N-Methyl-4-piperidinol

Product Name: N-Methyl-4-piperidinol
CAS No.: 106-52-5
Chemical Name: N-Methyl-4-piperidinol
Synonyms: 1-methylpiperidin-4-ol;1-METHYL-4-PIPERIDINOL;4-Piperidinol, 1-methyl-;H431;NM4PPOL;-4-piperidinoL;N-Methylpiperidol;N-Methyl-4-hydroxy;TIMTEC-BB SBB004301;1-methyl-4-piperidino
CBNumber: CB8852683
Molecular Formula: C6H13NO
Formula Weight: 115.17
MOL File: 106-52-5.mol

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N-Methyl-4-piperidinol Property

Melting point:: 29-31 °C(lit.)
Boiling point:: 200 °C(lit.)
Density: 0.98 g/mL at 20 °C(lit.)
vapor pressure: 8.13-11Pa at 25℃
refractive index: n20/D 1.479
Flash point:: 190 °F
storage temp.: 2-8°C
form: Liquid After Melting
pka: 14.87±0.20(Predicted)
color: Clear colorless to brown
Water Solubility: MISCIBLE
Sensitive: Hygroscopic
BRN: 103024
LogP: -0.14-0.756 at 25℃
CAS DataBase Reference: 106-52-5(CAS DataBase Reference)
NIST Chemistry Reference: 4-Hydroxy-N-methylpiperidine(106-52-5)
EPA Substance Registry System: 4-Piperidinol, 1-methyl- (106-52-5)

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Safety

Hazard Codes: Xi,C
Risk Statements: 37/38-41-36/37/38-34
Safety Statements: 26-37/39-45-36/37/39-27
WGK Germany: 3
Hazard Note: Irritant
TSCA: Yes
HS Code: 29333999

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: H42206
Product name: N-Methyl-4-piperidinol
Purity: 98%
Packaging: 100g
Price: $92.3
Updated: 2025/07/31

TCI Chemical

Product number: M0933
Product name: 4-Hydroxy-1-methylpiperidine
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $28
Updated: 2025/07/31

TCI Chemical

Product number: M0933
Product name: 4-Hydroxy-1-methylpiperidine
Purity: >98.0%(GC)(T)
Packaging: 500g
Price: $221
Updated: 2025/07/31

TRC

Product number: H972453
Product name: 4-Hydroxy-1-methylpiperidine
Packaging: 50g
Price: $95
Updated: 2021/12/16

TRC

Product number: H972453
Product name: 4-Hydroxy-1-methylpiperidine
Packaging: 25g
Price: $70
Updated: 2021/12/16

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N-Methyl-4-piperidinol Chemical Properties,Usage,Production

Chemical Properties

clear colorless to yellowish liquid after melting

Uses

Reactant for:• ;Optimization of Novobiocin scaffold to product antitumor agents1• ;Substitution about the rigidifying ring for histamine H4 receptor antagonist synthesis2Reactant for synthesis of:• ;CaMKII inhibitors3• ;VEGFR and FGFR kinase inhibitors4• ;Phosphoinositide-3-kinase inhibitors5• ;Protein lysine methyltransferase G9a inhibitors6

Uses

4-Hydroxy-1-methylpiperidine is used as reactant for optimization of Novobiocin scaffold to product antitumor agents, substitution about the rigidifying ring for histamine H4 receptor antagonist synthesis. It is also used as a reactant in the synthesis of CaMKII, VEGFR and FGFR kinase inhibitors and Phosphoinositide-3-kinase, Protein lysine methyltransferase G9a inhibitors.

Flammability and Explosibility

Not classified

Synthesis

1445-73-4

106-52-5

The general procedure for the synthesis of 1-methyl-4-piperidinol from N-methyl-4-piperidone was as follows: in standard experiments, the catalyst complex 1 (6.1 mg, 10 mol%) and the hydrogenation reagent H[BAr'4]-(Et2O)2 (10.1 mg, 10 mol%) were dissolved in a 100 mL thick-walled glass reactor fitted with a TEFLON stopper and stirring bar of THF (2.0 mL). Subsequently, the substrate to be hydrogenated (0.5 mmol) was added. The reaction system was degassed by a freeze-pump-thaw cycle and then charged with hydrogen (1 or 4 atm). The reaction mixture was stirred at a set temperature (25-60 °C) until the reaction was complete. At the end of the reaction, the solvent was removed by evaporation and the residue was initially purified by passing through a silica gel column. After removal of solvent under reduced pressure, the crude product was dissolved in CDCl3 and analyzed by 1H NMR. The final product was further purified by column chromatography or preparative thin layer chromatography (TLC) using hexane/ethyl acetate (3:1, v/v) as eluent. The purified products were characterized by 1H NMR and GC-MS, and the spectral data were consistent with those reported in the literature or real samples.

