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Hesperetin

Product Name
Hesperetin
CAS No.
520-33-2
Chemical Name
Hesperetin
Synonyms
(S)-2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-benzopyrone;2,3-DIHYDRO-5,7-DIHYDROXY-2S-(3-HYDROXY-4-METHOXPHENYL)-4H-1-BENZOPYRAN-4-ONE;4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (2S)-;YSO2;NSC 57654;HESPERETIN;HESPERETINE;HESPERETIN(P);Hesperetin>Prestwick_908
CBNumber
CB4304735
Molecular Formula
C16H14O6
Formula Weight
302.28
MOL File
520-33-2.mol
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Hesperetin Property

Melting point:
230-232°C
Boiling point:
363.32°C (rough estimate)
Density 
1.2514 (rough estimate)
refractive index 
-4 ° (C=1.8, EtOH)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
7.49±0.40(Predicted)
color 
White to Pale Yellow
Water Solubility 
Soluble in water (partly), dilute alkalis, and ethanol (50 mg/ml).
Merck 
14,4670
BRN 
309850
InChIKey
AIONOLUJZLIMTK-AWEZNQCLSA-N
LogP
2.90
CAS DataBase Reference
520-33-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37/39-27-37
WGK Germany 
3
HS Code 
29329990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
H0721
Product name
Hesperetin
Purity
>97.0%(HPLC)(T)
Packaging
5g
Price
$17
Updated
2024/03/01
TCI Chemical
Product number
H0721
Product name
Hesperetin
Purity
>97.0%(HPLC)(T)
Packaging
25g
Price
$49
Updated
2024/03/01
Alfa Aesar
Product number
B20528
Product name
3',5,7-Trihydroxy-4'-methoxyflavanone, 97%
Packaging
1g
Price
$30.65
Updated
2024/03/01
Alfa Aesar
Product number
B20528
Product name
3',5,7-Trihydroxy-4'-methoxyflavanone, 97%
Packaging
5g
Price
$88.65
Updated
2024/03/01
Alfa Aesar
Product number
B20528
Product name
3',5,7-Trihydroxy-4'-methoxyflavanone, 97%
Packaging
25g
Price
$345.65
Updated
2024/03/01
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Hesperetin Chemical Properties,Usage,Production

Description

Hesperetin is a flavonoid that has been found in citrus fruits and has diverse biological activities. It reduces ApoB protein levels, ACAT2 expression, and LDL degradation in HepG2 cells when used at a concentrations ranging from 10 to 200 μM. Hesperetin inhibits IgG-induced β-hexosaminidase release from RBL-2H3 cells (IC50 = 0.099 mg/ml). It inhibits LPS-induced nitric oxide (NO) production and reduces levels of inducible nitric oxide synthase (iNOS), IL-6, and IL-1β in BV-2 microglial cells. Hesperetin (5 mg/kg) inhibits passive cutaneous anaphylaxis in mice. It reduces body weight loss, colon shortening, and ulcer severity in a mouse model of TNBS-induced ulcerative colitis. Hesperetin reduces cortical and hippocampal neuronal apoptosis and increases time spent in the target quadrant in the Morris water maze in a mouse model of LPS-induced neuronal inflammation.

Chemical Properties

Beige to Light Brown Crystalline Solid

Uses

The aglucon of Hesperidin (H281185), a flavanone found in citrus fruits.

Uses

antiallergic

Uses

(±)-Hesperetin is an antioxidant flavonoid. Induces G1-phase cell cycle arrest. Anti-inflammatory. (±)-Hesperetin suppresses NF-κB activation. Reduces cholesterol biosynthesis. Inhibits lipid peroxidation. Neuroprotective against neuronal oxidative damage.

Definition

ChEBI: Hesperetin is a trihydroxyflavanone having the three hydroxy gropus located at the 3'-, 5- and 7-positions and an additional methoxy substituent at the 4'-position. It has a role as an antioxidant, an antineoplastic agent and a plant metabolite. It is a monomethoxyflavanone, a trihydroxyflavanone, a member of 3'-hydroxyflavanones and a member of 4'-methoxyflavanones. It is a conjugate acid of a hesperetin(1-).

Purification Methods

Crystallise it from EtOAc or ethanol. The natural S(-) form crystallises from EtOH and has m 216-218o and [] D -37.6o (c 2, EtOH). Note that C2 is chiral. [Beilstein 18 II 204, 18 III/IV 3215, 18/5 V 214.]

