ChemicalBook > CAS DataBase List > 5-Aminooxindole

5-Aminooxindole

Product Name
5-Aminooxindole
CAS No.
20876-36-2
Chemical Name
5-Aminooxindole
Synonyms
5-AMINOOXINDOLE;5-AMINO-2-OXINDOLE;CHEMBRDG-BB 4006397;TIMTEC-BB SBB010120;5-Aminooxindole >5-amino-2-indolinone;5-Amino-1,3-dihydro-indol...;REF DUPL: 5-Amino-2-oxindole;5-AMINO-1,3-DIHYDRO-INDOL-2-ONE;5-Amino-1,3-dihydro-2H-indol-2-one
CBNumber
CB5254804
Molecular Formula
C8H8N2O
Formula Weight
148.16
MOL File
20876-36-2.mol
More
Less

5-Aminooxindole Property

Melting point:
182-186°C
Boiling point:
416.8±45.0 °C(Predicted)
Density 
1.307±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
13.91±0.20(Predicted)
form 
Solid
color 
Dark Green to Brown
InChI
InChI=1S/C8H8N2O/c9-6-1-2-7-5(3-6)4-8(11)10-7/h1-3H,4,9H2,(H,10,11)
InChIKey
JPUYXUBUJJDJNL-UHFFFAOYSA-N
SMILES
N1C2=C(C=C(N)C=C2)CC1=O
CAS DataBase Reference
20876-36-2(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-22
Safety Statements 
26-36/37/39
HazardClass 
IRRITANT
HS Code 
2933790090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

More
Less

N-Bromosuccinimide Price

TCI Chemical
Product number
A2668
Product name
5-Aminooxindole
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$98
Updated
2025/07/31
TCI Chemical
Product number
A2668
Product name
5-Aminooxindole
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$423
Updated
2023/06/20
TRC
Product number
A612255
Product name
5-Amino-2-indolinone
Packaging
1g
Price
$65
Updated
2021/12/16
TRC
Product number
A612255
Product name
5-Amino-2-indolinone
Packaging
10g
Price
$465
Updated
2021/12/16
Matrix Scientific
Product number
018890
Product name
5-Amino-1,3-dihydro-indol-2-one
Packaging
500mg
Price
$54
Updated
2021/12/16
More
Less

5-Aminooxindole Chemical Properties,Usage,Production

Uses

5-Amino-2-indolinone is useful in the synthesis of anticancer drugs, Cyclin dependent kinase inhibitors and spleen tyrosine kinase (Syk) inhibitors.

Synthesis

20870-79-5

20876-36-2

General procedure for the synthesis of 5-amino-dihydroindol-2-one from 5-nitroindol-2-one: 5-nitrodihydroindol-2-one (5 g, 1 equiv.) was suspended in ethanol (50 mL), activated charcoal (1 g) and ferric chloride (1 g) were added. The reaction mixture was heated to 78 °C and stirred continuously for 10 minutes. Subsequently, 80% aqueous hydrazine hydrate (8 eq.) was slowly added dropwise to the reaction system over 5 minutes. After the dropwise addition was completed, the reaction mixture was continued to be stirred at 78°C for 8-10 hours. Upon completion of the reaction, the mixture was cooled to room temperature and filtered to remove the activated carbon residue. The filtrate was concentrated in vacuum to give the crude product, which was purified by recrystallization with ethanol (about 15 mL) to give the final 5-amino dihydroindol-2-one as a light yellow solid in 91.9% yield.

References

[1] Patent: US2004/39019, 2004, A1. Location in patent: Page/Page column 6
[2] Patent: US6268391, 2001, B1
[3] Journal of Antibiotics, 2018, vol. 71, # 10, p. 887 - 897
[4] European Journal of Medicinal Chemistry, 2015, vol. 105, p. 274 - 288
[5] Patent: WO2016/198597, 2016, A1. Location in patent: Page/Page column 18; 19

