ChemicalBook > CAS DataBase List > Neosperidin dihydrochalcone

Neosperidin dihydrochalcone

Product Name: Neosperidin dihydrochalcone
CAS No.: 20702-77-6
Chemical Name: Neosperidin dihydrochalcone
Synonyms: E-959;Neo-DHC;FEMA 3811;nci-c60764;Happy Sweet;Neohesperidin DC;Neohesperidin DHC;NEOHESPERIDINE DC;Hesperidin Impurity 4;Neohesperidin DC(NHDC)
CBNumber: CB3218194
Molecular Formula: C28H36O15
Formula Weight: 612.58
MOL File: 20702-77-6.mol

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Neosperidin dihydrochalcone Property

Melting point:: 156-158 °C(lit.)
Boiling point:: 927.1±65.0 °C(Predicted)
Density: 1.61±0.1 g/cm3(Predicted)
vapor pressure: 0Pa at 20℃
FEMA: 3811 | NEOHESPERIDIN DIHYDROCHALCONE
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: Practically insoluble in water, freely soluble in dimethyl sulfoxide, soluble in methanol, practically insoluble in methylene chloride.
form: crystalline
pka: 6.85±0.40(Predicted)
color: light yellow
Odor: at 100.00 %. bland odor
Odor Type: odorless
biological source: synthetic
Water Solubility: Insoluble
Merck: 14,6452
Stability:: Hygroscopic
InChIKey: ITVGXXMINPYUHD-CUVHLRMHSA-N
LogP: 0.67 at 20℃
CAS DataBase Reference: 20702-77-6(CAS DataBase Reference)
EPA Substance Registry System: Neohesperidin dihydrochalcone (20702-77-6)

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Safety

WGK Germany: 3
RTECS: LZ5785000
HS Code: 29389090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: W381101
Product name: Neohesperidin dihydrochalcone
Purity: ≥96%, FG
Packaging: 1 unit
Price: $53.48
Updated: 2025/07/31

Sigma-Aldrich

Product number: W381101
Product name: Neohesperidin dihydrochalcone
Purity: ≥96%, FG
Packaging: 1 unit
Price: $53.48
Updated: 2025/07/31

Sigma-Aldrich

Product number: W381101
Product name: Neohesperidin dihydrochalcone
Purity: ≥96%, FG
Packaging: 25g
Price: $81.9
Updated: 2025/07/31

Sigma-Aldrich

Product number: W381101
Product name: Neohesperidin dihydrochalcone
Purity: ≥96%, FG
Packaging: 100g
Price: $132
Updated: 2025/07/31

Sigma-Aldrich

Product number: N0399000
Product name: Neohesperidin dihydrochalcone
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 125 mg
Price: $156
Updated: 2025/07/31

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Neosperidin dihydrochalcone Chemical Properties,Usage,Production

Chemical Properties

Neohesperidin dihydrochalcone occurs as a white or yellowish white powder with an intensely sweet taste. The sweetness is about 1500-1800 times that of sucrose, and its sweetness time is slightly later than saccharin sodium and much faster than glycyrrhizin (5:7:23s). The sweetness retention time of the three is 42:57:133s, which is also between Between the two, it is closer to sodium saccharin. It is soluble in water, slightly soluble in ethanol, but insoluble in ether and benzene.

Uses

Neohesperidin dihydrochalcone hydrate, is a flavonoid sweetening agent with potent antioxidant activity. It is antioxidant agent. artificial sweetener, especially in chewing gum and dentifrices.

Uses

Preparation from Naringen, a flavanone glycoside occurring naturally in grapefruit. It is used as sweetening agent, especially in chewing gum and dentifrices.

Production Methods

Neohesperidin dihydrochalcone is synthesized commercially from either of the bitter-flavanones neohesperidin or naringin by catalytic hydrogenation under alkaline conditions in a process first described in the 1960s, in which neohesperidin is purified by recrystallization from water solutions.Neohesperidin dihydrochalcone is obtained by the alkaline hydrogenation of neohesperidin.

Preparation

Neosperidin dihydrochalcone is produced from Neohespendin (an isomer of Hesperidin), derived from the peel of the Seville Orange.

