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Fmoc-8-amino-3,6-dioxaoctanoic acid

Product Name
Fmoc-8-amino-3,6-dioxaoctanoic acid
CAS No.
166108-71-0
Chemical Name
Fmoc-8-amino-3,6-dioxaoctanoic acid
Synonyms
FMOC-AEEA-OH;FMOC-AEEA;FMOC-AEEAC-OH;1-(9H-Fluoren-9-yl)-3-oxo-2,7,10-trioxa-4-azadodecan-12-oic acid;FMoc-NH-PEG2-CH2COOH;FMOC-AEEAC;FMOC-8-AMINO-3,6-DIOXAOCTANOIC ACID;Fmoc-Ado-OH;N-formylglycine t-butylester;9-FLUORENYLMETHOXYCARBONYL-8-AMINO-3,6-DIOXAOCTANOIC ACID
CBNumber
CB2169923
Molecular Formula
C21H23NO6
Formula Weight
385.41
MOL File
166108-71-0.mol
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Fmoc-8-amino-3,6-dioxaoctanoic acid Property

Melting point:
90-92℃
Boiling point:
631.4±45.0 °C(Predicted)
Density 
1.265±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,2-8°C
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka
3.40±0.10(Predicted)
form 
Crystalline Powder
color 
White
InChI
InChI=1S/C21H23NO6/c23-20(24)14-27-12-11-26-10-9-22-21(25)28-13-19-17-7-3-1-5-15(17)16-6-2-4-8-18(16)19/h1-8,19H,9-14H2,(H,22,25)(H,23,24)
InChIKey
XQPYRJIMPDBGRW-UHFFFAOYSA-N
SMILES
C(O)(=O)COCCOCCNC(=O)OCC1C2=C(C=CC=C2)C2=C1C=CC=C2
CAS DataBase Reference
166108-71-0(CAS DataBase Reference)
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
HS Code 
29189900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
95003
Product name
{2-[2-(Fmoc-amino)ethoxy]ethoxy}acetic acid
Purity
≥95.0% (HPLC)
Packaging
500mg
Price
$234
Updated
2024/03/01
Sigma-Aldrich
Product number
8.51037
Product name
Fmoc-NH-(PEG)-COOH (9 atoms)
Purity
Novabiochem?
Packaging
1g
Price
$453
Updated
2024/03/01
TCI Chemical
Product number
F0719
Product name
8-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3,6-dioxa-n-octanoic Acid
Purity
>97.0%(HPLC)
Packaging
1g
Price
$265
Updated
2024/03/01
TCI Chemical
Product number
F0719
Product name
8-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3,6-dioxa-n-octanoic Acid
Purity
>97.0%(HPLC)
Packaging
200mg
Price
$89
Updated
2024/03/01
Alfa Aesar
Product number
H63641
Product name
(2-[2-(Fmoc-amino)ethoxy]ethoxy)acetic acid, 95%
Packaging
250mg
Price
$114
Updated
2024/03/01
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Fmoc-8-amino-3,6-dioxaoctanoic acid Chemical Properties,Usage,Production

Description

Fmoc-NH-PEG2-CH2COOH is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Chemical Properties

White solid

Uses

Hydrophillic spacer group.

Uses

8-(Fmoc-amino)-3,6-dioxaoctanoic Acid is a hydrophilic, heterobifunctional spacer.

Application

Fmoc-8-amino-3,6-dioxaoctanoic acid is a cleavable ADC linker for the synthesis of antibody-drug couplings (ADCs). It is also a PEG linker for the synthesis of PROTAC. It is widely used in drug delivery systems as it is mainly used to enhance the solubility or targeting of drugs and improve their bioavailability.

