9-Fluorenylmethyl chloroformate

Product Name: 9-Fluorenylmethyl chloroformate
CAS No.: 28920-43-6
Chemical Name: 9-Fluorenylmethyl chloroformate
Synonyms: FMOC-CL;FoMc-Cl;(9H-fluoren-9-yl)Methyl carbonochloridate;fmoc-ci;9-Fluorenylmethyl;FMOC-C;FMOC-CHLORIDE;1-(9-fluorenyl)methylchloroformate;9-FLUORENYLMETHOXYCARBONYL CHLORIDE;Fluorenylmethyloxycarbonyl chloride
CBNumber: CB7234569
Molecular Formula: C15H11ClO2
Formula Weight: 258.7
MOL File: 28920-43-6.mol

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9-Fluorenylmethyl chloroformate Property

Melting point:: 62-64 °C(lit.)
Boiling point:: 365.79°C (rough estimate)
Density: 1.1780 (rough estimate)
refractive index: 1.5330 (estimate)
storage temp.: 2-8°C
solubility: dioxane: 0.1 g/mL, clear, colorless
form: Crystalline Powder
color: White to very pale yellow
Sensitive: Moisture Sensitive
BRN: 2279177
Stability:: Hygroscopic, Moisture Sensitive
InChI: InChI=1S/C15H11ClO2/c16-15(17)18-9-14-12-7-3-1-5-10(12)11-6-2-4-8-13(11)14/h1-8,14H,9H2
InChIKey: IRXSLJNXXZKURP-UHFFFAOYSA-N
SMILES: C(Cl)(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O
LogP: 3.45
CAS DataBase Reference: 28920-43-6(CAS DataBase Reference)

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Safety

Hazard Codes: C,T
Risk Statements: 34-20/21/22
Safety Statements: 26-36/37/39-45-27
RIDADR: UN 3261 8/PG 2
WGK Germany: 3
RTECS: LQ6250000
F: 10-21
TSCA: No
HazardClass: 6.1
PackingGroup: II
HS Code: 29159020
Storage Class: 8A - Combustible corrosive hazardous materials
Hazard Classifications: Eye Dam. 1
Skin Corr. 1B

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.52259
Product name: (9-Fluorenylmethyl) chloroformate
Purity: Novabiochem?
Packaging: 25g
Price: $56
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.18203
Product name: (9-Fluorenylmethyl) chloroformate
Purity: for synthesis
Packaging: 500mg
Price: $35.1
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.52259
Product name: (9-Fluorenylmethyl) chloroformate
Purity: Novabiochem?
Packaging: 100g
Price: $158
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.18203
Product name: (9-Fluorenylmethyl) chloroformate
Purity: for synthesis
Packaging: 5G
Price: $119
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.18203
Product name: (9-Fluorenylmethyl) chloroformate
Purity: for synthesis
Packaging: 25g
Price: $307
Updated: 2025/07/31

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9-Fluorenylmethyl chloroformate Chemical Properties,Usage,Production

Description

9-Fluorenylmethyl chloroformate (Fmoc-C1) is a significant biochemical reagent introduced by Carpino. It has been widely utilized as a reagent for the introduction of the 9-fluorenylmethoxycarbonyl (Fmoc moiety) in both peptide and nucleotide synthesis, as well as serving as a coupling agent in peptide synthesis^[1]. Furthermore, Fmoc-C1 can function as a versatile fluorescent labeling reagent for primary and secondary amines^[2].

Chemical Properties

9-Fluorenyl chloroformate appears as white crystals with a melting point of 62–64 °C. It is soluble in organic solvents such as CH₂Cl₂, THF, and dioxane. It reacts with alcohols, ammonia or amines, and water.

Uses

9-Fluorenylmethyl chloroformate can be used as N-protecting reagent for oligonucleotide and peptide syntheses. It can act as reagent for the introduction of Fmoc-amino-protecting group, which is stable towards acids but is readily cleaved under mildly basic non-hydrolytic conditions.

