ChemicalBook > CAS DataBase List > 9-Fluorenylmethyl chloroformate

9-Fluorenylmethyl chloroformate

Product Name
9-Fluorenylmethyl chloroformate
CAS No.
28920-43-6
Chemical Name
9-Fluorenylmethyl chloroformate
Synonyms
FMOC-CL;FoMc-Cl;(9H-fluoren-9-yl)Methyl carbonochloridate;fmoc-ci;9-Fluorenylmethyl;FMOC-C;FMOC-CHLORIDE;1-(9-fluorenyl)methylchloroformate;9-FLUORENYLMETHOXYCARBONYL CHLORIDE;Fluorenylmethyloxycarbonyl chloride
CBNumber
CB7234569
Molecular Formula
C15H11ClO2
Formula Weight
258.7
MOL File
28920-43-6.mol
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9-Fluorenylmethyl chloroformate Property

Melting point:
62-64 °C(lit.)
Boiling point:
365.79°C (rough estimate)
Density 
1.1780 (rough estimate)
refractive index 
1.5330 (estimate)
storage temp. 
2-8°C
solubility 
dioxane: 0.1 g/mL, clear, colorless
form 
Crystalline Powder
color 
White to very pale yellow
Sensitive 
Moisture Sensitive
BRN 
2279177
Stability:
Hygroscopic, Moisture Sensitive
InChI
InChI=1S/C15H11ClO2/c16-15(17)18-9-14-12-7-3-1-5-10(12)11-6-2-4-8-13(11)14/h1-8,14H,9H2
InChIKey
IRXSLJNXXZKURP-UHFFFAOYSA-N
SMILES
C(Cl)(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O
LogP
3.45
CAS DataBase Reference
28920-43-6(CAS DataBase Reference)
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Safety

Hazard Codes 
C,T
Risk Statements 
34-20/21/22
Safety Statements 
26-36/37/39-45-27
RIDADR 
UN 3261 8/PG 2
WGK Germany 
3
RTECS 
LQ6250000
F 
10-21
TSCA 
No
HazardClass 
6.1
PackingGroup 
II
HS Code 
29159020
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.52259
Product name
(9-Fluorenylmethyl) chloroformate
Purity
Novabiochem?
Packaging
25g
Price
$54.5
Updated
2024/03/01
Sigma-Aldrich
Product number
8.18203
Product name
(9-Fluorenylmethyl) chloroformate
Purity
for synthesis
Packaging
500mg
Price
$34.2
Updated
2024/03/01
Sigma-Aldrich
Product number
8.52259
Product name
(9-Fluorenylmethyl) chloroformate
Purity
Novabiochem?
Packaging
100g
Price
$154
Updated
2024/03/01
Sigma-Aldrich
Product number
8.18203
Product name
(9-Fluorenylmethyl) chloroformate
Purity
for synthesis
Packaging
5G
Price
$116
Updated
2024/03/01
Sigma-Aldrich
Product number
8.18203
Product name
(9-Fluorenylmethyl) chloroformate
Purity
for synthesis
Packaging
25g
Price
$299
Updated
2024/03/01
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9-Fluorenylmethyl chloroformate Chemical Properties,Usage,Production

Chemical Properties

White to off white crystalline powder

Uses

9-Fluorenylmethyl chloroformate is an N-Protecting agent for peptides research and was used for the pre-column derivatization of the biogenic amines (BAs) cadaverine (Cad), histamine (Him), octopami ne (Ocp), phenylethylamine (Pea), putrescine (Put), spermidine (Spd), spermine (Spm), tyramine (Tym).

Uses

9-Fluorenylmethyl chloroformate can act as reagent for the introduction of Fmoc-amino-protecting group, which is stable towards acids but is readily cleaved under mildly basic non-hydrolytic conditions.

Uses

9-Fluorenylmethyl chloroformate can be used as N-protecting reagent for oligonucleotide and peptide syntheses.

General Description

Fmoc chloride is a derivatizing agent.

Flammability and Explosibility

Not classified

Safety Profile

A poison. Mutation data reported. A corrosive. When heated to decomposition it emits toxic vapors of Cl-.

Purification Methods

If the IR contains no OH bands (at ~3000 cm-1) due to the hydrolysis product 9-fluorenylmethanol, then purify it by recrystallisation from dry Et2O. IR (CHCl3) has a band at 1770 cm-1 (C=O), and the NMR (CDCl3) has  at 4-4.6 (m 2H, CHCH2) and 7.1-7.8 (m, 8 aromatic H) ppm. The azide (FMOC-N3) has m 89-90o (from -1hexane) and IR (CHCl3) at 2135 (N3) and 1730 (C=O) cm , and the carbazate (FMOC-NHNH2) has m 171o(dec) (from nitromethane), IR (KBr) 3310, 3202 (NH) and 1686 (CONH) cm-1. [Caprino & Han J Org Chem 37, 3404 1972 , J Am Chem Soc 92 5748 1970, Koole et al. J Org Chem 59 1657 1989, Fürst et al. J Chromatogr 499 537 1990.]

