Hesperetin

ChemicalBook > CAS DataBase List > Hesperetin

Product Name: Hesperetin
CAS No.: 520-33-2
Chemical Name: Hesperetin
Synonyms: (S)-2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-benzopyrone;2,3-DIHYDRO-5,7-DIHYDROXY-2S-(3-HYDROXY-4-METHOXPHENYL)-4H-1-BENZOPYRAN-4-ONE;4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (2S)-;YSO2;NSC 57654;HESPERETIN;HESPERETINE;HESPERETIN(P);Hesperetin>Prestwick_908
CBNumber: CB4304735
Molecular Formula: C16H14O6
Formula Weight: 302.28
MOL File: 520-33-2.mol

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Hesperetin Property

Melting point:: 230-232°C
Boiling point:: 363.32°C (rough estimate)
Density: 1.2514 (rough estimate)
refractive index: -4 ° (C=1.8, EtOH)
storage temp.: Inert atmosphere,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 7.49±0.40(Predicted)
color: White to Pale Yellow
Water Solubility: Soluble in water (partly), dilute alkalis, and ethanol (50 mg/ml).
Merck: 14,4670
BRN: 309850
InChIKey: AIONOLUJZLIMTK-AWEZNQCLSA-N
LogP: 2.90
CAS DataBase Reference: 520-33-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39-27-37
WGK Germany: 3
HS Code: 29329990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: H0721
Product name: Hesperetin
Purity: >97.0%(HPLC)(T)
Packaging: 5g
Price: $17
Updated: 2024/03/01

TCI Chemical

Product number: H0721
Product name: Hesperetin
Purity: >97.0%(HPLC)(T)
Packaging: 25g
Price: $49
Updated: 2024/03/01

Alfa Aesar

Product number: B20528
Product name: 3',5,7-Trihydroxy-4'-methoxyflavanone, 97%
Packaging: 1g
Price: $30.65
Updated: 2024/03/01

Alfa Aesar

Product number: B20528
Product name: 3',5,7-Trihydroxy-4'-methoxyflavanone, 97%
Packaging: 5g
Price: $88.65
Updated: 2024/03/01

Alfa Aesar

Product number: B20528
Product name: 3',5,7-Trihydroxy-4'-methoxyflavanone, 97%
Packaging: 25g
Price: $345.65
Updated: 2024/03/01

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Hesperetin Chemical Properties,Usage,Production

Description

Hesperetin is a flavonoid that has been found in citrus fruits and has diverse biological activities. It reduces ApoB protein levels, ACAT2 expression, and LDL degradation in HepG2 cells when used at a concentrations ranging from 10 to 200 μM. Hesperetin inhibits IgG-induced β-hexosaminidase release from RBL-2H3 cells (IC₅₀ = 0.099 mg/ml). It inhibits LPS-induced nitric oxide (NO) production and reduces levels of inducible nitric oxide synthase (iNOS), IL-6, and IL-1β in BV-2 microglial cells. Hesperetin (5 mg/kg) inhibits passive cutaneous anaphylaxis in mice. It reduces body weight loss, colon shortening, and ulcer severity in a mouse model of TNBS-induced ulcerative colitis. Hesperetin reduces cortical and hippocampal neuronal apoptosis and increases time spent in the target quadrant in the Morris water maze in a mouse model of LPS-induced neuronal inflammation.

Chemical Properties

Beige to Light Brown Crystalline Solid

Uses

The aglucon of Hesperidin (H281185), a flavanone found in citrus fruits.

Uses

antiallergic

Uses

(±)-Hesperetin is an antioxidant flavonoid. Induces G1-phase cell cycle arrest. Anti-inflammatory. (±)-Hesperetin suppresses NF-κB activation. Reduces cholesterol biosynthesis. Inhibits lipid peroxidation. Neuroprotective against neuronal oxidative damage.

Definition

ChEBI: Hesperetin is a trihydroxyflavanone having the three hydroxy gropus located at the 3'-, 5- and 7-positions and an additional methoxy substituent at the 4'-position. It has a role as an antioxidant, an antineoplastic agent and a plant metabolite. It is a monomethoxyflavanone, a trihydroxyflavanone, a member of 3'-hydroxyflavanones and a member of 4'-methoxyflavanones. It is a conjugate acid of a hesperetin(1-).