References

[1] Journal of Medicinal Chemistry, 1997, vol. 40, # 16, p. 2474 - 2481
[2] Patent: US2015/336862, 2015, A1. Location in patent: Paragraph 0038; 0054
[3] Patent: US2767190, 1950,
[4] Patent: US2776293, 1950,
[5] Journal of the American Chemical Society, 1948, vol. 70, p. 1826

N-Methyl-4-piperidinol Preparation Products And Raw materials

Raw materials

1-Methyl-4-piperidone

Preparation Products

4-(1-METHYLPIPERIDIN-4-YLOXY)-3,5-DICHLOROBENZENAMINE

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N-Methyl-4-piperidinol Suppliers

Americas 1 Belgium 3 Canada 1 China 229 Europe 3 France 1 Germany 10 India 44 Italy 1 Japan 5 Slovakia 1 South Korea 3 Switzerland 4 The Netherlands 1 Ukraine 1 United Kingdom 17 United States 62 Global 387

Shanghai Hobor Chemical Co., Ltd

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View Lastest Price from N-Methyl-4-piperidinol manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: N-Methyl-4-piperidinol 106-52-5
Price: US $0.10/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 1000 tons
Release date: 2024-08-05

Anhui Ruihan Technology Co., Ltd

Product: 1-Methyl-4-piperidinol 106-52-5
Price: US $30.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000t/year
Release date: 2023-09-21

Jinan Ande Pharmaceutical Co.,Ltd.

Product: N-Methyl-4-piperidinol 106-52-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100
Release date: 2021-12-20

106-52-5, N-Methyl-4-piperidinol Related Search:

1-Methyl-4-piperidone Triacetonediamine Tribenuron methyl Pirimiphos-methyl Kresoxim-methyl Haloperidol Methyl salicylate METSULFURON METHYL 2,2,6,6-Tetramethyl-4-piperidinol Methyl acetate CHLOROPHOSPHONAZO III Thiophanate-methyl Methyl STRYCHNINE 1-BENZYL-4-CYANO-4-HYDROXYPIPERIDINE Tropine Parathion-methyl 10,11-Dimethoxystrychnine

1-methyl-4-piperidino

1-Methylpiperidinol-(4)

4-Piperidinol, 1-methyl-

N-Methylpiperidol

4-HYDROXY-1-METHYLPIPERIDINE

4-HYDROXY-N-METHYLPIPERIDINE

N-METHYL-4-HYDROXY PIPERIDINE

NM4PPOL

N-METHYL-4-PIPERIDINOL

1-HYDROXY-4-METHYLPIPERIDINE

1-METHYL-4-PIPERIDINOL

1-METHYL-4-PIPERIDINOL HCL

1-METHYL-4-PIPERIDINOLHYDROCHOLORIDE

1-METHYL-4-HYDROXYPIPERIDINE

TIMTEC-BB SBB004301

1-methylpiperidin-4-ol

N-Methyl-4-hydroxy

4-Hydroxy-1-methylpiperidine 98%

1-Methyl-4-piperidinol, 4-Hydroxy-1-methylpiperidine

4-Hydroxy-l-methylpiperidine

N-METIL-4-IDROSSIPIPERIDINA

4-Hydroxy-N-Methylpiperidine, 98% 100GR

H431

1- Methyl-4- piperidinealcohol

N-Methyl-4-piperidinol, 98%+

4-Hydroxy-1-methylpiperidine,98%

N-Methyl-4-piperidinol 98%

1-methyl-4-piperidin-1-iumol

Pimavanserin Impurity 12

4-Hydroxy-1-methylpiperidine&gt

-4-piperidinoL

4-Hydro xy-Ninethylp iperidine

Loratadine Impurity 40

N-Methyl-4-hydroxy-piperidine (NMHP)

106-52-5 N-Methyl-4-piperidinol

<i>N</i>-Methyl-4-piperidinol

N-Methyl-4-hydroxypiperidine 98%

106-52-5

102-52-5

Building Blocks

Heterocyclic Building Blocks

Piperidines

Building Blocks

C5 to C7

Chemical Synthesis

Heterocyclic Building Blocks

Piperidines

PHARMACEUTICAL INTERMEDIATES

Piperidine