5-Aminooxindole Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

5-Aminooxindole Suppliers

Americas 1 China 136 Europe 1 France 1 Germany 2 India 12 Japan 1 Russia 1 South Korea 1 United Kingdom 8 United States 29 Global 193
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
Advantage
56
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
Advantage
66
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Shanghai Ennopharm Co., Ltd.
Tel
+86 (21) 6435-5022
Country
China
ProdList
4267
Advantage
65
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7811
Advantage
57
SpringPharma Tech Co.,Ltd
Tel
+86-25-68710855, +86-25-68710897
Fax
025-68710856
Email
sales@springpharma.net
Country
China
ProdList
1261
Advantage
62
Nanjing Vital Chemical Co., Ltd.
Tel
Please Send Email 18652950785
Fax
025-87193546
Email
chemweiao@163.com
Country
China
ProdList
4378
Advantage
65
Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
Fax
+86-571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
6387
Advantage
52
Acorn PharmaTech Co., Ltd.
Tel
025-58395930
Fax
025-5861-9182
Email
sales@acornpharma.com
Country
China
ProdList
982
Advantage
60
SuZhou ShiYa Biopharmaceuticals, Inc.
Tel
86(512)5235 8471 17715136450
Fax
86(512)5235 6881
Email
sales@shiyabiopharm.com
Country
China
ProdList
4169
Advantage
58
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
18209
Advantage
56
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9546
Advantage
55
EnliPharma Technology Co., Ltd
Tel
0551-66399836 18955197623
Email
sales@enlipharma.com
Country
China
ProdList
1876
Advantage
55
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3506
Advantage
58
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Beijing Wuyunyongchang Science and Technology Co., Ltd.
Tel
15210642910
Email
moon5.1days@126.com
Country
China
ProdList
202
Advantage
56
ChongQing Purel Bio-Pharmaceutical Technology Co., Ltd.
Tel
023-89130144 18523560356
Fax
023-67534737
Email
zhyong1011@163.com
Country
China
ProdList
290
Advantage
58
Finetech Industry Limited
Tel
027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
Country
China
ProdList
9637
Advantage
58
ShangHai KenEn Chemical Technology Co., Ltd.
Tel
13120367189
Fax
021-50315529
Email
mychess007@163.com
Country
China
ProdList
1994
Advantage
55
Nanjing YiFan Biological Technology Co., Ltd.
Tel
025-025-52700520 18914499889
Fax
025-52700520
Email
sales@yfbiotech.com
Country
China
ProdList
495
Advantage
58
Shanghai Na Qian Chemical Technology Co. Ltd.
Tel
13598610367
Fax
QQ:2468833170
Email
2841375912@qq.com
Country
China
ProdList
2788
Advantage
52
Shanghai Song Yuan Chemical Technology Co., Ltd.
Tel
010-1234567 18521000990
Fax
86-021-33275113
Email
sonyuanchemical@163.com
Country
China
ProdList
6479
Advantage
50
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66028182 18626450290
Email
yftan@aikonchem.com
Country
China
ProdList
16679
Advantage
50
SPIRO PHARMA
Tel
Fax
-
Email
eric_feng1954@126.com
Country
China
ProdList
9248
Advantage
55
Tcichem, Inc.
Tel
13918644899
Fax
-
Email
tianchong009@hotmail.com
Country
China
ProdList
1818
Advantage
55
Wuhan Chemwish Technology Co.， Ltd
Tel
027-67849912
Fax
027-87531808
Email
sales@chemwish.com
Country
China
ProdList
9148
Advantage
60
ShangHai Angti Biotechnology Co., Ltd.
Tel
13764913901
Fax
-
Email
info@angtibio.com
Country
China
ProdList
4984
Advantage
55
Codow Chemical Co.,Ltd.
Tel
18620099427
Fax
+86-20-62619665
Email
amy@howeipharm.com
Country
China
ProdList
6687
Advantage
55
Nanjing YaoCheng Pharmaceutical Co., Ltd.
Tel
025-57043319 15261831516
Fax
025-57043319
Email
307514552@qq.com
Country
China
ProdList
251
Advantage
50
Shanghai Xilong Biochemical Technology Co., Ltd.
Tel
021-52907766-8042
Fax
021-52906523
Country
China
ProdList
9941
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Shandong Xiya Chemical Co., Ltd.
Tel
4009903999 13395398332
Fax
0539-6365991
Email
sales@xiyashiji.com
Country
China
ProdList
20794
Advantage
60
Chengdu Huachun Technology Co., Ltd
Tel
400-1166-196 15982826727
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
14603
Advantage
60
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Wuhan EEChem Technologies Co., Ltd
Tel
0711-3617768 13308685235
Fax
0711-3616558
Email
lihongcai4360@sina.com
Country
China
ProdList
1510
Advantage
55
Amatek Scientific Co. Ltd.
Tel
0512-56316828
Fax
0512-56316826
Email
info@amateksci.com
Country
China
ProdList
28785
Advantage
58
Shandong Ono Chemical Co., Ltd.
Tel
0539-6362799 20）
Fax
0539-6362799（To 20）
Country
China
ProdList
10007
Advantage
58
Shanghai BaiShun Biological Technology Co., Ltd
Tel
021-37581181
Fax
021-57456066
Email
sales@chem-mall.com
Country
China
ProdList
10330
Advantage
58
Wuxi AppTec
Tel
022-59987777 13552403979
Email
jia_guoqiang@wuxiapptec.com
Country
China
ProdList
22345
Advantage
58
Shanghai Zhen Li Biological Technology Co., Ltd
Tel
021-16621358918; 18516310516
Fax
13045646768
Email
zhenlipharma888@163.com
Country
China
ProdList
19035
Advantage
58
Wuhan FengyaoTonghui Chemical Products Co., Ltd.
Tel
027-87466105 15377573527
Email
2678564200@qq.com
Country
China
ProdList
17987
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 400821072
Fax
021-58955996
Email
malulu@leyan.com
Country
China
ProdList
25000
Advantage
58
Suzhou Devi Pharma Technology Co., Ltd.
Tel
0512-66565816 18651107528
Fax
0512-66565816
Country
China
ProdList
1040
Advantage
58
Jinan Yaoyan Pharmaceutical Co., Ltd.
Tel
Fax
-
Email
jnyaoyan@163.com
Country
China
ProdList
3069
Advantage
58
3A Chemicals
Tel
400-668-9898
Fax
010-51582189
Email
service@3achem.com
Country
China
ProdList
20557
Advantage
58
Nanjing holy chemical co., LTD
Tel
19951936396
Email
1815156226@qq.com
Country
China
ProdList
2947
Advantage
58
Shanghai Benso Pharmaceutical Technology Co., Ltd.
Tel
15088289376
Email
248775804@qq.com
Country
China
ProdList
4995
Advantage
58
More
Less