9-Fluorenylmethyl chloroformate Preparation Products And Raw materials

Raw materials

9-Fluorenemethanol

Preparation Products

2-Ethylpiperazine Fmoc-8-amino-3,6-dioxaoctanoic acid 3-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-ISONICOTINIC ACID FMOC-2-AMINONICOTINIC ACID
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9-Fluorenylmethyl chloroformate Suppliers

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View Lastest Price from 9-Fluorenylmethyl chloroformate manufacturers

Hebei Kingfiner Technology Development Co.Ltd
Product
9-Fluorenylmethyl chloroformate 28920-43-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
50000kg
Release date
2023-11-14
Henan Fengda Chemical Co., Ltd
Product
9-Fluorenylmethyl chloroformate 28920-43-6
Price
US $8.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-03-29
TAIZHOU DKD CHEMICAL CO., LTD.
Product
9-Fluorenylmethyl chloroformate 28920-43-6
Price
US $0.00/kg
Min. Order
25kg
Purity
99%
Supply Ability
20 tons
Release date
2022-11-09

28920-43-6, 9-Fluorenylmethyl chloroformateRelated Search:

Benzoyl chloride Trimethoxymethane Dimethyl succinate Fmoc-Aib-OH Methyl benzoylformate Acryloyl chloride Benzenesulfonyl chloride N-(9-Fluorenylmethoxycarbonyloxy)succinimide Methyl anthranilate Methyl formate Chloroacetyl chloride Tosyl chloride Methyl acrylate Oxalyl chloride Methyl benzoate Methylparaben Diethyl phthalate Benzyl chloroformate

  • 1-(9-fluorenyl)methylchloroformate
  • CHLOROFORMIC ACID 9-FLUORENYLMETHYL ESTER
  • EMOCCI
  • FMOC-CL
  • FMOC-CHLORIDE
  • fmoc-ci
  • 9-FLUORENYLMETHYL CHLOROFORMATE (FMOC CL)
  • Fmoc-Cl(9-FluorenylmethoxycarbonylChloride)
  • Fmoc-Clsee22072
  • 9-Fluorenylmethyl
  • (9h-fluoren-9-ylmethoxy)carbonyl chloride
  • FMOC-CL CHLOROFORMIC ACID 9-FLUORENYLMETHYL ESTER
  • 9-Fluorenylmethoxycarbonyl chloride (Fmoc-Cl)
  • FMOC-CL, 9-FLLUORENYLMETHYL CHLOROFOMATE
  • Fmco-chloride(9-Fluorenyl methyl chloroformate)
  • Chloroformic acid 9H-fluoren-9-ylmethyl ester
  • 9-Fluorenylmethyl Chloroformate [N-Protecting Agent for Peptides Research]
  • 9-Fluorenylmethylchloroformate,98%
  • 9-FLUOROMETHANOL ( FMOC )
  • 9-FLUOROMETHANOL ( FMOC-ONSU )
  • FMOC-CL (9-FLUORENYLMETHYL CHLOROFORMATE)
  • 9-Fluorenylmethylchloroformate (Fmoc-chloride)
  • 9-Fluorenylmethoxycarbonyl chloride, 9-Fluorenylmethyl chloroformate, Fmoc-Cl
  • 9-Fluorenylmethyl chlorocarbonate
  • AminoTag
  • FMoc chloride 97%
  • FMOC chloride [FMOC-CL]
  • 9-FluorenylMethyl ChloroforMate, 97+%
  • Fmoc chloride, >=98%
  • 9 - fluorene chlorine Methyl forMate
  • Fmoc-Chloride≥ 98% (HPLC)
  • (9-Fluorenylmethyl) chloroformate Novabiochem
  • (9-Fluorenylmethyl) chloroformate for synthesis
  • 9-Fluorenylmethyl chloroformat
  • (9H-Fluoren-9-yl)MethOxy]Carbonyl Cl
  • Chloroformic acid 9-fluorenylmethyl ester(Fmoc-CL)
  • 9-Fluorenylmethyl chloroformate, Chloroformic acid 9-fluorenylmethyl este, Fmoc-Cl
  • chloro-formicacifluoren-9-ylmethylester
  • Formicacid,chloro-,fluoren-9-ylmethylester
  • N-9-FLUORENYLMETHYL CHLOROFORMATE
  • RARECHEM FM OC 0001
  • 9h-fluoren-9-ylmethyl chloroformate
  • 9-FLUORENYLMETHYLOXYCARBONYL CHLORIDE
  • 9-FLUOROENYLMETHYL CHLOROFORMATE
  • 9-FLUORENEMETHYL CHLOROFORMATE
  • 9-FLUORENMETHYL CHLOROFORMATE
  • 9-FLUORENYLMETHYL CHLOROFORMATE
  • 9-FLUORENYLMETHOXYCARBONYL CHLORIDE
  • 9-(Chloroformyloxymethyl)-9H-fluorene
  • Chloridocarbonic acid (9H-fluoren-9-yl)methyl ester
  • Chlorocarbonic acid (9H-fluoren-9-ylmethyl) ester
  • Chloroformic acid (9H-fluoren-9-yl)methyl
  • CARBONOCHLORIDIC ACID, 9H-FLUOREN-9-YLMETHYL ESTER
  • 9-Fluoroe
  • Fmoc chloride,9-Fluorenylmethoxycarbonyl chloride, 9-Fluorenylmethyl chloroformate, Fmoc-Cl
  • Chloroformic acid 9-
  • (9H-Fluoren-9-yl)methyl carbonochloridoate
  • 9-FluorenylMethyl chloroforMate, 98% 1GR