Hesperetin
- Product Name
- Hesperetin
- CAS No.
- 520-33-2
- Chemical Name
- Hesperetin
- Synonyms
- (S)-2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-benzopyrone;2,3-DIHYDRO-5,7-DIHYDROXY-2S-(3-HYDROXY-4-METHOXPHENYL)-4H-1-BENZOPYRAN-4-ONE;4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (2S)-;YSO2;NSC 57654;HESPERETIN;HESPERETINE;HESPERETIN(P);Hesperetin>Prestwick_908
- CBNumber
- CB4304735
- Molecular Formula
- C16H14O6
- Formula Weight
- 302.28
- MOL File
- 520-33-2.mol
Hesperetin Property
- Melting point:
- 230-232°C
- Boiling point:
- 363.32°C (rough estimate)
- Density
- 1.2514 (rough estimate)
- refractive index
- -4 ° (C=1.8, EtOH)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 7.49±0.40(Predicted)
- color
- White to Pale Yellow
- Water Solubility
- Soluble in water (partly), dilute alkalis, and ethanol (50 mg/ml).
- Merck
- 14,4670
- BRN
- 309850
- InChIKey
- AIONOLUJZLIMTK-AWEZNQCLSA-N
- LogP
- 2.90
- CAS DataBase Reference
- 520-33-2(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39-27-37
- WGK Germany
- 3
- HS Code
- 29329990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- H0721
- Product name
- Hesperetin
- Purity
- >97.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $17
- Updated
- 2024/03/01
- Product number
- H0721
- Product name
- Hesperetin
- Purity
- >97.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $49
- Updated
- 2024/03/01
- Product number
- B20528
- Product name
- 3',5,7-Trihydroxy-4'-methoxyflavanone, 97%
- Packaging
- 1g
- Price
- $30.65
- Updated
- 2024/03/01
- Product number
- B20528
- Product name
- 3',5,7-Trihydroxy-4'-methoxyflavanone, 97%
- Packaging
- 5g
- Price
- $88.65
- Updated
- 2024/03/01
- Product number
- B20528
- Product name
- 3',5,7-Trihydroxy-4'-methoxyflavanone, 97%
- Packaging
- 25g
- Price
- $345.65
- Updated
- 2024/03/01
Hesperetin Chemical Properties,Usage,Production
Description
Hesperetin is a flavonoid that has been found in citrus fruits and has diverse biological activities. It reduces ApoB protein levels, ACAT2 expression, and LDL degradation in HepG2 cells when used at a concentrations ranging from 10 to 200 μM. Hesperetin inhibits IgG-induced β-hexosaminidase release from RBL-2H3 cells (IC50 = 0.099 mg/ml). It inhibits LPS-induced nitric oxide (NO) production and reduces levels of inducible nitric oxide synthase (iNOS), IL-6, and IL-1β in BV-2 microglial cells. Hesperetin (5 mg/kg) inhibits passive cutaneous anaphylaxis in mice. It reduces body weight loss, colon shortening, and ulcer severity in a mouse model of TNBS-induced ulcerative colitis. Hesperetin reduces cortical and hippocampal neuronal apoptosis and increases time spent in the target quadrant in the Morris water maze in a mouse model of LPS-induced neuronal inflammation.
Chemical Properties
Beige to Light Brown Crystalline Solid
Uses
The aglucon of Hesperidin (H281185), a flavanone found in citrus fruits.
Uses
antiallergic
Uses
(±)-Hesperetin is an antioxidant flavonoid. Induces G1-phase cell cycle arrest. Anti-inflammatory. (±)-Hesperetin suppresses NF-κB activation. Reduces cholesterol biosynthesis. Inhibits lipid peroxidation. Neuroprotective against neuronal oxidative damage.
Definition
ChEBI: Hesperetin is a trihydroxyflavanone having the three hydroxy gropus located at the 3'-, 5- and 7-positions and an additional methoxy substituent at the 4'-position. It has a role as an antioxidant, an antineoplastic agent and a plant metabolite. It is a monomethoxyflavanone, a trihydroxyflavanone, a member of 3'-hydroxyflavanones and a member of 4'-methoxyflavanones. It is a conjugate acid of a hesperetin(1-).
Purification Methods
Crystallise it from EtOAc or ethanol. The natural S(-) form crystallises from EtOH and has m 216-218o and [] D -37.6o (c 2, EtOH). Note that C2 is chiral. [Beilstein 18 II 204, 18 III/IV 3215, 18/5 V 214.]
Hesperetin Preparation Products And Raw materials
Raw materials
Preparation Products
Hesperetin Suppliers
- Tel
- --
- Fax
- --
- sales-fht@ferrer.com
- Country
- Spain
- ProdList
- 8
- Advantage
- 58
View Lastest Price from Hesperetin manufacturers
- Product
- HESPERETIN 520-33-2
- Price
- US $190.00/KG
- Min. Order
- 1KG
- Purity
- 97%
- Supply Ability
- 10000KG
- Release date
- 2021-06-02
- Product
- Hesperetin 520-33-2
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99.8%
- Supply Ability
- 1000 kg
- Release date
- 2024-04-01
- Product
- Hesperetin 520-33-2
- Price
- US $8.70/KG
- Min. Order
- 10KG
- Purity
- 98.0% min
- Supply Ability
- 10000kg
- Release date
- 2024-08-21