Fmoc-8-amino-3,6-dioxaoctanoic acid

Uses

Product Name: Fmoc-8-amino-3,6-dioxaoctanoic acid
CAS No.: 166108-71-0
Chemical Name: Fmoc-8-amino-3,6-dioxaoctanoic acid
Synonyms: FMOC-AEEA-OH;FMOC-AEEA;FMOC-AEEAC-OH;1-(9H-Fluoren-9-yl)-3-oxo-2,7,10-trioxa-4-azadodecan-12-oic acid;FMoc-NH-PEG2-CH2COOH;FMOC-AEEAC;FMOC-8-AMINO-3,6-DIOXAOCTANOIC ACID;Fmoc-Ado-OH;N-formylglycine t-butylester;9-FLUORENYLMETHOXYCARBONYL-8-AMINO-3,6-DIOXAOCTANOIC ACID
CBNumber: CB2169923
Molecular Formula: C21H23NO6
Formula Weight: 385.41
MOL File: 166108-71-0.mol

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Fmoc-8-amino-3,6-dioxaoctanoic acid Property

Melting point:: 90-92℃
Boiling point:: 631.4±45.0 °C(Predicted)
Density: 1.265±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,2-8°C
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka: 3.40±0.10(Predicted)
form: Crystalline Powder
color: White
InChI: InChI=1S/C21H23NO6/c23-20(24)14-27-12-11-26-10-9-22-21(25)28-13-19-17-7-3-1-5-15(17)16-6-2-4-8-18(16)19/h1-8,19H,9-14H2,(H,22,25)(H,23,24)
InChIKey: XQPYRJIMPDBGRW-UHFFFAOYSA-N
SMILES: C(O)(=O)COCCOCCNC(=O)OCC1C2=C(C=CC=C2)C2=C1C=CC=C2
CAS DataBase Reference: 166108-71-0(CAS DataBase Reference)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
HS Code: 29189900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 95003
Product name: {2-[2-(Fmoc-amino)ethoxy]ethoxy}acetic acid
Purity: ≥95.0% (HPLC)
Packaging: 500mg
Price: $234
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.51037
Product name: Fmoc-NH-(PEG)-COOH (9 atoms)
Purity: Novabiochem?
Packaging: 1g
Price: $453
Updated: 2024/03/01

TCI Chemical

Product number: F0719
Product name: 8-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3,6-dioxa-n-octanoic Acid
Purity: >97.0%(HPLC)
Packaging: 1g
Price: $265
Updated: 2024/03/01

TCI Chemical

Product number: F0719
Product name: 8-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3,6-dioxa-n-octanoic Acid
Purity: >97.0%(HPLC)
Packaging: 200mg
Price: $89
Updated: 2024/03/01

Alfa Aesar

Product number: H63641
Product name: (2-[2-(Fmoc-amino)ethoxy]ethoxy)acetic acid, 95%
Packaging: 250mg
Price: $114
Updated: 2024/03/01

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Fmoc-8-amino-3,6-dioxaoctanoic acid Chemical Properties,Usage,Production

Uses

[2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid is a hydrophilic, heterobifunctional spacer.

Description

Fmoc-NH-PEG2-CH2COOH is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Chemical Properties

White solid

Uses

Hydrophillic spacer group.

Uses

8-(Fmoc-amino)-3,6-dioxaoctanoic Acid is a hydrophilic, heterobifunctional spacer.

Application

Fmoc-8-amino-3,6-dioxaoctanoic acid is a cleavable ADC linker for the synthesis of antibody-drug couplings (ADCs). It is also a PEG linker for the synthesis of PROTAC. It is widely used in drug delivery systems as it is mainly used to enhance the solubility or targeting of drugs and improve their bioavailability.