View Lastest Price from 5-Aminooxindole manufacturers

Career Henan Chemical Co
Product
5-Aminooxindole 20876-36-2
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2019-07-11

20876-36-2, 5-AminooxindoleRelated Search:

6-Aminocaproic acid Dehydroepiandrosterone 3-Aminoacetophenone ALTRENOGEST Neosperidin dihydrochalcone AMINOACETONITRILE HYDROGEN SULFATE 2-Amino-5-chlorobenzophenone cis-Octahydroisoindole Glycine Tris(hydroxymethyl)aminomethane 1-(2,6-Dichlorophenyl)-2-hydroindole 5-Nitroisatin 5-AMINOISATIN 6-Aminooxindole 7-Aminooxindole Oxindole 5-Aminoindole 1-METHYL-5-NITRO-ISATIN

  • 5-Amino-1,3-dihydro-2H-indol-2-one, 5-Aminoindolin-2-one
  • 5-amino-3,3a-dihydro-1H-indol-2(7aH)-one
  • REF DUPL: 5-Amino-2-oxindole
  • 5-Amino-1,3-dihydro-indol...
  • 5-amino-1,3-dihydro-2H-indol-2-one(SALTDATA: HCl)
  • 5-amino-2-indolinone
  • TIMTEC-BB SBB010120
  • CHEMBRDG-BB 4006397
  • 5-AMINO-1,3-DIHYDRO-INDOL-2-ONE
  • 5-AMINO-2-OXINDOLE
  • 5-AMINOOXINDOLE
  • 2H-INDOL-2-ONE, 5-AMINO-1,3-DIHYDRO-
  • 5-Amino-1,3-dihydro-2H-indol-2-one
  • 5-Aminooxindole, 5-Amino-2-oxoindoline
  • 5-Aminooxindole &gt
  • 20876-36-2
  • Indoline & Oxindole
  • Indoles
  • Amines
  • blocks
  • IndolesOxindoles