Uses

9-Fluorenylmethyl chloroformate is an N-Protecting agent for peptides research and was used for the pre-column derivatization of the biogenic amines (BAs) cadaverine (Cad), histamine (Him), octopami ne (Ocp), phenylethylamine (Pea), putrescine (Put), spermidine (Spd), spermine (Spm), tyramine (Tym).

General Description

Fmoc chloride is a derivatizing agent.

Flammability and Explosibility

Not classified

Safety Profile

A poison. Mutation data reported. A corrosive. When heated to decomposition it emits toxic vapors of Cl-.

Purification Methods

If the IR contains no OH bands (at ~3000 cm-1) due to the hydrolysis product 9-fluorenylmethanol, then purify it by recrystallisation from dry Et2O. IR (CHCl3) has a band at 1770 cm-1 (C=O), and the NMR (CDCl3) has at 4-4.6 (m 2H, CHCH2) and 7.1-7.8 (m, 8 aromatic H) ppm. The azide (FMOC-N3) has m 89-90o (from -1hexane) and IR (CHCl3) at 2135 (N3) and 1730 (C=O) cm , and the carbazate (FMOC-NHNH2) has m 171o(dec) (from nitromethane), IR (KBr) 3310, 3202 (NH) and 1686 (CONH) cm-1. [Caprino & Han J Org Chem 37, 3404 1972 , J Am Chem Soc 92 5748 1970, Koole et al. J Org Chem 59 1657 1989, Fürst et al. J Chromatogr 499 537 1990.]

References

[1] S. TANTRY; V. V B; G Vasanthakumar. Synthesis of peptides employing 9-fluorenylmethyl chloroformate as a coupling agent[J]. Letters in peptide science?: LIPS, 2006, 10 1: 51-55. DOI:10.1007/BF02443642.
[2] H. A. MOYE A. B. A Versatile Fluorogenic Labelling Reagent for Primary and Secondary Amines: 9-Fluorenylmethyl Chloroformate[J]. Analytical Letters, 1979, 12 1: 25-35. DOI:10.1080/00032717908082516.

9-Fluorenylmethyl chloroformate Preparation Products And Raw materials

Raw materials

9-Fluorenemethanol

Preparation Products

2-Ethylpiperazine Fmoc-8-amino-3,6-dioxaoctanoic acid 3-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-ISONICOTINIC ACID FMOC-2-AMINONICOTINIC ACID

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9-Fluorenylmethyl chloroformate Suppliers

Americas 1 Belgium 1 Canada 1 China 519 Europe 5 France 1 Germany 15 India 28 Japan 10 Slovakia 1 South Korea 2 Switzerland 5 Ukraine 1 United Kingdom 15 United States 67 Global 672

Suzhou Highfine Biotech Co., Ltd

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Wuhan Tianjia Tingle Chemical Co., Ltd.

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Lianyungang Guanxin Pharmaceutical Technology Co., Ltd

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Gill polypeptide biopharmaceutical (dalian) co., LTD

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Binhai gill polypeptide co. LTD

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Tianjin Yixing Biotechnology Co. , Ltd.

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Nanjing Jubai Biomedical Technology Co., Ltd.

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J & K SCIENTIFIC LTD.

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Meryer (Shanghai) Chemical Technology Co., Ltd.

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INTATRADE GmbH

Tel: +49 3493/605464
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Email: sales@intatrade.de
Country: Germany
ProdList: 3572
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View Lastest Price from 9-Fluorenylmethyl chloroformate manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 9-Fluorenylmethyl chloroformate 28920-43-6
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98
Supply Ability: 10000KGS
Release date: 2025-12-16

Xinxiang Juyuan Biological Technology Co., Ltd.

