4-Cyanopiperidine

Product Name: 4-Cyanopiperidine
CAS No.: 4395-98-6
Chemical Name: 4-Cyanopiperidine
Synonyms: PIPERIDINE-4-CARBONITRILE;4-cyanopiperdine;4-CYANOPIPERIDINE;sonipecotonitrile;Isonipecotonitrile;CHEMBRDG-BB 4009819;Piperidine-4-carboni;5-AMINOPHTHALONITRILE;4-CYANOPIPERIDINE >98%;Piperidin-4-carbonitrile
CBNumber: CB9265756
Molecular Formula: C6H10N2
Formula Weight: 110.16
MOL File: 4395-98-6.mol

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4-Cyanopiperidine Property

Melting point:: 0°C
Boiling point:: 0°C
Density: 0.987 g/mL at 25 °C
refractive index: 1.4755
Flash point:: 0°C
storage temp.: 2-8°C
solubility: Soluble in chloroform.
form: Liquid
pka: 9.26±0.10(Predicted)
color: Colorless to pale yellow
InChI: InChI=1S/C6H10N2/c7-5-6-1-3-8-4-2-6/h6,8H,1-4H2
InChIKey: FSDNTQSJGHSJBG-UHFFFAOYSA-N
SMILES: N1CCC(C#N)CC1
CAS DataBase Reference: 4395-98-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 20/21/22-36/37/38-41-22
Safety Statements: 26-36/37/39-36-39
RIDADR: 3276
WGK Germany: 3
Hazard Note: Harmful
HazardClass: 6.1
PackingGroup: III
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 749583
Product name: Piperidine-4-carbonitrile
Purity: 97%
Packaging: 5g
Price: $96.7
Updated: 2023/01/07

Sigma-Aldrich

Product number: 749583
Product name: Piperidine-4-carbonitrile
Purity: 97%
Packaging: 25g
Price: $203
Updated: 2023/01/07

TRC

Product number: C987540
Product name: 4-Cyanopiperidine
Packaging: 2.5g
Price: $115
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC04742
Product name: 4-Cyanopiperidine
Packaging: 25g
Price: $150
Updated: 2021/12/16

Oakwood

Product number: 024547
Product name: 4-Cyanopiperidine
Packaging: 25g
Price: $188
Updated: 2021/12/16

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4-Cyanopiperidine Chemical Properties,Usage,Production

Chemical Properties

Yellowish-Orangish Oil

Uses

4-Cyanopiperidine is used as an intermediate for the preparation of pharmaceutical substances like antidepressants and anti-inflammatory. It is used as a precursor for the synthesis of piperidine derivatives.

Synthesis

91419-52-2

4395-98-6

The general procedure for the synthesis of 4-cyanopiperidine from N-Boc-4-cyanopiperidine is as follows: Step A: Preparation of 4-cyanopiperidine hydrochloride (mt17-1) N-Boc-4-cyanopiperidine (4.00 g, 19.0 mmol) was dissolved in 20 mL of 4M HCl/EtOAc solution and stirred at room temperature for 30 min. After completion of the reaction, the mixture was concentrated under vacuum to give 2.10 g of 4-cyanopiperidine hydrochloride (mt17-1) as a white solid in 100% yield. 1H-NMR (DMSO-d6) δ: 9.32 (br, 1H), 3.18-3.08 (m, 3H), 2.97-2.92 (m, 2H), 2.08-2.04 (m, 2H), 1.95-1.85 (m, 2H).

References

[1] Patent: WO2014/178, 2014, A1. Location in patent: Page/Page column 102
[2] Patent: WO2014/4416, 2014, A1. Location in patent: Page/Page column 102
[3] Patent: US2014/5103, 2014, A1. Location in patent: Paragraph 0459; 0460
[4] Patent: US2015/197531, 2015, A1. Location in patent: Paragraph 0460
[5] Chemical and Pharmaceutical Bulletin, 2001, vol. 49, # 7, p. 822 - 829

4-Cyanopiperidine Preparation Products And Raw materials

Raw materials

1,1'-Carbonyldiimidazole Di-tert-butyl dicarbonate Potassium carbonate Chloroform 1,4-Dioxane Tetrahydrofuran Trifluoroacetic anhydride Ethyl acetate Isonipecotic acid Thionyl chloride Ammonia

Preparation Products

NORMEPERIDINE

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4-Cyanopiperidine Suppliers

Belgium 1 Canada 4 CHINA 146 France 1 Germany 11 India 19 Ireland 1 Switzerland 1 The Netherlands 1 United Kingdom 16 United States 51 Global 252

Shanghai Meilv Pharmatech Co. Ltd

Tel: 21-53530655 18930806002
Email: 652583651@qq.com
Country: China
ProdList: 257
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

Ark Pharm, Inc.

Tel: 847-367-3680
Fax: 847-367-3681
Email: sales@arkpharminc.com
Country: United States
ProdList: 1670
Advantage: 56

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Shanghai Sinch Parmaceuticals Tech. Co. Ltd.

Tel: +86-21-54098501
Fax: +86-21-54096319
Email: sales@sinch.com.cn
Country: China
ProdList: 11598
Advantage: 64

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10186
Advantage: 62

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View Lastest Price from 4-Cyanopiperidine manufacturers

Career Henan Chemical Co

Product: 4-Cyanopiperidine 4395-98-6
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: as request
Release date: 2018-12-21

4395-98-6, 4-CyanopiperidineRelated Search:

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PIPERIDINE-4-CARBONITRILE

4-CYANOPIPERIDINE

CHEMBRDG-BB 4009819

4-CYANOPIPERIDINE >98%

4-CYANO PIPERIDINE PIPERIDINE-4-CARBONITRILE

5-AMINOPHTHALONITRILE

piperidine-4-carbonitrile(SALTDATA: HCl)

4-cyanopiperdine

Piperidin-4-carbonitrile

4-Piperidinecarbonitrile hydrochloride

Piperidine-4-carbonitrile hydrochloride 98%

sonipecotonitrile

4-Cyanopiperidine, Isonipecotonitrile

Isonipecotonitrile

4-Cyano-piperidine hydroc...

Piperidine-4-carboni

4-Cyanopiperidine(HCl salt form)

4-Piperidinecarbonitrile (9CI, ACI)

Piperidine-4-carbonitrile - [C4799]

4395-98-6

Amines and Anilines

Boron, Nitrile, Thio,& TM-Cpds

Aromatics

Piperidine