1-Boc-4-cyanopiperidine

Product Name: 1-Boc-4-cyanopiperidine
CAS No.: 91419-52-2
Chemical Name: 1-Boc-4-cyanopiperidine
Synonyms: TERT-BUTYL 4-CYANOPIPERIDINE-1-CARBOXYLATE;tert-Butyl 4-Cyano-1-piperidinecarboxylate;1-Boc-4-cyanopiperid;Boc-4-cyanopiperidine;N-boc-4-cyanopiperidie;1-Boc-4-cynopiperidine;1-BOC-4-CYANOPIPERIDINE;N-Boc 4-cyano piperdine;N-BOC-4-CYANO-PIPERIDINE;1-N-BOC-4-CYANO-PIPERIDINE
CBNumber: CB9684610
Molecular Formula: C11H18N2O2
Formula Weight: 210.27
MOL File: 91419-52-2.mol

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1-Boc-4-cyanopiperidine Property

Melting point:: 60-63 °C
Boiling point:: 325.3±35.0 °C(Predicted)
Density: 1.07±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Chloroform
pka: -3.08±0.40(Predicted)
form: Crystalline Powder
color: White to off-white
InChI: InChI=1S/C11H18N2O2/c1-11(2,3)15-10(14)13-6-4-9(8-12)5-7-13/h9H,4-7H2,1-3H3
InChIKey: UQADQTBQNVARAP-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCC(C#N)CC1
CAS DataBase Reference: 91419-52-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,N
Risk Statements: 20/21/22-50-36-22
Safety Statements: 36-36/37/39-61-26
RIDADR: 3439
WGK Germany: 3
Hazard Note: Harmful
HazardClass: 6.1
PackingGroup: III
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H400Very toxic to aquatic life

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 696447
Product name: N-Boc-piperidine-4-carbonitrile
Purity: 97%
Packaging: 1g
Price: $46.41
Updated: 2025/07/31

TCI Chemical

Product number: B3962
Product name: 1-tert-Butoxycarbonyl-4-cyanopiperidine
Purity: >97.0%(GC)
Packaging: 1g
Price: $63
Updated: 2025/07/31

TCI Chemical

Product number: B3962
Product name: 1-tert-Butoxycarbonyl-4-cyanopiperidine
Purity: >97.0%(GC)
Packaging: 5g
Price: $214
Updated: 2025/07/31

Matrix Scientific

Product number: 071968
Product name: 1-Boc-4-Cyanopiperidine
Purity: 95+%
Packaging: 5g
Price: $24
Updated: 2021/12/16

AK Scientific

Product number: J52112
Product name: 1-N-Boc-4-cyanopiperidine
Packaging: 5g
Price: $25
Updated: 2021/12/16

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1-Boc-4-cyanopiperidine Chemical Properties,Usage,Production

Chemical Properties

Yellowish Oil

Uses

Reactant for synthesis of:

Aminomethylated fluoropiperidines
Protein kinase B inhibitors
GlyT1 inhibitors
Piperidinecarboxylic acids via nitrilase-catalyzed enantioselective synthesis

Reactant for

Replacement in CB2 receptor inhibitors
Double addition reactions of methyllithium and n-butyllithium to unsaturated nitriles

Synthesis

91419-48-6

91419-52-2

The general procedure for the synthesis of N-Boc-4-cyanopiperidine from tert-butyl 4-carbamoylpiperidine-1-carboxylate is as follows: to a solution of ethyl acetate (EtOAc, 1 mL, 1 M) containing an aldoxime or amide (1.0 mmol) and triethylamine (Et3N, 1.5 mmol) was added batchwise to XtalFluor-E (1.1 mmol) at room temperature. ). The reaction mixture was stirred at room temperature for 1 hour. Subsequently, the reaction was quenched with saturated sodium bicarbonate (NaHCO3) solution and extracted with aqueous sodium carbonate (Na2CO3) and dichloromethane (CH2Cl2, 2 × 10 mL). The combined organic layers were washed sequentially with water and brine, dried over anhydrous magnesium sulfate (MgSO4) and concentrated under reduced pressure to give the crude product. If necessary, the crude product can be purified by fast column chromatography.

References

[1] Synthesis (Germany), 2015, vol. 47, # 23, p. 3758 - 3766
[2] Patent: WO2004/2483, 2004, A1. Location in patent: Page/Page column 21-22; 39-40
[3] Chemistry of Heterocyclic Compounds, 2009, vol. 45, # 12, p. 1503 - 1507
[4] European Journal of Medicinal Chemistry, 1984, vol. 19, # 2, p. 181 - 186
[5] Chemical and Pharmaceutical Bulletin, 2001, vol. 49, # 7, p. 822 - 829

1-Boc-4-cyanopiperidine Preparation Products And Raw materials

Raw materials

Ammonium hydroxide Isonipecotamide Di-tert-butyl dicarbonate Phosphorus oxitrichloride Chloroform Isonipecotic acid Thionyl chloride

Preparation Products

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1-Boc-4-cyanopiperidine Suppliers

Americas 1 Belgium 1 Canada 3 China 276 Europe 3 France 1 Germany 6 India 28 Japan 2 Switzerland 3 The Netherlands 1 United Kingdom 19 United States 69 Global 413

Chengdu Firster Pharmaceutical Co., Ltd.

