ChemicalBook > CAS DataBase List > N-Methyl-4-piperidinol

N-Methyl-4-piperidinol

Product Name
N-Methyl-4-piperidinol
CAS No.
106-52-5
Chemical Name
N-Methyl-4-piperidinol
Synonyms
1-methylpiperidin-4-ol;1-METHYL-4-PIPERIDINOL;4-Piperidinol, 1-methyl-;H431;NM4PPOL;-4-piperidinoL;N-Methylpiperidol;N-Methyl-4-hydroxy;TIMTEC-BB SBB004301;1-methyl-4-piperidino
CBNumber
CB8852683
Molecular Formula
C6H13NO
Formula Weight
115.17
MOL File
106-52-5.mol
More
Less

N-Methyl-4-piperidinol Property

Melting point:
29-31 °C(lit.)
Boiling point:
200 °C(lit.)
Density 
0.98 g/mL at 20 °C(lit.)
vapor pressure 
8.13-11Pa at 25℃
refractive index 
n20/D 1.479
Flash point:
190 °F
storage temp. 
2-8°C
form 
Liquid After Melting
pka
14.87±0.20(Predicted)
color 
Clear colorless to brown
Water Solubility 
MISCIBLE
Sensitive 
Hygroscopic
BRN 
103024
LogP
-0.14-0.756 at 25℃
CAS DataBase Reference
106-52-5(CAS DataBase Reference)
NIST Chemistry Reference
4-Hydroxy-N-methylpiperidine(106-52-5)
EPA Substance Registry System
4-Piperidinol, 1-methyl- (106-52-5)
More
Less

Safety

Hazard Codes 
Xi,C
Risk Statements 
37/38-41-36/37/38-34
Safety Statements 
26-37/39-45-36/37/39-27
WGK Germany 
3
Hazard Note 
Irritant
TSCA 
Yes
HS Code 
29333999
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
H42206
Product name
N-Methyl-4-piperidinol
Purity
98%
Packaging
100g
Price
$92.3
Updated
2025/07/31
TCI Chemical
Product number
M0933
Product name
4-Hydroxy-1-methylpiperidine
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$28
Updated
2025/07/31
TCI Chemical
Product number
M0933
Product name
4-Hydroxy-1-methylpiperidine
Purity
>98.0%(GC)(T)
Packaging
500g
Price
$221
Updated
2025/07/31
TRC
Product number
H972453
Product name
4-Hydroxy-1-methylpiperidine
Packaging
25g
Price
$70
Updated
2021/12/16
TRC
Product number
H972453
Product name
4-Hydroxy-1-methylpiperidine
Packaging
50g
Price
$95
Updated
2021/12/16
More
Less

N-Methyl-4-piperidinol Chemical Properties,Usage,Production

Chemical Properties

clear colorless to yellowish liquid after melting

Uses

Reactant for:• ;Optimization of Novobiocin scaffold to product antitumor agents1• ;Substitution about the rigidifying ring for histamine H4 receptor antagonist synthesis2Reactant for synthesis of:• ;CaMKII inhibitors3• ;VEGFR and FGFR kinase inhibitors4• ;Phosphoinositide-3-kinase inhibitors5• ;Protein lysine methyltransferase G9a inhibitors6

Uses

4-Hydroxy-1-methylpiperidine is used as reactant for optimization of Novobiocin scaffold to product antitumor agents, substitution about the rigidifying ring for histamine H4 receptor antagonist synthesis. It is also used as a reactant in the synthesis of CaMKII, VEGFR and FGFR kinase inhibitors and Phosphoinositide-3-kinase, Protein lysine methyltransferase G9a inhibitors.

Flammability and Explosibility

Not classified

Synthesis

1445-73-4

106-52-5

The general procedure for the synthesis of 1-methyl-4-piperidinol from N-methyl-4-piperidone was as follows: in standard experiments, the catalyst complex 1 (6.1 mg, 10 mol%) and the hydrogenation reagent H[BAr'4]-(Et2O)2 (10.1 mg, 10 mol%) were dissolved in a 100 mL thick-walled glass reactor fitted with a TEFLON stopper and stirring bar of THF (2.0 mL). Subsequently, the substrate to be hydrogenated (0.5 mmol) was added. The reaction system was degassed by a freeze-pump-thaw cycle and then charged with hydrogen (1 or 4 atm). The reaction mixture was stirred at a set temperature (25-60 °C) until the reaction was complete. At the end of the reaction, the solvent was removed by evaporation and the residue was initially purified by passing through a silica gel column. After removal of solvent under reduced pressure, the crude product was dissolved in CDCl3 and analyzed by 1H NMR. The final product was further purified by column chromatography or preparative thin layer chromatography (TLC) using hexane/ethyl acetate (3:1, v/v) as eluent. The purified products were characterized by 1H NMR and GC-MS, and the spectral data were consistent with those reported in the literature or real samples.