Fmoc-8-amino-3,6-dioxaoctanoic acid Preparation Products And Raw materials

Raw materials

Phthalimide Triethylene glycol Hydrazinium hydroxide solution N,N-Dimethylformamide Potassium carbonate Chromium(VI) oxide Triethylamine Tosyl chloride DBU 9-Fluorenylmethyl chloroformate Ethyl acetate Hydrochloric acid Dichloromethane Sodium hydroxide N-(9-Fluorenylmethoxycarbonyloxy)succinimide Sulfuric acid

Preparation Products

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Fmoc-8-amino-3,6-dioxaoctanoic acid Suppliers

Americas 1 Canada 1 China 366 Europe 1 France 3 Germany 6 India 8 Japan 4 Switzerland 4 The Netherlands 1 United Kingdom 5 United States 52 Global 452
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28387
Advantage
80
Watanabe Chemical Industries, Ltd.
Tel
--
Fax
--
Email
inquiry@watanabechem.co.jp
Country
Japan
ProdList
1918
Advantage
50
Peptide Institute, Inc.
Tel
--
Fax
--
Email
info@peptide.co.jp
Country
Japan
ProdList
992
Advantage
70
Watanabe Chemical Industries, Ltd.
Tel
--
Fax
--
Country
Japan
ProdList
4811
Advantage
42
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View Lastest Price from Fmoc-8-amino-3,6-dioxaoctanoic acid manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
Fmoc-AEEA-OH 166108-71-0
Price
US $0.00-0.00/kg
Min. Order
0.10000000149011612kg
Purity
98%;99%
Supply Ability
1T+
Release date
2024-03-06
PUSHAN INDUSTRIAL (SHAANXI) CO.,LTD
Product
Fmoc-8-amino-3,6-dioxaoctanoic acid 166108-71-0
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1000 kgs
Release date
2024-05-17
Zibo Hangyu Biotechnology Development Co., Ltd
Product
[2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid 166108-71-0
Price
US $60.00-600.00/KG
Min. Order
1KG
Purity
0.99
Supply Ability
20 tons
Release date
2023-10-25

166108-71-0, Fmoc-8-amino-3,6-dioxaoctanoic acidRelated Search:

6-Aminocaproic acid 2-Aminothiazole-4-acetic acid 4-Aminophenylacetic acid Nitrilotriacetic acid DIETHOXYMETHANE Ethoxyethyne Glycine N-(9-Fluorenylmethoxycarbonyloxy)succinimide Ethoxyquin Ethyl 2-(Chlorosulfonyl)acetate 9-Fluorenylmethyl chloroformate Fmoc-Phe-OH Iminodiacetic acid Fmoc-Lys(Boc)-OH METHOXYCARBONYLSULFENYL CHLORIDE Ethoxyamine hydrochloride FMOC-THR(TBU)-OL 17-Amino-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanoic Acid

