N-Methoxy-N-methylacetamide

Product Name: N-Methoxy-N-methylacetamide
CAS No.: 78191-00-1
Chemical Name: N-Methoxy-N-methylacetamide
Synonyms: N-Methoxy-N-methylacetamid;N-ACETYL-N,O-DIMETHYLHYDROXYLAMINE;N-Methoxy-N-methyL;N-METHOXY-N-METHLACETAMIDE;N-METHOXY-N-METHYLACETAMIDE;N-Methyl-N-methoxyacetamide;N-Methoxyl-N-methylacetamide;AcetaMide, N-Methoxy-N-Methyl-;N-Methoxy-N-methylacetamide>N-Methoxy-N-methylacetamide, 98 %
CBNumber: CB6466684
Molecular Formula: C4H9NO2
Formula Weight: 103.12
MOL File: 78191-00-1.mol

More

Less

N-Methoxy-N-methylacetamide Property

Boiling point:: 152 °C (lit.)
Density: 0.97 g/mL at 25 °C (lit.)
refractive index: n20/D 1.426(lit.)
Flash point:: 121 °F
storage temp.: Inert atmosphere,Room Temperature
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Liquid
color: Colorless
Water Solubility: Soluble
InChI: InChI=1S/C4H9NO2/c1-4(6)5(2)7-3/h1-3H3
InChIKey: OYVXVLSZQHSNDK-UHFFFAOYSA-N
SMILES: C(N(OC)C)(=O)C
CAS DataBase Reference: 78191-00-1(CAS DataBase Reference)

More

Less

Safety

Risk Statements: 10
Safety Statements: 16-24/25
RIDADR: UN 1993 3/PG 3
WGK Germany: 3
HazardClass: 3
PackingGroup: III
HS Code: 29280000

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H226Flammable liquid and vapour

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 513253
Product name: N-Methoxy-N-methylacetamide
Purity: 98%
Packaging: 5g
Price: $104
Updated: 2025/07/31

TCI Chemical

Product number: M0919
Product name: N-Methoxy-N-methylacetamide
Purity: >98.0%(GC)
Packaging: 10g
Price: $46
Updated: 2025/07/31

TCI Chemical

Product number: M0919
Product name: N-Methoxy-N-methylacetamide
Purity: >98.0%(GC)
Packaging: 25g
Price: $90
Updated: 2025/07/31

TRC

Product number: M263295
Product name: N-Methoxy-N-methylacetamide
Packaging: 5g
Price: $80
Updated: 2021/12/16

Matrix Scientific

Product number: 075518
Product name: N-Methoxy-N-methylacetamide
Purity: 95+%
Packaging: 25g
Price: $48
Updated: 2021/12/16

More

Less

N-Methoxy-N-methylacetamide Chemical Properties,Usage,Production

Chemical Properties

clear colorless liquid

Uses

N-Methoxy-N-methylacetamide, is a Weinreb amide used in the synthesis of marine natural products myriaporone and usneoidone as a ketone synthon.

Preparation

N-Methoxy-N-methylacetamide can be prepared by reaction of Acetyl Chloride with commercially available N,O-Dimethylhydroxylamine hydrochloride in pyridine, followed by distillation at reduced pressure (65%).

General Description

Simple Weinreb amide used in the synthesis of marine natural products myriaporone and usneoidone as a ketone synthon.

Synthesis

6638-79-5

75-36-5

78191-00-1

N-Methoxy-N-methylacetamide (105) was synthesized as follows: pyridine (10 mL, 124 mmol) was slowly added dropwise to a well-stirred suspension of O,N-dimethylhydroxylamine hydrochloride (6 g, 62 mmol) and acetyl chloride (4.15 mL, 59 mmol) in dichloromethane (85 mL) under argon protection. The reaction mixture was gradually warmed to room temperature and stirred continuously for 3 hours. Subsequently, the reaction mixture was partitioned between brine (55 mL) and ether (85 mL). The aqueous phase was extracted with additional ether and the combined organic layers were dried over anhydrous sodium sulfate, concentrated and purified by reduced pressure distillation to afford Weinreb amide 105 (4.54 g, 72% yield) as a colorless liquid. The boiling point of the product was 42-44 °C/20 mmHg; IR (pure sample) showed absorption peaks located at 3497, 2971, 2941, 2824, 1663 cm-1; 1H NMR (CDCl3, 300 MHz) δ 3.62 (s, 3H), 3.11 (s, 3H), 2.05 (s, 3H); 13C NMR (CDCl3. 75.4 MHz) δ 171.8 (C), 61.0 (CH3), 31.9 (CH3), 19.6 (CH3). The spectral data of the obtained products are in agreement with literature reports.

storage

N-Methoxy-N-methylacetamide is stable but should be protected from moisture; use in a fume hood.

