5-Aminooxindole
- Product Name
- 5-Aminooxindole
- CAS No.
- 20876-36-2
- Chemical Name
- 5-Aminooxindole
- Synonyms
- 5-AMINOOXINDOLE;5-AMINO-2-OXINDOLE;CHEMBRDG-BB 4006397;TIMTEC-BB SBB010120;5-Aminooxindole >5-amino-2-indolinone;5-Amino-1,3-dihydro-indol...;REF DUPL: 5-Amino-2-oxindole;5-AMINO-1,3-DIHYDRO-INDOL-2-ONE;5-Amino-1,3-dihydro-2H-indol-2-one
- CBNumber
- CB5254804
- Molecular Formula
- C8H8N2O
- Formula Weight
- 148.16
- MOL File
- 20876-36-2.mol
5-Aminooxindole Property
- Melting point:
- 182-186°C
- Boiling point:
- 416.8±45.0 °C(Predicted)
- Density
- 1.307±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 13.91±0.20(Predicted)
- form
- Solid
- color
- Dark Green to Brown
- InChI
- InChI=1S/C8H8N2O/c9-6-1-2-7-5(3-6)4-8(11)10-7/h1-3H,4,9H2,(H,10,11)
- InChIKey
- JPUYXUBUJJDJNL-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=C(N)C=C2)CC1=O
- CAS DataBase Reference
- 20876-36-2(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-22
- Safety Statements
- 26-36/37/39
- HazardClass
- IRRITANT
- HS Code
- 2933790090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- A2668
- Product name
- 5-Aminooxindole
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $98
- Updated
- 2025/07/31
- Product number
- A2668
- Product name
- 5-Aminooxindole
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $423
- Updated
- 2023/06/20
- Product number
- A612255
- Product name
- 5-Amino-2-indolinone
- Packaging
- 10g
- Price
- $465
- Updated
- 2021/12/16
- Product number
- A612255
- Product name
- 5-Amino-2-indolinone
- Packaging
- 1g
- Price
- $65
- Updated
- 2021/12/16
- Product number
- N783
- Product name
- 5-Amino-2-oxindole
- Packaging
- 1g
- Price
- $81
- Updated
- 2021/12/16
5-Aminooxindole Chemical Properties,Usage,Production
Uses
5-Amino-2-indolinone is useful in the synthesis of anticancer drugs, Cyclin dependent kinase inhibitors and spleen tyrosine kinase (Syk) inhibitors.
Synthesis
20870-79-5
20876-36-2
General procedure for the synthesis of 5-amino-dihydroindol-2-one from 5-nitroindol-2-one: 5-nitrodihydroindol-2-one (5 g, 1 equiv.) was suspended in ethanol (50 mL), activated charcoal (1 g) and ferric chloride (1 g) were added. The reaction mixture was heated to 78 °C and stirred continuously for 10 minutes. Subsequently, 80% aqueous hydrazine hydrate (8 eq.) was slowly added dropwise to the reaction system over 5 minutes. After the dropwise addition was completed, the reaction mixture was continued to be stirred at 78°C for 8-10 hours. Upon completion of the reaction, the mixture was cooled to room temperature and filtered to remove the activated carbon residue. The filtrate was concentrated in vacuum to give the crude product, which was purified by recrystallization with ethanol (about 15 mL) to give the final 5-amino dihydroindol-2-one as a light yellow solid in 91.9% yield.
References
[1] Patent: US2004/39019, 2004, A1. Location in patent: Page/Page column 6
[2] Patent: US6268391, 2001, B1
[3] Journal of Antibiotics, 2018, vol. 71, # 10, p. 887 - 897
[4] European Journal of Medicinal Chemistry, 2015, vol. 105, p. 274 - 288
[5] Patent: WO2016/198597, 2016, A1. Location in patent: Page/Page column 18; 19
5-Aminooxindole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Aminooxindole manufacturers
- Product
- 5-Aminooxindole 20876-36-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-11