  • Fmoc-8-amino-3,6-dioxaoctanoic acid, Fmoc-AEEA
  • Fmoc-PEG2-acetic acid
  • {2-[2-(Fmoc-amino)ethoxy]ethoxy}acetic acid≥ 99% (HPLC)
  • Fmoc-NH-(PEG)-COOH (9 atoms) Novabiochem
  • 1-(9H-Fluoren-9-yl)-3-oxo-2,7,1-trioxa-4-azadodecan-12-oic acid
  • 9-FLUORENYLMETHOXYCARBONYL-8-AMINO-3,6-DIOXAOCTANOIC ACID
  • 8-(FMOC-AMINO)-3,6-DIOXA-OCTANOIC ACID
  • 8-FLUORENYLMETHOXYCARBONYLAMINO-3,6-DIOXAOCTANOIC ACID
  • 8-(9-FLUORENYLMETHOXYCARBONYL-AMINO)-3,6-DIOXA-OCTANOIC ACID
  • 8-(9-FLUORENYLMETHYLOXYCARBONYL-AMINO)-3,6-DIOXAOCTANOIC ACID
  • FMOC-O2OC-OH
  • FMOC-MINI-PEG(TM)
  • FMOC-[2-(2-AMINO-ETHOXY)-ETHOXY]-ACETIC ACID
  • FMOC-AEEA
  • FMOC-AEEAC-OH
  • FMOC-8-AMINO-3,6-DIOXAOCTANOIC ACID
  • 8-(9-Fluorenylmethyloxycarbonyl-amino)-3,6-dioxaoctanoicacid,{2-[2-(Fmoc-amino)ethoxy]ethoxy}aceticacid,1-(9H-Fuoren
  • 8-(9-FLUOROENYLMETHYLOXYCARBONYL-AMINO)-3,6-DIOXAOCTANOIC ACID
  • 1-(9H-Fluoren-9-yl)-3-oxo-2,7,10-trioxa-4-azadodecan-12-oic acid
  • Fmoc-PEG2- CH2COOH (Fmoc-AEEA)
  • 6-dioxaoctanoic acid
  • Fmoc-8-amino-3
  • Fmoc-NH-(PEG)-COOH (9 atoms)
  • MOC-AEEAC-OH
  • [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid, 97.0%
  • 2-{2-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)ethoxy]ethoxy}acetic acid
  • 8-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3,6-dioxa-n-octanoic Acid
  • 8-(9-Fluorenylmethyloxycarbonyl-amino)-3,6-dioxaoctanoic acid, {2-[2-(Fmoc-amino)ethoxy]ethoxy}acetic acid, 1-(9H-Fuoren-9-yl)-3-oxo-2,7,10-trioxa-4-azadodecan-12-oic acid, Fmoc-Ado, Fmoc-AEEA
  • 2-(2-(2-(((9H-fluoren-9-yl)Methoxy)carbonyl)ethoxy)ethoxy)acetic acid
  • 8-(Fmoc-amino)-3,6-dioxa-n-octanoic Acid [2-[2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]ethoxy]ethoxy]acetic Acid [2-[2-[(Fmoc-amino)ethoxy]ethoxy]acetic Acid
  • {2-[2-(FMoc-aMino)-ethoxy]-ethoxy}-acetic acid, 8-(FMoc-aMino)-3,6-dioxa-octanoic acid, FMoc-Adoa-OH
  • FMOC-AEEA-OH
  • [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid ,98.5%
  • {2-[2-(Fmoc-amino)ethoxy]ethoxy}acetic acid,8-(Fmoc-amino)-3,6-dioxaoctanoic acid
  • FMoc-NH-PEG2-CH2COOH
  • FMoc-2-(2- (2-aMinoethoxy)ethoxy) acetic acid
  • FMOC-AEEAC
  • RARECHEM EM WB 0032
  • Fmoc-NH-PEG2-CH2COOH,Fmoc-AEEA
  • 1-(9H-FUOREN-9-YL)-3-OXO-2,7,10-TRIOXA-4-AZADODECAN-12-OIC ACID
  • Fmoc-AEEA 1-(9H-Fluoren-9-yl)-3-oxo-2,7,10-trioxa-4-azadodecan-12-oic acid
  • (2-[2-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-ETHOXY]-ETHOXY)-ACETIC ACID
  • (2-[2-(FMOC-AMINO)-ETHOXY]-ETHOXY)-ACETIC ACID
  • 8-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3,6-dioxa-n-octanoicAcid&gt
  • 3,6,11-Trioxa-9-azadodecanoic acid, 12-(9H-fluoren-9-yl)-10-oxo-
  • Fmoc-AEEA/Fmoc-Mini-PEG
  • N-formylglycine t-butylester
  • Fmoc-Ado-OH
  • 2-[2-(Fmoc-amino)ethoxy]ethoxy]aceticaci
  • 8-(Fmoc-amino)-3,6-dioxa-n-octanoic Acid
  • [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid USP/EP/BP
  • Fmoc-N-Amido-PEG2-CH2COOH
  • Fmoc-N-amido-PEG2-acetic acid
  • Fluorene methoxycarbonyl dipolyethylene glycol acetic acid
  • Fmoc-8-amino-3,6-dioxaoctanoic acid (Fmoc-NH-PEG2-CH2COOH)
  • Fmoc-N-Me-Val/D-Val
  • 166108-71-0
  • Specialty Synthesis