Benzyl 4-hydroxy-1-piperidinecarboxylate

Product Name: Benzyl 4-hydroxy-1-piperidinecarboxylate
CAS No.: 95798-23-5
Chemical Name: Benzyl 4-hydroxy-1-piperidinecarboxylate
Synonyms: BENZYL 4-HYDROXYPIPERIDINE-1-CARBOXYLATE;BUTTPARK 93\50-53;1-Cbz-4-piperidinol;1-CBZ-4-hydroxypethidine;1-Cbz-4-hydroxypiperidine;N-CBZ-4-HYDROXYPIPERIDINE;N-CBZ-4-HYDROXY-1-PIPERIDINE;1-Carbobenzoxy-4-piperidinol;1-Carbobenzoxy-4-hydroxypiperidine;1-(Benzyloxycarbonyl)-4-piperidinol
CBNumber: CB5199534
Molecular Formula: C13H17NO3
Formula Weight: 235.28
MOL File: 95798-23-5.mol

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Benzyl 4-hydroxy-1-piperidinecarboxylate Property

Boiling point:: 167 °C/0.2 mmHg (lit.)
Density: 1.554 g/mL at 25 °C (lit.)
refractive index: n20/D 1.543(lit.)
Flash point:: >230 °F
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: Oil
pka: 14.79±0.20(Predicted)
color: Orange
InChI: InChI=1S/C13H17NO3/c15-12-6-8-14(9-7-12)13(16)17-10-11-4-2-1-3-5-11/h1-5,12,15H,6-10H2
InChIKey: JKIUUDJOCYHIGY-UHFFFAOYSA-N
SMILES: N1(C(OCC2=CC=CC=C2)=O)CCC(O)CC1
CAS DataBase Reference: 95798-23-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-37/39
WGK Germany: 3
Hazard Note: Irritant
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 513903
Product name: Benzyl 4-hydroxy-1-piperidinecarboxylate
Purity: 97%
Packaging: 10ml
Price: $174
Updated: 2023/06/20

TCI Chemical

Product number: B4869
Product name: Benzyl 4-Hydroxy-1-piperidinecarboxylate
Purity: >98.0%(GC)
Packaging: 5g
Price: $50
Updated: 2025/07/31

TCI Chemical

Product number: B4869
Product name: Benzyl 4-Hydroxy-1-piperidinecarboxylate
Purity: >98.0%(GC)
Packaging: 25g
Price: $161
Updated: 2025/07/31

TRC

Product number: B130108
Product name: Benzyl4-Hydroxypiperidine-1-carboxylate
Packaging: 10mg
Price: $45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB44151
Product name: Benzyl 4-hydroxy-1-piperidinecarboxylate
Packaging: 500g
Price: $750
Updated: 2021/12/16

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Benzyl 4-hydroxy-1-piperidinecarboxylate Chemical Properties,Usage,Production

Uses

Reactant for synthesis of:
Orally bioavailable P2Y12 antagonists for inhibition of platelet aggregation
Piperidine derivatives
Molecular rods
Oxazolidinone-quinolone hybrids and their antibacterial activity
Cyclic prodrug of RGD peptidomimetic

Reactant for oxidation of alcohols

Synthesis

5382-16-1

501-53-1

95798-23-5

General procedure for the synthesis of N-Benzyloxycarbonyl-4-hydroxypiperidine from 4-hydroxypiperidine and benzyl chloroformate: over 30 min, benzyl chloroformate (8.55 mL; 60 mmol) was slowly added dropwise to a well-stirred 4-hydroxypiperidine (5 g; 49.44 mmol), a 1N aqueous NaOH solution (60 mL; 60 mmol) and dioxane (60 mL) in a in a cooled mixture. After dropwise addition, the reaction mixture was continued to stir for 30 minutes. Upon completion of the reaction, the reaction mixture was treated with water and subsequently concentrated and acidified with hydrochloric acid to pH 2. The acidified aqueous phase was extracted with EtOAc, the organic phases were combined, washed with water and saturated brine in that order, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The crude product was purified by fast column chromatography (silica gel was the stationary phase, and the eluents were petroleum ether with 50% dichloromethane (60-80 °C) and 10% acetonitrile containing 2% methanol in chloroform solution). The final product was 12.5 g (99% yield) of N-Cbz-4-hydroxypiperidine as an oil; mass spectrum (chemical ionization): m/z 236 (M++1), 218, 192, 174, 91.

References

[1] Patent: WO2005/35495, 2005, A2. Location in patent: Page/Page column 129
[2] Patent: US7759387, 2010, B2. Location in patent: Page/Page column 113
[3] Bioorganic Chemistry, 2002, vol. 30, # 4, p. 285 - 301
[4] Chemistry - A European Journal, 2007, vol. 13, # 17, p. 4859 - 4872
[5] Angewandte Chemie - International Edition, 2014, vol. 53, # 12, p. 3236 - 3240

Benzyl 4-hydroxy-1-piperidinecarboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Benzyl 4-hydroxy-1-piperidinecarboxylate Suppliers

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View Lastest Price from Benzyl 4-hydroxy-1-piperidinecarboxylate manufacturers

Career Henan Chemical Co

Product: Benzyl 4-hydroxy-1-piperidinecarboxylate 95798-23-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 150KG
Release date: 2019-07-01

95798-23-5, Benzyl 4-hydroxy-1-piperidinecarboxylateRelated Search:

Benzyl benzoate 4-Nitrobenzyl chloroformate Benzyl acetate Benzyl chloride Benzyl formate Benzyl chloroformate CHLOROPHOSPHONAZO III Benzyl alcohol Benzoyl peroxide Azido-PEG1-CH2CO2H 4-HYDROXY-3-METHYLBENZOIC ACID Hexahydroisonicotinamide 4-Pyrimidinecarboxylic acid Isonipecotic acid 4,4-Piperidinediol hydrochloride Benzyl 4-Hydroxypiperidine trans-3,4-Dihydroxypiperidine-1-carboxylic acid benzyl ester

N-CBZ-4-HYDROXY-1-PIPERIDINE

4-hydroxy-2-piperidinecarboxylic acid (phenylmethyl) ester

BENZYL 4-HYDROXY-1-PIPERIDINECARBOXYLATE

BENZYL 4-HYDROXYPIPERIDINE-1-CARBOXYLATE

BENZYL 4-HYDROXYTETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE

BUTTPARK 93\50-53

N-Benzyloxycarbonyl-4-Hydroxypiperidine

1-Cbz-4-hydroxypiperidine

4-HYDROXY-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER

4-HYDROXYPIPERIDINE, N-CBZ PROTECTED

4-Hydroxypiperidine, N-CBZ protected 97%

N-CBZ-4-HYDROXYPIPERIDINE

Benzyl 4-hydroxy-1-piperidinecarboxylate 97%

1-CBZ-4-hydroxypethidine

1-(Benzyloxycarbonyl)-4-piperidinol

1-(benzyloxycarbonyl)-4-hydroxypiperidine

Benzyl 4-Hydroxy-1-piperidinecarboxylate &gt

1-Piperidinecarboxylic acid, 4-hydroxy-, phenylmethyl ester

1-Carbobenzoxy-4-hydroxypiperidine

1-Carbobenzoxy-4-piperidinol

1-Cbz-4-piperidinol

4-Hydroxy-1-piperidinecarboxylic Acid Benzyl Ester

95798-23-5

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API intermediates

Building Blocks

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Piperidines

pharmacetical