References

[1] Organic Letters, 2012, vol. 14, # 9, p. 2250 - 2253
[2] European Journal of Organic Chemistry, 2017, vol. 2017, # 2, p. 278 - 286
[3] Patent: EP1300403, 2003, A1
[4] Tetrahedron Letters, 1983, vol. 24, # 18, p. 1851 - 1854
[5] Tetrahedron Letters, 2007, vol. 48, # 3, p. 377 - 380

N-Methoxy-N-methylacetamide Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

N-Methoxy-N-methylacetamide Suppliers

Americas 1 Belgium 2 China 267 Czech Republic 1 Europe 1 France 2 Germany 4 India 14 Italy 1 Japan 1 South Korea 1 Switzerland 2 United Kingdom 7 United States 32 Global 336

Nanjing Jubai Biomedical Technology Co., Ltd.

Tel: 13585203734
Email: info@jbzml.com
Country: China
ProdList: 99
Advantage: 58

Hangzhou Baiji Biotechnology Co., LTD

Tel: 13615701454
Email: 616495203@qq.com
Country: China
ProdList: 23
Advantage: 58

Suzhou Highfine Biotech Co., Ltd

Tel: 0512-69209928 18796809688
Email: zhouyingxiang@highfine.com
Country: China
ProdList: 1356
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

ShangHai DEMO Chemical Co.,Ltd

Tel: 400-021-7337 2355568890
Fax: 0086-21-50182339
Email: sales@demochem.com
Country: China
ProdList: 2572
Advantage: 57

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Suzhou Highfine Biotech Co., Ltd

Tel: 0512-69209928 18796809688
Fax: 0512-68417696
Email: zhouyingxiang@highfine.com
Country: China
ProdList: 475
Advantage: 75

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

More

Less

View Lastest Price from N-Methoxy-N-methylacetamide manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: N-Methoxy-N-methylacetamide 78191-00-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-07-04

Shaanxi Dideu Medichem Co. Ltd

Product: N-Methoxy-N-methylacetamide 78191-00-1
Price: US $0.00-0.00/KG
Min. Order: 5mg
Purity: 99% HPLC
Supply Ability: 2000tons
Release date: 2019-12-30

Career Henan Chemical Co

Product: N-Methoxy-N-methylacetamide 78191-00-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2018-08-06

78191-00-1, N-Methoxy-N-methylacetamideRelated Search:

N-Methylacetamide Thioacetamide 2-Methoxyethanol Acetamide (Trifluoromethoxy)benzene Anisole N-Chlorosuccinimide N,N-Dimethylacetamide N,N'-Disuccinimidyl carbonate GMBS SPDP N-(Benzyloxycarbonyloxy)succinimide BOC-TRP-OSU BOLTON-HUNTER REAGENT N-Succinimidyl S-Acetylthioglycolate N-(2-Chlorobenzyloxycarbonyloxy)succinimide Fmoc-OSu SMCC crosslinker

N-ACETYL-N,O-DIMETHYLHYDROXYLAMINE

N-METHOXY-N-METHYLACETAMIDE

N-METHOXY-N-METHLACETAMIDE

N-Methoxy-N-methylacetamide, 98 %

N-Methoxy-N-methyL

AcetaMide, N-Methoxy-N-Methyl-

N-Methoxy-N-MethylacetaMide, 95+%

<i>N</i>-Methoxy-<i>N</i>-methylacetamide

N-Methyl-N-methoxyacetamide

N-Methoxyl-N-methylacetamide

N-Methoxy-N-MethylacetaMide, 98% 5GR

N-Methoxy-N-methylacetamide≥ 98%(GC)

N-Methoxy-N-methylacetamide&gt

N-Methoxy-N-methylacetamide ISO 9001：2015 REACH

N-Methoxy-N-methylacetamid

78191-00-1

CH3CONOCH3CH3

Organic Building Blocks

Building Blocks

Amides

Carbonyl Compounds

Hydroxylamines (O-Substituted)

Hydroxylamines (N-Substituted)

Hydroxylamines

Hydroxylamines (N-Substituted)

Hydroxylamines (O-Substituted)

Amides

Carbonyl Compounds

Organic Building Blocks

bc0001