Definition

ChEBI: Neohesperidin dihydrochalcone is a member of the dihydrochalcones that is 3,2',4',6'-tetrahydroxy-4-methoxydihydrochalcone attached to a neohesperidosyl residue at position 4' via glycosidic linkage. It is found in sweet orange. It has a role as an environmental contaminant, a xenobiotic, a plant metabolite and a sweetening agent. It is a neohesperidoside, a disaccharide derivative and a member of dihydrochalcones.

General Description

Off-white crystals or powder. Insoluble in water.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Neosperidin dihydrochalcone is a ether-alcohol derivative. The ether being relatively unreactive. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert alcohols to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides.

Fire Hazard

The flash point of Neosperidin dihydrochalcone has not been determined, but Neosperidin dihydrochalcone is probably combustible.

Flammability and Explosibility

Not classified

Pharmaceutical Applications

Neohesperidin dihydrochalcone is a synthetic intense sweetening agent approximately 1500–1800 times sweeter than sucrose and 20 times sweeter than saccharin. Structurally it is an analogue of neohesperidin, a flavanone that occurs naturally in Seville oranges (Citrus aurantium). Neohesperidin dihydrochalcone is used in pharmaceutical and food applications as a sweetening agent and flavor enhancer. The sweetness profile is characterized by a lingering sweet/menthol-like aftertaste.The typical level used in foods is 1–5 ppm although much higher levels may be used in certain applications such as chewing gum. Synergistic effects occur with other intense and bulk sweeteners such as acesulfame K, aspartame, polyols, and saccharin.
In pharmaceutical applications, neohesperidin dihydrochalcone is useful in masking the unpleasant bitter taste of a number of drugs such as antacids, antibiotics, and vitamins. In antacid preparations, levels of 10–30 ppm result in improved palatability.

Biological Activity

Flavonoid sweetening agent with potent antioxidant activity.

Safety

Neohesperidin dihydrochalcone is accepted for use in food products either as a sweetener or flavor modifier in a number of areas including Europe, USA, Australia, New Zealand, and several countries in Africa and Asia. It is also used in a number of oral pharmaceutical formulations.
Animal toxicity studies suggest that neohesperidin dihydrochalcone is a nontoxic, nonteratogenic, and noncarcinogenic material at the levels used in foods and pharmaceuticals.In Europe, an acceptable daily intake of 0–5 mg/kg body-weight has been established.

storage

Neohesperidin dihydrochalcone is stable for over three years when stored at room temperature.
Accelerated stability studies on aqueous solutions stored at 30–60°C and pH 1–7 for 140 days indicate that neohesperidin dihydrochalcone solutions are likely to be stable for 12 months at room temperature and pH 2–6.Solutions formulated with some or all of the water replaced by solvents with a lower dielectric constant are reported to have longer shelf-lives.
The bulk material should be stored in a cool, dry, place protected from light.

Regulatory Status

GRAS listed. Accepted for use as a food additive in Europe.

Neosperidin dihydrochalcone Preparation Products And Raw materials

Raw materials

Hesperetin Neohesperidin Naringin

Preparation Products

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View Lastest Price from Neosperidin dihydrochalcone manufacturers

Lianyungang Kaiyu Environmental Tech Co., Ltd.

Product: Neohesperidin Dihydrochalcone 20702-77-6
Price: US $1200.00-1100.00/ton
Min. Order: 1ton
Purity: 99%
Supply Ability: 1000T/M
Release date: 2025-10-22

Jinan Ruitong Biotech Co., Ltd.

Product: Neosperidin dihydrochalcone 20702-77-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1
Release date: 2025-09-05

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: Neosperidin dihydrochalcone 20702-77-6
Price: US $2.00-5.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-23

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1-(4-((2-o-[6-deoxy-α-l-mannopyranosyl]-β-d-glucopyranosyl)oxy)-2,6-dihydroxyphenyl)-3-[3-hydroxy-4-methoxyphenyl]-1-propanone

Neohesperidin Dihydrochalcone ( NHDC )

BETA-NEOHESPERIDINDIHYDROCHALCONE

1-(4-((2-O-[6-Deoxy-alpha-L-mannopyranosyl]-beta-D-glucopyranosyl)oxy)-2,6-dihydroxyphenyl)-3-[3-hydroxy-4-methoxyphenyl]-1-propanone

