ChemicalBook > CAS DataBase List > Fmoc-8-amino-3,6-dioxaoctanoic acid

Fmoc-8-amino-3,6-dioxaoctanoic acid

Product Name
Fmoc-8-amino-3,6-dioxaoctanoic acid
CAS No.
166108-71-0
Chemical Name
Fmoc-8-amino-3,6-dioxaoctanoic acid
Synonyms
FMOC-AEEA-OH;FMOC-AEEA;FMOC-AEEAC-OH;1-(9H-Fluoren-9-yl)-3-oxo-2,7,10-trioxa-4-azadodecan-12-oic acid;FMoc-NH-PEG2-CH2COOH;FMOC-AEEAC;FMOC-8-AMINO-3,6-DIOXAOCTANOIC ACID;Fmoc-Ado-OH;N-formylglycine t-butylester;9-FLUORENYLMETHOXYCARBONYL-8-AMINO-3,6-DIOXAOCTANOIC ACID
CBNumber
CB2169923
Molecular Formula
C21H23NO6
Formula Weight
385.41
MOL File
166108-71-0.mol
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Fmoc-8-amino-3,6-dioxaoctanoic acid Property

Melting point:
90-92℃
Boiling point:
631.4±45.0 °C(Predicted)
Density 
1.265±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,2-8°C
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka
3.40±0.10(Predicted)
form 
Crystalline Powder
color 
White
InChI
InChI=1S/C21H23NO6/c23-20(24)14-27-12-11-26-10-9-22-21(25)28-13-19-17-7-3-1-5-15(17)16-6-2-4-8-18(16)19/h1-8,19H,9-14H2,(H,22,25)(H,23,24)
InChIKey
XQPYRJIMPDBGRW-UHFFFAOYSA-N
SMILES
C(O)(=O)COCCOCCNC(=O)OCC1C2=C(C=CC=C2)C2=C1C=CC=C2
CAS DataBase Reference
166108-71-0(CAS DataBase Reference)
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
HS Code 
29189900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
95003
Product name
{2-[2-(Fmoc-amino)ethoxy]ethoxy}acetic acid
Purity
≥95.0% (HPLC)
Packaging
500mg
Price
$243
Updated
2025/07/31
Sigma-Aldrich
Product number
8.51037
Product name
Fmoc-NH-(PEG)-COOH (9 atoms)
Purity
Novabiochem?
Packaging
1g
Price
$465
Updated
2025/07/31
TCI Chemical
Product number
F0719
Product name
8-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3,6-dioxa-n-octanoic Acid
Purity
>97.0%(HPLC)
Packaging
1g
Price
$265
Updated
2025/07/31
TCI Chemical
Product number
F0719
Product name
8-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3,6-dioxa-n-octanoic Acid
Purity
>97.0%(HPLC)
Packaging
200mg
Price
$89
Updated
2025/07/31
TRC
Product number
F603515
Product name
8-(Fmoc-amino)-3,6-dioxaoctanoicAcid
Packaging
5g
Price
$820
Updated
2021/12/16
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Fmoc-8-amino-3,6-dioxaoctanoic acid Chemical Properties,Usage,Production

Description

Fmoc-NH-PEG2-CH2COOH is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Chemical Properties

White solid

Uses

Hydrophillic spacer group.

Uses

8-(Fmoc-amino)-3,6-dioxaoctanoic Acid is a hydrophilic, heterobifunctional spacer.

Application

Fmoc-8-amino-3,6-dioxaoctanoic acid is a cleavable ADC linker for the synthesis of antibody-drug couplings (ADCs). It is also a PEG linker for the synthesis of PROTAC. It is widely used in drug delivery systems as it is mainly used to enhance the solubility or targeting of drugs and improve their bioavailability.

reaction suitability

reagent type: cross-linking reagent

Fmoc-8-amino-3,6-dioxaoctanoic acid Preparation Products And Raw materials

Raw materials

Phthalimide Triethylene glycol Hydrazinium hydroxide solution N,N-Dimethylformamide Potassium carbonate Chromium(VI) oxide Triethylamine Tosyl chloride DBU 9-Fluorenylmethyl chloroformate Ethyl acetate Hydrochloric acid Dichloromethane Sodium hydroxide Fmoc-OSu Sulfuric acid

Preparation Products

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View Lastest Price from Fmoc-8-amino-3,6-dioxaoctanoic acid manufacturers

LAURENT
Product
Fmoc-NH-PEG2-CH2COOH 166108-71-0
Price
US $7560.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
300kg
Release date
2025-11-17
XIAMEN SINOPEG BIOTECH CO., LTD.
Product
8-(9-Fluorenylmethyloxycarbonyl-amino)-3,6-dioxaoctanoic acid 166108-71-0
Price
US $0.00-0.00/g
Min. Order
1g
Purity
98%
Supply Ability
1g/bottle, 10g/bottle, 100g/bottle
Release date
2025-09-12
Sichuan HongRi Pharma-Tech Co.,Ltd
Product
Fmoc-AEEA-OH 166108-71-0
Price
US $0.00-0.00/kg
Min. Order
0.10000000149011612kg
Purity
98%;99%
Supply Ability
1T+
Release date
2024-03-06

166108-71-0, Fmoc-8-amino-3,6-dioxaoctanoic acidRelated Search:

6-Aminocaproic acid 2-Aminothiazole-4-acetic acid 4-Aminophenylacetic acid Nitrilotriacetic acid DIETHOXYMETHANE Ethoxyethyne Glycine Ethoxyquin Fmoc-Phe-OH Fmoc-Lys(Boc)-OH Ethyl 2-(Chlorosulfonyl)acetate 9-Fluorenylmethyl chloroformate Iminodiacetic acid METHOXYCARBONYLSULFENYL CHLORIDE Ethoxyamine hydrochloride Fmoc-OSu FMOC-THR(TBU)-OL 17-Amino-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanoic Acid