References

[1] Journal of Medicinal Chemistry, 1997, vol. 40, # 16, p. 2474 - 2481
[2] Patent: US2015/336862, 2015, A1. Location in patent: Paragraph 0038; 0054
[3] Patent: US2767190, 1950,
[4] Patent: US2776293, 1950,
[5] Journal of the American Chemical Society, 1948, vol. 70, p. 1826

N-Methyl-4-piperidinol Preparation Products And Raw materials

Raw materials

1-Methyl-4-piperidone

Preparation Products

4-(1-METHYLPIPERIDIN-4-YLOXY)-3,5-DICHLOROBENZENAMINE
More
Less

N-Methyl-4-piperidinol Suppliers

Americas 1 Belgium 3 Canada 1 China 228 Europe 3 France 1 Germany 10 India 44 Italy 1 Japan 5 Slovakia 1 South Korea 3 Switzerland 4 The Netherlands 1 Ukraine 1 United Kingdom 17 United States 62 Global 386
GLR Innovations
Tel
+91 9891111994
Email
info@glrgroup.in
Country
India
ProdList
4535
Advantage
58
TCI Chemicals (India) Pvt. Ltd.
Tel
--
Fax
--
Email
sales-in@tcichemicals.com
Country
India
ProdList
6768
Advantage
58
SL Drugs and Pharmaceuticals Pvt. Ltd.
Tel
--
Fax
--
Email
enquiry@sldrugs.com
Country
India
ProdList
2683
Advantage
50
ALLCHEM LIFESCIENCE PVT. LTD
Tel
--
Fax
--
Email
info@allchemlifescience.com
Country
India
ProdList
317
Advantage
58
VASUDHA PHARMA CHEM LIMITED
Tel
--
Fax
--
Email
vasudha@vasudhapharma.com
Country
India
ProdList
76
Advantage
58
Alfa Aesar
Tel
--
Fax
--
Email
tech@alfa.com
Country
India
ProdList
6905
Advantage
58
Jyoti Chemical Centre
Tel
--
Fax
--
Country
India
ProdList
215
Advantage
58
HiMedia Laboratories
Tel
--
Fax
--
Email
o@himedialabs.com
Country
India
ProdList
1841
Advantage
58
Vamsi Labs Ltd.
Tel
--
Fax
--
Country
India
ProdList
14
Advantage
58
Medkem Laboratories
Tel
--
Fax
--
Email
info@medkem.com
Country
India
ProdList
295
Advantage
58
Fine Chemicals & Scientific Co.
Tel
--
Fax
--
Email
finechemicals@gmail.com
Country
India
ProdList
67
Advantage
58
Meruvax Pharma (South Asia)
Tel
--
Fax
--
Country
India
ProdList
105
Advantage
58
Nivon Specialties (India)
Tel
--
Fax
--
Email
info@nivonindia.com
Country
India
ProdList
154
Advantage
58
Advachem Biosciences Private Limited
Tel
--
Fax
--
Country
India
ProdList
20
Advantage
58
Tagoor Laboratories Pvt. Ltd.
Tel
--
Fax
--
Email
sales@tagoorchemicals.com
Country
India
ProdList
37
Advantage
58
Innovative Synthetic Molecules
Tel
--
Fax
--
Country
India
ProdList
526
Advantage
58
Oceanic Pharmachem Pvt., Ltd. (OPPL)
Tel
--
Fax
--
Email
info@oceanicpharmachem.com
Country
India
ProdList
946
Advantage
58
Saburi Life Sciences
Tel
--
Fax
--
Email
info@saburilifesciences.com
Country
India
ProdList
47
Advantage
58
Clarity Research Laboratory
Tel
--
Fax
--
Email
info@crlabindia.com
Country
India
ProdList
27
Advantage
58
Freesia Chemicals
Tel
--
Fax
--
Country
India
ProdList
25
Advantage
58
Sam Fine O Chem Limited
Tel
--
Fax
--
Email
info@samfinechem.com
Country
India
ProdList
60
Advantage
58
Sam Fine Chem Limited
Tel
--
Fax
--
Country
India
ProdList
18
Advantage
58
National Chemical Co.
Tel
--
Fax
--
Email
bijdeep@gmail.com
Country
India
ProdList
59
Advantage
58
Exim Corporation
Tel
--
Fax
--
Email
info@eximcorp.com
Country
India
ProdList
179
Advantage
58
Molecraft LifeSciences Pvt Ltd
Tel
--
Fax
--
Email
info@molecraft.com
Country
India
ProdList
757
Advantage
0
Lohitha Life Sciences Pvt Ltd
Tel
--
Fax
--
Country
India
ProdList
17
Advantage
58
Lohitha Life Sciences Private Limited
Tel
--
Fax
--
Country
India
ProdList
18
Advantage
58
SynZeal Research Pvt Ltd
Tel
--
Fax
--
Email
standards@synzeal.com
Country
India
ProdList
6514
Advantage
58
CHEMSWORTH
Tel
--
Fax
--
Email
info@chemsworth.com
Country
India
ProdList
6700
Advantage
30
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
Dr Prem's Molecules Pvt. Ltd.
Tel
--
Fax
--
Email
prem@dpmolecules.com
Country
India
ProdList
544
Advantage
50
Parth Antibiotics Pvt Ltd.
Tel
--
Fax
--
Country
India
ProdList
173
Advantage
50
Dr. Reddy's Laboratories Ltd.
Tel
--
Fax
--
Email
talent@drreddys.com
Country
India
ProdList
82
Advantage
82
S. Nihar Exports
Tel
--
Fax
--
Email
nihar@giasbm01.vsnl.net.in
Country
India
ProdList
232
Advantage
50
OCEAN TRADING CORPORATION
Tel
--
Fax
--
Email
otcchem@otcchem.com
Country
India
ProdList
6202
Advantage
58
More
Less