Neohesperidin DC

neohesperidi dihydrochalcone

1-(4-((2-O-[6-Deoxy-alpha-L-mannopyranosyl]-beta-D-glucopyranosyl)oxy)-2,6-dihydroxyphenyl)-3-[3-hydroxy-4-methoxyphenyl]-1-prop

Neo-DHC

Neohesperidin DC(NHDC)

neosperidin dihydrochalcone

1-Propanone, 1-[4-[[2-O-(6-deoxy-a-L-mannopyranosyl)-b-D-glucopyranosyl]oxy]-2,6-dihydroxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)-

Glucopyranoside, 3,5-dihydroxy-4-(3-hydroxy-4-methoxyhydrocinnamoyl)phenyl 2-O-(6-deoxy-a-L-mannopyranosyl)-, b-D-

Glucopyranoside, 3,5-dihydroxy-4-(3-hydroxy-4-methoxyhydrocinnamoyl)phenyl 2-O-a-L-rhamnopyranosyl-

Neohesperidin DHC

1-[4-[2-O-(6-Deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyloxy]-2,6-dihydroxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)propane-1-one

1-[4-[2-O-(α-L-Rhamnopyranosyl)-β-D-glucopyranosyloxy]-2,6-dihydroxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)-1-propanone

3,5-Dihydroxy-4-(3-hydroxy-4-methoxyhydrocinnamoyl)phenyl 2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside

Neohesperidin DC: HPLC96% Min

Neohesperidin dihydrochalcone,1-(4-((2-O-[6-Deoxy-α-L-mannopyranosyl]-β-D-glucopyranosyl)oxy)-2,6-dihydroxyphenyl)-3-[3-hydroxy-4-methoxyphenyl]-1-propanone

NEDC Neohesperidin dihydrochalcone

NEOHESPERIDIN DIHYDROCHALCONE

NEOHESPERIDIN DIHYDROCHALCONE HYDRATE

NEOHESPERIDINE DC

NEOHESPERIDINE DIHYDROCHALCONE

NEOHESPERIDINE DIHYDROCHALCONE HYDRATE

1-[4-[[2-O-(6-DEOXY-ALPHA-L-MANNOPYRANOSYL)-BETA-D-GLUCOPYRANOSYL]OXY]-2,6-DIHYDROXYPHENYL]-3-(3-HYDROXY-4-METHOXYPHENYL)-1-PROPANONE

FEMA 3811

E-959

beta-d--(6-deoxy-alpha-l-mannopyranosyl)

glucopyranoside,3,5-dihydroxy-4-(3-hydroxy-4-methoxyhydrocinnamoyl)phenyl-2-o

nci-c60764

neohesperidin dihydrochalcone from*citrus fruit

Neosperidin Dihydro halcone

Neohesperidine hydrate

Neohesperidin dihydrochalcone hydrate ,98%

NEOHESPERIDIN DIHYDROCHALCONE 85+%

Neohesperidin DC: HPLC

1-[4-[[2-O-(6-Deoxy-α-L-Mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,6-dihydroxyphenyl]-3-(3-hydroxy-4-Methoxyphenyl)-

Neohesperidin dihydrochalcone, 99%, from Citrus maxima

1-(4-(((2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxyMethyl)-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-Methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-2,6-dihydroxyphenyl)-3-(3-hydroxy-4-Methoxyphenyl)propan-1-one

Neohesperidin-dihydrochalcone CRS

NeohesperidinDihydrochalconeHydrate&gt

Hesperidin Impurity 4

NHP-DC， NEOHESPERIDIN DIHYDROCHALCONE

Neosperidin dihydrochalcone USP/EP/BP

Water-Soluble NEOHESPERIDIN DIHYDROCHALCONE(NHDC)

1-[4-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-2,6-dihydroxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)propan-1-one

4-Chloro-3,5-dimethylphenol 88-04-0

New hesperidin dihydrochalcone

Happy Sweet

Neohesperidin Dihydrochalcone (500 mg) (3,5-Dihydroxy-4-[3-(3-hydroxy-4-methoxyphenyl)propanoyl]phenyl 2-O-(alpha-L-rhamnopyranosyl)-Beta-D-glucopyranoside)