4-Hydroxypiperidine Property

Melting point:

86-90 °C

Boiling point:

108-114 °C/10 mmHg (lit.)

Density 

0.9903 (rough estimate)

vapor pressure 

13Pa at 25℃

refractive index 

1.4400 (estimate)

Flash point:

226 °F

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Solid

pka

14.94±0.20(Predicted)

color 

Off-White to pale Yellow

PH

11.5-11.7 (H2O)Aqueous solution

Water Solubility 

soluble

Sensitive 

Hygroscopic

BRN 

102738

InChIKey

HDOWRFHMPULYOA-UHFFFAOYSA-N

LogP

-0.35 at 25℃

CAS DataBase Reference

5382-16-1(CAS DataBase Reference)

NIST Chemistry Reference

4-Hydroxypiperidine(5382-16-1)

Safety

Hazard Codes 

Xi,C

Risk Statements 

36/37/38-34

Safety Statements 

26-36-37/39-45-36/37/39-27

RIDADR 

3263

WGK Germany 

3

Hazard Note 

Irritant

HazardClass 

8

PackingGroup 

III

HS Code 

29333999

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

4-Hydroxypiperidine Chemical Properties,Usage,Production

Chemical Properties

yellow to yellow-orange wet solid

Uses

4-Hydroxypiperidine (4-Piperidinol) can be used in the synthesis of a highly potent and selective IP (PGI(2) receptor) agonist. It can also be used in the study of copper-catalyzed N- versus O-arylation.

Uses

4-Hydroxypiperidine is used as a reagent for the synthesis of acridine (A190900) derivatives and fibrinogen receptor antagonists.

General Description

The molecular structure, vibrational spectra, NBO and UV-spectral analysis of 4-Hydroxypiperidine have been studied. The compounds with a substituted 4-piperidinol core have been found to be potent antagonists of the human H(3) receptor.

Flammability and Explosibility

Not classified