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Neosperidin dihydrochalcone

Product Name
Neosperidin dihydrochalcone
CAS No.
20702-77-6
Chemical Name
Neosperidin dihydrochalcone
Synonyms
E-959;Neo-DHC;FEMA 3811;nci-c60764;Neohesperidin DC;Neohesperidin DHC;NEOHESPERIDINE DC;Hesperidin Impurity 4;Neohesperidin DC(NHDC);Neohesperidine hydrate
CBNumber
CB3218194
Molecular Formula
C28H36O15
Formula Weight
612.58
MOL File
20702-77-6.mol
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Neosperidin dihydrochalcone Property

Melting point:
156-158 °C(lit.)
Boiling point:
927.1±65.0 °C(Predicted)
Density 
1.61±0.1 g/cm3(Predicted)
FEMA 
3811 | NEOHESPERIDIN DIHYDROCHALCONE
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
Practically insoluble in water, freely soluble in dimethyl sulfoxide, soluble in methanol, practically insoluble in methylene chloride.
pka
6.85±0.40(Predicted)
form 
crystalline
color 
light yellow
Water Solubility 
Insoluble
Merck 
14,6452
InChIKey
ITVGXXMINPYUHD-CUVHLRMHSA-N
CAS DataBase Reference
20702-77-6(CAS DataBase Reference)
EPA Substance Registry System
Neohesperidin dihydrochalcone (20702-77-6)
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Safety

WGK Germany 
3
RTECS 
LZ5785000
HS Code 
29389090
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
W381101
Product name
Neohesperidindihydrochalcone
Purity
≥96%,FG
Packaging
1 SAMPLE-K
Price
$50
Updated
2021/12/16
Sigma-Aldrich
Product number
W381101
Product name
Neohesperidin dihydrochalcone
Purity
≥96%, FG
Packaging
25 g
Price
$75
Updated
2021/12/16
Sigma-Aldrich
Product number
1458053
Product name
Neohesperidin dihydrochalcone
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
100mg
Price
$75.8
Updated
2021/12/16
Sigma-Aldrich
Product number
75041
Product name
Neohesperidin dihydrochalcone
Purity
analytical standard
Packaging
100mg
Price
$78.2
Updated
2021/12/16
Sigma-Aldrich
Product number
W381101
Product name
Neohesperidin dihydrochalcone
Purity
≥96%, FG
Packaging
100 g
Price
$117
Updated
2021/12/16
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Neosperidin dihydrochalcone Chemical Properties,Usage,Production

Chemical Properties

Crystal

Chemical Properties

Neohesperidin dihydrochalcone occurs as a white or yellowishwhite powder with an intensely sweet taste.

Uses

Neohesperidin dihydrochalcone hydrate, is a flavonoid sweetening agent with potent antioxidant activity. It is antioxidant agent. artificial sweetener.

Uses

Preparation from Naringen, a flavanone glycoside occurring naturally in grapefruit. It is used as sweetening agent, especially in chewing gum and dentifrices.

Uses

Sweetening agent, especially in chewing gum and dentifrices.

Definition

ChEBI: A member of the dihydrochalcones that is 3,2',4',6'-tetrahydroxy-4-methoxydihydrochalcone attached to a neohesperidosyl residue at position 4' via glycosidic linkage. It is found in sweet orange.

Production Methods

Neohesperidin dihydrochalcone is synthesized commercially from either of the bitter-flavanones neohesperidin or naringin by catalytic hydrogenation under alkaline conditions in a process first described in the 1960s, in which neohesperidin is purified by recrystallization from water solutions.Neohesperidin dihydrochalcone is obtained by the alkaline hydrogenation of neohesperidin.

General Description

Off-white crystals or powder. Insoluble in water.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Neosperidin dihydrochalcone is a ether-alcohol derivative. The ether being relatively unreactive. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert alcohols to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides.

Fire Hazard

The flash point of Neosperidin dihydrochalcone has not been determined, but Neosperidin dihydrochalcone is probably combustible.

