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Fmoc-8-amino-3,6-dioxaoctanoic acid

Product Name
Fmoc-8-amino-3,6-dioxaoctanoic acid
CAS No.
166108-71-0
Chemical Name
Fmoc-8-amino-3,6-dioxaoctanoic acid
Synonyms
FMOC-AEEA-OH;FMOC-AEEA;FMOC-AEEAC-OH;1-(9H-Fluoren-9-yl)-3-oxo-2,7,10-trioxa-4-azadodecan-12-oic acid;FMoc-NH-PEG2-CH2COOH;FMOC-AEEAC;FMOC-8-AMINO-3,6-DIOXAOCTANOIC ACID;Fmoc-Ado-OH;N-formylglycine t-butylester;9-FLUORENYLMETHOXYCARBONYL-8-AMINO-3,6-DIOXAOCTANOIC ACID
CBNumber
CB2169923
Molecular Formula
C21H23NO6
Formula Weight
385.41
MOL File
166108-71-0.mol
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Fmoc-8-amino-3,6-dioxaoctanoic acid Property

Melting point:
90-92℃
Boiling point:
631.4±45.0 °C(Predicted)
Density 
1.265±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,2-8°C
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka
3.40±0.10(Predicted)
form 
Crystalline Powder
color 
White
InChI
InChI=1S/C21H23NO6/c23-20(24)14-27-12-11-26-10-9-22-21(25)28-13-19-17-7-3-1-5-15(17)16-6-2-4-8-18(16)19/h1-8,19H,9-14H2,(H,22,25)(H,23,24)
InChIKey
XQPYRJIMPDBGRW-UHFFFAOYSA-N
SMILES
C(O)(=O)COCCOCCNC(=O)OCC1C2=C(C=CC=C2)C2=C1C=CC=C2
CAS DataBase Reference
166108-71-0(CAS DataBase Reference)
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
HS Code 
29189900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
95003
Product name
{2-[2-(Fmoc-amino)ethoxy]ethoxy}acetic acid
Purity
≥95.0% (HPLC)
Packaging
500mg
Price
$234
Updated
2024/03/01
Sigma-Aldrich
Product number
8.51037
Product name
Fmoc-NH-(PEG)-COOH (9 atoms)
Purity
Novabiochem?
Packaging
1g
Price
$453
Updated
2024/03/01
TCI Chemical
Product number
F0719
Product name
8-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3,6-dioxa-n-octanoic Acid
Purity
>97.0%(HPLC)
Packaging
1g
Price
$265
Updated
2024/03/01
TCI Chemical
Product number
F0719
Product name
8-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3,6-dioxa-n-octanoic Acid
Purity
>97.0%(HPLC)
Packaging
200mg
Price
$89
Updated
2024/03/01
Alfa Aesar
Product number
H63641
Product name
(2-[2-(Fmoc-amino)ethoxy]ethoxy)acetic acid, 95%
Packaging
250mg
Price
$114
Updated
2024/03/01
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Fmoc-8-amino-3,6-dioxaoctanoic acid Chemical Properties,Usage,Production

Description

Fmoc-NH-PEG2-CH2COOH is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Chemical Properties

White solid

Uses

Hydrophillic spacer group.

Uses

8-(Fmoc-amino)-3,6-dioxaoctanoic Acid is a hydrophilic, heterobifunctional spacer.

Application

Fmoc-8-amino-3,6-dioxaoctanoic acid is a cleavable ADC linker for the synthesis of antibody-drug couplings (ADCs). It is also a PEG linker for the synthesis of PROTAC. It is widely used in drug delivery systems as it is mainly used to enhance the solubility or targeting of drugs and improve their bioavailability.

