Fmoc-8-amino-3,6-dioxaoctanoic acid

Product Name: Fmoc-8-amino-3,6-dioxaoctanoic acid
CAS No.: 166108-71-0
Chemical Name: Fmoc-8-amino-3,6-dioxaoctanoic acid
Synonyms: FMOC-AEEA-OH;FMOC-AEEA;FMOC-AEEAC-OH;1-(9H-Fluoren-9-yl)-3-oxo-2,7,10-trioxa-4-azadodecan-12-oic acid;FMoc-NH-PEG2-CH2COOH;FMOC-AEEAC;FMOC-8-AMINO-3,6-DIOXAOCTANOIC ACID;Fmoc-Ado-OH;N-formylglycine t-butylester;9-FLUORENYLMETHOXYCARBONYL-8-AMINO-3,6-DIOXAOCTANOIC ACID
CBNumber: CB2169923
Molecular Formula: C21H23NO6
Formula Weight: 385.41
MOL File: 166108-71-0.mol

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Fmoc-8-amino-3,6-dioxaoctanoic acid Property

Melting point:: 90-92℃
Boiling point:: 631.4±45.0 °C(Predicted)
Density: 1.265±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,2-8°C
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka: 3.40±0.10(Predicted)
form: Crystalline Powder
color: White
InChI: InChI=1S/C21H23NO6/c23-20(24)14-27-12-11-26-10-9-22-21(25)28-13-19-17-7-3-1-5-15(17)16-6-2-4-8-18(16)19/h1-8,19H,9-14H2,(H,22,25)(H,23,24)
InChIKey: XQPYRJIMPDBGRW-UHFFFAOYSA-N
SMILES: C(O)(=O)COCCOCCNC(=O)OCC1C2=C(C=CC=C2)C2=C1C=CC=C2
CAS DataBase Reference: 166108-71-0(CAS DataBase Reference)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
HS Code: 29189900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 95003
Product name: {2-[2-(Fmoc-amino)ethoxy]ethoxy}acetic acid
Purity: ≥95.0% (HPLC)
Packaging: 500mg
Price: $243
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.51037
Product name: Fmoc-NH-(PEG)-COOH (9 atoms)
Purity: Novabiochem?
Packaging: 1g
Price: $465
Updated: 2025/07/31

TCI Chemical

Product number: F0719
Product name: 8-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3,6-dioxa-n-octanoic Acid
Purity: >97.0%(HPLC)
Packaging: 1g
Price: $265
Updated: 2025/07/31

TCI Chemical

Product number: F0719
Product name: 8-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3,6-dioxa-n-octanoic Acid
Purity: >97.0%(HPLC)
Packaging: 200mg
Price: $89
Updated: 2025/07/31

TRC

Product number: F603515
Product name: 8-(Fmoc-amino)-3,6-dioxaoctanoicAcid
Packaging: 5g
Price: $820
Updated: 2021/12/16

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Fmoc-8-amino-3,6-dioxaoctanoic acid Chemical Properties,Usage,Production

Description

Fmoc-NH-PEG2-CH2COOH is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Chemical Properties

White solid

Uses

Hydrophillic spacer group.

Uses

8-(Fmoc-amino)-3,6-dioxaoctanoic Acid is a hydrophilic, heterobifunctional spacer.

Application

Fmoc-8-amino-3,6-dioxaoctanoic acid is a cleavable ADC linker for the synthesis of antibody-drug couplings (ADCs). It is also a PEG linker for the synthesis of PROTAC. It is widely used in drug delivery systems as it is mainly used to enhance the solubility or targeting of drugs and improve their bioavailability.

reaction suitability

reagent type: cross-linking reagent

Fmoc-8-amino-3,6-dioxaoctanoic acid Preparation Products And Raw materials

Raw materials

Phthalimide Triethylene glycol Hydrazinium hydroxide solution N,N-Dimethylformamide Potassium carbonate Chromium(VI) oxide Triethylamine Tosyl chloride DBU 9-Fluorenylmethyl chloroformate Ethyl acetate Hydrochloric acid Dichloromethane Sodium hydroxide Fmoc-OSu Sulfuric acid

Preparation Products

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Fmoc-8-amino-3,6-dioxaoctanoic acid Suppliers

Americas 1 Canada 1 China 408 Europe 1 France 3 Germany 6 India 9 Japan 4 Switzerland 4 The Netherlands 1 United Kingdom 5 United States 52 Global 495

TCI AMERICA

Tel: 800-4238616
Fax: +1-888-520-1075 / +1-503-283-1987
Email: sales@tciamerica.com
Country: Americas
ProdList: 23653
Advantage: 75

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View Lastest Price from Fmoc-8-amino-3,6-dioxaoctanoic acid manufacturers

LAURENT

Product: Fmoc-NH-PEG2-CH2COOH 166108-71-0
Price: US $7560.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 300kg
Release date: 2025-11-17

XIAMEN SINOPEG BIOTECH CO., LTD.