Pharmaceutical Applications

Neohesperidin dihydrochalcone is a synthetic intense sweetening agent approximately 1500–1800 times sweeter than sucrose and 20 times sweeter than saccharin. Structurally it is an analogue of neohesperidin, a flavanone that occurs naturally in Seville oranges (Citrus aurantium). Neohesperidin dihydrochalcone is used in pharmaceutical and food applications as a sweetening agent and flavor enhancer. The sweetness profile is characterized by a lingering sweet/menthol-like aftertaste.The typical level used in foods is 1–5 ppm although much higher levels may be used in certain applications such as chewing gum. Synergistic effects occur with other intense and bulk sweeteners such as acesulfame K, aspartame, polyols, and saccharin.
In pharmaceutical applications, neohesperidin dihydrochalcone is useful in masking the unpleasant bitter taste of a number of drugs such as antacids, antibiotics, and vitamins. In antacid preparations, levels of 10–30 ppm result in improved palatability.

Safety

Neohesperidin dihydrochalcone is accepted for use in food products either as a sweetener or flavor modifier in a number of areas including Europe, USA, Australia, New Zealand, and several countries in Africa and Asia. It is also used in a number of oral pharmaceutical formulations.
Animal toxicity studies suggest that neohesperidin dihydrochalcone is a nontoxic, nonteratogenic, and noncarcinogenic material at the levels used in foods and pharmaceuticals.In Europe, an acceptable daily intake of 0–5 mg/kg body-weight has been established.

storage

Neohesperidin dihydrochalcone is stable for over three years when stored at room temperature.
Accelerated stability studies on aqueous solutions stored at 30–60°C and pH 1–7 for 140 days indicate that neohesperidin dihydrochalcone solutions are likely to be stable for 12 months at room temperature and pH 2–6.Solutions formulated with some or all of the water replaced by solvents with a lower dielectric constant are reported to have longer shelf-lives.
The bulk material should be stored in a cool, dry, place protected from light.

Regulatory Status

GRAS listed. Accepted for use as a food additive in Europe.

Neosperidin dihydrochalcone Preparation Products And Raw materials

Raw materials

Preparation Products

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Neosperidin dihydrochalcone Suppliers

Sichuan Benepure Pharmaceutical Co., Ltd.
Tel
028-86798880- ;028-86799990-101
Fax
028-86799924
Email
online@benepure.com;commercial@benepure.com
Country
China
ProdList
117
Advantage
58
Sichuan BioCrick Biotech Co., Ltd
Tel
86-28-8543-3893
Email
info@biocrick.com
Country
CHINA
ProdList
4991
Advantage
58
Zhejiang Invertin Biotechnology Co.,Ltd.td.
Tel
0572-2165030- ;0572-2165030- ;0572-2165030-
Fax
QQ:1169435659
Email
invertin@yeah.net;invertin@yeah.net;invertin@yeah.net
Country
China
ProdList
73
Advantage
58
QINGDAO WANYUAN MOUNTAIN BIOTECH CO.,LTD
Tel
0532-66720179- ;
Email
cuiningning@bionutrichem.com;cuiningning@bionutrichem.com
Country
China
ProdList
66
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
21-61259100-
Fax
86-21-61259102
Email
sh@meryer.com
Country
China
ProdList
40264
Advantage
62
INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3579
Advantage
66
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15877
Advantage
69
future industrial shanghai co., ltd
Tel
400-0066-400;021-60496031
Fax
021-55660885
Email
sales@jonln.com;sales@jonln.com
Country
China
ProdList
1999
Advantage
65
Chembest Research Laboratories Limited
Tel
021-20908456-
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
5947
Advantage
61
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View Lastest Price from Neosperidin dihydrochalcone manufacturers

Hebei Guanlang Biotechnology Co., Ltd.
Product
Neosperidin dihydrochalcone 20702-77-6
Price
US $1.00/PCS
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2021-07-14
Zhuozhou Wenxi import and Export Co., Ltd
Product
Neosperidin dihydrochalcone 20702-77-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Neosperidin dihydrochalcone 20702-77-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08

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