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Fmoc-8-amino-3,6-dioxaoctanoic acid Suppliers

Suzhou Highfine Biotech Co., Ltd
Tel
0512-68311833 18306219922
Fax
0512-68417696
Email
merry@highfine.com
Country
China
ProdList
499
Advantage
75
CAS Aldone(Dalian) Pharmaceutical Science and Technology Co, Ltd.
Tel
86-13062552990 13062552990
Email
sales@aldone.com.cn
Country
China
ProdList
132
Advantage
58
Chengdu Pukang Biotechnology Co., Ltd
Tel
028-82550498 19102685862
Fax
086-28-82550468
Email
sales@pu-kang.com
Country
China
ProdList
485
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66099280 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19915
Advantage
55
Shenzhen Readline Biotech CO., LTD.
Tel
0755-26659310 15915457431
Fax
0755-26659310
Email
linkunsheng@szreadline.com
Country
China
ProdList
110
Advantage
58
Jiangsu Jitai Peptide Technology Co., Ltd.
Tel
18801776727
Email
sales06@gtaipeptide.com
Country
China
ProdList
2010
Advantage
58
Binhai gill polypeptide co. LTD
Tel
021-61263389 13524856427
Fax
WeChat630417570
Email
Joetang@glschina.com
Country
China
ProdList
9924
Advantage
58
Zhejiang Zerui Biomedicine Co. , Ltd.
Tel
18967171527
Email
2187735310@qq.com
Country
China
ProdList
7
Advantage
58
Shandong Juntai Pharmaceutical Co. LTD
Tel
15106953682
Fax
qq 2477717102
Email
Sales2@h2opharm.com
Country
China
ProdList
181
Advantage
58
Chengdu Tachem Co., Ltd
Tel
028-61682518; 19983060238
Email
sales@tachem.cn
Country
China
ProdList
106
Advantage
58
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View Lastest Price from Fmoc-8-amino-3,6-dioxaoctanoic acid manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
Fmoc-AEEA-OH 166108-71-0
Price
US $0.00-0.00/kg
Min. Order
0.10000000149011612kg
Purity
98%;99%
Supply Ability
1T+
Release date
2024-03-06
PUSHAN INDUSTRIAL (SHAANXI) CO.,LTD
Product
Fmoc-8-amino-3,6-dioxaoctanoic acid 166108-71-0
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1000 kgs
Release date
2024-05-17
Zibo Hangyu Biotechnology Development Co., Ltd
Product
[2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid 166108-71-0
Price
US $60.00-600.00/KG
Min. Order
1KG
Purity
0.99
Supply Ability
20 tons
Release date
2023-10-25

166108-71-0, Fmoc-8-amino-3,6-dioxaoctanoic acidRelated Search:


  • Fmoc-8-amino-3,6-dioxaoctanoic acid, Fmoc-AEEA
  • Fmoc-PEG2-acetic acid
  • {2-[2-(Fmoc-amino)ethoxy]ethoxy}acetic acid≥ 99% (HPLC)
  • Fmoc-NH-(PEG)-COOH (9 atoms) Novabiochem
  • 1-(9H-Fluoren-9-yl)-3-oxo-2,7,1-trioxa-4-azadodecan-12-oic acid
  • 9-FLUORENYLMETHOXYCARBONYL-8-AMINO-3,6-DIOXAOCTANOIC ACID
  • 8-(FMOC-AMINO)-3,6-DIOXA-OCTANOIC ACID
  • 8-FLUORENYLMETHOXYCARBONYLAMINO-3,6-DIOXAOCTANOIC ACID
  • 8-(9-FLUORENYLMETHOXYCARBONYL-AMINO)-3,6-DIOXA-OCTANOIC ACID
  • 8-(9-FLUORENYLMETHYLOXYCARBONYL-AMINO)-3,6-DIOXAOCTANOIC ACID
  • FMOC-O2OC-OH
  • FMOC-MINI-PEG(TM)
  • FMOC-[2-(2-AMINO-ETHOXY)-ETHOXY]-ACETIC ACID
  • FMOC-AEEA
  • FMOC-AEEAC-OH
  • FMOC-8-AMINO-3,6-DIOXAOCTANOIC ACID
  • 8-(9-Fluorenylmethyloxycarbonyl-amino)-3,6-dioxaoctanoicacid,{2-[2-(Fmoc-amino)ethoxy]ethoxy}aceticacid,1-(9H-Fuoren
  • 8-(9-FLUOROENYLMETHYLOXYCARBONYL-AMINO)-3,6-DIOXAOCTANOIC ACID
  • 1-(9H-Fluoren-9-yl)-3-oxo-2,7,10-trioxa-4-azadodecan-12-oic acid
  • Fmoc-PEG2- CH2COOH (Fmoc-AEEA)
  • 6-dioxaoctanoic acid
  • Fmoc-8-amino-3
  • Fmoc-NH-(PEG)-COOH (9 atoms)
  • MOC-AEEAC-OH
  • [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid, 97.0%
  • 2-{2-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)ethoxy]ethoxy}acetic acid
  • 8-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3,6-dioxa-n-octanoic Acid
  • 8-(9-Fluorenylmethyloxycarbonyl-amino)-3,6-dioxaoctanoic acid, {2-[2-(Fmoc-amino)ethoxy]ethoxy}acetic acid, 1-(9H-Fuoren-9-yl)-3-oxo-2,7,10-trioxa-4-azadodecan-12-oic acid, Fmoc-Ado, Fmoc-AEEA
  • 2-(2-(2-(((9H-fluoren-9-yl)Methoxy)carbonyl)ethoxy)ethoxy)acetic acid
  • 8-(Fmoc-amino)-3,6-dioxa-n-octanoic Acid [2-[2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]ethoxy]ethoxy]acetic Acid [2-[2-[(Fmoc-amino)ethoxy]ethoxy]acetic Acid
  • {2-[2-(FMoc-aMino)-ethoxy]-ethoxy}-acetic acid, 8-(FMoc-aMino)-3,6-dioxa-octanoic acid, FMoc-Adoa-OH
  • FMOC-AEEA-OH
  • [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid ,98.5%
  • {2-[2-(Fmoc-amino)ethoxy]ethoxy}acetic acid,8-(Fmoc-amino)-3,6-dioxaoctanoic acid
  • FMoc-NH-PEG2-CH2COOH
  • FMoc-2-(2- (2-aMinoethoxy)ethoxy) acetic acid
  • FMOC-AEEAC
  • RARECHEM EM WB 0032
  • Fmoc-NH-PEG2-CH2COOH,Fmoc-AEEA
  • 1-(9H-FUOREN-9-YL)-3-OXO-2,7,10-TRIOXA-4-AZADODECAN-12-OIC ACID
  • Fmoc-AEEA 1-(9H-Fluoren-9-yl)-3-oxo-2,7,10-trioxa-4-azadodecan-12-oic acid
  • (2-[2-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-ETHOXY]-ETHOXY)-ACETIC ACID
  • (2-[2-(FMOC-AMINO)-ETHOXY]-ETHOXY)-ACETIC ACID
  • 8-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3,6-dioxa-n-octanoicAcid&gt
  • 3,6,11-Trioxa-9-azadodecanoic acid, 12-(9H-fluoren-9-yl)-10-oxo-
  • Fmoc-AEEA/Fmoc-Mini-PEG
  • N-formylglycine t-butylester
  • Fmoc-Ado-OH
  • 2-[2-(Fmoc-amino)ethoxy]ethoxy]aceticaci
  • 8-(Fmoc-amino)-3,6-dioxa-n-octanoic Acid
  • [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid USP/EP/BP
  • Fmoc-N-Amido-PEG2-CH2COOH
  • Fmoc-N-amido-PEG2-acetic acid
  • Fluorene methoxycarbonyl dipolyethylene glycol acetic acid
  • Fmoc-8-amino-3,6-dioxaoctanoic acid (Fmoc-NH-PEG2-CH2COOH)
  • Fmoc-N-Me-Val/D-Val
  • 166108-71-0
  • Specialty Synthesis