Fmoc-8-amino-3,6-dioxaoctanoic acid
- Product Name
- Fmoc-8-amino-3,6-dioxaoctanoic acid
- CAS No.
- 166108-71-0
- Chemical Name
- Fmoc-8-amino-3,6-dioxaoctanoic acid
- Synonyms
- FMOC-AEEA-OH;FMOC-AEEA;FMOC-AEEAC-OH;1-(9H-Fluoren-9-yl)-3-oxo-2,7,10-trioxa-4-azadodecan-12-oic acid;FMoc-NH-PEG2-CH2COOH;FMOC-AEEAC;FMOC-8-AMINO-3,6-DIOXAOCTANOIC ACID;Fmoc-Ado-OH;N-formylglycine t-butylester;9-FLUORENYLMETHOXYCARBONYL-8-AMINO-3,6-DIOXAOCTANOIC ACID
- CBNumber
- CB2169923
- Molecular Formula
- C21H23NO6
- Formula Weight
- 385.41
- MOL File
- 166108-71-0.mol
Fmoc-8-amino-3,6-dioxaoctanoic acid Property
- Melting point:
- 90-92℃
- Boiling point:
- 631.4±45.0 °C(Predicted)
- Density
- 1.265±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- pka
- 3.40±0.10(Predicted)
- form
- Crystalline Powder
- color
- White
- InChI
- InChI=1S/C21H23NO6/c23-20(24)14-27-12-11-26-10-9-22-21(25)28-13-19-17-7-3-1-5-15(17)16-6-2-4-8-18(16)19/h1-8,19H,9-14H2,(H,22,25)(H,23,24)
- InChIKey
- XQPYRJIMPDBGRW-UHFFFAOYSA-N
- SMILES
- C(O)(=O)COCCOCCNC(=O)OCC1C2=C(C=CC=C2)C2=C1C=CC=C2
- CAS DataBase Reference
- 166108-71-0(CAS DataBase Reference)
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
- HS Code
- 29189900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- 95003
- Product name
- {2-[2-(Fmoc-amino)ethoxy]ethoxy}acetic acid
- Purity
- ≥95.0% (HPLC)
- Packaging
- 500mg
- Price
- $234
- Updated
- 2024/03/01
- Product number
- 8.51037
- Product name
- Fmoc-NH-(PEG)-COOH (9 atoms)
- Purity
- Novabiochem?
- Packaging
- 1g
- Price
- $453
- Updated
- 2024/03/01
- Product number
- F0719
- Product name
- 8-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3,6-dioxa-n-octanoic Acid
- Purity
- >97.0%(HPLC)
- Packaging
- 1g
- Price
- $265
- Updated
- 2024/03/01
- Product number
- F0719
- Product name
- 8-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3,6-dioxa-n-octanoic Acid
- Purity
- >97.0%(HPLC)
- Packaging
- 200mg
- Price
- $89
- Updated
- 2024/03/01
- Product number
- H63641
- Product name
- (2-[2-(Fmoc-amino)ethoxy]ethoxy)acetic acid, 95%
- Packaging
- 250mg
- Price
- $114
- Updated
- 2024/03/01
Fmoc-8-amino-3,6-dioxaoctanoic acid Chemical Properties,Usage,Production
Description
Fmoc-NH-PEG2-CH2COOH is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Chemical Properties
White solid
Uses
Hydrophillic spacer group.
Uses
8-(Fmoc-amino)-3,6-dioxaoctanoic Acid is a hydrophilic, heterobifunctional spacer.
Application
Fmoc-8-amino-3,6-dioxaoctanoic acid is a cleavable ADC linker for the synthesis of antibody-drug couplings (ADCs). It is also a PEG linker for the synthesis of PROTAC. It is widely used in drug delivery systems as it is mainly used to enhance the solubility or targeting of drugs and improve their bioavailability.
Fmoc-8-amino-3,6-dioxaoctanoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Fmoc-8-amino-3,6-dioxaoctanoic acid manufacturers
- Product
- Fmoc-AEEA-OH 166108-71-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.10000000149011612kg
- Purity
- 98%;99%
- Supply Ability
- 1T+
- Release date
- 2024-03-06
- Product
- Fmoc-8-amino-3,6-dioxaoctanoic acid 166108-71-0
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000 kgs
- Release date
- 2024-05-17
- Product
- [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid 166108-71-0
- Price
- US $60.00-600.00/KG
- Min. Order
- 1KG
- Purity
- 0.99
- Supply Ability
- 20 tons
- Release date
- 2023-10-25