Fmoc-OSu

Product Name: Fmoc-OSu
CAS No.: 82911-69-1
Chemical Name: Fmoc-OSu
Synonyms: FMOC-OSU;Fomc-Osu;(9H-Fluoren-9-yl)Methyl (2,5-dioxopyrrolidin-1-yl) carbonate;FMOC N-HYDROXYSUCCINIMIDE ESTER;FMOC-SU;FMOC-ONSU;9-FLUORENYLMETHYL SUCCINIMIDYL CARBONATE;FMOC-Succinimide;9-fluorenylmethyl-n-succinimide carbonate;9-FLUORENYLMETHYL N-SUCCINIMIDYL CARBONATE
CBNumber: CB9428667
Molecular Formula: C19H15NO5
Formula Weight: 337.33
MOL File: 82911-69-1.mol

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Fmoc-OSu Property

Melting point:: 150-153 °C(lit.)
Boiling point:: 150-153°C
Density: 1.3460 (rough estimate)
refractive index: 1.5000 (estimate)
storage temp.: 2-8°C
solubility: Soluble in dimethyl sulfoxide and dimethyl formamide.
form: Microfine Powder
color: White or almost white
Sensitive: Moisture Sensitive
BRN: 3569540
Stability:: Moisture Sensitive
Major Application: peptide synthesis
InChI: InChI=1S/C19H15NO5/c21-17-9-10-18(22)20(17)25-19(23)24-11-16-14-7-3-1-5-12(14)13-6-2-4-8-15(13)16/h1-8,16H,9-11H2
InChIKey: WMSUFWLPZLCIHP-UHFFFAOYSA-N
SMILES: C(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)(=O)ON1C(=O)CCC1=O
CAS DataBase Reference: 82911-69-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,N,Xn
Risk Statements: 36/37/38-51/53-43-22
Safety Statements: 22-24/25-26/37/39-26-61-37-24
RIDADR: UN 3077 9 / PGIII
WGK Germany: 3
F: 10-21
Hazard Note: Moisture Sensitive
HazardClass: 9
HS Code: 29251995
Storage Class: 11 - Combustible Solids
Hazard Classifications: Acute Tox. 4 Oral
Aquatic Chronic 2
Skin Sens. 1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.51014
Product name: Fmoc-OSu
Purity: Novabiochem?
Packaging: 25g
Price: $137
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.51014
Product name: Fmoc-OSu
Purity: Novabiochem?
Packaging: 100g
Price: $414
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.51014
Product name: Fmoc-OSu
Purity: Novabiochem<SUP>®</SUP>
Packaging: 1 kg
Price: $2580
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.51014
Product name: Fmoc-OSu
Purity: Novabiochem<SUP>®</SUP>
Packaging: 1 kg
Price: $2580
Updated: 2025/07/31

Sigma-Aldrich

Product number: 46920
Product name: Fmoc N-hydroxysuccinimide ester
Purity: ≥98.0% (HPLC)
Packaging: 5G
Price: $93.4
Updated: 2025/07/31

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Fmoc-OSu Chemical Properties,Usage,Production

Description

Fmoc-OSu (N-(9-Fluorenylmethoxycarbonyloxy)succinimide) is a reagent used in solid-phase peptide synthesis (SPPS) for Fmoc protection of amino groups, particularly amino acids. This reagent contains an Fmoc functional group, which is stable under acidic conditions and cleaves under alkaline conditions. Fmoc-OSu reacts with amino groups to form stable amide bonds, helping to reduce the occurrence of side reactions. Additionally, Fmoc-OSu can also be used as a fluorescent reagent.

Chemical Properties

White powder

Uses

N-protecting reagent for oligonucleotide and peptide syntheses

Uses

Reagent for the preparation of pure Fmoc amino acids free from contamination by Fmoc-dipeptides.

Uses

N-(9-Fluorenylmethoxycarbonyloxy)succinimide is used in conjunction with Isothiocyanate to conduct partial Edman Degradation on biologically active peptides.

Mechanism of action

The protective mechanism of Fmoc-OSu involves the amine group (R-NH₂) of the protected molecule acting as a nucleophile and attacking the carbonyl carbon of the Fmoc-OSu molecule, forming a tetrahedral intermediate. where the nitrogen of the amine is now bonded to the carbonyl carbon of the Fmoc group, yielding an Fmoc-protected amine and a succinimide. The Fmoc group is typically removed using bases such as piperidine, which can remove the Fmoc group without hydrolyzing the peptide backbone. In solid-phase peptide synthesis (SPPS), the removal of the Fmoc group occurs via a two-step mechanism: first, the acidic proton at the 9-position of the naphthalene ring system is removed using a mild base (preferably a secondary amine), followed by a β-elimination reaction, generating a highly reactive dibenzofuran (DBF) intermediate, which is immediately captured by the secondary amine to form a stable adduct.