Hesperetin Preparation Products And Raw materials

Raw materials

Preparation Products

BETA-PHENYLPROPIOPHENONE Neosperidin dihydrochalcone
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Hesperetin Suppliers

Americas 1 Belgium 1 Canada 2 China 336 China Hong Kong 1 Czech Republic 1 Europe 3 France 1 Germany 7 India 13 Japan 3 Spain 1 Switzerland 5 United Kingdom 13 United States 57 USA 1 Global 446
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
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China
ProdList
94657
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Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
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China
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40228
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3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
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China
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future industrial shanghai co., ltd
Tel
400-0066400 13621662912
Fax
021-55660885
Email
sales@jonln.com
Country
China
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1995
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Chembest Research Laboratories Limited
Tel
+86-21-20908456
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021-58180499
Email
sales@BioChemBest.com
Country
China
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6005
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Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
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84
TAIYUAN RHF CO.,LTD.
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+86 351 7031519
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+86 351 7031519
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sales@RHFChem.com
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China
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TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
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Beijing HwrkChemical Technology Co., Ltd
Tel
010-89508211 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
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Energy Chemical
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021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
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China
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View Lastest Price from Hesperetin manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
Hesperetin 520-33-2
Price
US $45.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 tons
Release date
2024-11-29
BINBO BIOLOGICAL CO.,LTD
Product
Hesperetin 520-33-2
Price
US $0.00/kg
Min. Order
1kg
Purity
99.8%
Supply Ability
1000 kg
Release date
2024-04-01
Baoji Guokang Bio-Technology Co., Ltd.
Product
HESPERETIN 520-33-2
Price
US $190.00/KG
Min. Order
1KG
Purity
97%
Supply Ability
10000KG
Release date
2021-06-02

520-33-2, HesperetinRelated Search:

HESPERETIN-7-NEOHESPERIDOSIDE hplc,Neohesperidin，Hesperetin 7-neohesperidoside,HESPERETIN-7-NEOHESPERIDOSIDE,HESPERETIN-7-O-NEOHESPERIDOSIDE Paeoniflorin Quercetin dihydrate Naringin Resveratrol Ferulic Acid Citric acid Luteolin (+/-)-HESPERETIN,HESPERETIN hesperetin,7-(6-o-(6-deoxy-alpha-l-mannopyranosyl)-beta-d-glucopyranoside HESPERETIN LAURATE 4'-METHOXYFLAVANONE HESPERETIN, [3H(G)] HESPERETIN DIHYDROCHALCONE hesperetin 5-O-glucoside 4'-METHOXYFLAVANONE HESPERETIN CHALCONE HESPERETIN DIHYDROCHALCONE(RG)

  • 4'-METHOXY-3',5,7-TRIHYDROXYFLAVANONE
  • (+/-)-3',5,7-TRIHYDROXY-4'-METHOXYFLAVANONE
  • 3',5,7-TRIHYDROXY-4'-METHOXYFLAVANONE
  • 3',5,7-TRIHYDROXY-4-METHOXYFLAVANONE
  • 2,3-DIHYDRO-5,7-DIHYDROXY-2S-(3-HYDROXY-4-METHOXPHENYL)-4H-1-BENZOPYRAN-4-ONE
  • 5,7,3'-TRIHYDROXY-4'-METHOXYFLAVANONE
  • HESPERETINE
  • (+/-)-HESPERETIN
  • HESPERETIN
  • (S)-2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-benzopyrone
  • HESPERETIN 97%
  • 5,7-DIHYDROXY-2-(3-HYDROXY-4-METHOXY-PHENYL)-CHROMAN-4-ONE
  • (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxy-phenyl)chroman-4-one
  • HESPERETIN(P)
  • HESPERETIN hplc
  • HESPERETIN WITH HPLC
  • 4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (2S)-
  • Nano Liposomal Hesperetin
  • Hesperetin 520-33-2
  • Diosmin ep imp G
  • (2S)-2-(3-Hydroxy-4-methoxyphenyl)-5,7-dihydroxy-2,3-dihydro-4H-1-benzopyran-4-one
  • (2S)-2-(3-Hydroxy-4-methoxyphenyl)-5,7-dihydroxy-2H-1-benzopyran-4(3H)-one
  • (S)-3',5,7-Trihydroxy-4'-methoxyflavanone
  • [S,(-)]-2,3-Dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one
  • Eriodictyol 4'-monomethyl ether
  • (2S)-2,3-Dihydro-5,7-dihydroxy-2-(3-hydroxy-4-Methoxyphenyl)-4H-1-benzopyran-4-one
  • NSC 57654
  • (S)-5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one
  • 2,3-Dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one
  • Diosmin Impurity G
  • Hesperetin&gt
  • (S)-Hesperetin
  • Hesperetin Discontinued. Please see H289480 or H289501
  • (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydrochromen-4-one
  • hesperetin extract
  • (S)-2,3-Dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-benzopyron
  • Hesperitin（mixture of isomers）
  • 13C,2H3]-Hesperetin
  • Hesperetin (6CI)
  • (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydro-4H-1-benzopyran-4-one (hesperetin).
  • Hesperetin (diosmine EP impurity G)
  • Prestwick_908
  • YSO2
  • 520-33-2
  • C16H14O6
  • Flavonoids
  • HA -HT
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