6-Aminoindole

Product Name: 6-Aminoindole
CAS No.: 5318-27-4
Chemical Name: 6-Aminoindole
Synonyms: NSC 82379;6-Indolamine;6-AMINOINDOLE;INDOLE-6-AMINE;6-AMINOINDOLINE;indolin-6-amine;Indol-6-ylamine;1H-INDOL-6-AMINE;6-AMINO-1H-INDOLE;6-Aminoindole >
CBNumber: CB8257417
Molecular Formula: C8H8N2
Formula Weight: 132.16
MOL File: 5318-27-4.mol

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6-Aminoindole Property

Melting point:: 75-79 °C
Boiling point:: 161-166°C 2mm
Density: 1.268±0.06 g/cm3(Predicted)
Flash point:: 161-166°C/2mm
storage temp.: -20°C
solubility: soluble in Methanol
pka: 18.23±0.30(Predicted)
form: Crystalline Powder
color: White to brown
Sensitive: Air Sensitive
BRN: 112190
InChI: InChI=1S/C8H8N2/c9-7-2-1-6-3-4-10-8(6)5-7/h1-5,10H,9H2
InChIKey: MIMYTSWNVBMNRH-UHFFFAOYSA-N
SMILES: N1C2=C(C=CC(N)=C2)C=C1
CAS DataBase Reference: 5318-27-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-36/37/38
Safety Statements: 26-36
WGK Germany: 3
Hazard Note: Harmful
HazardClass: IRRITANT-HARMFUL, KEEP COLD
PackingGroup: III
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 630721
Product name: 6-Aminoindole
Purity: 97%
Packaging: 1g
Price: $81
Updated: 2025/07/31

Sigma-Aldrich

Product number: 630721
Product name: 6-Aminoindole
Purity: 97%
Packaging: 5g
Price: $352
Updated: 2025/07/31

TCI Chemical

Product number: A2067
Product name: 6-Aminoindole
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $137
Updated: 2025/07/31

TRC

Product number: A612673
Product name: 6-Aminoindole
Packaging: 50mg
Price: $45
Updated: 2021/12/16

TRC

Product number: A612673
Product name: 6-Aminoindole
Packaging: 100mg
Price: $60
Updated: 2021/12/16

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6-Aminoindole Chemical Properties,Usage,Production

Chemical Properties

Solid

Uses

Reactant for preparation of:

Inhibitors of mammalian target of rapamycin (mTOR ) protein
Inhibitors of the AcrAB-TolC efflux pump
Inhibitors of Gli1-mediated transcription in the Hedgehog pathway
Potent DNA-topoisomerase II poisons and anti-MDR agents
Protein kinase C θ (PKCθ) inhibitors
Piperidine carboxamide as transient receptor potential cation channel subfamily V member 1 (TRPV1) antagonists
Potent and selective blockers of the Nav1.8 sodium channel as potential analgesics for the treatment of neuropathic and inflammatory pain
5,6-fused heteroaromatic ureas as TRPV1 antagonists
Allosteric enhancers of the A3 adenosine receptor
Human liver glycogen phosphorylase (HLGP) inhibitors for the treatment of type 2 diabetes

Synthesis

4769-96-4

5318-27-4

In Example 1, 6-nitroindole was used as a raw material and reacted at 4.0 MPa hydrogen pressure and 80°C for 48 hours to carry out a hydrogenation reduction reaction. Other steps were the same as in Example 1, and 6-aminoindole was finally obtained in 94% yield. The specific operation was as follows: 16.44 mg (0.04 mmol) of silver 4,4'-dimethoxy-2,2'-bipyridine and 11.22 mg (0.1 mmol) of potassium tert-butoxide were dissolved in 1 mL of 1,4-dioxane and added to an autoclave. After stirring well, 165.15 mg (1 mmol) of m-nitroacetophenone was added and the reaction was stirred at 80 °C for 8 hours. At the end of the reaction, the reaction solution was extracted with water and dichloromethane to separate the organic phase. The organic phase was dried over anhydrous Na2SO4, and then subjected to filtration, rotary evaporation and chromatographic separation to obtain a yellow solid 3-acetanilide in 96% yield.

References

[1] Journal of Medicinal Chemistry, 1990, vol. 33, # 9, p. 2437 - 2451
[2] Patent: US2005/70534, 2005, A1. Location in patent: Page/Page column 14
[3] Patent: CN106748834, 2017, A. Location in patent: Paragraph 0016; 0033; 0036
[4] Molecules, 2014, vol. 19, # 1, p. 925 - 939
[5] Catalysis Communications, 2016, vol. 84, p. 25 - 29

6-Aminoindole Preparation Products And Raw materials

Raw materials

tert-Butyl methyl ether Trichloroisocyanuric acid Nickel Indoline DBU Potassium nitrate

Preparation Products

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6-Aminoindole Suppliers

Americas 1 Canada 1 China 183 Europe 4 Germany 5 India 8 Japan 2 Russia 1 Switzerland 4 Ukraine 1 United Kingdom 16 United States 42 Global 268

Shanghai Titan Enterprise Development Co., Ltd

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Alfa Aesar

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Adamas Reagent, Ltd.

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View Lastest Price from 6-Aminoindole manufacturers

Chemwill Asia Co.,Ltd.

Product: 6-Aminoindole in stock Factory 5318-27-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: TOP 3 Factory in China
Supply Ability: Top 3 largest production capacity Factory
Release date: 2019-04-03

Career Henan Chemical Co

Product: 6-Aminoindole 5318-27-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95-99%
Supply Ability: 100kg/week
Release date: 2019-08-05

5318-27-4, 6-AminoindoleRelated Search:

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INDOLE-6-AMINE

1H-INDOL-6-AMINE

6-AMINOINDOLE

6-AMINO-1H-INDOLE

6-Indolamine

6-AMinoindole, 97+%

2,3-Dihydro-1H-indol-6-amine

6-Aminoindole ,98%

1H-Indol-6-ylaMine

indolin-6-amine

6-AMINOINDOLINE

6-AMINO-BENZOXAZOLE

Indol-6-ylamine

NSC 82379

6-Aminoindole in stock Factory

6-Aminoindole &gt

5318-27-4

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