  • Fmoc-8-amino-3,6-dioxaoctanoic acid, Fmoc-AEEA
  • Fmoc-PEG2-acetic acid
  • {2-[2-(Fmoc-amino)ethoxy]ethoxy}acetic acid≥ 99% (HPLC)
  • Fmoc-NH-(PEG)-COOH (9 atoms) Novabiochem
  • 1-(9H-Fluoren-9-yl)-3-oxo-2,7,1-trioxa-4-azadodecan-12-oic acid
  • 9-FLUORENYLMETHOXYCARBONYL-8-AMINO-3,6-DIOXAOCTANOIC ACID
  • 8-(FMOC-AMINO)-3,6-DIOXA-OCTANOIC ACID
  • 8-FLUORENYLMETHOXYCARBONYLAMINO-3,6-DIOXAOCTANOIC ACID
  • 8-(9-FLUORENYLMETHOXYCARBONYL-AMINO)-3,6-DIOXA-OCTANOIC ACID
  • 8-(9-FLUORENYLMETHYLOXYCARBONYL-AMINO)-3,6-DIOXAOCTANOIC ACID
  • FMOC-O2OC-OH
  • FMOC-MINI-PEG(TM)
  • FMOC-[2-(2-AMINO-ETHOXY)-ETHOXY]-ACETIC ACID
  • FMOC-AEEA
  • FMOC-AEEAC-OH
  • FMOC-8-AMINO-3,6-DIOXAOCTANOIC ACID
  • 8-(9-Fluorenylmethyloxycarbonyl-amino)-3,6-dioxaoctanoicacid,{2-[2-(Fmoc-amino)ethoxy]ethoxy}aceticacid,1-(9H-Fuoren
  • 8-(9-FLUOROENYLMETHYLOXYCARBONYL-AMINO)-3,6-DIOXAOCTANOIC ACID
  • 1-(9H-Fluoren-9-yl)-3-oxo-2,7,10-trioxa-4-azadodecan-12-oic acid
  • Fmoc-PEG2- CH2COOH (Fmoc-AEEA)
  • 6-dioxaoctanoic acid
  • Fmoc-8-amino-3
  • Fmoc-NH-(PEG)-COOH (9 atoms)
  • MOC-AEEAC-OH
  • [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid, 97.0%
  • 2-{2-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)ethoxy]ethoxy}acetic acid
  • 8-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3,6-dioxa-n-octanoic Acid
  • 8-(9-Fluorenylmethyloxycarbonyl-amino)-3,6-dioxaoctanoic acid, {2-[2-(Fmoc-amino)ethoxy]ethoxy}acetic acid, 1-(9H-Fuoren-9-yl)-3-oxo-2,7,10-trioxa-4-azadodecan-12-oic acid, Fmoc-Ado, Fmoc-AEEA
  • 2-(2-(2-(((9H-fluoren-9-yl)Methoxy)carbonyl)ethoxy)ethoxy)acetic acid
  • 8-(Fmoc-amino)-3,6-dioxa-n-octanoic Acid [2-[2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]ethoxy]ethoxy]acetic Acid [2-[2-[(Fmoc-amino)ethoxy]ethoxy]acetic Acid
  • {2-[2-(FMoc-aMino)-ethoxy]-ethoxy}-acetic acid, 8-(FMoc-aMino)-3,6-dioxa-octanoic acid, FMoc-Adoa-OH
  • FMOC-AEEA-OH
  • [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid ,98.5%
  • {2-[2-(Fmoc-amino)ethoxy]ethoxy}acetic acid,8-(Fmoc-amino)-3,6-dioxaoctanoic acid
  • FMoc-NH-PEG2-CH2COOH
  • FMoc-2-(2- (2-aMinoethoxy)ethoxy) acetic acid
  • FMOC-AEEAC
  • RARECHEM EM WB 0032
  • Fmoc-NH-PEG2-CH2COOH,Fmoc-AEEA
  • 1-(9H-FUOREN-9-YL)-3-OXO-2,7,10-TRIOXA-4-AZADODECAN-12-OIC ACID
  • Fmoc-AEEA 1-(9H-Fluoren-9-yl)-3-oxo-2,7,10-trioxa-4-azadodecan-12-oic acid
  • (2-[2-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-ETHOXY]-ETHOXY)-ACETIC ACID
  • (2-[2-(FMOC-AMINO)-ETHOXY]-ETHOXY)-ACETIC ACID
  • 8-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3,6-dioxa-n-octanoicAcid&gt
  • 3,6,11-Trioxa-9-azadodecanoic acid, 12-(9H-fluoren-9-yl)-10-oxo-
  • Fmoc-AEEA/Fmoc-Mini-PEG
  • N-formylglycine t-butylester
  • Fmoc-Ado-OH
  • 2-[2-(Fmoc-amino)ethoxy]ethoxy]aceticaci
  • 8-(Fmoc-amino)-3,6-dioxa-n-octanoic Acid
  • [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid USP/EP/BP
  • Fmoc-N-Amido-PEG2-CH2COOH
  • Fmoc-N-amido-PEG2-acetic acid
  • Fluorene methoxycarbonyl dipolyethylene glycol acetic acid
  • Fmoc-8-amino-3,6-dioxaoctanoic acid (Fmoc-NH-PEG2-CH2COOH)
  • Fmoc-N-Me-Val/D-Val
  • Fmoc-mini-PEG? Fmoc-8-Amino-3,6-Dioxaoctanoic Acid
  • 8-(Fmoc-amino)-3,6-dioxaoctanoic acid 98%