Tel: 028-87078428 028-87074958
Fax: 8772-8116
Email: chengzhenyong@cdfirster.com
Country: China
ProdList: 2598
Advantage: 60

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Tel: 021-57790084; 13918007836
Fax: 021-51685238
Email: sales@hoborchem.com
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AstaTech(Chengdu) Biopharmaceutical Corp.

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Email: sales@astatech.com.cn
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SHANGHAI HOHANCE CHEMICAL CO.,LTD

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Email: mary@hohance.com
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J & K SCIENTIFIC LTD.

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Chembest Research Laboratories Limited

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Email: sales@BioChemBest.com
Country: China
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Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
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Country: China
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TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
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Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
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View Lastest Price from 1-Boc-4-cyanopiperidine manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 1-Boc-4-cyanopiperidine 91419-52-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-17

Shaanxi Dideu New Materials Co. Ltd

Product: 1-Boc-4-cyanopiperidine 91419-52-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-02-23

AstaTech(Chengdu) Biopharmaceutical Corp.

Product: 1-Boc-4-cyanopiperidine 91419-52-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%min GC
Supply Ability: 20-40tons/year
Release date: 2022-01-11

91419-52-2, 1-Boc-4-cyanopiperidineRelated Search:

Butyl acetate Cyhalofop-butyl RESMETHRIN Haloperidol tert-Butanol Diisobutyl phthalate 4-Cyanopiperidine Methyl cyanoformate Isobutyl chloroformate tert-Butyl carbazate Methylene dithiocyanate Buprofezin Sodium cyanoborohydride 2-Butoxyethanol ETHYL 2-CYANOACRYLATE tert-Butyl peroxybenzoate Ethyl cyanoformate Butyl acrylate

1-Piperidinecarboxylic acid, 4-cyano-, 1,1-dimethylethyl ester

Boc-4-cyanopiperidine

1-BOC-PIPERIDINE-4-CARBONITRILE

N-Boc-piperidine-4-carbonitrile

N-boc-4-cyanopiperidie

1-Boc-4-cyanopiperid

N-tert-Butoxycarbonyl-4-cyanopiperidine

1-N-Boc-4-cyano-piperidine ,98%

1-tert-Butoxycarbonyl-4-cyanopiperidine

tert-Butyl 4-cyanopiperidine-1-carboxylate, 1-(tert-Butoxycarbonyl)piperidine-4-carbonitrile

1,1-Dimethylethyl 4-cyano-1-piperidinecarboxylate

4-Cyano-1-piperidinecarboxylic acid 1,1-dimethylethyl ester

N-BOC-4-CYANO-PIPERIDINE

TERT-BUTYL 4-CYANOPIPERIDINE-1-CARBOXYLATE

1-N-BOC-4-CYANO-PIPERIDINE

1-N-BOC-PIPERIDINE-4-CARBONITRILE

1-BOC-4-CYANOPIPERIDINE

4-CYANO-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

4-CYANOPIPERIDINE, N-BOC PROTECTED

1-tert-Butoxycarbonyl-4-cyanopiperidine &gt

N-Boc-piperidine-4-carbonitriL

1-Boc-4-piperidinecarbonitrile

1-tert-Butoxycarbonyl-4-piperidinecarbonitrile

4-Cyano-1-piperidinecarboxylic Acid tert-Butyl Ester

tert-Butyl 4-Cyano-1-piperidinecarboxylate

t-Butyl 4-cyanopiperidine-1-carboxylate

1-Piperidinecarboxylic acid, 4-cyano-, 1,1-dimethylethyl ester (9CI, ACI)

4-cyano-1-Piperidinecarboxylic acid 1,1-dimethylethyl ester (9CI ACI)

N-Boc 4-cyano piperdine

1-Boc-4-cynopiperidine

<i>N</i>-Boc-piperidine-4-carbonitrile

tert-butyl 3-cyanopiperidine-2-carboxylate

tert-Butyl 4-cyanopiperidin-1-carboxylate

91419-52-2

91419-53-4

Heterocyclic Building Blocks

pharmacetical

Pyrans, Piperidines &Piperazines

Piperidine

Piperazine

Aromatics

Pyrans, Piperidines & Piperazines

Boron, Nitrile, Thio,& TM-Cpds

Heterocycles