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Nitrilotriacetic acid

Product Name
Nitrilotriacetic acid
CAS No.
139-13-9
Chemical Name
Nitrilotriacetic acid
Synonyms
NTA;TRIGLYCINE;NITRILOTRIACETATE;NTA acid;TRILON A;Nitrilotriacetic;NITRILOACETIC ACID;2,2',2''-Nitrilotriacetic acid;nci-c02766;NITRILOACETATE
CBNumber
CB9241989
Molecular Formula
C6H9NO6
Formula Weight
191.14
MOL File
139-13-9.mol
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Nitrilotriacetic acid Property

Melting point:
245 °C (dec.)(lit.)
Boiling point:
326.86°C (rough estimate)
Density 
1.5784 (rough estimate)
vapor pressure 
0-0Pa at 20-25℃
refractive index 
1.4860 (estimate)
Flash point:
100 °C
storage temp. 
2-8°C
solubility 
0.1 M NaOH: 0.1 M at 20 °C, clear, colorless
form 
Powder
pka
3.03, 3.07, 10.70(at 20℃)
color 
White
Water Solubility 
Insoluble. <0.01 g/100 mL at 23 ºC
λmax
λ: 260 nm Amax: 1.5
λ: 280 nm Amax: 0.05
Merck 
14,6579
BRN 
1710776
LogP
-3.81 at 25℃
CAS DataBase Reference
139-13-9(CAS DataBase Reference)
NIST Chemistry Reference
Nitrilotriacetic acid(139-13-9)
IARC
2B (Vol. 48, 73) 1999
EPA Substance Registry System
Nitrilotriacetic acid (139-13-9)
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Safety

Hazard Codes 
Xn,T
Risk Statements 
22-36-40-36/37/38-45-20/21/22
Safety Statements 
26-36/37-45-36/37/39-53
RIDADR 
2811
WGK Germany 
2
RTECS 
AJ0175000
21
TSCA 
Yes
HazardClass 
8
PackingGroup 
II
HS Code 
29224995
Hazardous Substances Data
139-13-9(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: 1100 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

H351Suspected of causing cancer

Precautionary statements

P201Obtain special instructions before use.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
72559
Product name
Nitrilotriacetic acid
Purity
BioUltra, ≥99.0% (T)
Packaging
100g
Price
$85.4
Updated
2024/03/01
Sigma-Aldrich
Product number
1463950
Product name
Nitrilotriacetic acid
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
50mg
Price
$420
Updated
2024/03/01
TCI Chemical
Product number
N0098
Product name
Nitrilotriacetic Acid
Purity
>98.0%(T)
Packaging
25g
Price
$22
Updated
2024/03/01
TCI Chemical
Product number
N0098
Product name
Nitrilotriacetic Acid
Purity
>98.0%(T)
Packaging
500g
Price
$65
Updated
2024/03/01
Alfa Aesar
Product number
A11936
Product name
Nitrilotriacetic acid, 99%
Packaging
100g
Price
$30.8
Updated
2024/03/01
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Nitrilotriacetic acid Chemical Properties,Usage,Production

Chemical Properties

Nitrilotriacetic acid, also known as NTA, is a white crystalline powder. It can dissolve in ammonia and alkali solutions while being slightly soluble in hot water. However, it is insoluble in water and most organic solvents. NTA can form mono-, di-, and tribasic salts, all of which are soluble in water. Combustible. 70% biodegradable.

Uses

Nitrilotriacetic acid is a chelating agent which forms coordination compounds with metal ions. Nitrilotriacetic acid is used in complexometric titrations and as well as for protein isolation and purification in the His-tag method. This compound is a contaminant of emerging concern (CECs).

Uses

Used in sequestration of metals; chelometric analysis.

Definition

ChEBI: Nitrilotriacetic acid is a tricarboxylic acid and a NTA. It has a role as a nephrotoxic agent and a carcinogenic agent. It is a conjugate acid of a nitrilotriacetate(1-).

Preparation

The synthesis of nitrilotriacetic acid involves the following steps:
Chloroacetic acid is reacted with sodium hydroxide to produce sodium chloroacetate.
Sodium chloroacetate then reacts with ammonium chloride to form sodium aminotriacetate.
The resulting sodium aminotriacetate is acidified to obtain nitrilotriacetic acid.

Synthesis Reference(s)

The Journal of Organic Chemistry, 15, p. 46, 1950 DOI: 10.1021/jo01147a008

Air & Water Reactions

Water Insoluble.

Reactivity Profile

Nitrilotriacetic acid is incompatible with strong oxidizers, aluminum, copper, copper alloy and nickel. Nitrilotriacetic acid is also incompatible with strong bases.

Hazard

Possible carcinogen.

Health Hazard

Toxicity and health hazard of Nitrilotriacetic acid is low. Contact with eyes causes irritation.

Fire Hazard

Flash point data for Nitrilotriacetic acid are not available; however, Nitrilotriacetic acid is probably combustible.

Flammability and Explosibility

Non flammable

Safety Profile

Confirmed carcinogen with experimental carcinogenic and neoplastigenic data. Poison by intraperitoneal route. Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of NOx,.

Potential Exposure

Nitrilotriacetic acid (NTA) was used as a phosphate replacement in laundry detergents in the late 1960s. In 1971, the use of NTA was discontinued. The possibility of resumed use arose in 1980. NTA is now used in laundry detergents in states where phosphates are banned. NTA is also used as a boiler feed-water additive at a maximum use level of 5 ppm of trisodium salt. Currently, the remaining nondetergent uses of NTA are for water treatment, textile treatment; metal plating and cleaning; and pulp and paper processing.

Carcinogenicity

Nitrilotriacetic acid is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

Shipping

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

Waste Disposal

Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.

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Nitrilotriacetic acid Suppliers

shandongxinhenghuagongyouxiangongsi
Tel
1526-9160602 15269160602
Email
15269160602@163.com
Country
China
ProdList
406
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NANJING YIHUA BIOTECHNOLOGY Co., Ltd
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15171470753
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3105244229@qq.com
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China
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58
Zhuhai Anzhe Biotechnology Co,Ltd.
Tel
13169972583
Email
513211116@qq.com
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China
ProdList
3006
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58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
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China
ProdList
96815
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Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
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Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
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84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
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Energy Chemical
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021-021-58432009 400-005-6266
Fax
021-58436166
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sales8178@energy-chemical.com
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China
ProdList
44689
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Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
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sales@capotchem.com
Country
China
ProdList
18207
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shanghai science Bio-Pharmceutical.co,ltd.
Tel
021-021-57872719 13761402923
Fax
02157872719
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245662540@qq.com
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China
ProdList
309
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View Lastest Price from Nitrilotriacetic acid manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Nitrilotriacetic acid 139-13-9
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-15
Hebei Weibang Biotechnology Co., Ltd
Product
Nitrilotriacetic acid 139-13-9
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10 mt
Release date
2024-11-14
Hebei Weibang Biotechnology Co., Ltd
Product
Nitrilotriacetic acid 139-13-9
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-31

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