- Product Name
- CAS No.
- Chemical Name
- Brucin;Brucina;BRUCINE;BrucineGr;l-Brucine;BrucineA.R.;(-)-BRUCINE;BRUCINE ALKALOID;BRUCINE FREE BASE;brucine,anhydrous
- Molecular Formula
- Formula Weight
- MOL File
- Melting point:
- 175-178 °C (dec.)(lit.)
- -118 º (c=2.5 in chloroform)
- Boiling point:
- 518.67°C (rough estimate)
- 1.2119 (rough estimate)
- refractive index
- 1.6300 (estimate)
- storage temp.
- Store at RT
- 8.28(at 25℃)
- White to light beige
- Water Solubility
- Soluble in alcohol, chloroform, and benzene, slightly soluble in water, ether, and glycerol
- Stable. Combustible. Incompatible with strong oxidizing agents.
- CAS DataBase Reference
- 357-57-3(CAS DataBase Reference)
- NIST Chemistry Reference
- EPA Substance Registry System
- Strychnidin-10-one, 2,3-dimethoxy-(357-57-3)
- Hazard statements
H300Fatal if swallowed
H330Fatal if inhaled
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
P320Specific treatment is urgent (see … on this label).
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P405Store locked up.
10,11-Dimethoxystrychnine Chemical Properties,Usage,Production
10,11-Dimethoxystrychnine can be used for antineoplastic, convulsant.
Brucine occurs in the seeds of strychnosspecies (Strychnos nux vomica L. and otherspecies). It is used for denaturing alcoholsand oils; for separating racemic mixtures;and as an additive to lubricants. It is alsoused for colorimetric analysis of nitrate.Therapeutically, it is used as a stimulant.
A white crystalline solid. Combustible but may require some effort to ignite. Toxic by inhalation (vapor, dust, etc.) and ingestion.
Air & Water Reactions
Slightly soluble in water.
Poison by ingestion and inhalation.
The toxicity of brucine is similar to that ofstrychnine. It is a very poisonous alkaloid. Itis a strong convulsant; excites all portions ofthe central nervous system. Toxic symptomsinclude headache, tremor, muscular rigidity,and convulsions. Death may occur fromrespiratory arrest after a few convulsions.
LD50 value, subcutaneous (mice): 60 mg/kg.
Chemical is toxic if inhaled, swallowed, or absorbed through skin. Inhalation produces intense bitter taste. Ingestion causes nausea, vomiting, restlessness, excitement, twitching, and (rarely) convulsions. Contact with dust irritates eyes.
Special Hazards of Combustion Products: Toxic oxides of nitrogen may form in fires.
Rodenticide: Used in the manufacture of other chemicals, in perfumes, as a medication for animals, and as a poison for rodents
DOLCO MOUSE CEREAL®; PIED PIPER MOUSE SEED® (Brucine)
A poison by subcutaneous, intravenous, and intraperitoneal routes. An alkaloid-like strychnine, but one-sixth as toxic. When heated to decomposition it emits toxic fumes of Nx,. See also STRYCHNINE
Crystallise brucine once from water or aqueous Me2CO (as the tetrahydrate), then suspend it in CHCl3 and shake with anhydrous Na2SO4 (to dehydrate the brucine, which then dissolves). Precipitate it by pouring the solution into a large bulk of dry pet ether (b 40-60o), filter and heat to 120o in a high vacuum [Turner J Chem Soc 842 1951]. The tetrahydrate crystallises from a mixture of EtOH and H2O as colourless elongated needles [Eeles Acta Cryst 6 809 1953, Beilstein 27 III/IV 7875.] VERY POISONOUS