1-Methylpiperidin-4-amine

Uses

Product Name: 1-Methylpiperidin-4-amine
CAS No.: 41838-46-4
Chemical Name: 1-Methylpiperidin-4-amine
Synonyms: N-Methyl-4-aminopiperidine;4-Amino-1-methyL;1-Methylpiperidin-4-;1-Methylpiperidin-4-amin;4-Amino-1-methylpiperdine;1-Methylpiperidin-4-amine;1-Methyl-4-piperidinaMine;1-Methylpiperidine-4-amine;1-Methyl-4-Amino Piperidine;(1-methyl-4-piperidyl)amine
CBNumber: CB4758082
Molecular Formula: C6H14N2
Formula Weight: 114.19
MOL File: 41838-46-4.mol

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1-Methylpiperidin-4-amine Property

Melting point:: 203-207
Boiling point:: 62-64°C 1mm
Density: 0.91
refractive index: 1.4700-1.4740
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
form: clear liquid
pka: 9.92±0.20(Predicted)
color: Colorless to Light orange to Yellow
InChI: InChI=1S/C6H14N2/c1-8-4-2-6(7)3-5-8/h6H,2-5,7H2,1H3
InChIKey: ALOCUZOKRULSAA-UHFFFAOYSA-N
SMILES: N1(C)CCC(N)CC1
CAS DataBase Reference: 41838-46-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-22-34-11
Safety Statements: 26-36/37/39-45-22-16-9
RIDADR: 2920
HazardClass: IRRITANT
PackingGroup: Ⅱ
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H226Flammable liquid and vapour

H314Causes severe skin burns and eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: A2046
Product name: 4-Amino-1-methylpiperidine
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $55
Updated: 2025/07/31

TCI Chemical

Product number: A2046
Product name: 4-Amino-1-methylpiperidine
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $158
Updated: 2025/07/31

TRC

Product number: M320875
Product name: 1-Methylpiperidin-4-amine
Packaging: 1g
Price: $45
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-1-M2
Product name: 4-Amino-1-methylpiperidine
Purity: 97%
Packaging: 5G
Price: $16
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK975626
Product name: 4-Amino-1-methylpiperidine
Purity: 98%
Packaging: 1g
Price: $18
Updated: 2021/12/16

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1-Methylpiperidin-4-amine Chemical Properties,Usage,Production

Uses

4-Amino-1-methylpiperidine is used as an organic reagent and pharmaceutical intermediate.

Chemical Properties

Clear colorless to yellow liquid

Synthesis

359878-09-4

41838-46-4

N-((4-methoxyphenyl)methyl)-4-amino-1-methylpiperidine (1 g, 4.27 mmol) was used as starting material, which was dissolved in a methanol solution of 4% formic acid (60 mL). Under argon protection, 10% Pd/C (1 g) was added to the reaction system and the reaction mixture was subsequently heated to reflux for 24 hours. Upon completion of the reaction, the mixture was filtered through diatomaceous earth and the filtrate was acidified with concentrated hydrochloric acid to a pH of about 1. The resulting solution was concentrated to give a yellow oily substance. The oily substance was purified by fast chromatography (eluent: methanol/dichloromethane = 3:7 with 3.5% ammonia) to give 249 mg (51% yield) of 4-amino-1-methylpiperidine (57-MBT36B) as a white solid. Thin layer chromatography (TLC) Rf value was 0.13 (unfolding agent: 10% dichloromethane solution in methanol with 3.5% ammonia). High performance liquid chromatography-mass spectrometry (HPLC-MS, Method B) showed the molecular ion peak MH+ = 115. ultraviolet/mass spectrometry (UV/MS) detection showed a percent purity of -/100.

References

[1] Patent: WO2007/124136, 2007, A1. Location in patent: Page/Page column 126-127

1-Methylpiperidin-4-amine Preparation Products And Raw materials

Raw materials

Ammonium hydroxide Potassium hydroxide Formaldehyde Formic acid Isonipecotic acid Bromine Methanol Thionyl chloride

Preparation Products

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1-Methylpiperidin-4-amine Suppliers

Americas 1 Canada 2 China 191 Europe 3 France 2 Germany 6 India 30 Japan 2 Slovakia 1 South Korea 1 Switzerland 1 Ukraine 2 United Kingdom 19 United States 34 Global 295

Chengdu HappySyn Pharmaceutical Technology Co., Ltd.

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JinYan Chemicals(ShangHai) Co.,Ltd.

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View Lastest Price from 1-Methylpiperidin-4-amine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 1-Methylpiperidin-4-amine 41838-46-4
Price: US $49.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 1000 tons
Release date: 2025-08-26

Jiangsu Monade Biological Technology Co., Ltd.

Product: 1-Methylpiperidin-4-amine 41838-46-4
Price: US $1.00/KG
Min. Order: 1000KG
Purity: 99.99%
Supply Ability: 10000t
Release date: 2021-09-01

Career Henan Chemical Co

Product: 1-Methylpiperidin-4-amine 41838-46-4
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 100KG
Release date: 2018-12-21

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4-AMino-1-Methyl piperidine 41838-46-4

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1-Methylpiperidin-4-amin

41838-46-4

C9H13BrN4

API intermediate

Pyridine

API intermediates