1-Methyl-4-piperidone
- Product Name
- 1-Methyl-4-piperidone
- CAS No.
- 1445-73-4
- Chemical Name
- 1-Methyl-4-piperidone
- Synonyms
- N-METHYL-4-PIPERIDONE;1-METHYL-4-PIPERIDINONE;1-Methyl-piperidin-4-one;N-METHYL-GAMMA-PIPERIDONE;1-METHYLTETRAHYDROPYRIDIN-4(1H)-ONE;NSC 66491;AKOS BBS-00004237;N-METHYLPIPERIDONE;N-Methyl-4-Pperidone;-Methyl-4-piperidone
- CBNumber
- CB9684827
- Molecular Formula
- C6H11NO
- Formula Weight
- 113.16
- MOL File
- 1445-73-4.mol
1-Methyl-4-piperidone Property
- Melting point:
- 192-193 °C(Solv: ethyl acetate (141-78-6))
- Boiling point:
- 55-60 °C11 mm Hg(lit.)
- Density
- 0.92 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.460
- Flash point:
- 140 °F
- storage temp.
- Store below +30°C.
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
- pka
- 8.02±0.20(Predicted)
- form
- Liquid
- Specific Gravity
- 0.92
- color
- Clear yellow to orange
- PH
- 12 (100g/l, H2O, 20℃)
- Water Solubility
- MISCIBLE
- Sensitive
- Air Sensitive
- BRN
- 106924
- CAS DataBase Reference
- 1445-73-4(CAS DataBase Reference)
- NIST Chemistry Reference
- 4-Piperidinone, 1-methyl-(1445-73-4)
Safety
- Hazard Codes
- C,Xi
- Risk Statements
- 34-10-36/37/38
- Safety Statements
- 23-24/25-37/39-26
- RIDADR
- UN 1224 3/PG 3
- WGK Germany
- 3
- Hazard Note
- Irritant
- HazardClass
- 3
- PackingGroup
- III
- HS Code
- 29333999
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H226Flammable liquid and vapour
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
N-Bromosuccinimide Price
- Product number
- 130036
- Product name
- N-Methyl-4-piperidone
- Purity
- 97%
- Packaging
- 5ml
- Price
- $37.8
- Updated
- 2024/03/01
- Product number
- 130036
- Product name
- N-Methyl-4-piperidone
- Purity
- 97%
- Packaging
- 100ml
- Price
- $129
- Updated
- 2024/03/01
- Product number
- 8.20828
- Product name
- 1-Methyl-4-piperidinone
- Purity
- for synthesis
- Packaging
- 100mL
- Price
- $150
- Updated
- 2024/03/01
- Product number
- M0530
- Product name
- 1-Methyl-4-piperidone
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $33
- Updated
- 2024/03/01
- Product number
- M0530
- Product name
- 1-Methyl-4-piperidone
- Purity
- >98.0%(GC)(T)
- Packaging
- 100g
- Price
- $86
- Updated
- 2024/03/01
1-Methyl-4-piperidone Chemical Properties,Usage,Production
Chemical Properties
clear yellow to orange liquid
Uses
1-Methyl-4-piperidone, are widely used in artificial fibre industry. They are polymerizable and used as nylon precursors. They have excellent applications as solvents and as intermediates for organic synthesis. They are used in the aqueous carrier medium and amide penetrants in inks and water soluble paints.
Application
N-Methyl-4-piperidone can be used as a reactant to prepare:
Spiropiperidine rings by reacting with malononitrile and electrophiles or Michael acceptors.
(3E,5E)-1-Methyl-3,5-bis(phenylmethylene)-4-piperidinone by reacting with benzaldehyde via Michael addition, followed by intramolecular O-cyclization/elimination sequential reactions.
N,N′-Dimethylbispidinone by utilizing a double Mannich condensation method.
Preparation
[JACS (1948) vol 70 p 1820] for the synthesis of 1-methyl-4-piperidone:
To a one-liter flask containing 350 ml of 20 % hydrochloric acid was added 86 g. of 1-methyl-3-carbethoxy-4-piperidone hyrdrochloride. After refluxing for one hour, the ferric chloride reagent gave no coloration. The solution was evaporated to dryness on a steam-bath at 10 mm. pressure. The solid product, heated at 100 °C for 4 hours at 0.1 mm and further dried over solid KOH for 24 hours, weighed 57.7 g, m.p. 80 - 120 °C.
Although this melting range goes above that of the pure comound 0.45 of crude material dissolved in 90 ml. of hot acetone gave 0.40 g of pure compoundd melting at 93 - 95 °C. Other samples of crude piperidone hydrochloride showed even higher melting points than the one mentioned above, yet this apperently impure material always gave good yields of sharp melting product when recrystallized.
Purification Methods
It is best purified by fractional distillation The hydrochloride of the hydrate (4-diol) has m 94.7-95.5o, but the anhydrous hydrochloride which crystallises from CHCl3/Et2O has m 165-168o (164-167o) and can also be obtained by sublimation at 120o/2mm. The oxime has m 130-132o (from Me2CO). The methiodide crystallises from MeOH, the crystals with 1MeOH have m 189-190o, and the solvent-free iodide has m 202-204o(dec). [Lyle et al. J Org Chem 24 342 1959, Bowden & Greeen J Chem Soc 1164 1952, Tomita Yakugaku Zasshi (J Pharm Soc Japan) 71 1053 1951, Beilstein 21 IIII/IV 3183, 21/6 V 419.]
1-Methyl-4-piperidone Preparation Products And Raw materials
Raw materials
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View Lastest Price from 1-Methyl-4-piperidone manufacturers
- Product
- 1-Methyl-4-piperidone 1445-73-4
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000kg
- Release date
- 2024-03-18
- Product
- N-methyl-4-piperidone 1445-73-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000KG
- Release date
- 2024-04-22
- Product
- 1-Methyl-4-piperidone 1445-73-4
- Price
- US $110.00-90.00/kilogram
- Min. Order
- 1kilogram
- Purity
- 99%
- Supply Ability
- 10 tons/per week
- Release date
- 2024-01-04