View Lastest Price from N-Methyl-4-piperidinol manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
N-Methyl-4-piperidinol 106-52-5
Price
US $0.10/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000 tons
Release date
2024-08-05
Anhui Ruihan Technology Co., Ltd
Product
1-Methyl-4-piperidinol 106-52-5
Price
US $30.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000t/year
Release date
2023-09-21
Jinan Ande Pharmaceutical Co.,Ltd.
Product
N-Methyl-4-piperidinol 106-52-5
Price
US $0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100
Release date
2021-12-20

106-52-5, N-Methyl-4-piperidinol Related Search:

1-Methyl-4-piperidone Triacetonediamine Tribenuron methyl Pirimiphos-methyl Kresoxim-methyl Haloperidol Methyl salicylate METSULFURON METHYL 2,2,6,6-Tetramethyl-4-piperidinol Methyl acetate CHLOROPHOSPHONAZO III Thiophanate-methyl Methyl STRYCHNINE 1-BENZYL-4-CYANO-4-HYDROXYPIPERIDINE Tropine Parathion-methyl 10,11-Dimethoxystrychnine

  • 1-methyl-4-piperidino
  • 1-Methylpiperidinol-(4)
  • 4-Piperidinol, 1-methyl-
  • N-Methylpiperidol
  • 4-HYDROXY-1-METHYLPIPERIDINE
  • 4-HYDROXY-N-METHYLPIPERIDINE
  • N-METHYL-4-HYDROXY PIPERIDINE
  • NM4PPOL
  • N-METHYL-4-PIPERIDINOL
  • 1-HYDROXY-4-METHYLPIPERIDINE
  • 1-METHYL-4-PIPERIDINOL
  • 1-METHYL-4-PIPERIDINOL HCL
  • 1-METHYL-4-PIPERIDINOLHYDROCHOLORIDE
  • 1-METHYL-4-HYDROXYPIPERIDINE
  • TIMTEC-BB SBB004301
  • 1-methylpiperidin-4-ol
  • N-Methyl-4-hydroxy
  • 4-Hydroxy-1-methylpiperidine 98%
  • 1-Methyl-4-piperidinol, 4-Hydroxy-1-methylpiperidine
  • 4-Hydroxy-l-methylpiperidine
  • N-METIL-4-IDROSSIPIPERIDINA
  • 4-Hydroxy-N-Methylpiperidine, 98% 100GR
  • H431
  • 1- Methyl-4- piperidinealcohol
  • N-Methyl-4-piperidinol, 98%+
  • 4-Hydroxy-1-methylpiperidine,98%
  • N-Methyl-4-piperidinol 98%
  • 1-methyl-4-piperidin-1-iumol
  • Pimavanserin Impurity 12
  • 4-Hydroxy-1-methylpiperidine&gt
  • -4-piperidinoL
  • 4-Hydro xy-Ninethylp iperidine
  • Loratadine Impurity 40
  • N-Methyl-4-hydroxy-piperidine (NMHP)
  • 106-52-5 N-Methyl-4-piperidinol
  • <i>N</i>-Methyl-4-piperidinol
  • N-Methyl-4-hydroxypiperidine 98%
  • 106-52-5
  • 102-52-5
  • Building Blocks
  • Heterocyclic Building Blocks
  • Piperidines
  • Building Blocks
  • C5 to C7
  • Chemical Synthesis
  • Heterocyclic Building Blocks
  • Piperidines
  • PHARMACEUTICAL INTERMEDIATES
  • Piperidine