Product: 8-(9-Fluorenylmethyloxycarbonyl-amino)-3,6-dioxaoctanoic acid 166108-71-0
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 1g/bottle, 10g/bottle, 100g/bottle
Release date: 2025-09-12

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Fmoc-AEEA-OH 166108-71-0
Price: US $0.00-0.00/kg
Min. Order: 0.10000000149011612kg
Purity: 98%;99%
Supply Ability: 1T+
Release date: 2024-03-06

166108-71-0, Fmoc-8-amino-3,6-dioxaoctanoic acidRelated Search:

6-Aminocaproic acid 2-Aminothiazole-4-acetic acid 4-Aminophenylacetic acid Nitrilotriacetic acid DIETHOXYMETHANE Ethoxyethyne Glycine Ethoxyquin Fmoc-Phe-OH Fmoc-Lys(Boc)-OH Ethyl 2-(Chlorosulfonyl)acetate 9-Fluorenylmethyl chloroformate Iminodiacetic acid METHOXYCARBONYLSULFENYL CHLORIDE Ethoxyamine hydrochloride Fmoc-OSu FMOC-THR(TBU)-OL 17-Amino-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanoic Acid

Fmoc-8-amino-3,6-dioxaoctanoic acid, Fmoc-AEEA

Fmoc-PEG2-acetic acid

{2-[2-(Fmoc-amino)ethoxy]ethoxy}acetic acid≥ 99% (HPLC)

Fmoc-NH-(PEG)-COOH (9 atoms) Novabiochem

1-(9H-Fluoren-9-yl)-3-oxo-2,7,1-trioxa-4-azadodecan-12-oic acid

9-FLUORENYLMETHOXYCARBONYL-8-AMINO-3,6-DIOXAOCTANOIC ACID

8-(FMOC-AMINO)-3,6-DIOXA-OCTANOIC ACID

8-FLUORENYLMETHOXYCARBONYLAMINO-3,6-DIOXAOCTANOIC ACID

8-(9-FLUORENYLMETHOXYCARBONYL-AMINO)-3,6-DIOXA-OCTANOIC ACID

8-(9-FLUORENYLMETHYLOXYCARBONYL-AMINO)-3,6-DIOXAOCTANOIC ACID

FMOC-O2OC-OH

FMOC-MINI-PEG(TM)

FMOC-[2-(2-AMINO-ETHOXY)-ETHOXY]-ACETIC ACID

FMOC-AEEA

FMOC-AEEAC-OH

FMOC-8-AMINO-3,6-DIOXAOCTANOIC ACID

8-(9-Fluorenylmethyloxycarbonyl-amino)-3,6-dioxaoctanoicacid,{2-[2-(Fmoc-amino)ethoxy]ethoxy}aceticacid,1-(9H-Fuoren

8-(9-FLUOROENYLMETHYLOXYCARBONYL-AMINO)-3,6-DIOXAOCTANOIC ACID

1-(9H-Fluoren-9-yl)-3-oxo-2,7,10-trioxa-4-azadodecan-12-oic acid

Fmoc-PEG2- CH2COOH (Fmoc-AEEA)

6-dioxaoctanoic acid

Fmoc-8-amino-3

Fmoc-NH-(PEG)-COOH (9 atoms)

MOC-AEEAC-OH

[2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid, 97.0%

2-{2-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)ethoxy]ethoxy}acetic acid

8-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3,6-dioxa-n-octanoic Acid

8-(9-Fluorenylmethyloxycarbonyl-amino)-3,6-dioxaoctanoic acid, {2-[2-(Fmoc-amino)ethoxy]ethoxy}acetic acid, 1-(9H-Fuoren-9-yl)-3-oxo-2,7,10-trioxa-4-azadodecan-12-oic acid, Fmoc-Ado, Fmoc-AEEA

2-(2-(2-(((9H-fluoren-9-yl)Methoxy)carbonyl)ethoxy)ethoxy)acetic acid

8-(Fmoc-amino)-3,6-dioxa-n-octanoic Acid [2-[2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]ethoxy]ethoxy]acetic Acid [2-[2-[(Fmoc-amino)ethoxy]ethoxy]acetic Acid

{2-[2-(FMoc-aMino)-ethoxy]-ethoxy}-acetic acid, 8-(FMoc-aMino)-3,6-dioxa-octanoic acid, FMoc-Adoa-OH

FMOC-AEEA-OH

[2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid ,98.5%

{2-[2-(Fmoc-amino)ethoxy]ethoxy}acetic acid,8-(Fmoc-amino)-3,6-dioxaoctanoic acid

FMoc-NH-PEG2-CH2COOH

FMoc-2-(2- (2-aMinoethoxy)ethoxy) acetic acid

FMOC-AEEAC

RARECHEM EM WB 0032

Fmoc-NH-PEG2-CH2COOH,Fmoc-AEEA

1-(9H-FUOREN-9-YL)-3-OXO-2,7,10-TRIOXA-4-AZADODECAN-12-OIC ACID

Fmoc-AEEA 1-(9H-Fluoren-9-yl)-3-oxo-2,7,10-trioxa-4-azadodecan-12-oic acid

(2-[2-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-ETHOXY]-ETHOXY)-ACETIC ACID

(2-[2-(FMOC-AMINO)-ETHOXY]-ETHOXY)-ACETIC ACID

8-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3,6-dioxa-n-octanoicAcid&gt

3,6,11-Trioxa-9-azadodecanoic acid, 12-(9H-fluoren-9-yl)-10-oxo-

Fmoc-AEEA/Fmoc-Mini-PEG

N-formylglycine t-butylester

Fmoc-Ado-OH

2-[2-(Fmoc-amino)ethoxy]ethoxy]aceticaci

8-(Fmoc-amino)-3,6-dioxa-n-octanoic Acid

[2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid USP/EP/BP

Fmoc-N-Amido-PEG2-CH2COOH

Fmoc-N-amido-PEG2-acetic acid

Fluorene methoxycarbonyl dipolyethylene glycol acetic acid

Fmoc-8-amino-3,6-dioxaoctanoic acid (Fmoc-NH-PEG2-CH2COOH)

Fmoc-N-Me-Val/D-Val

Fmoc-mini-PEG? Fmoc-8-Amino-3,6-Dioxaoctanoic Acid

8-(Fmoc-amino)-3,6-dioxaoctanoic acid 98%