Product: FMOC-CL 28920-43-6
Price: US $750.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 50tons
Release date: 2025-08-04

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 9-Fluorenylmethyl chloroformate 28920-43-6
Price: US $45.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2024-12-20

28920-43-6, 9-Fluorenylmethyl chloroformateRelated Search:

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1-(9-fluorenyl)methylchloroformate

CHLOROFORMIC ACID 9-FLUORENYLMETHYL ESTER

EMOCCI

FMOC-CL

FMOC-CHLORIDE

fmoc-ci

9-FLUORENYLMETHYL CHLOROFORMATE (FMOC CL)

Fmoc-Cl(9-FluorenylmethoxycarbonylChloride)

Fmoc-Clsee22072

9-Fluorenylmethyl

(9h-fluoren-9-ylmethoxy)carbonyl chloride

FMOC-CL CHLOROFORMIC ACID 9-FLUORENYLMETHYL ESTER

9-Fluorenylmethoxycarbonyl chloride (Fmoc-Cl)

FMOC-CL, 9-FLLUORENYLMETHYL CHLOROFOMATE

Fmco-chloride(9-Fluorenyl methyl chloroformate)

Chloroformic acid 9H-fluoren-9-ylmethyl ester

9-Fluorenylmethyl Chloroformate [N-Protecting Agent for Peptides Research]

9-Fluorenylmethylchloroformate,98%

9-FLUOROMETHANOL ( FMOC )

9-FLUOROMETHANOL ( FMOC-ONSU )

FMOC-CL (9-FLUORENYLMETHYL CHLOROFORMATE)

9-Fluorenylmethylchloroformate (Fmoc-chloride)

9-Fluorenylmethoxycarbonyl chloride, 9-Fluorenylmethyl chloroformate, Fmoc-Cl

9-Fluorenylmethyl chlorocarbonate

AminoTag

FMoc chloride 97%

FMOC chloride [FMOC-CL]

9-FluorenylMethyl ChloroforMate, 97+%

Fmoc chloride, >=98%

9 - fluorene chlorine Methyl forMate

Fmoc-Chloride≥ 98% (HPLC)

(9-Fluorenylmethyl) chloroformate Novabiochem

(9-Fluorenylmethyl) chloroformate for synthesis

9-Fluorenylmethyl chloroformat

(9H-Fluoren-9-yl)MethOxy]Carbonyl Cl

Chloroformic acid 9-fluorenylmethyl ester(Fmoc-CL)

9-Fluorenylmethyl chloroformate, Chloroformic acid 9-fluorenylmethyl este, Fmoc-Cl

chloro-formicacifluoren-9-ylmethylester

Formicacid,chloro-,fluoren-9-ylmethylester

N-9-FLUORENYLMETHYL CHLOROFORMATE

RARECHEM FM OC 0001

9h-fluoren-9-ylmethyl chloroformate

9-FLUORENYLMETHYLOXYCARBONYL CHLORIDE

9-FLUOROENYLMETHYL CHLOROFORMATE

9-FLUORENEMETHYL CHLOROFORMATE

9-FLUORENMETHYL CHLOROFORMATE

9-FLUORENYLMETHYL CHLOROFORMATE

9-FLUORENYLMETHOXYCARBONYL CHLORIDE

9-(Chloroformyloxymethyl)-9H-fluorene

Chloridocarbonic acid (9H-fluoren-9-yl)methyl ester

Chlorocarbonic acid (9H-fluoren-9-ylmethyl) ester

Chloroformic acid (9H-fluoren-9-yl)methyl

CARBONOCHLORIDIC ACID, 9H-FLUOREN-9-YLMETHYL ESTER

9-Fluoroe

Fmoc chloride,9-Fluorenylmethoxycarbonyl chloride, 9-Fluorenylmethyl chloroformate, Fmoc-Cl

Chloroformic acid 9-

(9H-Fluoren-9-yl)methyl carbonochloridoate

9-FluorenylMethyl chloroforMate, 98% 1GR