Fmoc-8-amino-3,6-dioxaoctanoic acid Preparation Products And Raw materials

Raw materials

Phthalimide Triethylene glycol Hydrazinium hydroxide solution N,N-Dimethylformamide Potassium carbonate Chromium(VI) oxide Triethylamine Tosyl chloride DBU 9-Fluorenylmethyl chloroformate Ethyl acetate Hydrochloric acid Dichloromethane Sodium hydroxide N-(9-Fluorenylmethoxycarbonyloxy)succinimide Sulfuric acid

Preparation Products

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Fmoc-8-amino-3,6-dioxaoctanoic acid Suppliers

Americas 1 Canada 1 China 344 Europe 1 France 3 Germany 6 India 8 Japan 4 Switzerland 4 The Netherlands 1 United Kingdom 5 United States 51 Global 429

Suzhou Highfine Biotech Co., Ltd

Tel: 0512-68417696 13962195629
Fax: 0512-68417696
Email: qirl@highfine.com
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Nanjing Quantong Pharmaceutical Technology Co., Ltd

Tel: 13062552990; 13062552990
Email: sales@aldone.com.cn
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Chengdu Pukang Biotechnology Co., Ltd

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Fax: 086-28-82550468
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Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66099280 17798518460
Fax: (1)02557626880
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Country: China
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Shenzhen Readline Biotech CO., LTD.

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Fax: 0755-26659310
Email: linkunsheng@szreadline.com
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Jiangsu Jitai Peptide Technology Co., Ltd.

Tel: 18762539991 17851618148
Email: sales04@gtaipeptide.com
Country: China
ProdList: 2008
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Binhai gill polypeptide co. LTD

Tel: 021-61263389 13524856427
Fax: WeChat630417570
Email: Joetang@glschina.com
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ProdList: 9594
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Zhejiang Zerui Biomedicine Co. , Ltd.

Tel: 18967171527
Email: 2187735310@qq.com
Country: China
ProdList: 7
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Shandong Juntai Pharmaceutical Co. LTD

Tel: 15853135817
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Email: sales@h2opharm.com
Country: China
ProdList: 151
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Chengdu Tachem Co., Ltd

Tel: 028-61682518; 19983060238
Email: sales@tachem.cn
Country: China
ProdList: 109
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View Lastest Price from Fmoc-8-amino-3,6-dioxaoctanoic acid manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Fmoc-AEEA-OH 166108-71-0
Price: US $0.00-0.00/kg
Min. Order: 0.10000000149011612kg
Purity: 98%;99%
Supply Ability: 1T+
Release date: 2024-03-06

PNP Biotech Co. Ltd

Product: Fmoc-8-amino-3,6-dioxaoctanoic acid 166108-71-0
Price: US $0.00/KG
Min. Order: 25KG
Purity: 98%
Supply Ability: Inquiry
Release date: 2022-09-29

Zibo Hangyu Biotechnology Development Co., Ltd

Product: [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid 166108-71-0
Price: US $60.00-600.00/KG
Min. Order: 1KG
Purity: 0.99
Supply Ability: 20 tons
Release date: 2023-10-25

166108-71-0, Fmoc-8-amino-3,6-dioxaoctanoic acidRelated Search:

6-Aminocaproic acid 2-Aminothiazole-4-acetic acid 4-Aminophenylacetic acid Nitrilotriacetic acid DIETHOXYMETHANE Ethoxyethyne Glycine N-(9-Fluorenylmethoxycarbonyloxy)succinimide Ethoxyquin Ethyl 2-(Chlorosulfonyl)acetate 9-Fluorenylmethyl chloroformate Fmoc-Phe-OH Iminodiacetic acid Fmoc-Lys(Boc)-OH METHOXYCARBONYLSULFENYL CHLORIDE Ethoxyamine hydrochloride FMOC-THR(TBU)-OL 17-Amino-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanoic Acid

Fmoc-8-amino-3,6-dioxaoctanoic acid, Fmoc-AEEA

Fmoc-PEG2-acetic acid

{2-[2-(Fmoc-amino)ethoxy]ethoxy}acetic acid≥ 99% (HPLC)

Fmoc-NH-(PEG)-COOH (9 atoms) Novabiochem

1-(9H-Fluoren-9-yl)-3-oxo-2,7,1-trioxa-4-azadodecan-12-oic acid

9-FLUORENYLMETHOXYCARBONYL-8-AMINO-3,6-DIOXAOCTANOIC ACID

8-(FMOC-AMINO)-3,6-DIOXA-OCTANOIC ACID

8-FLUORENYLMETHOXYCARBONYLAMINO-3,6-DIOXAOCTANOIC ACID

8-(9-FLUORENYLMETHOXYCARBONYL-AMINO)-3,6-DIOXA-OCTANOIC ACID

8-(9-FLUORENYLMETHYLOXYCARBONYL-AMINO)-3,6-DIOXAOCTANOIC ACID

FMOC-O2OC-OH

FMOC-MINI-PEG(TM)

