Isonipecotic acid Property

Melting point:

>300 °C(lit.)

Boiling point:

239.22°C (rough estimate)

Density 

1.1426 (rough estimate)

refractive index 

1.4587 (estimate)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

Water

form 

Powder

pka

pK1:3.73(+1);pK2:10.72(0) (25°C)

color 

White to faint pink-beige

Water Solubility 

soluble

Merck 

14,5189

BRN 

112553

CAS DataBase Reference

498-94-2(CAS DataBase Reference)

EPA Substance Registry System

4-Piperidinecarboxylic acid (498-94-2)

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-37/39

WGK Germany 

3

RTECS 

NS5150000

TSCA 

T

HazardClass 

IRRITANT

HS Code 

29333999

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

Isonipecotic acid Chemical Properties,Usage,Production

Chemical Properties

white to faint pink-beige powder

Uses

A GABA-A receptor partial agonist

Synthesis Reference(s)

Synthesis, p. 623, 1984
Tetrahedron Letters, 35, p. 8783, 1994 DOI: 10.1016/S0040-4039(00)78497-8

Purification Methods

It crystallises from H2O or EtOH as needles. The hydrochloride recrystallises from H2O or aqueous HCl with m 293odec (also 298odec, 300odec). [Wibaut Recl Trav Chim Pays-Bas 63 141 1944, IR: Zacharius et al. J Am Chem Soc 76 2908 1954, Beilstein 22/1 V 244.]