9-Fluorenylmethyl chloroformate
- Product Name
- 9-Fluorenylmethyl chloroformate
- CAS No.
- 28920-43-6
- Chemical Name
- 9-Fluorenylmethyl chloroformate
- Synonyms
- FMOC-CL;FoMc-Cl;(9H-fluoren-9-yl)Methyl carbonochloridate;fmoc-ci;9-Fluorenylmethyl;FMOC-C;FMOC-CHLORIDE;1-(9-fluorenyl)methylchloroformate;9-FLUORENYLMETHOXYCARBONYL CHLORIDE;Fluorenylmethyloxycarbonyl chloride
- CBNumber
- CB7234569
- Molecular Formula
- C15H11ClO2
- Formula Weight
- 258.7
- MOL File
- 28920-43-6.mol
9-Fluorenylmethyl chloroformate Property
- Melting point:
- 62-64 °C(lit.)
- Boiling point:
- 365.79°C (rough estimate)
- Density
- 1.1780 (rough estimate)
- refractive index
- 1.5330 (estimate)
- storage temp.
- 2-8°C
- solubility
- dioxane: 0.1 g/mL, clear, colorless
- form
- Crystalline Powder
- color
- White to very pale yellow
- Sensitive
- Moisture Sensitive
- BRN
- 2279177
- Stability:
- Hygroscopic, Moisture Sensitive
- InChI
- InChI=1S/C15H11ClO2/c16-15(17)18-9-14-12-7-3-1-5-10(12)11-6-2-4-8-13(11)14/h1-8,14H,9H2
- InChIKey
- IRXSLJNXXZKURP-UHFFFAOYSA-N
- SMILES
- C(Cl)(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O
- LogP
- 3.45
- CAS DataBase Reference
- 28920-43-6(CAS DataBase Reference)
Safety
- Hazard Codes
- C,T
- Risk Statements
- 34-20/21/22
- Safety Statements
- 26-36/37/39-45-27
- RIDADR
- UN 3261 8/PG 2
- WGK Germany
- 3
- RTECS
- LQ6250000
- F
- 10-21
- TSCA
- No
- HazardClass
- 6.1
- PackingGroup
- II
- HS Code
- 29159020
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 8.52259
- Product name
- (9-Fluorenylmethyl) chloroformate
- Purity
- Novabiochem?
- Packaging
- 25g
- Price
- $54.5
- Updated
- 2024/03/01
- Product number
- 8.18203
- Product name
- (9-Fluorenylmethyl) chloroformate
- Purity
- for synthesis
- Packaging
- 500mg
- Price
- $34.2
- Updated
- 2024/03/01
- Product number
- 8.52259
- Product name
- (9-Fluorenylmethyl) chloroformate
- Purity
- Novabiochem?
- Packaging
- 100g
- Price
- $154
- Updated
- 2024/03/01
- Product number
- 8.18203
- Product name
- (9-Fluorenylmethyl) chloroformate
- Purity
- for synthesis
- Packaging
- 5G
- Price
- $116
- Updated
- 2024/03/01
- Product number
- 8.18203
- Product name
- (9-Fluorenylmethyl) chloroformate
- Purity
- for synthesis
- Packaging
- 25g
- Price
- $299
- Updated
- 2024/03/01
9-Fluorenylmethyl chloroformate Chemical Properties,Usage,Production
Chemical Properties
White to off white crystalline powder
Uses
9-Fluorenylmethyl chloroformate is an N-Protecting agent for peptides research and was used for the pre-column derivatization of the biogenic amines (BAs) cadaverine (Cad), histamine (Him), octopami ne (Ocp), phenylethylamine (Pea), putrescine (Put), spermidine (Spd), spermine (Spm), tyramine (Tym).
Uses
9-Fluorenylmethyl chloroformate can act as reagent for the introduction of Fmoc-amino-protecting group, which is stable towards acids but is readily cleaved under mildly basic non-hydrolytic conditions.
Uses
9-Fluorenylmethyl chloroformate can be used as N-protecting reagent for oligonucleotide and peptide syntheses.
General Description
Fmoc chloride is a derivatizing agent.
Flammability and Explosibility
Not classified
Safety Profile
A poison. Mutation data reported. A corrosive. When heated to decomposition it emits toxic vapors of Cl-.
Purification Methods
If the IR contains no OH bands (at ~3000 cm-1) due to the hydrolysis product 9-fluorenylmethanol, then purify it by recrystallisation from dry Et2O. IR (CHCl3) has a band at 1770 cm-1 (C=O), and the NMR (CDCl3) has at 4-4.6 (m 2H, CHCH2) and 7.1-7.8 (m, 8 aromatic H) ppm. The azide (FMOC-N3) has m 89-90o (from -1hexane) and IR (CHCl3) at 2135 (N3) and 1730 (C=O) cm , and the carbazate (FMOC-NHNH2) has m 171o(dec) (from nitromethane), IR (KBr) 3310, 3202 (NH) and 1686 (CONH) cm-1. [Caprino & Han J Org Chem 37, 3404 1972 , J Am Chem Soc 92 5748 1970, Koole et al. J Org Chem 59 1657 1989, Fürst et al. J Chromatogr 499 537 1990.]
9-Fluorenylmethyl chloroformate Preparation Products And Raw materials
Raw materials
Preparation Products
9-Fluorenylmethyl chloroformate Suppliers
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View Lastest Price from 9-Fluorenylmethyl chloroformate manufacturers
- Product
- 9-Fluorenylmethyl chloroformate 28920-43-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 50000kg
- Release date
- 2023-11-14
- Product
- 9-Fluorenylmethyl chloroformate 28920-43-6
- Price
- US $8.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-03-29
- Product
- 9-Fluorenylmethyl chloroformate 28920-43-6
- Price
- US $0.00/kg
- Min. Order
- 25kg
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2022-11-09