Purification Methods

Recrystallise the carbonate from CHCl3/Et2O, or from pet ether (b 40-60o). [Pauet Can J Chem 60 976 1982, Lapatsaris et al. Synthesis 671 1983.]

Fmoc-OSu Preparation Products And Raw materials

Raw materials

Preparation Products

Fmoc-8-amino-3,6-dioxaoctanoic acid

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Fmoc-OSu Suppliers

Americas 1 Belgium 2 Canada 4 China 623 Europe 4 France 2 Germany 13 India 31 Japan 9 Poland 1 Slovakia 1 South Korea 1 Switzerland 6 United Kingdom 19 United States 73 Global 790

Suzhou Highfine Biotech Co., Ltd

Tel: 0512-68417696 13962195629
Fax: 0512-68417696
Email: minhan.zhao@highfine.com
Country: China
ProdList: 475
Advantage: 75

Hubei Jingxiang Technology Co., Ltd.

Tel: 13347833233
Email: 549483679@qq.com
Country: China
ProdList: 27
Advantage: 58

Shanghai GL Peptide Ltd.

Tel: +86-21-61263340; 17609490614 13764994101
Fax: 021-61263399
Email: fisherwang@glschina.com
Country: China
ProdList: 8256
Advantage: 55

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Wuhan Ying Yuan Bei Biological Limited

Tel: 13349903920 13349903920;
Email: 1540154086@qq.com
Country: China
ProdList: 3003
Advantage: 58

Changzhou Union Chemicals Co.,Ltd.

Tel: 0519-86802352
Fax: 0519 86396223
Email: info@union-chems.com
Country: China
ProdList: 485
Advantage: 58

Shanghai Leju Biotechnology Co., Ltd.

Tel: 021-56328558 13917766064;13671549194
Email: sales2@reliablebiochem.com
Country: China
ProdList: 300
Advantage: 58

Chengdu Jiuding Chemical Technology Co., Ltd. - Song Bo

Tel: 18584079237
Email: 312074905@qq.com
Country: China
ProdList: 2516
Advantage: 58

C N C H E M U N I O N C O . , L T D .

Tel: 17653471880
Email: david@cnchemunion.com
Country: China
ProdList: 108
Advantage: 58

Changzhou Huihan Biotechnology Co., Ltd.

Tel: 15380463325 15380463325
Fax: 025-84209270
Email: 819573646@qq.com
Country: China
ProdList: 88
Advantage: 55

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View Lastest Price from Fmoc-OSu manufacturers

.GZ HONESTCHEM CO.,LTD

Product: N-(9-Fluorenylmethoxycarbonyloxy)succinimide 82911-69-1
Price: US $10.00/KG
Min. Order: 1000KG
Purity: 99.99%
Supply Ability: 10 tons
Release date: 2025-10-10

Shaanxi Dideu Medichem Co. Ltd

Product: Fmoc-OSu 82911-69-1
Price: US $0.10/KG
Min. Order: 1KG
Purity: 99%+
Supply Ability: 2000 kgs
Release date: 2025-09-13

Shaanxi Dideu Medichem Co. Ltd

Product: FMOC-OSU N-(9-FluorenylMethoxycarbonyloxy)succiniMide 82911-69-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 10MT
Release date: 2025-09-11

82911-69-1, Fmoc-OSuRelated Search:

Fmoc-Aib-OH Bismaleimide Tris(trimethylsilyl)phosphate Barium carbonate Zinc carbonate N-Hydroxysuccinimide 9-Fluorenylmethyl chloroformate Lithium carbonate Ethylene carbonate Ammonium carbonate O-Phthalimide Dimethyl carbonate Sodium carbonate Succinimide Calcium carbonate DIALIFOS N-Methoxy-N-methylacetamide 9-Fluorenemethanol

1-[[(9h-fluoren-9-ylmethoxy)carbonyl]oxy]-5-pyrrolidinedione

9-fluorenylmethoxycarbonyloxysuccinimide

9-fluorenylmethyl-n-succinimide carbonate

N-(9-FluorenylmethoxyCarbonyloxy)Succinimide9-Fluorenylmethylsuccinimidylcarbonate