FMOC-[2-(2-AMINO-ETHOXY)-ETHOXY]-ACETIC ACID

FMOC-AEEA

FMOC-AEEAC-OH

FMOC-8-AMINO-3,6-DIOXAOCTANOIC ACID

8-(9-Fluorenylmethyloxycarbonyl-amino)-3,6-dioxaoctanoicacid,{2-[2-(Fmoc-amino)ethoxy]ethoxy}aceticacid,1-(9H-Fuoren

8-(9-FLUOROENYLMETHYLOXYCARBONYL-AMINO)-3,6-DIOXAOCTANOIC ACID

1-(9H-Fluoren-9-yl)-3-oxo-2,7,10-trioxa-4-azadodecan-12-oic acid

Fmoc-PEG2- CH2COOH (Fmoc-AEEA)

6-dioxaoctanoic acid

Fmoc-8-amino-3

Fmoc-NH-(PEG)-COOH (9 atoms)

MOC-AEEAC-OH

[2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid, 97.0%

2-{2-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)ethoxy]ethoxy}acetic acid

8-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3,6-dioxa-n-octanoic Acid

8-(9-Fluorenylmethyloxycarbonyl-amino)-3,6-dioxaoctanoic acid, {2-[2-(Fmoc-amino)ethoxy]ethoxy}acetic acid, 1-(9H-Fuoren-9-yl)-3-oxo-2,7,10-trioxa-4-azadodecan-12-oic acid, Fmoc-Ado, Fmoc-AEEA

2-(2-(2-(((9H-fluoren-9-yl)Methoxy)carbonyl)ethoxy)ethoxy)acetic acid

8-(Fmoc-amino)-3,6-dioxa-n-octanoic Acid [2-[2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]ethoxy]ethoxy]acetic Acid [2-[2-[(Fmoc-amino)ethoxy]ethoxy]acetic Acid

{2-[2-(FMoc-aMino)-ethoxy]-ethoxy}-acetic acid, 8-(FMoc-aMino)-3,6-dioxa-octanoic acid, FMoc-Adoa-OH

FMOC-AEEA-OH

[2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid ,98.5%

{2-[2-(Fmoc-amino)ethoxy]ethoxy}acetic acid,8-(Fmoc-amino)-3,6-dioxaoctanoic acid

FMoc-NH-PEG2-CH2COOH

FMoc-2-(2- (2-aMinoethoxy)ethoxy) acetic acid

FMOC-AEEAC

RARECHEM EM WB 0032

Fmoc-NH-PEG2-CH2COOH,Fmoc-AEEA

1-(9H-FUOREN-9-YL)-3-OXO-2,7,10-TRIOXA-4-AZADODECAN-12-OIC ACID

Fmoc-AEEA 1-(9H-Fluoren-9-yl)-3-oxo-2,7,10-trioxa-4-azadodecan-12-oic acid

(2-[2-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-ETHOXY]-ETHOXY)-ACETIC ACID

(2-[2-(FMOC-AMINO)-ETHOXY]-ETHOXY)-ACETIC ACID

8-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3,6-dioxa-n-octanoicAcid&gt

3,6,11-Trioxa-9-azadodecanoic acid, 12-(9H-fluoren-9-yl)-10-oxo-

Fmoc-AEEA/Fmoc-Mini-PEG

N-formylglycine t-butylester

Fmoc-Ado-OH

2-[2-(Fmoc-amino)ethoxy]ethoxy]aceticaci

8-(Fmoc-amino)-3,6-dioxa-n-octanoic Acid

[2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid USP/EP/BP

Fmoc-N-Amido-PEG2-CH2COOH

Fmoc-N-amido-PEG2-acetic acid

Fluorene methoxycarbonyl dipolyethylene glycol acetic acid

166108-71-0

Specialty Synthesis

Peptide PEGylation

Peptide Synthesis