Purification Methods

Crystallise it from EtOAc or ethanol. The natural S(-) form crystallises from EtOH and has m 216-218o and [] D -37.6o (c 2, EtOH). Note that C2 is chiral. [Beilstein 18 II 204, 18 III/IV 3215, 18/5 V 214.]

Hesperetin Preparation Products And Raw materials

Raw materials

Preparation Products

BETA-PHENYLPROPIOPHENONE Neosperidin dihydrochalcone

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Hesperetin Suppliers

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View Lastest Price from Hesperetin manufacturers

Hebei Kingfiner Technology Development Co.Ltd

Product: Hesperetin 520-33-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 50000kg
Release date: 2024-06-19

BINBO BIOLOGICAL CO.,LTD

Product: Hesperetin 520-33-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99.8%
Supply Ability: 1000 kg
Release date: 2024-04-01

Baoji Guokang Bio-Technology Co., Ltd.

Product: HESPERETIN 520-33-2
Price: US $190.00/KG
Min. Order: 1KG
Purity: 97%
Supply Ability: 10000KG
Release date: 2021-06-02

520-33-2, HesperetinRelated Search:

HESPERETIN-7-NEOHESPERIDOSIDE hplc,Neohesperidin，Hesperetin 7-neohesperidoside,HESPERETIN-7-NEOHESPERIDOSIDE,HESPERETIN-7-O-NEOHESPERIDOSIDE Paeoniflorin Quercetin dihydrate Naringin Resveratrol Ferulic Acid Citric acid Luteolin (+/-)-HESPERETIN,HESPERETIN hesperetin,7-(6-o-(6-deoxy-alpha-l-mannopyranosyl)-beta-d-glucopyranoside HESPERETIN LAURATE 4'-METHOXYFLAVANONE HESPERETIN, [3H(G)] HESPERETIN DIHYDROCHALCONE hesperetin 5-O-glucoside 4'-METHOXYFLAVANONE HESPERETIN CHALCONE HESPERETIN DIHYDROCHALCONE(RG)

4'-METHOXY-3',5,7-TRIHYDROXYFLAVANONE

(+/-)-3',5,7-TRIHYDROXY-4'-METHOXYFLAVANONE

3',5,7-TRIHYDROXY-4'-METHOXYFLAVANONE

3',5,7-TRIHYDROXY-4-METHOXYFLAVANONE

2,3-DIHYDRO-5,7-DIHYDROXY-2S-(3-HYDROXY-4-METHOXPHENYL)-4H-1-BENZOPYRAN-4-ONE

5,7,3'-TRIHYDROXY-4'-METHOXYFLAVANONE

HESPERETINE

(+/-)-HESPERETIN

HESPERETIN

(S)-2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-benzopyrone

HESPERETIN 97%

5,7-DIHYDROXY-2-(3-HYDROXY-4-METHOXY-PHENYL)-CHROMAN-4-ONE

(2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxy-phenyl)chroman-4-one

HESPERETIN(P)

HESPERETIN hplc

HESPERETIN WITH HPLC

4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (2S)-

Nano Liposomal Hesperetin

Hesperetin 520-33-2

Diosmin ep imp G

(2S)-2-(3-Hydroxy-4-methoxyphenyl)-5,7-dihydroxy-2,3-dihydro-4H-1-benzopyran-4-one

(2S)-2-(3-Hydroxy-4-methoxyphenyl)-5,7-dihydroxy-2H-1-benzopyran-4(3H)-one

(S)-3',5,7-Trihydroxy-4'-methoxyflavanone

[S,(-)]-2,3-Dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one

Eriodictyol 4'-monomethyl ether

(2S)-2,3-Dihydro-5,7-dihydroxy-2-(3-hydroxy-4-Methoxyphenyl)-4H-1-benzopyran-4-one

NSC 57654

(S)-5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one

2,3-Dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one

Diosmin Impurity G

Hesperetin&gt

(S)-Hesperetin

Hesperetin Discontinued. Please see H289480 or H289501

(2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydrochromen-4-one

hesperetin extract

(S)-2,3-Dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-benzopyron

Hesperitin（mixture of isomers）

13C,2H3]-Hesperetin

Hesperetin (6CI)

(2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydro-4H-1-benzopyran-4-one (hesperetin).

Hesperetin (diosmine EP impurity G)

Prestwick_908

YSO2

520-33-2

C16H14O6

Flavonoids

HA -HT

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