CARBONIC ACID 2,5-DIOXO-PYRROLIDIN-1-YL ESTER 9H-FLUOREN-9-YLMETHYL ESTER

CARBONIC ACID FLUORENYLMETHYL SUCCIN-N-YL-ESTER

FMOC-OSU

FMOC-ONSU

FMOC N-HYDROXYSUCCINIMIDE ESTER

FMOC-SU

FLUORENYLMETHYL SUCCINIMIDYL CARBONATE

9-FLUORENMETHYL SUCCINIMIDYL CARBONATE

9-FLUORENYLMETHOXYCARBONYL-N-HYDROXYSUCCINIMIDE

9-FLUORENYLMETHYL N-HYDROXYSUCCINIMIDYL CARBONATE

9-FLUORENYLMETHYL N-SUCCINIMIDYL CARBONATE

9-FLUORENYLMETHYLOXYCARBONYL-N-HYDROXYSUCCINIMIDE

9-FLUORENYLMETHYL SUCCINIMIDYL CARBONATE

2,5-PYRROLIDINEDIONE,1-[[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]OXY]-

1-(9H-FLUORENYLMETHOXYCARBONYLOXY)2,5-PYRROLIDINEDIONE

RARECHEM FM OC 0002

N-(9-FLUORENEMETHOXYCARBONYLOXY)-SUCCINIMIDE

N-(9-FLUORENYLMETHOXYCARBONYL)SUCCINIMIDE

N-(9-FLUORENYLMETHOXYCARBONYLOXY)SUCCINIMIDE

N-(9H-FLUOREN-9-YLMETHOXY-CARBONYLOXY)SUCCINIMIDE

N-(9H-FLUOREN-2-YLMETHOXYCARBONYLOXY)SUCCINIMIDE

N-(9-FLUORENYLMETHYLOXYCARBONYLOXY)-SUCCINIMIDE

FMOC-ONSU, N(9-FLUORENYMETHOXYCARBONYLOXY) SUCCINIMIDE

(9H-Fluorene-9-ylmethyl)succinimidylcarbonate

9H-Fluorene-9-ylmethylsuccinimidyl=carbonate

Carbonic acid (2,5-dioxo-1-pyrrolidinyl)=(9H-fluorene-9-yl)methyl ester

Carbonic acid (9H-fluorene-9-ylmethyl)2,5-dioxo-1-pyrrolidinyl ester

Carbonic acid 2,5-dioxopyrrolizino=9H-fluorene-9-ylmethyl ester

N-(9H-Fluorene-9-ylmethoxycarbonyloxy)succinimide

9-Fluorenylmethyl succinimidyl carbonate / N-(9-Fluorenylmethoxycarbonyloxy)succinimide

N-(9H-Fluoren-2-ylmethoxycarbonyloxy)succinimide,98%

9-Fluorenylmethyl N-succinimidyl carbonate, N-(9-Fluorenylmethoxycarbonyloxy)succinimide, Fmoc-OSu

9-Fluorenylmethyl N-succinimidyl carbonate, N-(9-Fluorenylmethoxycarbonyloxy)succinimide, Fmoc N-hydroxysuccinimide ester, Fmoc-OSu

Fmoc N-hydroxysuccinimide ester ,98%

9-FLUORENYLMETHYOXYCARBONYL SUCCINIMIDE FMOC-OSU

Fmoc-Osu N-(9-Fluorenylmethoxycarbonyloxy)succinimide

9-Fluorenylmethyloxycarbonyl-N-hydroxy-succinimide//Fmoc-Osu

N-(9-Fluorenylmethox

(9H-Fluoren-9-yl)methyl N-succinimidyl carbonate, FMOC-ONSu

Fmoc-SuSEE11742

N-(9-Fluorenylmethoxy

n-(fmoc-oxy)succinimide

1-{[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]OXY}PYRROLIDINE-2,5-DIONE

9-FLUORENYLMETHYL-N-SUCCINIMIDYLCARBONATE(FMOC-OSU)

TIMTEC-BB SBB005973

Fluorenylmethyloxycarbonyl-N-hydroxysuccinimide ester

Fmoc-Osu N-(9-fluorenylmethoxycarbonyloxy)

Fluoren-9-ylmethyl succinimidyl carbonate

N-(9H-FLUOREN-2-YLMETHOXYCARBONYLOXY)SUCCINIMIDE, FMOCOSU

9-Fluorenylmethyl succinimidyl carbonate, 98+%

Fmoc-OSu (9-Fluorenylmethyl succinimidyl carbonate)

9-Fluorenylmethyl succinimidyl carbonate 9-fluorenylmethoxycarbonyloxysuccinimide

9-fluorenylmethylsuccinimidyl carbonate n-(9h-fluoren-2-ylmethoxycarbonyloxy)succinimide

9-Fluorenylmethyl Succinimidyl Carbonate(FMOC-ONSu)