 1,8-Diazabicyclo[5.4.0]undec-7-ene, 98% 5GR
  • 1,8-Diazabicyclo[5.4.0]undec-7-ene,2,3,4,6,7,8,9,10-Octahydropyrimidol[1,2-a]azepine, DBU
  • 8-Diazabicyclo[5.4.0]undec-7-ene (DBU)
  • Lupragen N700 (Diazabicycloundecene)
  • DBU 2,3,4,6,7,8,9,10-Octahydropyrimido[1,2-a]azepine
  • 1,8-Diazabicyclo[5.4.0]undec-7-ene, 2,3,4,6,7,8,9,10-OctahydropyriMido[1,2-a]azepine
  • 1,8-DIAZABICYCLO[5.4.0]UNDEC-7-ENE FOR S
  • 1,8- twoazabicyclo[5.4.0] eleven carbon-7- ene
  • 1,8-Diazabicyclo[5.4.0]undec-7-ene puriss., >=99.0% (GC)
  • 1,8-Diazabicyclo[5.4.0]-7-undecene, 98.0%(GC&T)
  • Is a
  • 1,8-Diazabicyclo[5.4.0]undec-7-ene solution 1 M in ethyl acetate
  • 1,8-Diazabicyclo[5.4.0]undec-7-ene solution
  • 1,5-Diaza(5,4,0)undec-5-ene
  • 1,5-Diazabicyclo[5.4.0]-5-undecene
  • 2,3,4,6,7,8,9,10-Octahydropyrimido(1,2-alpha)azepine
  • 2-a]azepine,2,3,4,6,7,8,9,10-octahydro-pyrimido[
  • 2-a]azepine,2,3,4,6,7,8,9,10-octahydro-Pyrimido[1
  • Diazabicycloundecene
  • Pyrimido[1,2-a]azepine, 2,3,4,6,7,8,9,10-octahydro-
  • Pyrimido[1,2-a]azepine,2,3,4,6,7,8,9,10-octahydro-
  • 2,3,4,6,7,8,9,1-Octahydropyrimido[1,2-a]azepine
  • Diazabicycloundecene (DBU)
  • 1,8-Diazabicyclo[5.4.0]undec-7-ene, 1 M in ethyl acetate, J&KSeal
  • 1,8-Diazabicyclo[5.4.0]undec-7-ene, 1 M in THF, J&KSeal
  • Baloxavir Impurity 44
  • 2,3,4,6,7,8,9,10-Octahydropyrimido[1,2-a]azepine, DBU
  • 1,8-DIAZABICYCLO[5.4.0]UNDEC-7-ENE (DBU)
  • 1,8-diazabicyclo[5,4,0]-undecen-(7)
  • Dicyclo[5,4,0]-1,8-Diazole-7-Nonylene
  • 2,3,4,6,7,8,9,10-Octahydropyrimidol[1,2-A]Aze
  • 1,8-Diazabicyclo[5,4,0]undec-7
  • 1,8-Diaza-7-bicyclo[5.4.0]undecene.
  • 1,8-Diazabicyclo(5.4.0)undec-7-en
  • 2,3,4,6,7,8,9,10-OCTAHYDROPYRIMIDO[1,2-A]AZEPINE
  • 2,3,4,6,7,8,9,10-OCTAHYDROPYRIMIDOL[1,2-A]AZEPINE
  • 2,3,4,6,7,8,9,10-OCTA-HYDRO-PYRIMIDOL[1,2-ALPHA]AZEPINE
  • DBU
  • LUPRAGEN(R) N 700
  • POLYCAT(R) 18
  • POLYCAT(R) 48
  • OCTAHYDROPYRIMIDO(1,2:A)AZEPINE
  • 1,8-DIAZABICYCLO [5.4.0] UNDEC-7-ENE (AKA) DBU
  • 1,8-Diazabicyclo5.4.0üundec-7-ene, 99%
  • 2,3,4,6,7,8,9,10-Octahydropyrimidol[1,2-a]azepine, DBU