1-Methyl-4-piperidone

Product Name: 1-Methyl-4-piperidone
CAS No.: 1445-73-4
Chemical Name: 1-Methyl-4-piperidone
Synonyms: N-METHYL-4-PIPERIDONE;1-METHYL-4-PIPERIDINONE;1-Methyl-piperidin-4-one;N-METHYL-GAMMA-PIPERIDONE;1-METHYLTETRAHYDROPYRIDIN-4(1H)-ONE;NSC 66491;AKOS BBS-00004237;N-METHYLPIPERIDONE;N-Methyl-4-Pperidone;-Methyl-4-piperidone
CBNumber: CB9684827
Molecular Formula: C6H11NO
Formula Weight: 113.16
MOL File: 1445-73-4.mol

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1-Methyl-4-piperidone Property

Melting point:: 192-193 °C(Solv: ethyl acetate (141-78-6))
Boiling point:: 55-60 °C11 mm Hg(lit.)
Density: 0.92 g/mL at 25 °C (lit.)
refractive index: n20/D 1.460
Flash point:: 140 °F
storage temp.: Store below +30°C.
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
pka: 8.02±0.20(Predicted)
form: Liquid
Specific Gravity: 0.92
color: Clear yellow to orange
PH: 12 (100g/l, H2O, 20℃)
Water Solubility: MISCIBLE
Sensitive: Air Sensitive
BRN: 106924
CAS DataBase Reference: 1445-73-4(CAS DataBase Reference)
NIST Chemistry Reference: 4-Piperidinone, 1-methyl-(1445-73-4)

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Safety

Hazard Codes: C,Xi
Risk Statements: 34-10-36/37/38
Safety Statements: 23-24/25-37/39-26
RIDADR: UN 1224 3/PG 3
WGK Germany: 3
Hazard Note: Irritant
HazardClass: 3
PackingGroup: III
HS Code: 29333999

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H226Flammable liquid and vapour

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 130036
Product name: N-Methyl-4-piperidone
Purity: 97%
Packaging: 5ml
Price: $37.8
Updated: 2024/03/01

Sigma-Aldrich

Product number: 130036
Product name: N-Methyl-4-piperidone
Purity: 97%
Packaging: 100ml
Price: $129
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.20828
Product name: 1-Methyl-4-piperidinone
Purity: for synthesis
Packaging: 100mL
Price: $150
Updated: 2024/03/01

TCI Chemical

Product number: M0530
Product name: 1-Methyl-4-piperidone
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $33
Updated: 2024/03/01

TCI Chemical

Product number: M0530
Product name: 1-Methyl-4-piperidone
Purity: >98.0%(GC)(T)
Packaging: 100g
Price: $86
Updated: 2024/03/01

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1-Methyl-4-piperidone Chemical Properties,Usage,Production

Chemical Properties

clear yellow to orange liquid

Uses

1-Methyl-4-piperidone, are widely used in artificial fibre industry. They are polymerizable and used as nylon precursors. They have excellent applications as solvents and as intermediates for organic synthesis. They are used in the aqueous carrier medium and amide penetrants in inks and water soluble paints.

Application

N-Methyl-4-piperidone can be used as a reactant to prepare:
Spiropiperidine rings by reacting with malononitrile and electrophiles or Michael acceptors.
(3E,5E)-1-Methyl-3,5-bis(phenylmethylene)-4-piperidinone by reacting with benzaldehyde via Michael addition, followed by intramolecular O-cyclization/elimination sequential reactions.
N,N′-Dimethylbispidinone by utilizing a double Mannich condensation method.

Preparation

[JACS (1948) vol 70 p 1820] for the synthesis of 1-methyl-4-piperidone:
To a one-liter flask containing 350 ml of 20 % hydrochloric acid was added 86 g. of 1-methyl-3-carbethoxy-4-piperidone hyrdrochloride. After refluxing for one hour, the ferric chloride reagent gave no coloration. The solution was evaporated to dryness on a steam-bath at 10 mm. pressure. The solid product, heated at 100 °C for 4 hours at 0.1 mm and further dried over solid KOH for 24 hours, weighed 57.7 g, m.p. 80 - 120 °C.
Although this melting range goes above that of the pure comound 0.45 of crude material dissolved in 90 ml. of hot acetone gave 0.40 g of pure compoundd melting at 93 - 95 °C. Other samples of crude piperidone hydrochloride showed even higher melting points than the one mentioned above, yet this apperently impure material always gave good yields of sharp melting product when recrystallized.

Purification Methods

It is best purified by fractional distillation The hydrochloride of the hydrate (4-diol) has m 94.7-95.5o, but the anhydrous hydrochloride which crystallises from CHCl3/Et2O has m 165-168o (164-167o) and can also be obtained by sublimation at 120o/2mm. The oxime has m 130-132o (from Me2CO). The methiodide crystallises from MeOH, the crystals with 1MeOH have m 189-190o, and the solvent-free iodide has m 202-204o(dec). [Lyle et al. J Org Chem 24 342 1959, Bowden & Greeen J Chem Soc 1164 1952, Tomita Yakugaku Zasshi (J Pharm Soc Japan) 71 1053 1951, Beilstein 21 IIII/IV 3183, 21/6 V 419.]

References

[1] Robert E. Lyle, Laurence Ladd, Richard Munk. “The Asinger Reaction with 1-Methyl-4-piperidone.” The Journal of Organic Chemistry 30 1 (1965): 293–294.
[2] Wildau, Martha. “Ein acidimetrisches Bestimmungsverfahren alkylsubstituierter 1-Methyl-4-piperidone.” Analytical and Bioanalytical Chemistry 147 3 (1955): 231–231.

1-Methyl-4-piperidone Preparation Products And Raw materials

Raw materials

Preparation Products

N-Methyl-3-carbomethoxy-4-piperidone hydrochloride 4-Chloro-N-methylpiperidine 2-AMINO-6-METHYL-4,5,6,7-TETRAHYDROTHIENO[2,3-C]PYRIDINE-3-CARBONITRILE N-Methyl-4-piperidinol

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1-Methyl-4-piperidone Suppliers

Americas 1 Belgium 3 Canada 2 China 385 Europe 4 France 3 Germany 6 India 64 Japan 5 Russia 1 Slovakia 1 South Korea 3 Switzerland 4 The Netherlands 1 Ukraine 2 United Kingdom 19 United States 58 Global 562

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View Lastest Price from 1-Methyl-4-piperidone manufacturers

HebeiShuoshengImportandExportco.,Ltd

Product: 1-Methyl-4-piperidone 1445-73-4
Price: US $6.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000KG/Month
Release date: 2024-08-07

hebei hongtan Biotechnology Co., Ltd

Product: 1-Methyl-4-piperidone 1445-73-4
Price: US $30.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000kg
Release date: 2024-05-13

Hebei Weibang Biotechnology Co., Ltd

Product: 1-Methyl-4-piperidone 1445-73-4
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-12-06

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1445-73-4

445-73-4

971445-73-4

Building Blocks

Heterocyclic Building Blocks

Piperidones

KETONE

Miscellaneous

Piperidines, Piperidones, Piperazines

PHARMACEUTICAL INTERMEDIATES

Amines and Anilines

Carbonyl Compounds

Piperidine

Heterocycles

Miscellaneous Reagents

Building Blocks

Heterocyclic Building Blocks

Piperidones